Yu dɔn notis wantɛm wantɛm se yu de si chenj, yu yay de pen, ɔ yu an ɛn fut dɛn de swɛ ɔ wik? I kin bi ɔda tin. Tide wi de tɔk bɔt wan kɔndishɔn we nɔ kin rili kɔmɔn na wi kɔntri, bɔt i rili impɔtant fɔ mek wi no bɔt am. Dat na Nyuromaylaytis Ɔptika Spɛktrum Disɔda , ɔ NMOSD fɔ shɔt tɛm. Dis na ɔtoimyun sik we kin mɔs afɛkt yu yay ɛn yu spɛnal kɔd.
Wetin na NMOSD? Aw Enspryng de wok?
Fɔ tɔk am simpul wan, NMOSD na we yu bɔdi in yon imyun sistɛm, di sistɛm we de protɛkt wi frɔm sik, mistek bigin fɔ atak yu yon wɛlbɔdi sɛl dɛn. spεshal wan, yu bכdi de stat fכ mek antibodi dεm agens wan spεsifi k protin na yu nεv sεstem we dεn kכl `aquaporin-4 (AQP4).'
Dis atak kin mek yu gɛt inflamɛns, ɔ inflamɛns, rawnd yu optik nerve (di nerve we de kɛr mɛsej bitwin yu yay ɛn yu bren) ɛn spɛshal kɔd. As dis de kɔntinyu, i kin mek yu nɔ de si fayn ɛn i nɔ kin izi fɔ waka.
No mɛrɛsin nɔ de fɔ NMOSD yet. Di tritmɛnt dɛn kin mɔs fɔ ridyus di inflamɛns, kɔntrol di sayn dɛm , ɛn fɔ mek i nɔ gɛt di sik bak.
Dis na di say we Enspryng de kam in. Enspryng na nyu biyolojikal mɛrɛsin. Dis mɛrɛsin kin ɛp fɔ mek NMOSD nɔ kam bak, mɔ if yu gɛt di anti-AQP4 antibodi dɛm we wi bin dɔn tɔk bɔt fɔs na yu blɔd.
Enspryng de wok bay we i de blכk כda protin na wi bכdi we dεn kכl ``interleukin-6 (IL-6).`` biכs dis protin we dεn kכl IL-6 de involv bak insay di inflameshn we di anti-APQ4 antibodi dεm de mek. So we dɛn blok IL-6, di inflamɛns kin ridyus, dɛn kin kɔntrol di sayn dɛm, ɛn di sik kin ridyus.
| Di eria we dɛn afɛkt ɛn di kɔndishɔn | Simptom dɛm wae yu kin fil |
|---|---|
| Optik Nyuraytis | |
| Transvas Maylaytis we gɛt di sik |
Aw a fɔ yuz dis mɛrɛsin?
Enspryng na injεkshכn we dεn kin put insay di bכdi . Dɛn kin gi am na di bɛlɛ we de dɔŋ ɔ di fɔs midul pat na di shɔl.
- Dɛn fɔ gi di fɔs tri injɛkshɔn dɛn ɛvri tu wik.
- Afta dat, yu jɔs gɛt fɔ hit am wan tɛm insay di mɔnt.
I rili impɔtant fɔ mɛmba di rayt de dɛn we yu nid fɔ gɛt dɛn injɛkshɔn ya. Sɛt wan mɛsej fɔ mɛmba na kalenda ɔ na yu fon. If yu mis injɛkshɔn, yu fɔ rili tɔk to yu dɔktɔ bɔt wetin fɔ du nɛks.
Nɔ wɔri, yu dɔktɔ go tren yu bɔt aw fɔ gi yusɛf dis injɛkshɔn, usay fɔ gi am, ɛn aw fɔ chenj di sayt ɛvri tɛm. Wash yu an fayn fayn wan ɔltɛm bifo yu gi di injɛkshɔn.
Aw a fɔ kip di mɛrɛsin?
Dis mɛrɛsin fɔ de na frij . Bɔt nɔ kip am na friza. Dɔn bak, nɔ shek di mɛrɛsin. Tek di mɛrɛsin kɔmɔt 30 minit bifo di injɛkshɔn ɛn lɛ i kam na rum tɛmpracha. Nɔ ɛva wam di mɛrɛsin na maykrowev ɔ wit ɔt wata.
I impɔtant fɔ tɔk to yu dɔktɔ bɔt ɛni vaysin we yu fɔ gɛt we yu de tek Enspryng. Sɔm vaysin dɛn nɔ kin fayn we yu de tek dis mɛrɛsin.
Aw dɛn dɔn du risach bɔt dis mɛrɛsin?
Tu big stɔdi dɛn dɔn du fɔ luk di sef ɛn ɛfɛktiv we Enspryng gɛt. Dɛn tin ya kɔmpia Enspryng to wan plasɛbo, wan mɛrɛsin we nɔ gɛt ɛni aktif ingridiɛnt. Dis na di tɛm we wi kin rili no if di mɛrɛsin rili bɛnifit ɔ i bad.
Ɔl di wan dɛn we tek pat pan dis stɔdi bin gɛt NMOSD, istri fɔ rilaps, ɛn wan mak bitwin 0 ɛn 6.5 pan di Expanded Disability Status Scale (EDSS), we na wan skel we de mɛzhɔ dɛn lɛvɛl fɔ disabiliti. (EDSS mak we na 0 min se nɔ gɛt disabiliti, 6.5 min sɔm limiteshɔn fɔ waka.)
