We wi yɛri di wɔd brɔst kansa, bɔku pan wi kin fred. Bɔt di impɔtant tin we wi fɔ ɔndastand na dat nɔto ɔl di bɔdi kansa na di sem. Difrɛn kayn dɛn de. wan pan di tכp dεm we kכmכn pas כl na ‘εstrojen rεsεptכr positifu’ כ as wi mεdikal kכl am , ER+ (Estrogen-Receptor-Positive) brεst kεnsar . infakt, na 80% pan di brεst kεnsar dεm we dεn no se na dis kayn. So tide wi go tɔk bɔt wan nyu, saksesful klas ɔf drɔgs we dɛn dɔn fɛn fɔ trit dɛn ER+ brɔst kansa ya.
Fɔs, lɛ wi si, wetin na ER+ brɔst kansa?
Fɔ tɔk am simpul wan, di ɔmon we dɛn kɔl ɛstrojen we de na wi bɔdi de ɛp dɛn kansa sɛl dɛn ya fɔ gro. imajin se dεn kεnsar sεl dεm ya gεt spεshal ‘lכk' (rεsεptor) dεm na dεn sεf we di εstrojen כmon kin atak pan. we di ‘ki’ we dεn kכl εstrojen כmon fit insay dis ‘lכk’, di kεnsar sεl dεm de gεt ‘sayn’ fכ divayd εn gro.
Dis na di rizin we mek dɔktɔ dɛn kin trit ER+ kansa wit ɔmon tɛrapi . dis tritmεnt dεm de wok bay we dεn de blכk di ‘ki’ (εstrojen) fכ biεn di ‘lכk’ (rεsεpכta dεm). Bɔt sɔntɛnde, mɔ we di kansa dɔn skata ɔlsay na di bɔdi (advans ɔ metastatic), dɛn kansa sɛl ya kin rili kɔni. Dɛn kin bi resistant to dɛn ɔmon tritmɛnt ya, we min se dɛn nɔ kin ansa fayn to tritmɛnt. Dis na di tɛm we wi nid nyu tritmɛnt dɛn we go wok fayn.
di ‘growth switch’ fכ di kεnsar sεl dεm - PI3K εn PIK3CA jin dεm
As dɔktɔ ɛn sayɛnsman dɛn bin de luk fɔ di tin dɛn we kin mek dɛn kansa ya we nɔ gɛt ɔmon, dɛn bin fɛn sɔntin we spɛshal: wan prɔblɛm we de na di PI3K (Phosphatidylinositol-3-Kinase) pathway , we na wan impɔtant signal sistɛm we de kɔntrol aw di sɛl dɛn na wi bɔdi de gro, sheb, ɛn liv.
tink bɔt dis PI3K path as wan big ‘switchboard’ insay wan sɛl. I de kɔntrol di tin dɛn we dɛn kin disayd if di sɛl fɔ gro ɔ sheb. wan pan di men jin dεm we de kכntro dis swichbכd na di PIK3CA jin .
pan sɔm kansa sik pipul dɛm, dis PIK3CA jin gɛt muteshon , we min se i chenj ɔ i nɔ fayn. I tan lek se di ‘growth’ switch na di switchboard de stik en olwes ‘on’. Dɔn di sɛl dɛn kin bigin fɔ sheb ɛn gro we dɛn nɔ ebul fɔ kɔntrol. Dis na di men tin we kin mek pɔsin gɛt kansa. Risach dɔn sho se lɛk 40% pan di pasɛnt dɛn we gɛt ER+ brɛst kansa gɛt dis PIK3CA jin muteshɔn.
So wetin na dɛn PI3K Inhibitors ya?
Na ya, as sɔlv fɔ dis prɔblɛm, dɛn de introduks wan klas ɔf drɔgs we dɛn kɔl PI3K inhibito . di simpul tin we dεn drog ya de du na fכ deaktiv di ‘grכwth switch' (PI3K pathway) we a bin mεnshכn bifo we stכk ‘on’ fayn fayn wan.
Fɔ tɔk am simpul wan, dɛn drɔgs ya tan lɛk ilɛktrishian we sabi du in wok. I kam insay ɛn fiks da switchbɔd de we gɛt shɔt sɔrkwit, ɛn stɔp di kɔrɛnt we nɔ nid. di sem we, di PI3K Inhibitors de stכp di signal we nכ nid fכ gro to di kεnsar sεl dεm, we de mek di kεnsar sεl dεm day εn εp di tכmכro dεm fכ shrink.
Dɛn tin ya kin kam insay di we aw dɛn kin tek mɛrɛsin we dɛn kin it. Bɔku tɛm, dɛn kin gi dis mɛrɛsin to di wan dɛn we sik wit di ɔmon tɛrapi we wi bin dɔn tɔk bɔt (ɛstrojen blɔk).
Aw a go no if dis tritmɛnt fayn fɔ mi?
Dis na kwɛstyɔn we rili impɔtant. Dɛn nɔ de gi PI3K inhibitor to ɔl di wan dɛn we gɛt bɔdi kansa. Dɛn mek dɛn spɛshal wan fɔ:
- Fɔ uman dɛn we dɔn pas mɛnopauz ɛn man pasɛnt dɛn.
- Di kansa fɔ bi HR+ (Hɔmɔn-Rɛsɛptɔ-Positiv) ɛn HER2-Nɛgitiv .
