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Wetin na ɛparin? Wetin mek HIT kin apin?
Fɔ tɔk am simpul wan, ɛparin na wan antikɔagulant (blɔd tin we de mek yu blɔd tan). Dɛn kin yuz am fɔ mek blɔd nɔ klɔt na wi blɔd vesel dɛn. Dɔktɔ dɛn kin gi am afta dɛn dɔn du big ɔpreshɔn, ɔ fɔ sɔlv wan blɔd we dɔn ɔlrɛdi fɔm. Bɔt nɔto ɔltɛm, we dɛn gi sɔm pipul dɛn ɛparin, i kin mek dɛn gɛt bad bad tin fɔ du. Dis na we wi imyun sistɛm mistek kɔba wit ɛprin ɛn mek wi yon pletlɛt dɛn wok. Plɛtlɛt na wan kayn sɛl we de ɛp fɔ stɔp wi blɔd. so, we di pletlεt dεm de aktibכt dis we, insted fכ stכp di bכdi fכ fכm, dεn de stat fכ fכm blכd kכlכt we nכ nid (thrombosis). di sem tεm, di nכmba fכ di pletlεt dεm de dכn bak kwik kwik wan (thrombocytopenia). dis na di rizin we mek sכmtεm dεn kin kכl dis kכndyushכn Hεparin-Induse Thrombocytopenia and Thrombosis (HITT).Imajin, i strenj smɔl se wan mɛrɛsin we dɛn gi fɔ mek blɔd nɔ klɔt go mek blɔd klɔt mɔ ɛn mek di pletlɛt dɛn nɔ bɔku, nɔto so? Bɔt i kin apin.
Tu men kayn HIT dɛn de.
Dɔktɔ dɛn kin sheb dis (HIT) kɔndishɔn to tu men kayn: 1. HIT I (Tayp 1): Insay dis kes, yu pletlɛt lɛvɛl kin go dɔŋ smɔl insay di fɔs de afta yu dɔn bigin fɔ yuz ɛparin, bɔt dɛn kin kam bak to nɔmal insay sɔm dez. Dis nɔto denja sik , ɛn no risk nɔ de fɔ mek blɔd klɔt, so dɛn nɔ nid spɛshal tritmɛnt. 2. HIT II (Type 2): Dis na di kayn we wi nid fɔ wɔri bɔt. insay dis kes, wi imyun sistεm de mek di pletlεt dεm wok fכ ansa to hεparin. Dis kin mek di pletlet lɛvɛl go dɔŋ, ɛn risk de fɔ mek di blɔd klɔt bad bad wan . Bɔku tɛm, we wi de tɔk bɔt (HIT), bɔku tɛm wi kin min dis kayn denja we dɛn kɔl (HIT II).
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Check Availability →Udat kin gɛt dis HIT mɔ?
Ɛnibɔdi we de yuz ɛprin, ilɛksɛf di doz ɔ aw lɔng i de yuz am, kin gɛt dis sik. Bɔt dɛn dɔn si se uman dɛn we dɔn pas 40 ia kin gɛt am smɔl. Dɔktɔ dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin mek sɔm pipul dɛn gɛt dis riakshɔn to heparin ɛn ɔda wan dɛn nɔ kin gɛt. DisI nɔ kin rili kɔmɔn. Dis (HIT) kכndyushכn kin apin pan sכm grup fכ pipul dεm, we na lεk 5%, we de tek εparin fכ pas fכ de.Wetin na di sayn dɛm fɔ HIT? Aw wi kin no am?
If yu de tek ɛprin, bɔku tɛm yu dɔktɔ go chɛk di nɔmba fɔ di sɛl dɛn na yu blɔd, mɔ di nɔmba fɔ di pletlɛt dɛn. If di pletlɛt dɛn nɔ bɔku, dat kin bi di fɔs sayn fɔ HIT. Na lɛk af pan pipul dɛm wae gɛt HIT kin gɛt nyu blɔd klɔt. dis kin bi dip vein trombosis (DVT) na di leg כ pulmonary embolism (PE). Wach fɔ dɛn sayn ya:- Pen, swɛlin, rɛd, ɔ tend na an ɔ leg.
- Wan wantɛm, bad bad pen na di chɛst (lɛk at atak).
- Ay blɔd prɛshɔn ( haypatɛyshɔn ).
- Diziz , fɔdɔm, fil fɔ diziz.
- Di at rit we de go ɔp ( tachycardia ).
- Kɔf ɛn kol .
- I nɔ kin izi fɔ yu fɔ blo .
- We pɔsin de swet pasmak .
- Fiva ɛn kol kol.
Di tin we impɔtant pas ɔl: If yu de tek ɛparin ɛn yu gɛt ɛni wan pan dɛn sik ya, go to dɔktɔ kwik kwik wan. Dis nɔto sɔntin we wi fɔ delay.
Ustɛm HIT kin apin?
Bɔrku tɛm, di sayn dɛm kin bigin insay fayv dez to tu wiks afta yu bigin fɔ tek ɛp. Bɔt dɛn kin apin ɔda tɛm dɛn bak:- HIT we kin bigin kwik kwik wan: Dis kin apin insay wan to tri dez afta yu bigin fɔ yuz ɛparin. Dis kin apin mɔ if yu dɔn yuz ɛparin bifo (bɔku tɛm insay tri mɔnt). afta dat, yu bכdi de "mεmba" di εparin, de mek antibodi dεm agens am, εn i rεdi fכ riak kwik.
