Yala aw bɛ aw ka tile fana daminɛ ni kɔ gɛlɛya ni dimi ye ni aw kununna sɔgɔma wa? Yala o dimi bɛ dɔgɔya ni aw bɛ taama dɔɔni, ka baara dɔw kɛ, ka caya tuguni ni aw sigilen don wa? Ninnu bɛ se ka kɛ bana dɔ taamasiɲɛw ye minnu bɛ wele ko Ankylosing Spondylitis (AS). Nin ye bana ye min bɛ mɔgɔ dimi tiɲɛ na, min bɛ don o don ɲɛnamaya bali. O furakɛcogo la, dɔgɔtɔrɔw bɛ dimimadafura (AINE) sɛbɛn fɔlɔ. Ni ninnu tɛ bana kunbɛn, u bɛ se ka aw bila pikiriw la minnu bɛ wele ko biologics. Nka, mɔgɔ dɔw tɛ lafiya sɔrɔ furakɛli ninnu na, walima u kɔlɔlɔw muɲuni ka gɛlɛn. Yala i fana bɛ ka o ko kelen de sɔrɔ wa? N’o don, aw kana aw hakili ɲagami. Furakɛcogo dɔnniya ɲɛtaa fɛ, furakɛli kura wɛrɛ min ɲɛnabɔra, o bɔra kɛnɛ kan sisan. O ye Janus Kinase (JAK) balilanw ye . An ka kuma o kan bi.
JAK Inhibitors ye mun ye?
JAK inhibiteurs ye fura suguya kura ye min bɛ kɛ ka ankylosing spondylitis furakɛ. I n’a fɔ biologikiw, u bɛ fura suguya dɔ la min bɛ wele ko bana caman sɛgɛsɛgɛli furaw (DMARDs). "Bana caman sɛgɛsɛgɛli" kɔrɔ ye ko nin fura ninnu tɛ dimi dɔgɔya dɔrɔn. U bɛ kɔkolo ni kolotuguda wɛrɛw tiɲɛni fana kɔlɔsi ani ka bana in taabolo sumaya.
Nka ninnu tɛ kɛ Ankylosing Spondylitis dɔrɔn de la. Nin fura suguya in dagalen don fana farikolo tangalanw ka bana damadɔ wɛrɛw la. O kɔrɔ ye ko bana minnu na farikolo tangalan bɛ bin a yɛrɛ ka farikolokisɛw kan.
- Ɲɛgɛnɛsiraw ka bana
- Course polyarticulaire juvenile idiopathique arthritis (JIA) .
- Jolidɛsɛ min bɛ sɔrɔ sɔgɔsɔgɔninjɛ fɛ
- Kɔnɔnatumuw (colite ulcéreuse).
Fɛn kɛrɛnkɛrɛnnen ye ko aw bɛ se ka ninnu ta furakisɛw ye sanni aw ka pikiri kɛ i n’a fɔ biologikiw. O la, nin ye lafiyaba ye mɔgɔ minnu bɛ siran pikiri ɲɛ.
Ankylosing Spondylitis suguya jumɛnw bɛ kɛ?
Sisan, JAK inhibitor suguya fila dagalen don Ankylosing Spondylitis furakɛli la.
- Tofasitinibi (a tɔgɔ: Xeljanz, Xeljanz-XR) .
- Upadacitinib (a tɔgɔ: Rinvoq) .
A ka ca a la, ninnu bɛ di banabagatɔw ma minnu ka bana taamasiɲɛw ma kunbɛn ni biologiki fura kelen walima caman ye minnu bɛ wele ko TNF inhibiteurs, walima minnu tɛ se ka o furaw kɔlɔlɔw muɲu. O la, aw ka dɔgɔtɔrɔ bɛna aw ka furakɛli tariku bɛɛ lajɛ ka ɲɛ sani aw ka fura in sɛbɛn.
Nin fura in bɛ baara kɛ cogo di?
Walasa k’o faamu, an ka misali fitinin dɔ ta. Miiri k’a filɛ, an farikolo farikolo tangalan ye kɛlɛboloba ye. Bana min bɛ i n’a fɔ Ankylosing Spondylitis, o kɛlɛbolo in bɛ cikan jugu sɔrɔ, k’a daminɛ ka bin a yɛrɛ ka jamana (an yɛrɛ farikolo) kolotugudaw kan. Nin binkanni in de bɛ dimi ni funu (funu) bila mɔgɔ la.
"Ciden" dɔw bɛ yen minnu bɛ o cikan jugu ninnu Ci. u bɛ wele ko JAK enzymes . O anzimu ninnu de bɛ taamasiɲɛ di farikolo tangalanw ma u ka "taama ka bin", o ye furakisɛw ye minnu bɛ wele ko sitokiniw.
