Sɛ oduruyɛfo no ka kyerɛ wo sɛ wowɔ nufu mu kokoram a, ɛbɛyɛ sɛ wotee ehu ne ahodwiriw kɛse nka. ‘Dɛn na mɛyɛ mprempren?’, ‘Aduru bɛn na wɔde bɛma me?’, ‘So mɛyɛ chemo ?’. Ɛbɛyɛ sɛ nsɛmmisa pii baa m’adwenem. Yenim sɛ kokoram a yɛbɛko atia no nyɛ akwantu a ɛyɛ mmerɛw. Nanso nnɛyi aduruyɛ ho nyansahu anya nkɔso kɛse. Wɔ bere a ɛte sɛɛ mu no, ɛnnɛ yɛreka sɔhwɛ titiriw bi a ɛboa nnuruyɛfo ma wosi ayaresa pɔtee a wɔde bɛma wo ho asɛm.
Dɛn ne Oncotype DX?
Sɛ yɛbɛka no tiawa a, Oncotype DX yɛ sɔhwɛ titiriw a ɛhwɛ wo nufu mu kokoram nkwammoaa no mu kɔ akyiri. Ɛnyɛ mogya mu nhwehwɛmu a wɔyɛ no daa. Ɛde kokoram ntini bi a wogye fii nipadua mu nhwehwɛmu mu di dwuma de si wo kokoram no so dua anaasɛ oprehyɛn a wɔyɛe de yi akisikuru no.
Saa sɔhwɛ yi hwɛ sɛnea awosu mu nkwaadɔm bi a ɛwɔ kokoram nkwammoaa mu no yɛ adwuma. Te sɛ yɛn nkwammoaa nyinaa no, kokoram nkwammoaa nso wɔ awosu mu nkwaadɔm. Saa awosu mu nkwaadɔm yi na ɛkyerɛ sɛnea kokoram no yɛ n’ade, kyerɛ sɛ, sɛnea emu yɛ den, sɛnea ebetumi atrɛw ntɛmntɛm, ne sɛnea ɛda adi sɛ ɛbɛsan aba bere a wɔasa no yare awie no.
Oncotype DX sɔhwɛ no twe adwene si awosu mu nkwaadɔm 21 so, na ɛno nti na ebia wobɛte sɛ wɔfrɛ no “21-gene signature” sɔhwɛ no. Ɛdenam awosu mu nkwaadɔm yi mu nhwehwɛmu so no, nnuruyɛfo betumi asua wo kokoram no ho nsɛm a ɛho hia pii.
Hena na wɔkamfo kyerɛ sɛ ɔnyɛ sɔhwɛ yi?
Saa nhwehwɛmu yi ho nhia mma ɔyarefo biara a ɔwɔ nufu mu kokoram. Ɛda adi sɛ wo duruyɛfo bɛkamfo nhwehwɛmu yi akyerɛ sɛ wowɔ tebea horow a edidi so yi mu biara a:
- Sɛ wowɔ kokoram a edi kan (Stage I anaa II): Eyi kyerɛ sɛ kokoram no nnya ntrɛwee wɔ nipadua no afã horow a ɛwɔ akyirikyiri.
- Sɛ kokoram no yɛ estrogen-receptor positive (ER+): Eyi kyerɛ sɛ kokoram nkwammoaa no nyin esiane hormone estrogen a wo nipadua no yɛ nti. Wɔtaa de hormone ayaresa na ɛsa kokoram a ɛte sɛɛ .
- Sɛ kokoram no ntrɛw nkɔ ntini a ɛwɔ nan no mu no mu a.
Bio nso, ɛtɔ mmere bi a wobetumi ayɛ sɔhwɛ yi ama nnipa a wɔwɔ kokoram a edi kan koraa a wɔfrɛ no DCIS (Ductal Carcinoma in Situ) , de aboa ma wɔasi gyinae sɛ ebia ɛho hia sɛ wɔde mframa a wɔde sa yare no di dwuma anaa.
Ade a ɛho hia sen biara ne sɛ mmoa kɛse a efi sɔhwɛ yi mu ne akwankyerɛ a wunya wɔ gyinae a wubesi sɛ ebia wuhia nnuru a wɔde sa yare de ka hormone ayaresa ho anaasɛ wunhia no mu.
Ɔkwan bɛn so na wokenkan sɔhwɛ mu nkontaahyɛde no?
Oncotype DX sɔhwɛ no ma wo “Recurrence Score” a ɛwɔ 0 kosi 100. Dodow a saa nkontabuo yi kɔ soro no, dodow no ara na asiane a ɛwɔ hɔ sɛ kokoram no bɛsan aba wɔ ayaresa akyi no yɛ kɛse. Nanso, ɔkwan a wɔfa so kenkan nkontaahyɛde yi bɛsono kakra a egyina mfe a woadi so.
