Biribiara a ɛsɛ sɛ wuhu fa ALP bo a ɛwɔ wo mogya amanneɛbɔ mu (Alkaline Phosphatase - ALP) .

So woayɛ mogya mu nhwehwɛmu pɛn, agye amanneɛbɔ no, ahwɛ nkyerɛwde ne nɔma a ɛwɔ so no, na woasusuw sɛ, "Dɛn ne eyi?" Wɔ nkyerɛwde pii te sɛ ALT, AST, ne GGT mu no, ebia woahu botae bi nso a wɔfrɛ no "ALP." Sɛ nnipa pii hu eyi a, ɛhaw wɔn kakra. Enti, ɛnnɛ yɛbɛka nea Alkaline Phosphatase yi, anaa ALP tiawa yi yɛ, nea ɛhwehwɛ wɔ sɔhwɛ yi mu, ne nea ɛsɛ sɛ yehu bere a ne gyinapɛn ahorow sesa no ho asɛm.

Dɛn ankasa ne ALP?

Sɛ yɛbɛka no tiawa a, Alkaline Phosphatase (ALP) yɛ enzyme bi a ɛwɔ yɛn nipadua nyinaa mu. Enzyme yɛ protein soronko bi a ɛwɔ yɛn nkwammoaa mu. Te sɛ afiri a ɛde ahoɔhare tu mmirika wɔ adwumayɛbea no, saa enzymes yi boa na ɛma nnuru ahorow kɔ yɛn nipadua mu ntɛmntɛm. Saa enzymes yi mpempem pii wɔ yɛn nipadua mu.

Ɛwom sɛ nnuruyɛfo ayɛ nhwehwɛmu wɔ ALP ho mfe pii de, nanso wɔda so ara nnim 100% yiye nea ɛyɛ ne dwumadi pɔtee. Nanso, wɔahu sɛ ɛka nneɛma pii a ɛho hia wɔ nipadua no mu ho.

Sɛ wɔreka ALP ho asɛm a, wɔtaa frɛ no "mrɛbo mu enzyme." Nea enti a ɛte saa ne sɛ ALP dodow no ara wɔ yɛn mmerɛbo mu. Nanso ɛnyɛ mmerɛbo no nkutoo mu. Wohu wɔ mmeae afoforo nso.

• Wo bile ntini: Ntini a ɛde bile a mmerɛbo no yɛ no kɔ akisikuru no mu, na ɛhɔ na wɔkora so.
• Wo nnompe mu: Ɛno kyerɛ sɛ wo nnompe mu.
• Wɔ asaabo mu.
• Ntini a ɛwɔ nipadua no mu.
• Ɛnanom a wɔyem awotwaa.

Enti, sɛ ALP dodow a ɛwɔ wo mogya mu no kɔ soro anaasɛ ɛba fam wɔ ɔkwan a ɛnteɛ so a, ɛyɛ sɛnkyerɛnne a ɛkyerɛ sɛ ebia ɔsɛe bi anaa nsakrae bi bɛba wɔ adeyɛ bi mu wɔ saa akwaa yi biako mu.

Dɛn ne ALP mogya mu nhwehwɛmu?

ALP mogya mu nhwehwɛmu kyerɛ ALP dodow a ɛwɔ wo mogya mu. Sɛnea yɛadi kan aka no, ɛwom sɛ wohu ALP wɔ nipadua no nyinaa mu de, nanso nneɛma atitiriw abien a ɛma ALP boaboa ano wɔ mogya no mu ne mmerɛbo ne nnompe. Enti, sɛ ALP dodow a ɛwɔ mogya no mu kɔ soro a, ebetumi ayɛ mmerɛbo mu yare anaa nnompe mu yare bi ho sɛnkyerɛnne. Nanso kae sɛ, ALP nhwehwɛmu nkutoo ntumi nhu yare bi.

ALP sɔhwɛ ahorow atitiriw abien na ɛwɔ hɔ.

