SERM ɛn SERD fɔ Brest Kansa? Lɛ wi tɔk bɔt dɛn mɛrɛsin ya insay simpul wɔd dɛn (SERM ɛn SERD fɔ Breast Cancer) .

Yu dɔktɔ dɔn tɛl yu bɔt wan kayn mɛrɛsin we dɛn kɔl SERM ɔ SERD fɔ trit bɔdi kansa? Nɔ wɔri, dɛn nem ya kin tan lɛk se dɛn kɔmplikt smɔl. Tide, wi go tɔk simpul wan bɔt wetin dɛn bi, aw dɛn de wok, ɛn wetin yu nid fɔ no bɔt dɛn. Dis na tu kayn drɔgs we rili impɔtant we kin ɛp wi fɔ fɛt bɔdi kansa .

Wetin na SERM dɛn? Aw dɛn kin wok?

Fɔ tɔk am simpul wan, SERM (Selective Estrogen Receptor Modulators) na wan kayn mɛrɛsin we de stɔp di brɛst kansa sɛl dɛn we de gro. Bɔt dɛn kin jɔs wok pan wan patikyula kayn kansa. Dat na di kayn kansa we dɛn kɔl Estrogen Receptor-Positive . Na 75% pan di brɔst kansa dɛm we dɛn kin si na wi kɔntri de pan dis kayn.

imajin, dεn kεnsar sεl dεm ya gεt sכm "antena" dεm na dεn sεf. Insay mɛrɛsin, wi kin kɔl dɛn riseptɔ dɛn ya . we di כmon εstrojen na wi bכdi de atak dεn antena dεm ya, di kεnsar sεl de gεt signal fכ "divayd εn gro mכr."

Dis na wetin SERM dɛn kin du:

Dɛn kin go ɛn blok dɛn ɛntena dɛn de, dat na di riseptɔ dɛn. Dɔn di ɛstrojen ɔmon nɔ gɛt say fɔ kam ɛn atak insɛf. biכs i nכ de gεt di signal, di growth fכ di kεnsar sεl dεm de stכp כ dεn de kכntro bכku pan am.

Di kayn SERM dɛn ɛn aw dɛn de yuz dɛn

Bɔku men kayn SERM dɛn de we dɛn dɔn gri fɔ fɔ gɛt bɔdi kansa.

So wetin na SERD dɛn?

SERD (Selective Estrogen Receptor Downregulators) na wan kayn mɛrɛsin we de wok smɔl pas SERM. lεk SERM dεm, dεn de blכk di εstrojen rεsεpכta dεm bak. bכt apat frכm dat, di SERD dεm de ridyus di nכmba fכ di rεsεpכta dεm (dכwnrεgulεt) εn dεn de chenj di fכnshכn fכ di rεmεnεnt rεsεpכta dεm, we de mek dεn nכ de wok bכku.

Naw, tu kayn SERD dɛn de we dɛn dɔn gri fɔ:

• Fulvestrant we de du tin
• Elacestrant we dɛn kɔl Elacestrant

dis dεm dεn kin gi mεntal fכ advans, כmon rεsεptכr-positiv εn HER2-nεgεtiv brεst kεnsar dεm. HER2-nεgεtiv min se di kεnsar sεl dεm nכ gεt wan protin we dεn kכl HER2 na dεn sεf we de εp dεn fכ gro.

Aw fɔ yuz dis mɛrɛsin?

• SERMs: Bɔku pan dɛn kin kam insay pil fɔm. Yu dɔktɔ go tɛl yu fɔ tek 20mg to 40mg fɔ wan de. If yu de tek dɛn mɛrɛsin ya fɔ mek kansa nɔ kam bak, bɔku tɛm yu go nid fɔ kɔntinyu fɔ tek dɛn fɔ 5 to 10 ia.
• SERDs: Fɔ ɛgzampul, Fulvestrant de kam as injɛkshɔn.Tu. Dɛn kin gi dɛn tu injɛkshɔn ya na wan mɔsul na di bɔdi. Dɛn kin gi dɛn tri tɛm insay di fɔs mɔnt we dɛn de trit dɛn ɛn afta dat dɛn kin gi dɛn wan tɛm insay di mɔnt.

Insay us sityueshɔn dɛn kin gi SERM ɛn SERD?

Bɔku tin dɛn de we yu dɔktɔ kin tɛl yu fɔ gi yu dɛn tritmɛnt ya.

Wetin na di sayd ɛfɛkt ɛn risk dɛm wae dɛn tritmɛnt ya kin gɛt?

Lɛk ɛni mɛrɛsin, dɛn tin ya kin gɛt bad bad tin dɛn. Bɔt nɔto ɔlman kin gɛt dɛn. I impɔtant fɔ no bɔt di sayd ɛfɛkt dɛm we pɔsin kin gɛt.

Sayd ifɛkt dɛn we SERM dɛn gɛt

Di sayd efεkt dεm we dεn kin si bכku tεm na di sem lεk di wan dεm we dεn kin gεt we i de mεnopos.

• Hot flash dɛn we de shayn
• Vagina dray, dischaj, ɔ layt blɔd
• Nayt swet dɛn
• Vɔmit
• Di we aw pɔsin de fil kin chenj

Di sayd ɛfɛkt dɛn we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs:

• sכm sכm inkrεs pan di risk fכ uterin kεnsar
• Blɔd we de klɔt na di leg (Deep Vein Thrombosis, ɔ DVT) ɔ blɔd we de klɔt na di lɔng (Pulmonary Embolism) .
• Katarakt we pɔsin kin gɛt
• di bon dεm we uman dεn kin tכn bifo dεn mεnopos

Sayd ifekt dɛm fɔ SERD dɛm

• Pen fɔ sɔm tɛm na di say we dɛn injɛkshɔn
• Vɔmit
• Bɔn, mɔsul, ɔ jɔyn pen
• Ed de at
• Fɔ wok tranga wan
• Hot flash dɛn we de shayn

If yu dɔktɔ tɛl yu bɔt dis tritmɛnt, tɔk to am bɔt am. Nɔ fred fɔ aks kwɛstyɔn dɛn lɛk, "Us bɛnifit dis mɛrɛsin go gi mi?", "Us sayd ɛfɛkt a kin ɛkspɛkt?", ɛn "Aw lɔŋ a go nid fɔ tek dis mɛrɛsin?"