| Nkonimdi Range | Ahudeɛ | Nyansahyɛ a Ebetumi Ayɛ |
|---|---|---|
| 0 – 25 na ɛwɔ hɔ | Asiane a ɛba fam | Ebia hormone ayaresa nkutoo bɛdɔɔso. Hokwan kakraa bi pɛ na ɛwɔ hɔ sɛ wobenya mfaso foforo afi nnuru a wɔde sa yare mu. |
| 26 – 100 na ɛwɔ hɔ | Asiane a ɛkorɔn | Asiane a ɛwɔ hɔ sɛ kokoram no bɛsan aba no yɛ kɛse. Ebia wɔbɛkamfo nnuru a wɔde sa yare ne hormone ayaresa nso akyerɛ. |
| Nkonimdi Range | Ahudeɛ | Nyansahyɛ a Ebetumi Ayɛ |
|---|---|---|
| 0 – 15 na ɛwɔ hɔ | Asiane a ɛba fam | Ebia hormone ayaresa nkutoo bɛdɔɔso. Hokwan kakraa bi na ɛwɔ hɔ sɛ wobenya mfaso foforo afi nnuru a wɔde sa yare no mu. |
| 16 – 20 na ɛwɔ hɔ | Asiane a ɛba fam-mfinimfini | Ebia nnuru a wɔde sa yare no bɛma mfaso ketewaa bi aba, nanso ɛsɛ sɛ wo ne wo duruyɛfo susuw ho sɛ ebia mfaso a ɛwɔ so no fata bere a wɔde toto nea efi mu ba no ho anaa. |
| 21 – 25 na ɛwɔ hɔ | Asiane a ɛwɔ mfinimfini | Ebia mfaso a ɛwɔ nnuru a wɔde sa yare so no bɛboro asiane a ɛwɔ ne nsunsuanso bɔne mu no so. Ɛsɛ sɛ wo ne wo duruyɛfo susuw eyi ho na wusi gyinae. |
| 26 – 100 na ɛwɔ hɔ | Asiane a ɛkorɔn | Asiane a ɛwɔ hɔ sɛ kokoram bɛsan aba no yɛ kɛse. Ɛda adi sɛ wɔkamfo nnuru a wɔde sa yare kyerɛ kɛse ka hormone ayaresa ho. |
So sɛnkyerɛnne yi nkutoo na ɛsɛ sɛ ɛkyerɛ ayaresa?
Ɛnyɛ saa koraa. Eyi ho hia paa. Oncotype DX nkontabuo no yɛ ade baako pɛ a ɛyɛ den a ɛbɛboa wo ama woasi gyinaeɛ. Wo duruyɛfo no besusuw nneɛma afoforo pii ho ansa na wayɛ ayaresa nhyehyɛe a eye sen biara ama wo.
Nhwɛsoɔ:
- Tumor kɛse
- Tumor grade a wɔde ma
- Nnuru a ɛma nipadua no nya ahoɔdennuru dodow a ɛwɔ kokoram nkwammoaa mu
- Wo mfe a woadi ne w’akwahosan nyinaa
Saa nneɛma yi nyinaa bom si gyinae a etwa to. Enti, sɔhwɛ amanneɛbɔ yi yɛ adwinnade biako pɛ a ebetumi aboa wo duruyɛfo ma wayɛ ayaresa nhyehyɛe a eye sen biara ama wo.
So awosu mu nhwehwɛmu afoforo te sɛ eyi wɔ hɔ?
Yiw, awosu mu nhwehwɛmu afoforo pii wɔ hɔ a wɔde yɛ nufu mu kokoram. Nanso nea wɔde di dwuma kɛse no da so ara yɛ Oncotype DX. Momma yensua afoforo no ho ade tiawa.
- MammaPrint: Eyi hwehwɛ awosu mu nkwaadɔm 70 mu. Ɛboa ma wɔkyerɛ asiane a ɛwɔ hɔ sɛ kokoram bɛtrɛw wɔ nufu no akyi. Wobetumi de adi dwuma ama ER+ ne ER- ahorow nyinaa.
- Mammostrat: Eyi sɔ awosu mu nkwaadɔm 5 hwɛ na ɛkyerɛ asiane a ɛwɔ hɔ sɛ nufu mu kokoram a ɛwɔ hormone-receptor a ɛwɔ mfiase no bɛsan aba bio.
- Prosigna: Wɔde eyi di dwuma ma nufu mu kokoram a ɛwɔ hormone-receptor-positive wɔ mmea a wɔagyae brayɛ akyi. Ɛhwehwɛ awosu mu nkwaadɔm 58 mu na ɛkyerɛ asiane a ɛwɔ hɔ sɛ kokoram no bɛsan aba nipadua no mu mmeae afoforo wɔ mfe 10 ntam.
Eyinom nyinaa yɛ sɔhwɛ ahorow a ɛkɔ akyiri. Wo duruyɛfo no besi gyinae sɛ ebia wuhia eyinom mu biako ne nea ɛfata sen biara.
Nkrasɛm a Wɔde Kɔ Fie
- Oncotype DX yɛ sɔhwɛ titiriw bi a ɛhwehwɛ nufu mu kokoram nkwammoaa mu awosu mu nkwaadɔm mu de boa ma wohu asiane a ɛwɔ hɔ sɛ kokoram bɛsan aba bio ne sɛ ebia nnuru a wɔde sa yare ho hia anaa.
- Wɔde kokoram ntini bi a wogye fi nipadua mu nhwehwɛmu anaa oprehyɛn mu na ɛyɛ eyi, na ɛnyɛ mogya mu.
- Saa sɔhwɛ yi ho nhia mma obiara. Wɔtaa de di dwuma kɛse ma kokoram a ɛyɛ Stage I/II, ER+, na ɛntrɛw nkɔ ntini a ɛma mogya tu no mu.
- Sɔhwɛ mu nkontaahyɛde no yɛ ayaresa nhyehyɛe no fã biako pɛ. Wo duruyɛfo no besusuw nneɛma afoforo pii ho, te sɛ kokoram no kɛse, sɛnea emu yɛ den, ne mfe a woadi.
- Sɛ wowɔ nsɛmmisa anaa nsɛm bi a ɛhaw wo wɔ eyi ho a, hwɛ hu sɛ wo ne wo duruyɛfo bɛkasa pefee . Akyinnye biara nni ho sɛ ɔbɛboa wo ma woapaw nea eye ma wo.
Oncotype DX Sinhala, Nufu mu Kokoram, Nnuru Ayaresa, Kokoram Awosu mu Nhwehwɛmu, Kokoram a Ɛsan Ba, ER Positive Cancer , Kokoram Ayaresa
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