If pɔsin na yu famili, sɔntɛm na mama, papa, grani ɔ anti we yu lɛk, gɛt Alzaima sik, wi no aw i kin mek yu fil pen. I nɔ kin izi fɔ tɔk bɔt di pen we yu de fil as yu de wach aw yu de mɛmba smɔl smɔl ɛn yu nɔ ebul fɔ no yusɛf. Pan ɔl we di mɛrɛsin dɛn we dɛn de yuz naw fɔ dis sik kin kɔntrol di sik dɛn te to sɔm mak, dɛn stil nɔ gɛt ɛni mɛrɛsin fɔ mɛn am. Bɔt, mɛrɛsin sayɛns nɔ de ɛva giv ɔp. Naw, sayɛnsman dɛn ɔlsay na di wɔl de du risach bɔt wan vaysin we go mɛn, kɔntrol ɛn ivin mek i nɔ gɛt dis sik. So lɛ wi tɔk bɔt dis nyu op tide.
Us vaysin kin ɛp fɔ gɛt Alzaima sik?
Infakt, sɔm stɔdi dɔn sho se big pipul dɛn we gɛt sɔm vaysin fɔ sik dɛn lɛk chikinpoks (fɔ ɛgzampul, di shingles vaysin) ɛn vaysin fɔ sik dɛn lɛk mizɛl kin gɛt smɔl smɔl risk fɔ gɛt Alzaima sik. Bɔt dɛn wan ya nɔto vaysin dɛn we de tɔk mɔ bɔt di sik we dɛn kɔl Alzaima.
We sayɛnsman dɛn de mek wan patikyula vaysin fɔ Alzaima sik, dɛn kin pe atɛnshɔn mɔ pan tri men chenj dɛn we di sik kin mek na di bren. Fɔ tɔk am simpul wan, tri men "kulprit" dɛn de insay di bren fɔ pɔsin we gɛt Alzaima.
1. Tau protein tangles: Dɛn kin gɛda insay di nεv sεl dεm na di bren.
2. Beta-amyloid plek dεm: dεn ya kin kכmכt bitwin di nεv sεl dεm, dat na, na di spεs bitwin tu sεl dεm.
3. Inflameshɔn na di bren: Dɛn tu pipul ya kin mek di bren inflamɛns, ɔ inflamɛns ɔltɛm.
Di gol fɔ ɛvri vaysin we dɛn de mek naw na fɔ kɔntrol wan ɔ mɔ pan dɛn pipul ya we du di bad tin. Lɛ wi luk ɛni kayn vaysin sɛf sɛf.
| Di kayn vaksin ɛn di target | Di prɔses ɛn di impak we i gɛt |
|---|---|
| Vaksin dεm we de tכk bכt Tau protin dεm | Imajin se insay di nεv sεl dεm na yu bren, wan strכkchכ de lεk relwe sistεm fכ transpכt nyutriεnt dεm go εn go bifo. dis protin we dεn kכl ‘tau’ na in de mek dεn ‘rel rod dεm’ stebul. pan Alzaima sik, dεn tau protin dεm ya kin bi misshap, insted fכ bi lεk trak, dεn kin tכng tכgeda εn bi lεk ‘bכl dεm fכ tכd’. Dɔn di transpɔt insay di sɛl dɛn kin stɔp, ɛn di sɛl dɛn kin bigin fɔ day. Dɛn vaysin ya kin tray fɔ stɔp dis tangle. Di vaksin dɛm we de na di tɛst faz naw na AADvac1 ɛn ACI-35.030/JACI-35.054 . |
| Beta-amyloid-target vaksin dɛn we dɛn kin yuz | dis lεk ‘garbage’ כ ‘glu lεk dεbris’ we de kכmכt bitwin di nεv sεl dεm na di bren. dis pat dεm fכ wan protin we dεn kכl beta-amyloid de kכmכt εn fכm dεposit dεm we dεn kכl ‘pleks’. dis de mek di nεv sεl dεm nכ de kכmכnik fayn fayn wan wit dεn wan dεm, we min se dεn de mek dεn nכ de sεnd ‘sayn dεm’. wetin dεn vaksin ya de du na fכ mek di bכdi in imyun sistεm fכ pul dis ‘garbage’. Vaksin dɛm lɛk ALZ-101, ABvac40, ɛn UB-311 de insay dis kategori. |
| Vaksin dɛm we de tɔch di bren inflamɛns | Insay bren we gɛt wɛlbɔdi, spɛshal sɛl dɛn de we dɛn kɔl maykroglia. Dɛn tan lɛk di bren in ‘klin kru’. Dɛn wok na fɔ pul dɔti ɛn pɔyzin we dɛn nɔ want. Bɔt pan Alzaima sik, dɛn wokman ya kin go haywire. Bifo dɛn pul dɔti, dɛn kin mek kemikal dɛn we kin mek pɔsin in bren wam ɔltɛm. Dis kin pwɛl di wɛlbɔdi nerv sɛl dɛn bak. Dɛn vaysin ya de tray fɔ mek dis ‘mɛsi klin sistɛm’ kam bak. GV1001 ɛn Protollin na tu pan dɛn ɛkspirimɛnt vaksin ya. |
So, ustɛm wi go gɛt Alzaima vaysin?
