Sɛ wohu sɛ wowɔ nufu mu kokoram a, wo duruyɛfo bɛyɛ nhwehwɛmu pii de ahu kokoram nkwammoaa no ho nsɛm pii. Wɔtaa yɛ eyi denam kokoram no ntini no fã bi a wɔfa oprehyɛn anaa nipadua mu nhwehwɛmu so. Saa sɔhwɛ ahorow yi mu biako ne sɛ wɔbɛhwɛ sɛ kokoram nkwammoaa no wɔ ‘ hormone receptors ’ anaa. Fa saa ntini ahorow yi ho asɛm sɛ ‘aponkɛse’ nketenkete a ɛwɔ nkwammoaa no ani. Sɛ ‘nsafe’ a wɔfrɛ no hormone no hyɛ saa nkɔnsɔnkɔnsɔn yi mu a, nkwammoaa no nsa ka nkrasɛm bi ma enyin.
Progesterone yɛ hormone a efi awosu mu yɛ wɔ yɛn nipadua mu. Ɛho hia paa ma nneɛma te sɛ mmabunbere, brayɛ, ne nyinsɛn wɔ mmea mu. Nufu mu kokoram nkwammoaa binom wɔ nneɛma a ɛma wonya kokoram wɔ wɔn ani a ebetumi akyekyere saa hormone yi. Wɔfrɛ saa kokoram yi progesterone-receptor positive, anaasɛ PR-positive (PR+) nufu mu kokoram kɛkɛ. Nea ɛba wɔ asɛm yi mu ne sɛ hormone progesterone no ba na ɛkyekyere kokoram nkwammoaa no na ɛboa ma wonyin kɔ akyiri. Enti, ayaresa ahorow a wɔde sa eyi no bɔ mmɔden sɛ wobegyae saa hormone adeyɛ yi.
Hormone foforo a ɛyɛ adwuma wɔ ɔkwan a ɛte saa ara so ne estrogen. Sɛ kokoram nkwammoaa no wɔ estrogen agyefo a, wɔfrɛ no estrogen-receptor positive, anaa ER-positive (ER+) kokoram.
Hena na ɔwɔ asiane kɛse mu sɛ obenya tebea yi?
Sɛ wo kokoram nkwammoaa no wɔ PR, ER, anaa n’abien nyinaa a, wɔtaa frɛ no hormone-receptor positive (HR+) nufu mu kokoram. Nea eye ne sɛ, nufu mu kokoram 10 a wohu no mu bɛyɛ 7 pɛ na ɛyɛ saa. Ɛwom sɛ kokoram a ɛte sɛɛ betumi anya mfe biara de, nanso ɛtaa ba mmea a wɔatwa brayɛ mu no mu.
Mpɛn pii no, asiane ahorow koro no ara a ɛka nufu mu kokoram biara nso ka kokoram a ɛwɔ HR-positive. Momma yɛnhwɛ nea wɔyɛ.
| Asiane a ɛde ba | Sɛ yɛbɛka no tiawa a... |
|---|---|
| Ɔbea a obi yɛ | Mmea wɔ asiane kɛse mu sɛ wɔde toto mmarima ho a. |
| Mpanyinyɛ | Asiane no kɔ soro bere a obi nyin no. |
| Nneɛma a ɛnteɛ wɔ nufu mu nkwammoaa mu | Sɛ woadi kan anya nkwammoaa nyin a ɛnteɛ wɔ nufu no mu (e.g. LCIS ). |
| Abusua abakɔsɛm | Sɛ abusua muni bi a ɔbɛn no anya nufu mu kokoram a. |
| Mmabunbere mfiase | Brayɛ fi ase ansa na wadi mfe 12. |
| Mmofra a wɔbɛwo akyiri | Wo ba a odi kan a wobɛwo bere a wadi mfe 35 akyi anaasɛ worennyinsɛn da. |
| Bere a obi gyae bratwa akyiri yi | Menopause bere a wadi mfe 55 akyi. |
| Hormone ayaresa a wɔnom | Aduru a wɔde si hormone ananmu a wɔnom bere a wɔagyae brayɛ akyi. |
Dɛn ne sɛnkyerɛnne ahorow no?
Mpɛn pii no, mmea dodow no ara nni sɛnkyerɛnne biara bere a wohu sɛ wɔwɔ nufu mu kokoram no. Mmom no, wohu no wɔ akwanhyia mu bere a wɔreyɛ nufu mu nhwehwɛmu a wɔyɛ no daa no.
Nufu mu kokoram a ɛwɔ HR no ho sɛnkyerɛnne te sɛ nufu mu kokoram ahorow afoforo de . Nsɛnkyerɛnne a ɛtaa ba no bi ni.
| Nsɛnkyerɛnne a ɛkyerɛ | Hwɛ eyi so yiye. |
|---|---|
| Akuru foforo a ɛba nufu no mu | Akuru foforo biara a wubetumi ate nka, sɛ ɛnyɛ yaw mpo a. |
| Nufu mu a ɛho ahonhon | Nufu no nyinaa anaa ne fã bi a ɛho ahonhon. |
| Nufu anaa nufu mu yaw | Ɛyaw a ɛyɛ soronko a ɛkɔ so daa. |
| Honam ani nsakrae | Wora a akɔ fam, akutu a ɛyɛ fɛ, honam ani a ɛyɛ den, ɛyɛ kɔkɔɔ, anaasɛ honam ani a ɛyɛ nwunu na ɛyɛ nsensanee. |
| Nufusu no sesa | Nufu no mu yɛ den anaasɛ nsu fi mu ba. |
| Ntini a ɛma mogya tu a ahonhon | Nkuruwankuruwa a ɛwɔ abasa mu anaa kɔn ho a wotumi kyere wɔ nsa no mu. |
Ɔkwan bɛn so na wɔde hormone ayaresa di dwuma?