1. ALP sɔhwɛ a wɔyɛ no daa: Eyi ne sɔhwɛ a wɔtaa yɛ sen biara. Mpɛn pii no, sɛ oduruyɛfo bi ka kyerɛ wo sɛ yɛ `Comprehensive Metabolic Panel (CMP)` anaa `Liver Panel (LFT)`, a ɛhwɛ mmerɛbo no a, akyinnye biara nni ho sɛ ɛbɛka ALP bo no ho.

2. ALP isoenzyme sɔhwɛ: .Eyi yɛ sɔhwɛ titiriw kakra. ALP nhwehwɛmu a wɔyɛ no daa no kyerɛ wo ALP dodow a ɛwɔ wo mogya mu nkutoo. Nanso saa isoenzyme nhwehwɛmu yi betumi akyerɛ wo pɛpɛɛpɛ sɛ ebia ALP a ɛboro so a ɛwɔ wo mogya mu no fi wo mmerɛbo, wo nnompe, anaa baabi foforo. Sɛ wo ALP dodow kɔ soro yiye a, ebia wo duruyɛfo bɛhyɛ nhwehwɛmu yi na ama wahu nea ɛde ba ankasa. Nanso ɛyɛ den kakra na ne bo yɛ den, enti ɛnyɛ lab nyinaa na wɔyɛ.

Dɛn nti na yehia ALP sɔhwɛ yi?

Ebia nneɛma pii nti na wo duruyɛfo betumi ahyɛ sɛ wɔnyɛ ALP nhwehwɛmu.

• Nhwehwɛmu: Ɛtɔ mmere bi a, sɛ sɛnkyerɛnne biara nni hɔ mpo a, wɔhwɛ ALP sɛ wo afe afe nhwehwɛmu a woyɛ daa CMP anaa LFT amanneɛbɔ no fã na ama wɔanya ɔhaw bi a ɛwɔ mmerɛbo mu anaa baabi foforo ho nsɛnkyerɛnne ansa na sɛnkyerɛnne ahorow no ada adi.
• Hwɛ: Sɛ wowɔ mmerɛbo anaa nnompe mu yare dedaw a, wɔde nhwehwɛmu yi nso di dwuma de hwɛ sɛ ebia tebea no retu mpɔn, ɛrekɔ so ayɛ nea ɛte saa ara, anaasɛ ɛreyɛ kɛse bere a wɔde sa yare no.
• Sɛ́ mmoa a wɔde hu yare no: Sɛ wowɔ sɛnkyerɛnne ahorow a ɛfa mmerɛbo anaa nnompe mu yare bi ho a, ALP nhwehwɛmu yɛ ade titiriw a ɛma wohu yare no.

Nsɛnkyerɛnne a ebetumi ama oduruyɛfo asusuw ALP nhwehwɛmu ho

Sɛ wowɔ sɛnkyerɛnne a ɛwɔ ase ha yi a, ebia wo duruyɛfo de wo bɛkɔ akɔyɛ nhwehwɛmu yi.

Dɛn na ɛba ansa na wɔreyɛ mogya mu nhwehwɛmu ne bere a wɔreyɛ no?

Sɛ wo duruyɛfoɔ ka kyerɛ wo sɛ yɛ saa ALP nhwehwɛmu yi sɛ CMP fã a, ɛbɛhia sɛ wodi mmuada bɛyɛ nnɔnhwereɛ 10-12. Nanso wubetumi anom nsu. Nanso, sɛ wɔka kyerɛ wo sɛ yɛ mogya mu nhwehwɛmu a, wo duruyɛfo bɛma wo akwankyerɛ pɔtee a ɛfa nea ɛsɛ sɛ woyɛ ansa na wɔayɛ no ho. Ɛho hia paa sɛ yedi saa akwankyerɛ ahorow no akyi.

Eyinom ne nneɛma a ɛtaa si bere a wɔtwe mogya no.

1. Wɔbɛtra akongua so, na ɔyarehwɛfo anaa oduruyɛfo bi behu ntini bi a ɛfata wɔ wo basa mu a wobɛtwe mogya afi mu. Eyi taa yɛ wo nsateaa mu.

2. Sɛ wuhu ntini no wie a, fa biribi te sɛ nsa a wɔde petepete baabi no ho yiye.

3. Afei, wɔde ade ketewaa bi hyɛ ntini no mu na wɔfa mogya. Saa bere yi de, ebia wobɛte nka sɛ worebɔ wo kakra, te sɛ ntɛtea ketewa bi a ɔrebɔ wo.

