Thaum peb hnov lo lus 'cholesterol', feem ntau ntawm peb ntshai me ntsis, puas yog? Tshwj xeeb tshaj yog thaum tus kws kho mob hais tias, "Koj cov roj cholesterol phem, uas yog, LDL theem, siab me ntsis," peb ntshai me ntsis. Yam peb noj thiab haus, txawm peb ua si lossis tsis ua, thiab qee zaum cov yam ntxwv ntawm caj ces kuj cuam tshuam rau qhov no. Yog li, yuav luag txhua tus ntawm peb tau hnov txog cov tshuaj 'statin' uas muab los tswj cov roj cholesterol. Tab sis rau qee tus neeg, cov tshuaj no ib leeg tsis txaus, lossis lawv siv tsis tau. Niaj hnub no peb tab tom tham txog ib hom tshuaj tshiab uas siv rau hauv cov xwm txheej zoo li no. Ntawd yog Repatha.
Repatha yog dab tsi? Nws txo cov roj cholesterol li cas?
Hais yooj yim xwb, Repatha yog ib qho tshuaj txhaj uas txo cov roj cholesterol "phem", lossis LDL (Low-Density Lipoprotein) hauv peb lub cev. Qhov no tsis yog ib qho tshuaj uas peb feem ntau noj, tab sis yog ib qho tshuaj txhaj uas txhaj rau hauv qab daim tawv nqaij.
Tam sim no saib seb qhov no ua haujlwm li cas, nws zoo kawg nkaus. Xav txog tias peb lub siab yog lub lim dej uas tshem tawm cov roj cholesterol phem ntawm cov ntshav. Tab sis peb lub cev kuj muaj ib qho protein hu ua PCSK9 (Proprotein Convertase Subtilisin Kexin hom 9) . Qhov no zoo li ib tug neeg uas txo qhov ua haujlwm ntawm lub lim dej ntawd, cuam tshuam rau nws. Thaum cov protein PCSK9 nce ntxiv, lub siab lub peev xwm tshem tawm LDL ntawm cov ntshav txo qis.
Qhov uas Repatha ua yog tiv thaiv qhov kev ua haujlwm ntawm cov protein PCSK9 uas 'ua puas tsuaj' . Thaum nws raug tso tseg, lub lim dej ntawm lub siab tuaj yeem ua haujlwm tau zoo tshaj plaws dua yam tsis muaj kev cuam tshuam, ntes thiab tshem tawm cov roj cholesterol phem (LDL) hauv cov ntshav. Koj puas nkag siab? Qhov no txhais tau tias cov tshuaj no pab peb lub cev txoj kev ua haujlwm ntuj uas tswj cov roj cholesterol.
Cov tshuaj Repatha no puas pom zoo rau leej twg?
Cov tshuaj no tsis yog rau txhua tus. Tus kws kho mob tsuas yog yuav pom zoo kom siv rau ob peb qho xwm txheej xwb.
- Rau cov neeg laus uas muaj kab mob plawv lawm: Cov tshuaj no yog siv los txo qhov kev pheej hmoo ntawm kev mob plawv nres, mob hlwb, lossis lwm yam kab mob plawv. Feem ntau nws yog muab nrog lwm cov tshuaj cholesterol, xws li statins.
- Rau cov neeg uas muaj roj cholesterol ntau los ntawm caj ces: Ib txhia neeg muaj roj cholesterol ntau heev vim yog cov mob caj ces uas tau kis mus rau ib tiam dhau ib tiam. Cov mob no hu ua Heterozygous Familial Hypercholesterolemia (HeFH) thiab Homozygous Familial Hypercholesterolemia (HoFH) . Repatha raug pom zoo rau cov neeg laus thiab cov menyuam yaus hnub nyoog tshaj 10 xyoo uas muaj cov mob no los tswj cov roj LDL.
Qhov tseem ceeb tshaj plaws, nws yog ib qho tseem ceeb kom ua raws li kev noj zaub mov zoo thiab kev tawm dag zog thaum siv cov tshuaj no.Repatha tsis yog khawv koob, nws tsuas yog ib feem ntawm txoj kev kho mob xwb.
Cov tshuaj no muaj txiaj ntsig thiab cov teebmeem dab tsi?
Cov kev tshawb fawb kho mob ntawm Repatha tau pom tias muaj txiaj ntsig zoo. Cov kev tshawb fawb no piv Repatha nrog cov tshuaj placebo (kev kho mob cuav) thiab nrog lwm cov tshuaj cholesterol, xws li statins.
Cia peb piav qhia ntxiv txog qhov no nrog lub rooj hauv qab no.
| Cov tshuaj no yog rau leej twg? | Cov txiaj ntsig tseem ceeb uas tau ua pov thawj los ntawm kev sim |
|---|---|
| Cov neeg laus uas twb muaj kab mob plawv lawm (nrog rau lwm yam tshuaj xws li statins) | Txo qhov kev pheej hmoo ntawm kev mob plawv, mob hlwb, thiab kev tuag los ntawm kab mob plawv. |
| Cov neeg laus thiab cov menyuam yaus hnub nyoog tshaj 10 xyoo uas muaj cov roj cholesterol ntau vim yog cov caj ces. | Ua tau zoo heev thiab sai sai txo cov roj cholesterol "phem" (LDL) hauv cov ntshav. |
Koj paub li cas tias cov tshuaj ua haujlwm?
