Wetin mek dɛn nɔ stil gɛt mɛrɛsin fɔ Alzaima sik? Lɛ wi tɔk bɔt dis

Yu dɔn ɛva notis se yu mama, papa, ɔ pɔsin we yu lɛk we dɔn ol de fɔgɛt tin? Sɔntɛnde, fɔgɛt yu nem, adrɛs, ɔ ivin mɛmba usay yu glas de, na nɔmal tin as yu de ol. Bɔt if dis fɔgɛt de bɔku smɔl smɔl ɛn yu nɔ ebul fɔ du ivin di wok dɛn we yu de du ɛvride fɔ yusɛf, dat kin bi sayn fɔ Alzaima Sik. Dɔn di big kwɛstyɔn we kin kam na wi maynd na, ‘Wetin mek dis kayn divɛlɔp wɔl nɔ dɔn fɛn mɛrɛsin fɔ dis sik yet?’ Lɛ wi tɔk bɔt am dip wan tide.

Aw dɛn bin kam fɔ no bɔt dis sik fɔ di fɔstɛm?

Dis stori bigin pas 100 ia bifo dis tɛm, insay 1901. Wan Jaman dɔktɔ we nem Alois Alzheimer bin chɛk wan uman in bren we bin dɔn day bikɔs i gɛt dis maynia sik. I bin si sɔntin we rili strenj. Bitwin di nyuron dɛn na di bren, wan kayn prɔtin bin dɔn stika ɛn tan lɛk plek dɛn. Leta dɛn bin kɔl dɛn tin ya "plek." I bin si bak se ɔda kayn prɔtin dɔn tandul ɛn tan lɛk trɛd dɛn we de insay di nyuron dɛn. Dɛn bin de kɔl dɛn tin ya "tangles."

As tɛm de go, sayɛnsman dɛn kam fɔ no se di plek dɛn we tan lɛk skata na wan prɔtin we dɛn kɔl beta-amyloid . Dɛn bin kam fɔ no bak se dɛn mek di tin dɛn we tan lɛk trɛd wit ɔda prɔtin we dɛn kɔl tau . Afta sɔm tɛm, dɛn gi di sik di nem "Alzheimer's disease" fɔ ɔnɔ di dɔktɔ we fɛn am.

Di big stori bɔt di "Amyloid Hypothesis".

So, bay di 1990s, wan big aidia bin dɔn de bitwin di wan dɛn we de du risach. Dat na, di men tin we mek dis sik na di beta-amyloid plek dɛm we kin gɛda na di bren. Dɛn bin kɔl dis aidia "Amyloid Hypothesis." Fɔ tɔk am simpul wan, dɛn bin tink se na dɛn amyloid plek ya de mek di bren sɛl dɛn day ɛn di mɛmori nɔ de wok fayn.

Bɔt yu tink se dis dɔn wok fayn? Nɔto fɔ tru. Dɛn dɔn tray fɔ yuz bɔku bɔku drɔgs fɔ pul dɛn amyloid plek ya, bɔt nɔbɔdi nɔ dɔn mek big difrɛns na di layf fɔ di wan dɛn we sik. Drug dɛm wae de ridyus di amount of amyloid na in bren nɔr dɔn stɔp di pɔrsin in mɛmori ɔr mek in layf bɛtɛ ɛvride. Ivin di drɔg we dɛn jɔs dɔn gri fɔ `lecanemab` dɔn jɔs kɔntrol smɔl smɔl fɔ mek di sik wɔs, bɔt i nɔto mɛrɛsin.

Wi de stɔp na di sem rod?

Bikɔs ɔf dɛn rizɔlt ya we nɔ bin kɔmɔt fayn, bɔku pipul dɛn we de du risach de aks naw se, "Wi de go na di rɔng say?" Infakt, sayɛns nɔto sɔntin we go mek big chenj wan tɛm. I tan lɛk big ship, dɛn nɔ go ebul fɔ tɔn am wan tɛm. Risach pipul dɛn kin stɔdi di sem tɔpik fɔ lɔng lɔng tɛm, dɔn dɛn kin du mɔ risach bɔt di sem tɔpik. Dɔn, dɛn bil wan big grup fɔ pipul dɛn ɛn di tin dɛn we dɛn no rawnd di sem aidia. We yu go wok wit nyu aidia, di we dɛn we gɛt fɔ du wit am ɛn di ɛkspiriɛns nɔ de. So, insay di kes fɔ Alzaima, dis big ship bin de sel na di dairekshɔn fɔ "amyloid." So, dɛn nɔ bin pe atɛnshɔn tumɔs pan ɔda tin dɛn lɛk we pɔsin kin gɛt inflamɛns, difrɛn difrɛn infɛkshɔn dɛn, ɔ sik dɛn we pɔsin kin gɛt we i de fɛt insɛf.

