Yu gɛt blɔd prɔblɛm bak? Lɛ wi tɔk bɔt CMML (Chronic Myelomonocytic Leukemia)!

Yu dɔn ɛva yɛri bɔt wan sik we dɛn kɔl `CMML` ɔ Chronic Myelomonocytic Leukemia ? Sɔntɛm nɔto so. Na bikɔs na wan kayn blɔd kansa we nɔ kin apin so ɔltɛm. Bɔt i rili impɔtant fɔ mek wi no bɔt dis. Na bikɔs i kin afɛkt di we aw wi bɔdi de mek blɔd. Lɛ wi tɔk bɔt dis simpul wan, di we we yu go ɔndastand.

Wetin na CMML? Lɛ wi ɔndastand am simpul wan!

Fɔ tɔk am simpul wan, yu bon mɛro – di spɔnj pat insay yu bon dɛn – na in de mek blɔd. Pɔsin we gɛt CMML gɛt wan kayn wayt blɔd sɛl we dɛn kɔl monosayt . Dɛn abnɔmal monosayt dɛn ya kin krawd di wɛlbɔdi rɛd blɔd sɛl dɛn , di pletlɛt dɛn , ɛn ɔda wɛlbɔdi wayt blɔd sɛl dɛn we wi nid. Tink bɔt am lɛk gras we de na gadin we de krawd tik dɛn we gɛt wɛlbɔdi.

Dɔktɔ dɛn kin klas dis kɔndishɔn as Myeloproliferative neoplasm/Myelodysplastic syndrome (MPN/ MDS ). Pan ɔl we dis kin tan lɛk se na kɔmplikɛt kɔmbayn wɔd dɛn, i rili min:

• Myeloproliferative neoplasm (MPN): Dis na we yu bon mɛro de mek tumɔs pan wan kayn blɔd sɛl. We dɛn mek tumɔs pan jɔs wan kayn, di balans na di blɔd kin ambɔg ɛn di blɔd nɔ kin wok fayn.
• Myelodysplastic syndrome (MDS): Dis na wan sik we di blɔd sɛl dɛn we yu bon mɛrɔ de mek nɔ kin chenj ɛn nɔ shep fayn . Spɛshal wan, instead fɔ mek blɔd sɛl dɛn we gɛt wɛlbɔdi ɛn machɔ, dɛn kin mek mɔ sɛl dɛn we nɔ machɔ we dɛn kɔl blast sɛl.

Sɔntɛnde CMML kin gro rili sloslo. Bɔt sɔntɛnde, i kin kwik smɔl ɛn i kin tranga. Yu dɔktɔ go ɛksplen to yu bɔt di tritmɛnt dɛn we go ebul fɔ kɔntrol di we aw i de gro.

Wetin na di sayn dɛm fɔ CMML? Yu gɛt dɛn tin ya bak?

Di sayn dɛm fɔ CMML nɔ kin klia ɔltɛm. Sɔntɛnde, na blɔd tɛst na di fɔs tin we go mek pɔsin no. Ivin we di sayn dɛn de sho, dɛn kin kam smɔl smɔl. Si if dɛn sayn ya kin tan lɛk se yu sabi:

• Fɔ fil taya ɛn wik ɔltɛm: Dis kin bi bikɔs di rɛd blɔd sɛl dɛn de go dɔŋ, we na anemia .
• Sik ɛn infekshɔn ɔltɛm:Dis kin bi bikɔs di wayt blɔd sɛl dɛn kin go dɔŋ, we dɛn kɔl nyutropenia.
• blɔd we de kɔmɔt na yu nos bɔku tɛm, we de tɔn blu ivin we yu gɛt smɔl brus: Dis kin bi bikɔs di pletlɛt dɛn de go dɔŋ, we dɛn kɔl trombocytopenia.
• Splenomegaly : Na di splin we de big, we de na di ɔp lɛft say na yu bɛlɛ.
• Hepatomegaly : Di liva de big.
• We yu de lɔs yu wet we yu nɔ ɛksplen.
• Nayt swet dɛn.
• Bɔn pen.
• Fiva.

Mɛmba se nɔto ɔlman we gɛt dɛn sik ya gɛt CMML. Bɔt if dɛn sik ya kɔntinyu, i go fayn fɔ mek yu go to dɔktɔ.

Wan patikyula kɔz de fɔ CMML?

Risach pipul dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek pɔsin gɛt CMML. Bɔt dɛn dɔn no bɔku jin dɛn we gɛt fɔ du wit di sik. If dɛn no se yu gɛt CMML, i go mɔs bi se yu gɛt pas wan jin muteshon. Sɔm pan di jin dɛn we kin chenj pas ɔl na:

• `TET2`
• `SRSF2`
• `ASXL1`
• `RAS` (dis na di wan we kɔmɔn pas ɔl)

Yu dɔktɔ go tɛl yu mɔ bɔt dis jin.

Udat de pan ay risk fɔ gɛt CMML?

