We yu kam fɔ no se yu gɛt kansa, yu kin fred ɛn wɔri bad bad wan. Bɔt we di sayɛns we dɛn de yuz fɔ mɛn pipul dɛn dɔn go bifo, tide, dɛn dɔn gɛt bɔku bɔku we dɛn fɔ mɛn kansa. Tide, wi go tɔk bɔt wan nyu ɛn rili pawaful tritmɛnt we dɔn rili wok fayn fɔ trit bɔku kayn kansa , mɔ di wan dɛn we kin kam na di blɔd.
Wetin na CAR T-Sɛl Tɛrapi?
Fɔ tɔk am simpul wan, CAR T-Cell Therapy na immunotherapy we dɛn kin yuz fɔ trit sɔm kayn blɔd kansa . Wi yon imyun sɛl dɛn tan lɛk sojaman dɛn na wi bɔdi. Wetin dis tritmɛnt de du na fɔ tek sɔm pan dɛn sojaman ya na yu yon bɔdi, we dɛn kɔl T sɛl ( T sɛl ɔ T limfosayt ) , ɛn tɔn dɛn to supa fɛtman dɛn we de pwɛl kansa sɛl dɛn.
Imajin se yu de kɛr yu T sɛl dɛn go na lab , put nyu jin insay dɛn, ɛn gi dɛn “spɛshal lens” we go ebul fɔ no di kansa sɛl dɛn. Wi kin kɔl dɛn T sɛl dɛn ya we dɛn dɔn chenj CAR T-sɛl dɛn . `CAR` tinap fɔ `Kimɛrik Antijen Risɛptɔ`. Dɔn, dɛn kin mek bɔku bɔku pan dɛn supa-fayt sɛl dɛn ya ɛn put dɛn bak insay yu bɔdi. Dɔn dɛn sɛl ya kin travul ɔlsay na yu bɔdi, ɛn dɛn kin fɛn ɛn pwɛl di kansa sɛl dɛn. Sɔntɛnde, dis tritmɛnt kin ivin mɛn blɔd kansa kpatakpata.
Us kayn kansa dɛn kin yuz dis tritmɛnt fɔ?
Naw, dɛn kin jɔs yuz CAR T-Cell Therapy fɔ sɔm kayn blɔd kansa usay ɔda tritmɛnt dɛn nɔ wok ɔ usay di kansa dɔn kam bak. Di tebul we de dɔŋ ya de sho sɔm pan dɛn kayn kansa ya.
| Tayp fɔ Kansa | Wan shɔt introdukshɔn |
|---|---|
| B-sεl akyu limfoblastik lukimiya (ALL) . | Akyu limfoblastik lukimiya we de kכmכt frכm B-sεl dεm. |
| Difεs big B-sεl limfoma | Wan kayn lymphoma we de gro kwik kwik wan. |
| Fɔlikul limfoma | Wan kayn lymphoma we de gro sloslo. |
| Mantɛl sɛl limfoma | Wan kayn limfoma we nɔ kin bɔku, bɔt we kin agresiv. |
| Bɔku bɔku mayloma | Bɔn mɛro kansa we kin apin na di plasma sɛl dɛn. |
| Praymari mεdiεstinal big B-sεl limfoma | Na wan kayn limfoma we kin apin na di midul pat na di chɛst. |
Okay, naw mek wi si aw dis de wok.
Fɔ ɔndastand dis, lɛ wi fɔs lan smɔl mɔ bɔt di T sɛl dɛn we de na wi imyun sistɛm. εvri sεl na wi bכdi gεt protin dεm we dεn k כl antijen dεm na in sεf. Dɛn tin ya tan lɛk ID kad we ɔl sɛl gɛt. Di kansa sɛl dɛn gɛt wan ID kad we dɔn chenj ɛn we nɔmal.