Bɔt, dis amyloid stori nɔto ɔltin we nɔ rayt. Sɔntɛm di prɔblɛm de pan di mɛrɛsin. Ɔ, di tɛm we dɛn de gi di mɛrɛsin kin rɔng. Sɔntɛm dɛn fɔ bigin fɔ tek dɛn mɛrɛsin ya fɔ lɔng lɔng tɛm bifo di sik sho.

Wan ɔda prɔblɛm bin de. Te lɛk tɛn ia so dɔn pas, no we nɔ bin de fɔ 100% kɔnfɔm Alzaima sik we pɔsin de alayv, pas nɔmɔ fɔ chɛk dɛn bren afta dɛn dɔn day. So, sɔm pan de pipul dɛm wae tek pat pan de ol stɔdi nɔr bin rili gɛt Alzaima sik. So di data frɔm dɛn stɔdi dɛn de nɔ bin rayt, nɔto so?

Bɔt naw di tin dɔn difrɛn. wit nyu tεknכlכji, spεshal wan PET skan εn sεribrospεnal fכluid tεst, i pכsibul fכ no if amyloid εn tau protin dεm de na di bren fכ pכsin we de alayv.

Di ‘Trafik Jam’ Insay di Bren ɛn Nyu Risach

Naw, insted fɔ jɔs tink bɔt fɔ pul dɛn plek dɛn de, di wan dɛn we de stɔdi bɔt dis dɔn bigin fɔ luk di rut fɔ di prɔblɛm, ɛn dɛn de aks se, "Wetin mek dɛn plek ya kin fɔm?" I tan lɛk se yu nɔ go ebul fɔ sɔlv di prɔblɛm we yu nɔ no ustɛm i de. Naw, sɔm nyu tiori dɛn de bɔt dis. Lɛ wi si wetin dɛn bi.

So yu tink se natin nɔ de we wi go ebul fɔ du? Lɛ wi tɔk bɔt aw fɔ protɛkt yusɛf.

We yu yɛri ɔl dis, yu go tink se, ‘O, natin nɔ de we yu go du bɔt am.’ Bɔt nɔ tink so. De gud nyus na dat, Alzaima sik kin tek lɔng tɛm fɔ kam, lɛk 20 to 30 ia. Dat min se wi gɛt bɔku tɛm fɔ stɔp ɔ slo fɔ mek di sik go bifo.

Pan ɔl we di jɛnɛtik inflɔwɛns de, bɔku tin dɛn de we kin chenj we kin afɛkt di divɛlɔpmɛnt fɔ di Alzaima sik. Dɛn tin ya na:

• Fat
• Shuga
• Di sik we de ambɔg di at ɛn di blɔd
• Kɔlestɔl we bɔku
• Di ay blɔd prɛshɔn
• I nɔ de yɛri fayn igen
• Pwɛl hat ɛn fɔ de yu wan

Di big bɛnifit fɔ dɛn tin ya na dat dɛn nɔ kin gɛt bɔku prɔblɛm, dɛn nɔ kin dia, ɛn dɛn kin bɛtɛ fɔ wi ɔl wɛlbɔdi. Aw i valyu fɔ chenj di we aw wi de liv wi layf pas fɔ spɛn bɔku bɔku mɔni ɛvri ia fɔ tek nyu drɔgs?

Insay di fyuchu, Alzaima tritmɛnt, lɛk kansa tritmɛnt, kin involv fɔ jɔyn sɔm difrɛn we dɛn ɛn drɔgs, wan "kɔktɛl," pas wan mɛrɛsin. Bɔt di big op fɔ fɛt dis sik na fɔ mek sayɛnsman dɛn aks kwɛstyɔn bɔt wetin dɛn bin biliv trade ɛn fɛn nyu we dɛn.