Bɔku tin dɛn de we kin mek pɔsin gɛt prɔblɛm we kin afɛkt di divɛlɔpmɛnt fɔ CMML:

• Ej: De risk fɔ gɛt dis sik kin bɔku as yu de ol. Di avrej ej fɔ no di sik na bitwin 73 ɛn 75 ia. Dis min se af pan di wan dɛn we dɛn kin no se gɛt dis sik, yɔŋ pas dat, ɛn di ɔda af kin ol.
• Jɛnda: CMML kin bɔku pan man dɛn pas uman dɛn.
• Tritmɛnt fɔ kansa bifo: Na lɛk wan pan ɛvri tɛn pipul dɛn we gɛt CMML dɔn gɛt kemotɛrapi ɔ redyushɔn fɔ kansa bifo tɛm. Bɔt dɔktɔ dɛn kin jɔs gi dɛn tritmɛnt dɛn ya if i klia se di bɛnifit dɛn we di tritmɛnt go gɛt pas di risk fɔ gɛt kansa tumara bambay.

Us ɔda kɔmplikɛshɔn kin apin pan dis kɔndishɔn?

Na lɛk tu pan ɛvri tɛn pipul dɛn we gɛt CMML go gɛt ɔda siriɔs blɔd kansa we dɛn kɔl akyu mayloid lukimiya (AML). Tɔk to yu dɔktɔ bɔt yu risk fɔ gɛt AML bay aw yu dɔn no bɔt yu sik ɛn di tin dɛn we kin mek yu gɛt dis sik.

Aw dɔktɔ dɛn kin no se pɔsin gɛt CMML?

Yu dɔktɔ go aks bɔt yu sik ɛn tek yu mɛdikal histri. Dɔn dɛn go du bɔku tɛst dɛn fɔ chɛk yu blɔd sɛl dɛn. Dɛn tɛst ya kin bi:

• kכmplit bכdi kכnt (CBC): If di nכmba fכ di monosayt dεm tu hכy (monocytosis), i kin bi sayn fכ CMML.
• di pεrifεral bכdi smεr: if di monosayt dεm de sho se dεn nכ de rεgεl כ i nכ machכ (blast sεl dεm) we dεn luk am כnda maykroskכp, dis kin bi sayn bak fכ CMML.
• Bone marrow biopsy: Sɔntɛnde di dɔktɔ kin nid fɔ tek smɔl sampul pan bon marrow ɛn tɛst am na di lab fɔ si if ɛni abnɔmal monosayt de.
• Jɛnɛtik tɛst: Dɔktɔ dɛn kin luk bak fɔ di jin dɛn we kin chenj we gɛt fɔ du wit ɔda blɔd kansa dɛn. Dis kin mek dɛn nɔ ebul fɔ pul ɔda sik dɛn we gɛt di sem sayn ɛn blɔd tɛst rizɔlt.

Wetin na di stej dɛm fɔ CMML?

Dɔktɔ dɛn kin disayd aw fa CMML dɔn skata, ɔ aw i siriɔs (kansa stej), bay di nɔmba fɔ di blast sɛl dɛn na yu blɔd ɛn bon mɛro. Dɛn tu stej ya na:

• CMML-1: Fכ 4 pan 100 sεl dεm na yu bכdi na blast sεl dεm. fכ 9 pan 100 sεl dεm na yu bon mכro na blast sεl dεm.
• CMML-2: Bitwin 5 ɛn 19 pan 100 sɛl dɛn na yu blɔd na blast sɛl. bitwin 10 εn 19 pan 100 sεl dεm na yu bon mכro na blast sεl dεm.

Na dis stej yu dɔktɔ go disayd us tritmɛnt we go fayn ɛn we go wok fɔ yu.

Wetin na di tritmɛnt dɛm fɔ CMML?

Fɔs, yu kin nid tritmɛnt fɔ mek shɔ se yu gɛt inof wɛlbɔdi blɔd sɛl. Dis kin min fɔ tek mɛrɛsin fɔ mek yu blɔd sɛl dɛn bɔku ɔ fɔ tek blɔd ɔltɛm. Dis kin bi pat bak pan palliativ kia fɔ kɔntrol di simptom dɛm.

Ɔda tritmɛnt dɛn we de tɔch CMML dairekt wan na:

• Allogeneic stem cell transplant: Dis na di onli tritmεnt we kin kכmplit kכl CMML. Bɔt, i nɔ fayn fɔ ɔlman. I kin mek bak prɔblɛm dɛn we kin mek pɔsin in layf de pan denja lɛk graft-versus-host sik.
• Kimotɛrapi: Kimotɛrapi drɔgs kin stɔp di growth we di monosayt dɛn nɔ kin kɔntrol. Dis kin ɛp fɔ pul di sayn dɛm. Dis de yuz drɔgs lɛk Hydroxyurea ɛn Hypomethylating agents (HMA).
• Klinik trial dɛn:If ɔda tritmɛnt dɛn nɔ ɛp, yu dɔktɔ kin tɛl yu fɔ tek pat pan wan klinik trial. Naw, di klinik trial dɛm de invɛstigat di ɛfɛktiv we nyu tritmɛnt dɛm (e.g., targeted therapy, immunotherapy) de du fɔ CMML.