Wi T sɛl dɛn gɛt riseptɔ dɛn . dis rεsεpכta dεm na dεn we de rεkכgnεz invayda dεm lεk kεnsar sεl dεm we gεt כnusual ID kad (antijen dεm). Bɔt sɔntɛnde, kansa sɛl dɛn kin rili kɔni. Dɛn kin ayd frɔm dɛn T sɛl dɛn ya.
Dis na di say we wi nid di ɛp we di CAR T-sɛl dɛn de gi. dis na yu yon T sel dεm we dεn tren spεshal wan na di lab εn we dεn mכdify fכ no wan spεsifi k antijen pan kεnsar sεl dεm .
Dis tritmɛnt de mek dɛn sɛl ya nɔ jɔs kil di kansa sɛl dɛn, bɔt i de mek dɛn sheb ɛn bɔku insay di bɔdi. Dis min se yu kin gɛt lɔng tɛm sapɔt fɔ di sɛl dɛn we de fɛt kansa. Dis na di rizin we mek dɔktɔ dɛn kɔl dis tritmɛnt “drɔg we gɛt layf.”
Aw di tritmɛnt prɔses kin woke?
Dis ɔl di prɔses kin apin insay sɔm stej dɛn.
Bifo dɛn trit am
Fɔs, yu nid fɔ gɛda wayt blɔd sɛl dɛn, mɔ di T sɛl dɛn, frɔm yu bɔdi. Dɛn kɔl dis lukafɛrɛsis.Dis na tin we fiba di we aw pɔsin kin gi blɔd. Wan mashin kin tek sɔm pan yu blɔd, na di wayt blɔd sɛl dɛn nɔmɔ i kin sheb, dɔn i kin gi di ɔda blɔd bak to yu bɔdi.
afta dat dεn kin sεnd dεn T sεl dεm ya we dεn kכlekt to spεshal labכtכri fכ tכn to CAR T-sεl dεm. Dis prכsεs kin tek lεk 3 to 6 wik. Insay dis tɛm, dɛn kin gi yu ɔda tritmɛnt dɛn lɛk kemotɛrapi fɔ kɔntrol di kansa.
We yu rɛdi fɔ gɛt CAR T-sɛl dɛn, dɛn go gi yu wan tritmɛnt we dɛn kɔl lymphodepleting chemotherapy fɔ mek yu bɔdi nɔ rijek di nyu sɛl dɛn.
We dɛn de du tritmɛnt
Di rial tritmɛnt rili simpul. jכs lεk we yu gi salin, dεn nyu CAR T-sεl dεm ya we dεn mek de insay yu bכdi tru wan vein (IV layn) fכ 5 to 30 minit. Insay dis tɛm, yu go nid fɔ de na ɔspitul.
Afta dɛn dɔn trit am
Bikɔs dis na tritmɛnt we rili pawaful, sɔntɛnde, siriɔs sayd ɛfɛkt kin apin. So, yu kin gɛt fɔ de na ɔspitul fɔ lɛk 7-10 dez afta di tritmɛnt. I rili impɔtant fɔ de nia di ɔspitul usay yu bin gɛt tritmɛnt fɔ di fɔs mɔnt, ivin afta yu kɔmɔt na di ɔspitul. Bak,
- Sɔmbɔdi fɔ de wit yu 24 awa ɛvride fɔ kia fɔ yu if yu gɛt ɛni sayd ɛfɛkt.
- Nɔ drayv fɔ tu mɔnt afta yu dɔn gɛt tritmɛnt. Yu nid ɔda pɔsin fɔ du dat.
Wetin na di sayd ɛfɛkt dɛm fɔ dis tritmɛnt?