4. Sɛ woboaboa mogya dodow a ɛho hia ma nhwehwɛmu no ano gu afiri mu wie a, yi ade no na fa kotoku bi mia baabi a wɔfaa mogya no.

5. Sɛ mogya no gyae a, wɔde plaster ketewaa bi gu beae no na wɔyɛ adwuma no wie.

Adeyɛ no nyinaa gye nea ennu simma anum. Ebia ɛyaw ne akuru kakra wɔ baabi a wɔtwee mogya no. Nanso ɛno befi hɔ wɔ da koro anaa nnanu mu.

Wote amanneɛbɔ no mu nsɛm ase dɛn?

Mpɛn pii no wubetumi anya amanneɛbɔ no wɔ da koro anaa nna abien mu. Amanneɛbɔ no kura nsɛm te sɛ eyi:

• Sɔhwɛ no din (sɛ nhwɛso no, Alkaline Phosphatase).
• Nea efi mu ba (ALP bo a ɛwɔ wo mogya mu).
• Nneɛma a ɛkɔ so daa.
• Sɛ́ ebia wo bo yɛ nea ɛfata, ɛkorɔn, anaasɛ ɛba fam.

Nneɛma a wogye tom kɛse ne amanaman ntam 44 kosi 147 wɔ lita biara mu (44 kosi 147 IU/L). Nanso, wɔ mmeae bi no, wobu eyi nso sɛ IU/L 30 kosi 120.

Afei nso, ALP gyinapɛn ahorow a ɛfata no gu ahorow a egyina mfe a obi adi ne ɔbarima anaa ɔbea so.

• Mmofra ne mmerante ne mmabaa: Mmofra ne mmabun wɔ ALP dodow a ɛkɔ soro fi awosu mu efisɛ wɔn nnompe reyɛ kɛse.
• Mfe 15-50 ntam: Mmarima wɔ ALP dodow a ɛkɔ soro kakra sen mmea.
• Sɛ obi nyin a: ALP dodow kɔ soro kakra bio bere a yɛrenyin no.
• Bere a wɔyem: Ɛtaa ba sɛ ɛnanom a wɔyem no ALP dodow kɔ soro efisɛ wɔyɛ ALP wɔ awotwaa no mu.
• Sɛ dompe a abubu sa: Sɛ dompe bi bubu a, ALP dodow betumi akɔ soro bere a nnompe mu nkwammoaa yɛ adwuma bere a ɛsa no.

Dɛn na ALP a ɛkɔ soro no kyerɛ?

Sɛ wo ALP dodow kɔ soro a, ɛyɛ ade a ɛfata sɛ wobɛte nka sɛ wohaw wo ho kakra. Nanso, ade a edi kan a ɛsɛ sɛ yɛkae ne sɛ ɛnyɛ bere nyinaa na ALP dodow a ɛkɔ soro kakra no yɛ yare a emu yɛ den ho sɛnkyerɛnne. Ebia wo duruyɛfo besi gyinae sɛ ɔrenyɛ nhwehwɛmu foforo biara na wahwɛ wo ALP dodow so bio kɛkɛ wɔ bere tiaa bi mu.

Nanso, ALP dodow a ɛkɔ soro yiye no kyerɛ denneennen sɛ mmerɛbo asɛe anaasɛ nnompe mu yare. Sɛ w’amanneɛbɔ ka sɛ ALP kɔ soro a, wo duruyɛfo betumi ahyɛ sɛ wɔnyɛ nhwehwɛmu foforo (e.g., isoenzyme nhwehwɛmu, mmerɛbo mu nhwehwɛmu) na ama wɔahu nea ɛde ba.

Yebetumi akyekyɛ nneɛma atitiriw a ɛma ALP tumi kɔ soro no mu abien.