- Di tin we impɔtant pas ɔl: Di kansa sɛl dɛn fɔ gɛt di PIK3CA jin muteshɔn .
Fɔ no if yu kansa gɛt dis jenɛtik muteshɔn, yu dɔktɔ go du spɛshal tɛst. Dis kin involv fɔ tek blɔd sɛmpul ɔ smɔl pat pan di tisu (bayopsi) we dɛn tek frɔm di tumbu. Di rizɔlt fɔ da tɛst de go sho if dis tritmɛnt fayn fɔ yu.
| Fɔ fit fɔ gɛt tritmɛnt | Tɔk bɔt |
|---|---|
| Di kayn kansa we yu gɛt | i fכ bi advans brεst kεnsar we di HR+ (hכmon rεsεptכr positifu) εn HER2- (HER2 nεgεtiv) tכp. |
| Jɛnɛtik muteshɔn | di PIK3CA jin mכtεshכn mכst de. Dis kin bi bay we dɛn de du spɛshal tɛst. |
| Peshɛnt | Bɔku tɛm dɛn kin advays am fɔ uman dɛn we dɔn pas 40 ia ɛn man dɛn we dɔn pas. |
Us sayd ɛfɛkt dɛn mɛrɛsin ya kin mek?
Lεk εni kεnsar tritmεnt, PI3K inhibito dεm kin mek sכm sayd ifekt dεm. Bɔt dɛn tin ya nɔ kin apin to ɔlman di sem we. Dɔn bak, naw we dɛn de fɔ kɔntrol dɛn bad bad tin ya.
Sɔm pan di bad tin dɛn we kin apin to pɔsin na:
- Nɔs ɛn vɔmit
- I nɔ kin want fɔ it ɛn i nɔ kin gɛt bɔku bɔku bɔdi
- Sɔl dɛn na yu mɔt
- Di ia we de lɔs
- Ɛni ifɛkt pan di kidni, liva, ɔ pankrias wok
- Skin rash, sɔmtɛm i kin rili bad, kin apin, we kin mek di skin pul ɔ blista.
- di hεy Blכd Shuga: Dis na kכmכn sayd ifekt we spεsifi k fכ dis klas כf drog dεm, as di PI3K path de involv insay di shuga mεtabolism na wi bכdi.
Nɔ fred fɔ dɛn sayd ɛfɛkt ya. Yu dɔktɔ go de chɛk yu ɔltɛm fɔ si dɛn tin ya. If nid de, i go ridyus di doz fɔ di mɛrɛsin, stɔp fɔ tek am fɔ sɔm tɛm (mɛdikeshɔn ɔlide), ɔ gi yu ɔda mɛrɛsin fɔ kɔntrol di sayd ɛfɛkt dɛn. Nɔ ɛva stɔp fɔ tek yu mɛrɛsin ɔ chenj di doz we yu nɔ aks yu dɔktɔ.
Risach dɔn sho se if yu tek dayabitis mɛrɛsin fɔ kɔntrol di blɔd shuga ɔ yu fala it we nɔ gɛt bɔku kab ɛn bɔku fat ( ketogenic diet ) i kin mek dis mɛrɛsin wok fayn. Bɔt i impɔtant fɔ tɔk to yu dɔktɔ bifo yu chenj ɛnitin we yu de it.
Yu tink se dis tritmɛnt rili wok?
Yɛs. Dis na di tin we impɔtant pas ɔl. Bɔku klinik trayal dɛn dɔn sho se pasɛnt dɛn we gɛt ER+ brɔst kansa wit PIK3CA muteshɔn kin bɛnifit frɔm wan PI3K inhibito we dɛn jɔyn wit ɔmon tɛrapi.
Wan big stɔdi sho se di wan dɛn we gɛt dis kɔmbayn mɛrɛsin bin gɛt lɛk 11 mɔnt we nɔ bin de go bifo . Dis bin less dan 6 mכnt fכ pasεnshכn dεm we gεt di sem jεnεtik mכtεshכn we nכ bin gεt PI3K inhibito dεm. Dis na big chenj ɛn na big big op. Bikɔs ɔf dis sakrifays, dɛn de mek nyu drɔgs dɛn na dis klas ɔf drɔgs naw.
Mɛsej we dɛn kin kɛr go na os
- Nɔto ɔl di bɔdi kansa na di sem. Fɔ no di patikyula kayn kansa (e.g. ER+, HER2-, PIK3CA mutation) impɔtant fɔ pik di tritmɛnt we fit ɛn we go wok fayn.
- PI3K Inhibitors na wan mכdan, tכgεt tεrapi fכ brεst kεnsar wit ER+ εn PIK3CA jin mכtεshכn.
- Dis tritmɛnt nɔto fɔ ɔlman. Yu dɔktɔ go disayd if i fayn fɔ yu afta yu dɔn du spɛshal tɛst.
- Dɛn mɛrɛsin ya kin mek yu gɛt sayd ɛfɛkt, mɔ we yu gɛt bɔku shuga na yu blɔd, bɔt yu dɔktɔ kin ɛp yu fɔ kɔntrol ɛn kɔntrol dɛn.
- If yu no gud gud wan bɔt yu tritmɛnt plan ɛn tɔk opin wan wit yu dɔktɔ, dat go gi yu trɛnk ɛn kɔntrol pan dis joyn. Nɔ wɔri, mɔdan mɛrɛsin de go bifo ɛvride.
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