We dɛn no se yu ɔ pɔsin we de nia yu gɛt bɔdi kansa, yu go dɔn yɛri se dɔktɔ dɛn de yuz wɔd dɛn lɛk ‘ HER2-Positive ’ ɔ ‘HER2-low’. Dis na rili nem dɛn we dɛn kin yuz fɔ tɔk bɔt di kayn kansa sɛl dɛn. Naw, nyu, advans mɛrɛsin dɛn de fɔ mɛn dɛn kayn kansa ya. Wan pan dɛn spɛshal mɛrɛsin dɛn de na Enhertu. Tide, wi go tɔk bɔt dis insay wan simpul we we izi fɔ ɔndastand.
Us kayn mɛrɛsin na Enhertu? Aw i kin wok?
Fɔ tɔk am simpul wan, Enhertu na tritmɛnt we dɛn kin yuz fɔ mɛn pipul dɛn . fכ bi prεsis, na wan kayn dכg we dεn kכl `Antibody-Drug Conjugate (ADC).` Pan כl we di nem kin saund sכmtεm sכmtεm, di we aw i de wok na rili amazing.
Tink bɔt dis mɛrɛsin lɛk smat mishɔl. I gɛt tri pat dɛn:
1. di pat we de fכnshכn di tכgεt (Antibody): dis pat de fכn wan spεshal protin we dεn kכl `HER2` na di sεf fכ di kεnsar sεl dεm εn i de atak am. di wok we dis pat de du na fכ sεlekt fכ no εn protεkt כnli kεnsar sεl dεm, we nכ de ambɔg di hεlty sεl dεm.
2. Payload: Dis na di drɔg we de kil kansa sɛl dɛn. Fɔ tɔk di tru, dis na pawaful kayn kemotɛrapi.
3. Di pat we de kɔnɛkt dɛn tu ya (Linker): Di tu pat dɛn we wi dɔn tɔk bɔt ɔp, na dis linka de kɔnɛkt dɛn togɛda.
so, we yu gi dis dכg, di antibodi pat pan am de go stret to di kεnsar sεl dεm we gεt di `HER2` protin. Dɔn, di drɔg kin absɔb insay di sɛl. we di kεmo pat de kכmכt insay di sεl, i de kכmכt εn i de pwεl di kansa sεl. As di kansa sɛl dɛn de day, di kansa sɛl dɛn kin smɔl ɛn stɔp fɔ gro.
Di big bɛnifit fɔ dis we na dat di mɛrɛsin de tɔch di kansa sɛl dɛn nɔmɔ dairekt wan, so di damej we de pan wɛlbɔdi sɛl dɛn kin ridyus bad bad wan.
Aw dɛn kin gi Enhertu?
Enhertu na mɛrɛsin we dɛn kin gi insay di bɛlɛ. dis min se dεn de gi am insay di bכdi as salin sכlushכn (IV infushכn). Na pɔsin we sabi bɔt wɛlbɔdi biznɛs na ɔspitul, klinik, ɔ spɛshal tritmɛnt sɛnta go gi yu dis tritmɛnt.
- Aw fɔ tek am: Dɛn kin gi dis tritmɛnt wan tɛm ɛvri 3 wik .
- Doz: Di amount of mɛrɛsin we yu nid na bay yu bɔdi wet. Yu dɔktɔ go kɔl am di rayt we ɛn gi yu am.
- Di tɛm we dɛn fɔ spɛn:If yu kansa de ansa dis mɛrɛsin fayn fayn wan, yu dɔktɔ go advays yu fɔ kɔntinyu dis tritmɛnt fɔ lɔng tɛm. Bɔt if yu gɛt sɔm bad bad tin dɛn, yu go nid fɔ chenj di doz fɔ di mɛrɛsin, stɔp di tritmɛnt fɔ sɔm tɛm, ɔ ivin stɔp am ɔltogɛda. Yu dɔktɔ go tɔk to yu ɔl dɛn tin ya ɛn disayd fɔ du sɔntin.
Aw di Enhertu drɔg rili wok?
Tu klinik trayal dɛm we de invɛstigat di ɛfɛktiv we di Enhertu drɔg de wok dɔn gi rili gud rizɔlt.
1. Kɔmpia Enhertu ɛn Kadcyla (DESTINY-Breast03 trayal) .
Insay dis trayal, dɛn kɔmpia Enhertu wit Kadcyla (ado-trastuzumab emtansine), ɔda drɔg we de tɔch ``HER2.'' Dɛn sho di rizɔlt dɛn na di tebul we de dɔŋ ya.
| Pɔynt we yu kɔmpia am | Enhertu tritmɛnt | Kadcyla tritmɛnt |
|---|---|---|
| Progreshɔn-Fri Survival (Dis na di tɛm we i kin tek fɔ mek af pan di sik pipul dɛn gɛt dɛn kansa bak ɔ nɔ go skata) | 28.8 mɔnt | 6.8 mɔnt |
| Pasɛnt pan di sik pipul dɛm wae nɔr bin skata di sik afta 12 mɔnt | 75,2% . | 33,9% . |
| Pasεnt pan di sik pipul dɛm wae nɔr bin spre di sik afta 24 mɔnt | 53,7% . | 26,4% . |
2. Kɔmpia Enhertu ɛn kemotɛrapi (DESTINY-Breast04 trayal) .
Dis trayal kɔmpia Enhertu wit standad kemotɛrapi.
| Pɔynt we yu kɔmpia am | Enhertu tritmɛnt | Kimotɛrapi tritmɛnt |
|---|---|---|
| Progreshɔn-Fri Survival | 9.9 mɔnt | 5.1 mɔnt |
| Ɔl di wan dɛn we de sev (Dis na di tɛm we af pan di pasɛnt dɛn we bin gɛt tritmɛnt bin sev) | 23.4 mɔnt | 16.8 mɔnt |
Dis data sho se Enhertu na tritmɛnt we de wok fayn pas sɔm pan di tritmɛnt dɛn we de naw .