Ustɛm a fɔ go to di dɔktɔ?

Yu go nid fɔ go to yu dɔktɔ ɔltɛm (bɔku tɛm wan tɛm insay di mɔnt to wan tɛm ɛvri siks mɔnt). I rili impɔtant fɔ mek yu kip dɛn apɔntin dɛn ya. Insay dɛn apɔntinmɛnt ya, yu dɔktɔ go aks yu bɔt di sik dɛn we yu gɛt, du blɔd tɛst, chɛk aw yu tritmɛnt de wok fayn, ɛn mek ɛni ajɔstmɛnt we yu nid.

Insay da tɛm de, if yu gɛt ɛni bad bad tin we yu nɔ bin de tink se go apin to yu , tɔk to yu dɔktɔ wantɛm wantɛm . Yu dɔktɔ go tɛl yu us sayn fɔ wach, i go dipen pan di tritmɛnt we yu de gɛt.

Wetin yu kin ɛkspɛkt we yu de liv wit dis sik?

Di midyan layf we pɔsin we dɛn no se gɛt CMML kin liv na lɛk wan to tri ia. Agen, di "median" na midul valyu. Dis min se af pan di pipul dɛm kin gɛt shɔt layf ɛn af kin gɛt lɔng layf. Bɔt bɔku tin dɛn de we kin mek yu no wetin go apin to yu. Dɛn tin ya na:

• Blɔd tɛst rizɔlt: Di blɔd sɛl dɛn we yu de kɔnt kin gi yu tin dɛn we go ɛp yu fɔ no wetin go apin to yu. Yu monosayt, blast sɛl, ɛn pletlɛt kɔnt na impɔtant valyu dɛn. Yu ɛmoglobin lɛvɛl na impɔtant valyu bak we yu dɔktɔ go chɛk bɔku tɛm.
• jεnεtik mכtεshכn dεm: sכm jεnεtik mכtεshכn dεm, fכ egzampl wan mכtεshכn na di `ASXL1` jin, de sho se i gεt wכs prכgnosis.
• Di blɔd we dɛn kin gi yu ɔltɛm: If yu nɔ nid fɔ tek blɔd bɔku tɛm fɔ mek yu blɔd sɛl dɛn kam bak, bɔku tɛm di tin we kin apin to yu kin fayn.

yu prכgnosis de dipכnt bak pan if yu kכndyushכn de go bifo to `AML` (acute myeloid leukemia). Dis kin apin mɔ if yu gɛt `CMML-2`.

Wetin a go du fɔ mek a gɛt wɛlbɔdi ɛn fɔ gɛt trɛnk?

If yu gɛt CMML, wan pan de bɛst tin wae yu kin du na fɔ tek rispɔnsibiliti fɔ yu wɛl bɔdi ɔl kayn we . Dis tɛm, i impɔtant fɔ it tin dɛn we gɛt fayn fayn tin dɛn fɔ it ɛn slip fayn. Fɔ balans bitwin fɔ de du tin ɛn fɔ rɛst fayn fayn wan impɔtant bak. Fɔ gɛt kɔnekshɔn wit ɔda pipul dɛm wae de liv wit kansa na fayn we fɔ fɛt di filin wae de fil fɔ de yu wan. Tɔk to dɔktɔ we gɛt ɛkspiriɛns fɔ wok wit pipul dɛn we gɛt kansa.

Kansa kin mek pɔsin fil se i nɔ ebul fɔ du ɛnitin, bɔt mɛmba se yu stil de kɔntrol yu layf.Ɛn tritmɛnt dɛn de we go ɛp yu.

Fɔ liv wit CMML nɔ izi. Di tin we go apin to yu, dipen pan bɔku tin dɛn we yu nɔ go si. Aks yu dɔktɔ fɔ ɛksplen wetin na dɛn tin ya ɛn aw dɛn kin afɛkt yu prɔgnosis. Ɔndastand yu tritmɛnt opshɔn dɛm so dat yu go gɛt kɔnfidɛns se di kia we yu go pik go mit yu gol dɛm.

Di mɛsej we impɔtant pas ɔl fɔ kɛr go na os

CMML na siriɔs kɔndishɔn. Bɔt if yu no bɔt am, woke wit yu dɔktɔ, gɛt di rayt tritmɛnt, ɛn mek gud chenj na yu layf, yu kin tray fɔ liv fayn wit dis sik. Nɔ ɛva giv ɔp op. Yu famili, yu padi dɛn, ɛn dɔktɔ dɛn de fɔ ɛp yu. Nɔto yu wan de. If yu gɛt ɛni kwɛstyɔn ɔ tin we de mɔna yu, nɔ fred fɔ aks yu dɔktɔ. Na yu rayt.

` CMML, Kronik Maylomonosaytik Lukimia, Blɔd Kansa, Bɔn Mɛro, Monosayt, Simptom, Tritmɛnt