Di risach bin luk mɔ pan aw lɔng i tek fɔ mek di sik kam bak. Apat frɔm dat, dɛn bin pe atɛnshɔn to chenj dɛn na di `Visual Analog Scale (VAS)`, we de mɛzhɔ pen, ɛn di `Functional Assessment of Chronic Illness Therapy (FACIT)`, we de mɛzhɔ taya.
Wetin na di tin dɛn we dɛn dɔn du we dɛn du di risach?
Insay ɔl tu di stɔdi dɛn, di pasɛnt dɛn we tek Enspryng bin gɛt signifyant smɔl rilaps pas di wan dɛn we tek plasɛbo. Dis min se Enspryng kin ridyus yu simptom dɛm ɛn di nɔmba fɔ di wan dɛm wae kin kam bak.
Bɔt di pasɛnt dɛn we nɔ gɛt anti-AQP4 antibodi nɔ bin bɛnifit bɔku frɔm Enspryng we dɛn kɔmpia am wit plasɛbo.
| Rilaps rεt in pasεnshכn dεm wit anti-AQP4 antibodi dεm | ||
|---|---|---|
| Stɔdi | Enspryng kategori | Plɛsɛbo grup |
| Risach 1 (Enspryng nɔmɔ) . | 20% bin rilaps | 43% bin gɛt di sik bak |
| Stɔdi 2 (Enspryng wit ɔda mɛrɛsin dɛn) . | 30% bin rilaps | 50% bin rilaps |
Bɔt mɛmba se dɛn tin ya na tin dɛn we dɛn dɔn du we dɛn dɔn du risach. Yu rizulyt kin difrɛn. Yu ɛn yu dɔktɔ fɔ disayd togɛda if dis mɛrɛsin fayn fɔ yu ɛn if di bɛnifit dɛn pas di prɔblɛm dɛn we i go gɛt.
Aw fɔ kɔntrol di sayd ɛfɛkt dɛn if dɛn apin?
Di sayd ɛfɛkt dɛm we dis mɛrɛsin kin gɛt na di nos ɛn trot infɛkshɔn, ed we kin at, nɔs, skin rɔsh, gastritis, taya, ɛn pen na di limb ɔ jɔyn dɛm. Tɛl yu dɔktɔ if yu gɛt ɛni wan pan dɛn tin ya.
Infεkshכn dεm
Risk de fɔ mek yu gɛt kɔmɔn ɔ siriɔs infɛkshɔn we yu de tek Enspryng. Tɛl yu dɔktɔ if dɛn de trit yu fɔ infekshɔn. Dɔn bak, tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni wan pan dɛn sayn ya:
- Kol, bɔdi de at, fiva, trot we de at, kɔf ɔltɛm
- Skin de rɛd ɔ swel
- Bɛlɛ de at, dayarɛa
- Bɔn we yu de pis ɔ nid fɔ pis ɔltɛm
Kraw kraw
Tɛl yu dɔktɔ if yu gɛt skin rash we yu de tek di mɛrɛsin. If di rash skata ɔlsay na yu bɔdi wantɛm wantɛm, go na ɔspitul in imejensi rum (ETU) wantɛm wantɛm.
Nɔto dɛn wan ya nɔmɔ kin gɛt di bad tin dɛn we kin apin to pɔsin. If yu gɛt ɛni sayn we de mɔna yu, tɔk to yu dɔktɔ bɔt am.
Us tɛst dɛn fɔ du bifo dɛn bigin tritmɛnt ɛn we dɛn de du tritmɛnt?
Bifo yu bigin Enspryng, yu dɔktɔ go du sɔm blɔd tɛst fɔ chɛk aw yu liva de wok, epataytis B, TB, ɔ ɔda infɛkshɔn. Dɛn kin nid fɔ ripit dɛn tɛst ya we dɛn de trit am. So i rili impɔtant fɔ mek dɛn du yu tɛst dɛn di rayt tɛm.
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn?
Dɛn nɔ ripɔt ɛni big intarakshɔn bitwin Enspryng ɛn it ɔ ɔda mɛrɛsin dɛn. Bɔt i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud di mɛrɛsin dɛn fɔ ɔda sik dɛn, vaytamɛn dɛn, ɛbul mɛrɛsin dɛn, ɛn sɔpɔtmɛnt dɛn). Dis kin ɛp fɔ mek yu nɔ gɛt ɛni bad bad tin we yu nɔ want.
Mɛsej we dɛn kin kɛr go na os
- NMOSD na wan sik wae nɔr kin bɔrku bɔt wae kin siriɔs wae yu imyun sistɛm kin atak yu yay ɛn yu spɛnal kɔd.
- Enspryng na nyu mɛrɛsin we de ɛp fɔ ridyus di rilaps, mɔ pan di wan dɛn we gɛt anti-AQP4 antibodi.
- Dis na injɛkshɔn ɔnda di skin. I impɔtant fɔ mek yu gɛt di rayt trenin frɔm yu dɔktɔ.
- Tɛl yu dɔktɔ wantɛm wantɛm bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek ɛn ɛni sayd ɛfɛkt we go apin we yu de trit yu.
- Nɔ ɛva stɔp di tritmɛnt ɔ chenj di doz if yu dɔktɔ nɔ advays yu.
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