Ake sifunde nge-Zollinger-Ellison Syndrome ngamagama alula.

Wake wezwa nge- Zollinger-Ellison Syndrome ? Kungase kuzwakale njengegama elingavamile, kodwa kuyisimo esingathinta amathumbu ethu futhi kuyinto okufanele sikhathazeke ngayo. Sibangela izilonda zesisu ezinzima kanye nesifo sohudo esingamahlalakhona ngenxa yokukhiqizwa ngokweqile kwe-asidi esiswini sethu. Ngakho-ke, ake sixoxe ngakho ngemininingwane ethe xaxa namuhla, akunjalo?

Iyini ngempela i-Zollinger-Ellison Syndrome?

Kalula nje, imbangela eyinhloko yalesi simo esibizwa ngokuthi i-Zollinger-Ellison Syndrome (ZES) uhlobo lwesimila esincane esikhula emzimbeni wethu, ikakhulukazi kuma-pancreas noma engxenyeni engenhla yamathumbu amancane (i-duodenum). Sibiza lezi zimila ngokuthi ama-gastrinoma . Empeleni lezi zimila ziwuhlobo lwezimila ze-neuroendocrine .

Bheka manje, la ma-gastrinoma akhiqiza i-hormone ebizwa ngokuthi i-gastrin . Le hormone ye-gastrin yiyo etshela isisu sethu ukuthi "Kulungile, qala ukwenza i-asidi manje." Ngakho-ke, lapho la mathumba ekhiqiza i-hormone ye-gastrin eningi kakhulu, isisu sikhiqiza ne-asidi eningi kakhulu. Cabanga nje ngayo njengompompi ovuza amanzi ngaphandle kokuyivala ngokuqinile, i-asidi yethu yesisu iyanda ngokungalawuleki. Le asidi eningi kakhulu yiyo ebangela izinkinga ezifana nezilonda zesisu kanye ne-acid reflux.

Kuyakhathaza kancane ukuthi cishe ama-60% ala ma-gastrinoma angaba nomdlavuza . Kodwa ungakhathazeki, njengakho konke okunye, kukhona nokwelashwa kwalokhu. Ngezinye izikhathi odokotela babiza lesi simo ngokuthi "i-pancreatic ulcerogenic tumor syndrome."

Ziyini izimpawu zalokhu? Sizizwa kanjani?

Ngezinye izikhathi, i-Zollinger-Ellison syndrome (ZES) ingase ingabingeli zimpawu. Kodwa-ke, uma kuvela izimpawu, zingase zihlanganise:

• Ukushisa kwesisu noma ubuhlungu: Ungase uzwe umuzwa wokushisa esiswini sakho, noma sengathi kukhona okukudlayo. Lokhu kubangelwa yi-asidi eningi.
• Ukuhlanza igazi noma ukuphuma kwegazi endle: Lokhu kubangelwa ukuphuma kwegazi emanxebeni angaphakathi emathunjini (ukopha kwamathumbu).
• Ukukhathala nobuthakathaka: Njengoba kushiwo ngenhla, ngenxa yokulahlekelwa igazi, ungase uzizwe ukhathele futhi ubuthakathaka ngenxa ye-anemia.
• Indle enamafutha, entantayo: Abanye abantu bangase babone ushintsho ezindleleni zabo, okungenzeka ukuthi zinamafutha ngendlela ezibukeka ngayo.
• Isilungulela: Uma sikhuluma iqiniso, umuzwa oshisayo esifubeni obangelwa yi-asidi ephuma emhubheni.
• Ukuqunjelwa, ukungagayi kahle kokudla: Lokhu kungase kuzwakale ikakhulukazi ngemva kokudla ukudla okunamafutha.
• Ukudla akunambitheki.
• Isicanucanu nokuhlanza.
• Ukuba mncane ngaphandle kwesizathu.

Ubunzima balezi zimpawu buxhomeke kubukhulu kanye nenani lama-gastrinoma. Amathumba amakhulu akhiqiza i-gastrin eningi, okubangela ukuthi isisu sikhiqize i-asidi eningi. Lokhu kungenza izimpawu zesifo sesilonda se-peptic zibe zimbi kakhulu.

Khumbula, ngezinye izikhathi lezi zimila zingasakazeka esibindini, okuholela kumdlavuza wesibindi. Uma lokho kwenzeka, kungase kube nezimpawu ezifana nokulunywa, ukuphuzi kwamehlo amhlophe, kanye nokuphuzi kwesikhumba (i-jaundice).

Kungani sibhekene nalesi simo? Yiziphi izizathu?

Esikhathini esiningi, i-Zollinger-Ellison Syndrome (ZES) yenzeka ngezikhathi ezithile , okusho ukuthi kunzima ukukhomba imbangela eqondile.