Koj tus kws kho mob yuav kom koj kuaj ntshav (lipid profile tests) tsis tu ncua. Tom qab pib siv Repatha, koj yuav pom tias koj cov roj cholesterol LDL yuav txo qis ntau hauv 12 lub lis piam .
Cia peb kuj paub txog kev siv thiab cov kev mob tshwm sim ntawm Repatha.
Yuav siv qhov no li cas?
Tshuaj Repatha muaj nyob rau hauv daim ntawv ntawm lub koob txhaj tshuaj uas twb muaj lawm los yog ib lub cwj mem txhaj tshuaj. Nws raug txhaj rau hauv qab daim tawv nqaij txhua ob lub lis piam lossis ib hlis ib zaug, nyob ntawm seb koj tau noj tshuaj npaum li cas.
Qhov tseem ceeb tshaj plaws: Nws yog ib qho tseem ceeb heev uas yuav tsum kawm paub siv qhov no los ntawm koj tus kws kho mob ua ntej. Ua ntej siv nws thawj zaug, thov kom muaj kev qhia meej txog yuav ua li cas.
Cov kev mob tshwm sim yog dab tsi?
Ib yam li lwm yam tshuaj, Repatha tuaj yeem ua rau muaj kev phiv me me, txawm hais tias tsis yog txhua tus neeg tau txais.
| Cov kev mob tshwm sim feem ntau | Cov tswv yim los tiv thaiv lossis tswj hwm |
|---|---|
| Liab, mob, thiab mob nqaij ntawm qhov chaw txhaj tshuaj. | - Ib txwm tig qhov chaw txhaj tshuaj (piv txwv li, ib sab ntawm lub plab, lub sijhawm tom ntej tig sab tod). - Muab cov tshuaj tiv thaiv tawm hauv lub tub yees, cia nws zaum li 30-45 feeb , thiab tom qab ntawd txhaj tshuaj tom qab nws kub txog chav tsev. |
| Cov tsos mob zoo li mob khaub thuas (ua npaws, mob lub cev). | Feem ntau cov no tsuas yog ib ntus xwb. Yog tias koj muaj teeb meem dab tsi, nrog koj tus kws kho mob tham. |
| Mob nraub qaum, cov ntshav qab zib ntau. | Qhia rau koj tus kws kho mob yog tias muaj tej yam tshwm sim tsis zoo uas ua rau koj tsis xis nyob lossis tseem muaj. |
Cov ntsiab lus yuav tsum tau them sai sai rau:
- Kev Ua Xua Rau Cov Roj Hmab Latex: Tej koob txhaj tshuaj yuav muaj roj hmab latex nyob rau hauv lawv lub hnab. Yog tias koj muaj kev ua xua rau roj hmab latex, nco ntsoov qhia rau koj tus kws kho mob txog qhov no.
- Cev Xeeb Tub thiab pub niam mis: Yog tias koj cev xeeb tub, tab tom sim cev xeeb tub, lossis pub niam mis, nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob ua ntej siv cov tshuaj no, vim tias tsis muaj cov ntaub ntawv txaus txog nws txoj kev nyab xeeb hauv cov xwm txheej no.
Kuv yuav tau cov tshuaj no li cas?
Cov tshuaj no tsis yog cov tshuaj uas koj yuav tau ntawm lub tsev muag tshuaj. Yuav tsum tau daim ntawv qhia los ntawm kws kho mob.
Feem ntau, koj tus kws kho mob lossis tus kws kho mob plawv yuav txiav txim siab seb koj puas xav tau cov tshuaj no thiab pom zoo kom siv. Nyob ntawm koj tus kws kho mob cov lus qhia, koj yuav tau txais nws los ntawm cov khw muag tshuaj tshwj xeeb lossis tej zaum los ntawm koj lub tsev muag tshuaj hauv zos.
Tsis txhob pib, tsum, lossis hloov qhov ntau npaum li cas ntawm cov tshuaj yam tsis tau kev qhia los ntawm kws kho mob. Nco ntsoov sab laj nrog koj tus kws kho mob ua ntej koj txiav txim siab.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Repatha yog ib qho tshuaj txhaj rau hauv qab daim tawv nqaij uas txo cov roj cholesterol LDL ("phem") uas siab.
- Qhov no yog qhov tshwj xeeb tshaj yog rau cov neeg uas muaj feem yuav mob plawv thiab cov neeg uas muaj teeb meem roj cholesterol hauv cov noob caj noob ces.
- Nws thaiv ib qho protein hu ua PCSK9, pab lub siab tshem tawm cov roj cholesterol LDL ntawm cov ntshav.
- Qhov no tsuas yog tau nrog daim ntawv qhia los ntawm kws kho mob xwb. Nws yog ib qho tseem ceeb heev uas yuav tsum ua raws li koj tus kws kho mob cov lus qhia.
- Tej zaum yuav muaj tej yam tshwm sim xws li liab thiab mob khaub thuas ntawm qhov chaw txhaj tshuaj, thiab koj yuav tsum qhia rau koj tus kws kho mob txog tej ntawd.
- Cov txiaj ntsig zoo tshaj plaws tuaj yeem ua tiav los ntawm kev siv Repatha nrog rau kev ua neej noj qab haus huv.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus