Yu dɔktɔ dɔn gi yu mɛrɛsin fɔ mek yu gɛt ay blɔd prɛshɔn ɔ if yu na man, fɔ mek yu prɔstat big? If na so, i go mɔs bi se di mɛrɛsin na alfa-blɔk. Pan ɔl we di nem kin tan lɛk se i kɔmplikt smɔl, dɛn kayn mɛrɛsin ya na wan kayn mɛrɛsin we bɔku pipul dɛn kin yuz fɔ ɛp fɔ kɔntrol sɔm tin dɛn na wi bɔdi. So tide, lɛ wi tɔk bɔt dɛn alfa-blɔk ya insay wan simpul we we yu go ɔndastand.
Aw dɛn alfa-blɔk ya de wok?
Fɔ ɔndastand dis, lɛ wi tink bɔt di we aw wi bɔdi de tɔk to pipul dɛn. Wi nervɔs sistɛm tan lɛk posta savis. i de sεnd kεmikכl mεsej dεm (we wi kכl ``Nyurotransmitta'') to difrεn pat dεm na wi bכdi. fכ gεt dεn mεsej dεm ya, wi sεl dεm gεt spεshal ''rεsεpכta dεm''. I tan lɛk ki ɛn lɔk. na we di kεmikכl mεsej (di ki) kam εn fit insay di aprכpriet rεsεpכta (di lכk) nכmכ da sεl de aktibכt.
di alfa-rεsεptor dεm na wan kayn rεsεpכta na wi bכdi. Dɛn kin de mɔ na wi blɔd vesel ɛn na say dɛn lɛk di prɔstat gland. we dεn alfa-rεsεpכta dεm ya gεt mεsej, dεn sεl dεm de bigin fכ kכnstrikt. fכ egzampl, we di alfa-rεsεptor dεm na di bכdi vεsul dεm de wok, di bכdi vεsul dεm de kכnstrikt εn blכd prεshכn de go כp.
So, wetin alfa-blɔka de du na dat i tan lɛk fɔ put di rɔng ki insay tɔl ɛn blok am. Dis dכg de go εn atak dεn alfa-rεsεptor dεm εn mek dεn nכ gεt di rayt mεsej. dat min se i de `blכk` dεn rεsεpכta dεm de. Dɔn dɛn sɛl dɛn de nɔ kin kɔntrakt, dɛn kin rilaks. We di sɛl dɛn we de na di blɔd vesel dɛn rilaks, di blɔd vesel dɛn kin big, ɛn di blɔd prɛshɔn kin go dɔŋ. We di mɔsul dɛn na di prɔstat rilaks, i kin izi fɔ pis. Na dat jɔs de apin.
Tayp dεm fכ di alfa-rεsεptor dεm εn di fכnshכn dεm we dεn de du
tu men kayn alfa-rεsεptor dεm de: alfa-1 (A1) εn alfa-2 (A2). Dɛn ɔl tu gɛt difrɛn wok dɛn smɔl.
| Risɛptɔ Tayp | Di say we dɛn de ɛn di men wok dɛn we dɛn de du |
|---|---|
| Alfa-1 (A1) risepta |
|
| Alfa-2 (A2) rεsεptכr |
|
Us kɔndishɔn dɛn dɛn kin yuz alfa-blɔk fɔ?
Dɛn kin yuz dis kayn mɛrɛsin mɔ fɔ trit sɔm sik dɛn we pɔsin kin gɛt.
1. Ay blɔd prɛshɔn (Hypertension) .
Dis na di men yus. As wi bin dɔn tɔk, alfa-blɔk kin mek di blɔd vesel dɛn rilaks ɛn mek di blɔd prɛshɔn go dɔŋ. Dɛn kin yuz drɔgs lɛk Doxazosin, Prazosin, ɛn Terazosin fɔ dis.
2. Bɛnign Prɔstat Haypaplasia (BPH) .
BPH na wan sik we kin apin to man dɛn we dɛn de ol. pan dis kכndyushכn, di prכstat gland de big εn prεs pan di urethra, we de mek prכblεm lεk i at fכ pis εn di urine rεtεnshכn. di alfa-blכk dεm lεk Tamsulosin, Alfuzosin, εn Silodosin de rilaks di mכsul dεm na di prכstat εn blad nεk, we de mek i izi fכ di urine fכ fכlכ.
3. Ɔda yus dɛn (Off-label uses) .
Sɔntɛnde, dɔktɔ dɛn, bay wetin dɛn dɔn ɛkspiriɛns ɛn di pruf we dɛn gɛt frɔm di mɛrɛsin, kin gi dɛn wan mɛrɛsin fɔ ɔda tin dɛn we nɔto di wan we dɛn gri fɔ. Dɛn kɔl dis ‘ɔf-lɛbul’ yus.
- Kidni Ston: Dɛn kin gi mɛrɛsin lɛk Tamsulosin fɔ ɛp smɔl smɔl ston dɛn we dɔn stɔp na di urinary tract pas izi wan.
- Post-traumatic stress disorder (PTSD related nightmares): Sɔmtɛm dɛn kin yuse di drɔg Prazosin fɔ trit dis sik.
- Fiokromosaytoma: dis na wan kayn tכmכro we de divεlכp na di adrenal gland dεm εn i de mek bכku כmon dεm. Dɛn kin gi alfa-blɔk bak fɔ kɔntrol di ay blɔd prɛshɔn we dɛn tɔŋ ya kin mek.
Wetin na di sayd ɛfɛkt ɛn risk dɛm fɔ alfa-blɔk?
Lɛk ɛni mɛrɛsin, alfa-blɔk kin gɛt sayd ɛfɛkt. Na dat mek dɔktɔ dɛn kin rili tek tɛm we dɛn de gi dɛn mɛrɛsin ya. Di sayd ɛfɛkt dɛm wae yu kin gɛt kin difrɛn difrɛn wan fɔ di kayn mɛrɛsin wae yu de tek.
Wan tin we rili impɔtant na di "fɔs-doz ifɛkt." We yu tek di fɔs pil we gɛt alfa-blɔk, yu blɔd prɛshɔn kin go dɔŋ bad bad wan wantɛm wantɛm. Dis kin mek yu diziz , yu nɔ de si fayn, ɛn yu kin fil fɔ fɔdɔm we yu tinap (orthostatic hypotension) . Fɔ ridyus dis risk, yu dɔktɔ go tɛl yu fɔ tek di mɛrɛsin we yu de go slip ɛn bigin wit smɔl doz.
Na sɔm kɔmɔn sayd ɛfɛkt dɛn ya:
- Diziz ɔ yu nɔ de si fayn (espɛshali we yu tinap) .
- Ed de at
- Fɔ fil se yu taya
- Nasal kɔnjɛshɔn
- At bit kwik kwik wan (tachycardia) .
- Di tin dɛn we kin apin to di we aw pɔsin de du mami ɛn dadi biznɛs: Sɔm man dɛn kin gɛt wan sik we dɛn kɔl anejaculation. Na sכm tεm, wan pen we de mek yu εrekshכn we de te pas 4 awa (priapism) kin apin. Dis na wan sik wae nid fɔ gɛt mɛrɛsin kwik kwik wan.
Tin dɛn we yu fɔ mɛmba we yu de tek dis mɛrɛsin
- Intarakshɔn wit ɔda mɛrɛsin dɛm: Alfa-blɔk kin intarakt wit ɔda blɔd prɛshɔn mɛrɛsin dɛm, sɔm mɛrɛsin dɛm fɔ erectile dysfunction, ɛn ɔda mɛrɛsin dɛm. So, i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek.
- Fɔ drink rɔm: If yu drink rɔm, dat kin mek yu gɛt bɔku prɔblɛm dɛn lɛk we yu de tɔn ed .
- Katarakt ɔpreshɔn: If yu plan fɔ gɛt katarakt ɔpreshɔn, yu fɔ rili tɛl yu ay ɔpreshɔn se yu de tek alfa-blɔka, bikɔs dɛn mɛrɛsin ya kin mek yu gɛt prɔblɛm dɛn we yu de du di ɔpreshɔn.
- Fɔ stɔp di mɛrɛsin: Nɔ ɛva stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm if yu nɔ go to yu dɔktɔ. If yu du dat, i kin mek yu gɛt siriɔs sayd ɛfɛkt, lɛk ribaund haypatɛyshɔn. If yu nid fɔ stɔp fɔ tek di mɛrɛsin, du am di we we sef ɛn akɔdin to yu dɔktɔ in instrɔkshɔn.
Ustɛm yu fɔ go to dɔktɔ?
If yu gɛt ɛni kwɛstyɔn bɔt di mɛrɛsin, ɔ if di sayd ɛfɛkt dɛn de mek i nɔ izi fɔ du ɛvride, tɔk to yu dɔktɔ.
Bɔt if yu gɛt ɛni wan pan dɛn sik ya, go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm:
- I nɔ kin no natin ɔ i kin fɔdɔm
- Chɛst pen (`(Angina)`) .
- I nɔ kin izi fɔ yu fɔ blo
- Hat de bit kwik kwik wan ɔ i nɔ de bit ɔltɛm (palpitations) .
- di erekshכn we de mek yu fil pen we de las pas 4 awa (`(Priapism)`)
- Sayn dɛm fɔ siriɔs alɛji (e.g., rash, it, swel na di fes/trot, i nɔ izi fɔ swɛla)
Mɛsej we dɛn kin kɛr go na os
- Alfa-blɔka na impɔtant klas fɔ drɔgs we de trit kɔndishɔn lɛk ay blɔd prɛshɔn ɛn benign prostatic hyperplasia (BPH).
- Dɛn tin ya kin wok bay we dɛn kin rilaks di blɔd vesel ɛn mɔsul dɛn na di prɔstat gland.
- We yu bigin fɔ tek di mɛrɛsin, mɔ afta di fɔs doz, yu kin gɛt diziz , so tek am na nɛt, lɛk aw yu dɔktɔ tɛl yu.
- Tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek.
- Nɔ ɛva stɔp fɔ tek dɛn mɛrɛsin ya wantɛm wantɛm if yu dɔktɔ nɔ advays yu.
- If yu gɛt ɛni siriɔs sayd ɛfɛkt, go to dɔktɔ wantɛm wantɛm.
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