Fura minnu bɛ wele ko JAK inhibiteurs, olu bɛ min kɛ, o ye o ciden yɛrɛw (JAK enzymes) bali. O bɛ o cikan juguw bolicogo jɔ ani ka dɔ bɔ farikolo tangalanw ka se ka bin kolotugudaw kan.
Fura minnu bɛ bɔ fɛnɲɛnamaw la, olu bɛ baara kɛ cogo wɛrɛ la dɔɔni. Biologique bɛ sitokini kɛrɛnkɛrɛnnen dɔ laɲini ani k’a bali, i n’a fɔ TNF walima IL-17. JAK balilanw bɛ sitokini caman bɔli bali siɲɛ kelen. N’an y’a fɔ cogo nɔgɔman na, u bɛ gɛlɛya in bali fɔlɔ.
Yala kɔlɔlɔ dɔw bɛ a la wa?
I n’a fɔ fura tɔw bɛɛ, kɔlɔlɔ bɛ se ka sɔrɔ a la. Nka mɔgɔ fanba fɛ, u lafiyalen don. Aw ka dɔgɔtɔrɔ bɛna aw kɔlɔsi kosɛbɛ sani aw ka fura in tali daminɛ ani ka aw to a tali la.
| Kɔnɔnatumu suguya | Cogojirali |
|---|---|
| Kɔnɔnatumuw kɔlɔlɔ minnu ka teli ka sɔrɔ (a ka ca a la u tɛ juguya). |
|
| Kɔnɔnatumu juguman minnu man teli ka sɔrɔ (Ladilikan min bɛ kɛsu kɔnɔ) . |
Dɔɔni dɔɔni kɔlɔlɔ jugumanw kan
Ikomi fura ninnu bɛ farikolo tangalanw bali, farikolo ka se ka banakisɛw kɛlɛ i n’a fɔ banakisɛw ni banakisɛw, o bɛ dɔgɔya dɔɔni. O bɛ dɔ fara banakisɛw sɔrɔli kan.
Sɔgɔsɔgɔninjɛ (TB) sɛgɛsɛgɛli : Sani aw ka fura in daminɛ, aw ka dɔgɔtɔrɔ bɛna aw sɛgɛsɛgɛ ni sumaya tɛ aw la. Tubabubanakisɛ dogolenw bɛ se ka kɛ mɔgɔ dɔw fari la. Ni aw bɛ JAK balilan kɛ, nin banakisɛ sunɔgɔlen in bɛ se ka kɛ baara ye. O la, aw ka dɔgɔtɔrɔ bɛna aw kɔlɔsi o la furakɛli waati.
Nafama: Ni aw bɛ fura in ta, aw ka kan ka aw yɛrɛ tanga boloci ɲɛnamaw tali ma. Misaliw ye sumaya, sɔgɔsɔgɔninjɛ, rubɛli (MMR) ani rotavirus ye. Nin boloci ninnu bɛ se ka bana bila aw la barisa aw farikolo tangacogo bɛ dɔgɔya o waati la. Aw ye aw jija ka kuma aw ka dɔgɔtɔrɔ fɛ sani aw ka boloci si ta.
Ne ka kan ka mun makɔnɔ ni ne bɛ fura tali daminɛ?
Mɔgɔ dɔw bɛ a daminɛ ka lafiya sɔrɔ u ka bana taamasiɲɛw la dɔgɔkun fila dɔrɔn kɔnɔ fura in tali daminɛ kɔfɛ. Nka, a bɛ se ka kalo 6 kɛ walasa mɔgɔ dɔw ka lafiya pewu. O bɛ danfara don mɔgɔ ni mɔgɔ cɛ.
Ni aw ma kɛnɛya fura tali kɔfɛ kalo damadɔ kɔnɔ, aw kana siran ka kuma aw ka dɔgɔtɔrɔ fɛ o ko la ani ka laadilikanw sɔrɔ aw ka kan ka min kɛ kɔfɛ.
Take-Home cikan
- JAK inhibiteurs ye fura suguya kura ye minnu bɛ sɔrɔ furakisɛw ye ankylosing spondylitis la. A ka ca a la, u bɛ di mɔgɔw ma minnu ma se ka furakɛli wɛrɛw kɛ.
- Nin fura ninnu tɛ dimi dɔrɔn dɔgɔya, nka u bɛ kolotugudaw tiɲɛni fana bali.
- Ninnu tali ka nɔgɔn kosɛbɛ barisa u tɛ pikiriw wajibiya i n’a fɔ biologikiw.
- I n’a fɔ fura bɛɛ, nin fura in bɛ se ka kɔlɔlɔ lase a ma. O la, a nafa ka bon ka joli sɛgɛsɛgɛli kɛ tuma bɛɛ dɔgɔtɔrɔ dɔ ka kɔlɔsili kɔnɔ.
- Aw kana fura in daminɛ, ka a jɔ, walima ka a tata hakɛ Changer abada ni dɔgɔtɔrɔ ma a laadi.
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