Nneɛma a ɛde ba a ɛfa mmerɛbo ne bile ntini ho

• Cholestasis of pregnancy: Mmɛn mu yare a ebetumi aba wɔ nyinsɛn no fã a etwa to no mu.
• Mberɛbo mu yare: Mmerɛbo no sɛe daa bere a mmerɛbo mu nkwammoaa wuwu na wɔde akuru ntini si ananmu no.
• Hepatitis: Mmɛn mu yare a ɛyɛ hyew. Eyi betumi afi mmoawa, nsa, anaa nneɛma afoforo a ɛde ba.
• Bile duct obstruction: Ntini a ɛde bile fi mmerɛbo mu no siw esiane akisikuru, kokoram akisikuru, anaa nneɛma afoforo nti.
• Mononucleosis: Wɔsan frɛ no "afew yare," saa ɔyare mmoawa yi betumi ama ɛtɔ mmere bi a mmerɛbo no ahonhon.

Nnompe (nnompe) ho nneɛma a ɛde ba

• Paget yare a ɛfa dompe ho: Tebea a ɛntaa nsi a nnompe bubu na ɛsan nyin wɔ ɔkwan a ɛnteɛ so.
• Osteogenic sarcoma: Kokoram bi a efi ase wɔ nnompe mu.
• Nnompe a ɛkɔ mmeae afoforo: Kokoram fi beae foforo te sɛ nufu anaa ahurututu mu trɛw kɔ nnompe no mu.
• Hyperparathyroidism: Calcium dodow a ɛkɔ soro wɔ mogya no mu esiane hormone ahorow a parathyroid ntini no yi fi mu dodo nti.
• Hyperthyroidism: Nkwammoaa a thyroid ntini no yɛ dodo.
• Osteomalacia: Tebea a nnompe yɛ mmerɛw na ɛnyɛ den sɛ ebebubu esiane vitamin D a enni nipadua mu nti. Sɛ eyi ba mmofra so a, yɛfrɛ no Rickets.
• Akisikuru a ɛsa yare.

Dɛn ne nneɛma a ebetumi ama ALP dodow a ɛba fam aba?

Ɛntaa mma koraa sɛ ALP dodow bɛkɔ fam wɔ ɔkwan a ɛnteɛ so, nanso nneɛma pii wɔ hɔ a ebetumi ama eyi aba.

• Aduan pa a wonnya nni: Aduan pa a nipadua no hia a wonnya.
• Zinc a enni nipadua mu.
• Magnesium a enni nipadua mu.
• Hypothyroidism: Ntini a ɛma mogya tu no dwumadi so tew.
• Awosu mu nyarewa a ɛntaa nsi: Tebea horow a ɛntaa nsi te sɛ `Hypophosphatasia` ne `Wilson yare`.

So ɛsɛ sɛ mehaw me ho sɛ me ALP dodow kɔ soro anaasɛ ɛba fam a?

Ebia nnipa bɛyɛ 20 biara a wɔwɔ apɔwmuden mu biako benya sɔhwɛ mu aba a ɛboro nea ɛfata so. Nneɛma afoforo nso betumi aka ALP gyinapɛn ahorow.

• Nnuru bi: Nnuru bi, te sɛ nnuru a wɔde siw awo ano.
• W’aduan a wudi.
• Nyinsɛn a wɔde di dwuma.
• Mfe a wɔadi: Sɛnea yɛadi kan aka ho asɛm no, mfaso a ɛwɔ mmofra a wɔrenyin so no yɛ kɛse.
• Mfomso a ɛba bere a wɔregye mogya no, wɔde rekɔ, anaa wɔresɔ ahwɛ no.

Enti, wo duruyɛfo no renyina ALP bo nkutoo so nsi gyinae da. Obesusuw nea edidi so yi nyinaa ho:

• Wo aduruyɛ ho abakɔsɛm a edi mũ.
• Nnuru bɛn na worenom mprempren?
• Sɛnea wo ALP bo no korɔn anaasɛ ɛba fam.
• Nea efii sɔhwɛ afoforo a wɔhwɛɛ mu kaa ALP ho (e.g. ALT, GGT, Bilirubin) mu bae.
• So wowɔ sɛnkyerɛnne bi?

Sɛ wode eyinom nyinaa bom a, ɛbɛma woahu sɛ ebia wuhia nhwehwɛmu foforo anaa ayaresa.