Dis na di big kwɛstyɔn we de na ɔlman in maynd. Fɔ tɔk tru, dis go tek sɔm tɛm. Ɔl dɛn vaysin ya we wi dɔn tɔk bɔt stil de na di klinik trial stej. Dat min se dɛn stil de tɛst dɛn fɔ si if dɛn sef fɔ gi pipul dɛn ɛn aw dɛn de wok fayn.
Di tin we impɔtant pas ɔl na dat if dis risach go wok fayn, dɛn kin ebul fɔ avɔyd di sik we dɛn kɔl Alzaima ɔ ivin ebul fɔ trit am di fɔs tɛm tumara bambay.
Frɔm di infɔmeshɔn we de naw, pan di vaysin dɛn we wi dɔn tɔk bɔt, GV1001Di vaysin dɔn go bifo smɔl pan klinik trial, bɔt dɛn tin ya nɔto las rizɔlt yet.
Wetin wi kin du te da tɛm de?
I fayn fɔ gɛt op fɔ dis nyu vaysin. Bɔt te da tɛm de, if yu ɔ sɔmbɔdi na yu famili gɛt dis sik, di bɛst tin fɔ du na fɔ fala di tritmɛnt we yu dɔktɔ dɔn tɛl yu naw.
Dɛn dɔn sho se di mɛrɛsin dɛn we dɛn de yuz naw, lɛk Aducanumab ɛn Lecanemab, kin mek di sik slo to sɔm mak if dɛn no am kwik. So, i impɔtant fɔ de tɔk to yu dɔktɔ ɔltɛm ɛn fala wetin i tɛl yu fɔ du.
If yu intres fɔ tek pat pan klinik trial lɛk dis, yu kin tɔk bak to yu dɔktɔ bɔt am. I go ebul fɔ gi yu kɔrɛkt gayd fɔ no if fayn chans de fɔ yu ɛn if yu fit fɔ am.
Mɛsej we dɛn kin kɛr go na os
- Alzaima sik na wan kכndyushכn we de kכz bay kכmpleks chenj dεm na di bren (tau protin tangles, beta-amyloid dεposit, inflameshn).
- Sayɛnsman dɛn de wok tranga wan fɔ mek vaysin dɛn we go ebul fɔ tɔch dɛn chenj ya ɛn mek dɛn nɔ gɛt, mɛn, ɔ kɔntrol di sik.
- Bikɔs dɛn vaysin ya stil de na di risach stej, i go tek sɔm tɛm fɔ mek dɛn de ɔlsay.
- Di bɛst tin fɔ du dis tɛm na fɔ kɔntinyu di tritmɛnt we yu dɔktɔ tɛl yu fɔ du ɛn fala wetin i tɛl yu fɔ du.
- We dɛn dɔn mek wan vaysin fayn fayn wan tumara bambay, yu mɛdikal tim go tɛl yu bɔt am.
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