Aw a go de wach aw a de wɛl?
Enhertu kin bigin fɔ wok jɔs lɛk aw yu gɛt yu fɔs doz. Yu dɔktɔ go du difrɛn tɛst fɔ si aw yu bɔdi de du di mɛrɛsin.
- Skan: Dɛn kin du skan lɛk 6 wik afta dɛn dɔn bigin fɔ trit am fɔ chɛk aw di kansa de go bifo. Dɛn kin du dis bifo tɛm ɔ leta.
- Blɔd tɛst: Dɛn kin du blɔd tɛst ɔltɛm fɔ chɛk yu wayt blɔd sɛl, nyutrofil, ɛn pletlɛt dɛn. Dis go ɛp fɔ no if yu go ebul fɔ kɔntinyu fɔ tek di mɛrɛsin sef wan. If yu gɛt sayd ɛfɛkt, lɛk fɔ kɔf, yu kin mek dɛn du ɔda spɛshal tɛst dɛn bak fɔ luk fɔ dɛn.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Di sayd ɛfɛkt dɛn kin apin we dɛn de mɛn kansa. Dis na tru bak fɔ Enhertu. Di tin we impɔtant pas ɔl na fɔ tɛl yu dɔktɔ bɔt ɛni sayd ɛfɛkt we yu gɛt. Na in go disayd if dɛn siriɔs ɛn tɛl yu wetin fɔ du bɔt dɛn.
Fɔ mek yu nɔ gɛt di kɔmɔn sayd ɛfɛkt lɛk fɔ vɔmit ɛn nɔs, yu dɔktɔ kin gi yu ɔda mɛrɛsin fɔ tek bifo i gi yu di mɛrɛsin. I rili impɔtant fɔ fala dɛn instrɔkshɔn dɛn de di rayt we.
Apat frɔm dat, yu kin du simpul tin dɛn bak lɛk dɛn wan ya fɔ ɛp fɔ kɔntrol yu nɔs, vɔmit, ɛn dayarɛa:
- It bland it dɛn we nɔ gɛt bɔku ɔyl ɛn chili.
- Bifo yu it tri big it dɛn, it sɔm smɔl smɔl it dɛn ɛvride.
Dipen pan aw sɔm sayd ɛfɛkt dɛn kin tranga, yu dɔktɔ kin disayd fɔ ridyus di doz fɔ yu mɛrɛsin, stɔp di tritmɛnt fɔ sɔm tɛm, ɔ stɔp am ɔltogɛda. Nɔ wɔri bɔt am. Na ɔltin fɔ yu sef.
Ɛni spɛshal wɔnin dɛn de we wi fɔ no bɔt?
Yɛs. Enhertu gɛt wan rili siriɔs blak bɔks wɔnin . Dis na di ays wɔnin we di FDA (US Food and Drug Administration) dɔn gi.
1. Harm to di pikin we de na in bεlε: Yu fɔ avɔyd fɔ gɛt bɛlɛ kpatakpata we yu de tek dis mɛrɛsin. Dis kin rili ambɔg di pikin we nɔ bɔn yet. If yu ɔ yu patna de plan fɔ gɛt bɛlɛ, mek shɔ se yu tɛl yu dɔktɔ . Yu dɔktɔ go advays yu bɔt di rayt we fɔ kɔntrol bɔn pikin we yu fɔ yuz we yu de trit yu.
2. Lɔng damej: Dis mɛrɛsin kin mek yu gɛt siriɔs lɔng sik we dɛn kɔl `Interstitial Lung Disease (ILD).` So, yu dɔktɔ go de wach yu fɔ dis ɔl di tɛm we yu de trit yu. If yu gɛt sɔm sayn dɛn lɛk kɔf ɛn i nɔ izi fɔ blo, tɛl yu dɔktɔ wantɛm wantɛm.
Bikɔs ɔf dɛn tin ya, i rili impɔtant fɔ kɔntinyu fɔ tɔk to di dɔktɔ ɔltɛm ɛn fala in instrɔkshɔn dɛn di rayt we.
Mɛsej we dɛn kin kɛr go na os
- Enhertu na wan advans dכg we de tכk di HER2 protin we de insay brεst kεnsar εn i de kil כnli kεnsar sεl dεm.
- Dis na tritmɛnt we dɛn kin gi tru wan vein (IV) ɛvri 3 wik.
- Di klinik trial dɛn dɔn pruv se dis mɛrɛsin de wok fayn pas ɔda tritmɛnt dɛn we dɛn de yuz naw.
- Sɔm sayd ɛfɛkt lɛk fɔ nɔs ɛn vɔmit kin apin we yu de trit yu, ɛn we dɛn de fɔ kɔntrol dɛn. Tɛl yu dɔktɔ wantɛm wantɛm bɔt ɛnitin we nɔ fayn.
- If yu tek dis mɛrɛsin we yu gɛt bɛlɛ, dat kin mek di pikin we nɔ bɔn yet gɛt siriɔs prɔblɛm, ɛn i kin gɛt siriɔs sayd ɛfɛkt we go afɛkt di lɔng dɛn. Tɔk to yu dɔktɔ bɔt dis opin wan.
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