Kodwa-ke, cishe abantu abangu-25% abanalesi simo batholakale benesifo sofuzo esibizwa ngokuthi i-MEN Type 1 (Multiple Endocrine Neoplasia Type 1) . I-MEN Type 1 iyisimo esingavamile, esizuzwe njengefa lapho izimila zingakhula khona ezindlala eziningi ze-endocrine emzimbeni wethu.

Yiziphi izinkinga ezingavela kulesi simo? Ingabe kufanele ngikhathazeke?

Yebo, i-Zollinger-Ellison Syndrome (ZES) yisimo esingaba yingozi empilweni ngezinye izikhathi . Isibonelo, uma i-gastrinoma ivimba ingxenye engenhla yamathumbu amancane (i-duodenum), ingaqhuma. Ingasakazekela nasesibindini. Ukopha okukhulu kwamathumbu kungenzeka ngenxa ye-asidi eningi esiswini.

Kodwa-ke, ungesabi uma uzwa lezi zinto. Uma lesi sifo sitholakala kusenesikhathi futhi selashwa kahle, lezi zinkinga zingavinjelwa kakhulu.

Odokotela basithola kanjani lesi sifo? (Ukuxilongwa)

Uma unalezi zimpawu, udokotela uzoqala akuhlole, akubuze ngezimpawu zakho nokuthi ngabe kukhona yini emndenini wakho oke waba nalezi zimo. Bese, bangenza izivivinyo ezifana nalezi:

• Ukuhlolwa kwegazi: Lokhu kungahlola ukuthi amazinga e-gastrin hormone egazini lakho aphezulu kakhulu (i-hypergastrinemia).
• Ukuhlolwa kwezithombe: Kungenziwa i-CT scan noma i-MRI scan ukuze kubonakale ukuthi kukhona yini izimila ze-gastrinoma ku-pancreas noma i-duodenum.
• Ukuhlolwa kwe-asidi yesisu: Kulokhu kuhlolwa, udokotela ufaka ithubhu elincane esiswini ngekhala noma ngomlomo bese ethatha isampula ye-asidi lapho.

Uma lezi zivivinyo zokuqala zibona izimila, udokotela angenza ezinye izivivinyo eziningana:

• I-Endoscopy: Kulolu vivinyo, kufakwa ithubhu elincane elinekhamera enamathiselwe ngomlomo bese kuhlolwa umphimbo, isisu, ingxenye engenhla yamathumbu amancane (i-duodenum), kanye ne-pancreas.
• I-ultrasound ye-Endoscopic: Lokhu kuyinhlanganisela ye-ultrasound ne-endoscopy. Kungaveza izithombe ezicacile.
• I-ERCP (i-Endoscopic Retrograde Cholangiopancreatography): Lokhu futhi kuyindlela ekhethekile yokuskena. Ibheka ngaphakathi kwemisele ye-bile kanye nemisele ye-pancreatic.
• Ukufuthwa kwenaliti encane: Uma kukhona isimila, le ndlela isetshenziswa ukuthatha ingxenye yaso encane bese siyihlola amaseli omdlavuza (i-biopsy).

Yiziphi izindlela zokwelapha lokhu? (Ukwelashwa)

Izindlela zokwelapha zincike ekutheni izimpawu zakho zimbi kangakanani nokuthi i-gastrinoma inomdlavuza yini. Kunezinhlobo ezintathu eziyinhloko zokwelapha:

1. Imithi:

• Umuthi oyinhloko ovame ukunikezwa yi- proton pump inhibitors (PPIs) . Le mithi isebenza ngokunciphisa inani le-asidi ekhiqizwa esiswini. Kalula nje, ilawula i-asidi eningi ekhiqizwayo.

2. Ukuhlinzwa:

• Udokotela wakho angase akuncome ukuhlinzwa ukuze kususwe isimila. Kunezinhlobo eziningana zokuhlinzwa:
• Ukususwa kwe-Duodenectomy: Isimila sisuswa ngokusikwa okuncane engxenyeni engenhla yamathumbu amancane (i-duodenum).
• Ukususwa kwesisu: Ukususwa kwengxenye noma sonke isisu.
• Ukuhlinzwa kwesibindi: Uma kukhona izimila esibindini, ziyasuswa.
• Ukususwa kwe-pancreatectomy: Ukususwa kwengxenye noma yonke i-pancreas.
• Ukukhishwa kwezicubu: Uma kukhona izimila ekhanda le-pancreas, yizo kuphela ezisuswa ngokucophelela.

3. Ukwelashwa komdlavuza:

• Uma isimila sinomdlavuza, udokotela wakho angase ancome ukwelashwa okufana nokwelashwa ngamakhemikhali . Lokhu kwelashwa kungasiza ekunciphiseni izimpawu futhi kunciphise ukusabalala kwesimila.

Ingabe ukwelashwa kungayiqeda ngokuphelele?

Uma i-gastrinoma enomdlavuza ingasuswa ngokuphelele ngokuhlinzwa, lesi simo singase selapheke ngokuphelele . Kodwa-ke, lokhu kudinga ukususa wonke amangqamuzana omdlavuza emzimbeni. Ngisho noma ukuhlinzwa kuphumelele, kuzodingeka uphuze imithi yokulawula i-asidi yesisu impilo yakho yonke.

Uma nginalesi simo, yini okufanele ngiyilindele? (Isibikezelo)

Ukubikezela kwakho ngalesi simo kuncike ohlotsheni lwesimila. Ama-gastrinoma angewona umdlavuza awasongeli impilo. Kodwa-ke, uzodinga ukwelashwa okuqhubekayo ukulawula amazinga e-asidi esiswini.

Kodwa-ke, isimo siyashintsha uma unezimila ezinomdlavuza. Uma kunjalo, ungase udinge ukuhlinzwa nokwelashwa komdlavuza okulandelayo.

Amanani okusinda kwabantu abane-Zollinger-Ellison syndrome (ZES) ayahlukahluka. Ngokusho kwedatha, ngemva kokuba wonke ama-gastrinomas esusiwe ngokuhlinzwa, abantu abangaphezu kuka-90% baphila iminyaka emi-5 kuya kweyi-10 . Kodwa-ke, uma wonke amathumba engakwazi ukususwa, izinga lokusinda leminyaka emi-5 lehla laya ku-43%. Kubalulekile ukukhumbula ukuthi lezi yizibalo nje. Uma unalesi simo, khuluma nodokotela wakho ngalokho ongakulindela.

Ngingazinakekela kanjani? Ngingenzani?

Kuya ngesimo sakho. Abantu abaningi kufanele bathathe imithi yokunciphisa i-asidi yesisu impilo yabo yonke. I-Zollinger-Ellison syndrome (ZES) ibangelwa ama-gastrinoma. Iningi lala mathumba lingaba umdlavuza. Ngakho-ke, uma uke waba namathumba anomdlavuza, udinga ukuqhubeka nokubona udokotela wakho ukuze athole ukunakekelwa okulandelayo ukuze abone ukuthi abuye yini.

Kufanele ngiphinde ngimbone nini udokotela?

Ngemva kokwelashwa, uma izimpawu zakho ze-Zollinger-Ellison Syndrome (ZES) ziba zimbi kakhulu noma kuvela izimpawu ezintsha, kufanele ubonane nodokotela ngokushesha.

Uma uthola ukuthi unesifo esingavamile kangaka, ungase umangale futhi wesabe kancane. Kungaba nzima ukuzwa into efana nale ngokuzumayo, yize ungase ungabi nazimpawu. Ungase ube nemibuzo eminingi mayelana nokuthi i-ZES izokuthinta kanjani. Izimpendulo zaleyo mibuzo zingahluka kakhulu kuye ngesimo sakho.

Into ebaluleke kakhulu ukuxoxa ngayo yonke imibuzo yakho nokungabaza nodokotela. Bazokuchazela konke futhi bakunike ukwesekwa okudingayo.

Umyalezo Wokuya Ekhaya:

Kulungile, ake sikhumbule amanye amaphuzu abaluleke kakhulu kulokho esikhulume ngakho:

• I-Zollinger-Ellison Syndrome (ZES) yisimo esibangelwa isimila esibizwa ngokuthi i-gastrinoma, esibangela izilonda zesisu kanye nesifo sohudo ngenxa ye-asidi eningi esiswini.
• Izimpawu ezifana nobuhlungu besisu, ukuhlanza igazi, ubuhlungu besifuba, kanye nokwehla kwesisindo zingase zibe khona.
• Iningi lala mathumba lingaba umdlavuza.
• Lesi sifo sitholakala ngokuhlolwa kwegazi, ama-scan, kanye ne-endoscopy.
• Ukwelashwa kuhlanganisa imithi (ama-PPI), ukuhlinzwa, kanye ne-chemotherapy.
• Ukutholwa kusenesikhathi kanye nokwelashwa kungavimbela izinkinga futhi kukhuthaze ukululama.
• Uma unalesi simo, landela imiyalelo kadokotela wakho ngqo, uhlolwe ngesikhathi, bese ukhuluma nodokotela wakho ngaphandle kokugodla lutho.

Ngiyethemba ukuthi lolu lwazi luwusizo kuwe. Hlala uphilile!

I- Zollinger-Ellison Syndrome, i-gastrinoma, i-asidi yesisu, izilonda ze-peptic, isifo sohudo, ama-hormone, umdlavuza