Tu kayn sayd ɛfɛkt de wae kin pasmak ɛn wae fayn fɔ pe atɛnshɔn to wit dis tritmɛnt. Ɔda kɔmɔn sayd ɛfɛkt dɛn kin apin bak.
| Tayp fɔ di sayd ɛfɛkt | Di tin dɛn we pɔsin kin si |
|---|---|
| Saytokin Rilis Sindrom | Fiva, at fɔ blo (dyspnea), blɔd prɛshɔn we de dɔŋ. (Dis kin bi siriɔs tin) |
| Nyurolɔjik Isyu dɛn | Kɔnfyushɔn, at fɔ tɔk (aphasia), at fɔ rayt (dysgraphia), ed pen, siz, trem. |
| Ɔda | We yu de trit yu, yu kin gɛt alɛji, taya, blɔd kin kɔmɔt, yu kin gɛt di sik mɔ ɛn mɔ, ɛn yu nɔ kin gɛt bɛtɛ potashɔm (haypokalemia) ɛn sɔdiɔm (hayponatremia). |
Wetin na di bɛnifit ɛn sakses rɛt fɔ dis tritmɛnt?
Di big bɛnifit fɔ CAR T-Cell Therapy na dat i de gi nyu op to pasɛnt dɛn we nɔ ebul fɔ du ɔda tritmɛnt dɛn. Sɔmtɛm i kin mɛn di kansa ɔltogɛda (rɛmishɔn). If nɔto dat, dis tritmɛnt kin mek di sikman dɛn layf lɔng.
Fɔ ɛgzampul, wan stɔdi we dɛn bin du insay 2020 sho se pas 85% pan di pikin dɛn we bin gɛt dis tritmɛnt fɔ akyu limfoblastik lukimiya (ALL) bin wɛl ɔl afta dɛn dɔn trit dɛn. Dɔn bak, 60% pan dɛn bin stil nɔ gɛt kansa afta wan ia. Bɔt i impɔtant fɔ mɛmba se dis nɔto 100% saksesful tritmɛnt fɔ ɔlman, na mɛrɛsin fɔ ɔlman. Bɔt dis na big tin fɔ du fɔ mɛn kansa.
Ustɛm yu fɔ go to dɔktɔ?
Dis rili impɔtant. Sɔm pan di sayd ɛfɛkt dɛm we CAR T-Cell Therapy kin gɛt, mɔ di Cytokine Release Syndrome ɛn prɔblɛm wit di nervɔs sistɛm, kin mek pɔsin in layf de pan denja .
So bifo yu kɔmɔt na ɔspitul, mek shɔ se yu aks yu dɔktɔ us sayn dɛn yu fɔ wɔri mɔ bɔt. If yu gɛt sayn dɛn lɛk fiva, kol, ed we de at , ɛn nɔys , kɔl yu dɔktɔ wantɛm wantɛm, ɔ go na di ɔspitul in Imejɛnsi Dipatmɛnt (ETU).
Dis tritmɛnt stil na nyu fild we stil de divɛlɔp. So if yu gɛt blɔd kansa, tɔk to yu dɔktɔ fɔ no if dis tritmɛnt fayn fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- CAR T-Cell Therapy na wan tritmɛnt we gɛt bɔku pawa ɛn we pɔsin kin yuz fɔ mɛn sik dɛn we dɛn kin yuz fɔ mek sɔm kayn blɔd kansa dɛn .
- Dis min se yu fɔ chenj yu yon T-sɛl dɛn na lab ɛn afta dat yu fɔ put dɛn bak na yu bɔdi fɔ kil di kansa sɛl dɛn.
- Dis tritmɛnt de wok lɛk “drɔg we gɛt layf,” we de fɛt kansa fɔ lɔng tɛm na di bɔdi.
- Siriɔs afta tritmɛntI impɔtant fɔ mek di dɔktɔ de wach am gud gud wan bikɔs di sayd ɛfɛkt dɛn kin apin. Ɛni sayn we yu tink se yu gɛt, yu fɔ ripɔt to di dɔktɔ wantɛm wantɛm.
- Pan ɔl we dis de gi nyu op to di wan dɛn we nɔ gɛt ɔda tritmɛnt, na yu dɔktɔ nɔmɔ go disayd if i fayn fɔ yu.
CAR T-Sɛl Tɛrapi, kansa tritmɛnt, blɔd kansa, imyunotɛrapi, imyun tɛrapi, T sɛl, Sri Lanka
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