Sɛ woreyɛ w’ayaresa nhyehyɛe a, akyinnye biara nni ho sɛ wo duruyɛfo no besusuw wo kokoram no hormone tebea ho. Hormone ayaresa ne kokoram a PR-positive ayaresa titiriw ne nea ɛho hia sen biara. Botae no ne sɛ wobesiw kokoram nkwammoaa ano sɛ wɔmfa hormone nni dwuma nyin.
Sɛ yɛbɛka no tiawa a, hormone therapy twa ‘aduan’ (hormone) a kokoram no hia no mu.
Wobetumi afa akwan titiriw abien so ayɛ eyi:
- Oprehyɛn a wɔde yi awotwaa no : Eyi ma nipadua no mu nkwaadɔm a ɛma nipadua no yɛ adwuma no so tew.
- Hormone therapy pills anaa injections: Saa nnuru yi mma nipadua no ntumi nyɛ hormone, anaasɛ esiw receptors (locks) a ɛwɔ kokoram nkwammoaa so no ano, na ɛmma ɛnkyekyere hormone (keys).
Hormone ayaresa ko a wobenya nso begyina sɛ ebia woakɔ brayɛ mu anaa. Wobetumi de saa ayaresa yi adi dwuma wɔ kokoram no fã biara. Ɛdenam baabi a kokoram no kɔ so no, wɔde hormone ayaresa ma ka ayaresa afoforo te sɛ oprehyɛn anaa nnuru a wɔde sa yare ho.
Dɛn ne ayaresa afoforo?
Wɔ hormone ayaresa akyi no, wobetumi ama wo nea edidi so yi mu biako anaa nea ɛboro saa wɔ nufu mu kokoram a PR-positive ho .
- Oprehyɛn: Oprehyɛn a wɔyɛ de yi kokoram nkwammoaa fi hɔ. Sɛ nhwɛso no, sɛ wobeyi akuru no nkutoo afi hɔ (`Lumpectomy`) anaasɛ wobeyi nufu no nyinaa afi hɔ (`Mastectomy`).
- Nnuru a wɔde sa yare: Nnuru a ano yɛ den a wɔde ma de sɛe kokoram nkwammoaa.
- Mframa a wɔde sa yare : Ɛde mframa a ahoɔden wom kɛse di dwuma de sɛe kokoram nkwammoaa biara a aka.
- Targeted Therapy: Nnuru a wɔde si protein pɔtee bi a ɛboa ma kokoram nkwammoaa nyin so. Eyinom nso betumi ama hormone ayaresa a etu mpɔn no ayɛ kɛse.
Dɛn ne nkɔmhyɛ no?
Asɛmpa bi ni ma wo. Kokoram a ɛwɔ hormone-receptor-positive (HR+) no taa nyin brɛoo sen kokoram a ɛwɔ hormone-receptor-negative (HR-Negative) no. Afei nso, wowɔ mfaso wɔ ayaresa mu efisɛ ebetumi asiw hormone ahorow no dwumadi kwan na ama kokoram no anyin. Nanso, sɛnea ɛte wɔ kokoram biara ho no, daakye ayaresa no gyina sɛnea wobehu no ntɛm no so.
Nanso biribi wɔ hɔ a ɛsɛ sɛ yɛkae. Bere a hormone ayaresa tumi siw kokoram nyin ne ne trɛw so no, ɛtɔ mmere bi a ebetumi asi wɔ mfe pii akyi wɔ ayaresa akyi. Eyi nti na ɛtɔ mmere bi a nnuruyɛfo de hormone ayaresa ma bere tenten, ɛtɔ mmere bi a mfe 5 anaa 10.
Enti, ɛho hia yiye sɛ wo ne wo duruyɛfo bɛkasa pefee na emu ada hɔ afa wo kokoram no hormone receptor tebea ne sɛnea ɛbɛka w’ayaresa nhyehyɛe ne ɔkwan a wobɛfa so akɔ w’anim no ho.
Nkrasɛm a Wɔde Kɔ Fie
- PR-Positive (PR+) nufu mu kokoram kyerɛ sɛ kokoram nkwammoaa no de hormone progesterone di dwuma ma enyin.
- Kokoram a ɛte sɛɛ abu so kɛse, titiriw bere a obi agyae brayɛ akyi.
- Hormone ayaresa yɛ ayaresa kwan a etu mpɔn yiye na ɛyɛ titiriw a wɔde di dwuma ma eyi.
- Mpɛn pii no, kokoram ahorow yi ho nkɔmhyɛ yɛ papa efisɛ enyin nkakrankakra, nanso ɛho hia sɛ wɔde bere tenten sa yare ne aduruyɛ mu nhwehwɛmu a wɔyɛ no daa na amma ansan ankɔ so bio.
- Mma ntwentwɛn wo nan ase da sɛ wo ne wo duruyɛfo bɛkasa afa wo tebea, ayaresa, ne nneɛma biara a ɛhaw wo ho.
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