- Refractory HIT: Dis kכndyushכn kin de fכ wik afta dεn stכp di hεparin.
- Dilayed onset HIT: Dis kin apin afta dɛn dɔn stɔp di heparin tritmɛnt. Bɔku tɛm, i kin apin fayv dez ɔ mɔ afta dɛn dɔn stɔp di mɛrɛsin.
Wetin rili de mek dis HIT?
HIT de apin we di dכg we di hεparin de tay pan wan protin we dεn kכl PF4 (Platelet Factor 4) insay wi pletlet dεm. dis hεparin εn PF4 de kam togεda fכ fכm wan Hεparin-PF4 kכmpleks. we wi si dat Heparin-PF4 complex na wi bכdi, wi imyun sistεm de wכri εn bigin fכ mek antibodi dεm agens am. dis antibodi dεm de go εn biεn da Heparin-PF4 kכmpleks de. Na de ɔltin bigin. As soon as dεn antibodi dεm ya de tay, di pletlet dεm de aktibכt wantεm wantεm εn bigin fכ mek blכd kכlכt. dis we ya, mכr PF4 de kכmכt frכm di pletlet dεm we de mek bכdi kכlכt. afta dat dat nyu PF4 we de kam de biεn bak to hεparin, we de fכm mכr Heparin-PF4 kכmpleks. di antibodi dεm de kam bak εn tay am bak, mכr bכdi kכlכt dεm de fכm... Dis de kכntinyu lεk chen riakshכn. Bikɔs ɔf ɔl dis we de mek blɔd klɔt, di pletlɛt dɛn we de na di bɔdi kin yuz kwik kwik wan. Dis kin mek di pletlɛt lɛvɛl kin go dɔŋ. Bikɔs ɔf dis we blɔd kin klɔt pasmak, big big blɔd kin klɔt we kin mek wi day, ɛn i kin blok wi vein ɛn at.Wetin na di risk factor dɛm fɔ HIT?
Bɔku tin dɛn de we kin mek pɔsin gɛt HIT:- Yu jɛnɛral: Uman dɛn kin gɛt HIT mɔ.
- Di kayn heparin we dɛn kin yuz: Sɔm stɔdi dɛn dɔn sho se di risk fɔ gɛt HIT kin difrɛn difrɛn wan bay di kayn heparin we yu de tek. Fɔ ɛgzampul, sɔm pruf de fɔ se if yu yuz ɛprin we nɔ gɛt frakshɔn instead fɔ yuz ɛprin we nɔ gɛt bɔku mɔlikul wet, dat kin mek yu nɔ gɛt bɔku prɔblɛm. Bɔt dɛn nid fɔ du mɔ risach bɔt dis.
- Fɔ tek ɛparin afta dɛn dɔn du di ɔpreshɔn: Pipul dɛn we de tek ɛparin fɔ mek blɔd nɔ klɔt afta dɛn dɔn du di ɔpreshɔn, kin gɛt HIT pas di wan dɛn we de tek am fɔ trit wan blɔd we dɔn klɔt. Dis risk kin bɔku mɔ afta dɛn dɔn du ɔpreshɔn pan ɔtpidik, ɔpreshɔn pan at, ɛn baypass pan di at ɛn pulmonari .
Aw dɛn kin no se pɔsin gɛt HIT? (Diagnosis) .
Bɔku blɔd tɛst kin ɛp fɔ no if yu gɛt HIT:- di pletlet lεvεl dεm: Dis kin chεk if yu pletlet kכnt lכw (thrombocytopenia).
- Klɔt fɔmɛshɔn: Blɔd tɛst de sho if yu blɔd de klɔt.
- PF4 antibodi lεvεl dεm: di כmכnt כf PF4 antibodi dεm na yu bכdi kin sho if yu imyun sistεm de aktibכt pletlet dεm. dis antibodi tεst na in de kכnfכm di diagnosis fכ HIT.
Wetin na dis "4Ts test"?
Di 4Ts test na wan skɔring sistɛm we de ɛstimat aw yu go gɛt HIT. I de gi di infɔmeshɔn we yu nid fɔ bigin tritmɛnt we yu nɔ wet fɔ di rizɔlt fɔ di antibodi tɛst. Di dɔktɔ gi wan mak (frɔm 0 to 2) fɔ dɛn 4 tin ya:- Trombocytopenia (low pletlet count): Aw smɔl yu pletlɛt kɔnt?
- Taym (tεm we yu de riak to hεparin): Ustɛm yu pletlet lεvεl dεm dכn dכn?
- Trombosis (blɔd we de klɔt): Sayn dɛn de fɔ se blɔd dɔn klɔt?
- oDεn tin dεm we kin mek yu kכz: I kin bi se כda rizin de pas hεparin fכ yu lכw pletlεt kכnt?
Wetin na di tritmɛnt dɛm fɔ HIT?
Di fɔs tin we yu fɔ du fɔ trit yu na fɔ stɔp fɔ tek ɛparin wantɛm wantɛm. Dɔn, dɛn go chenj yu to ɔda mɛrɛsin we de mek yu blɔd tan. Yu pletlet kɔnt fɔ bigin fɔ go ɔp bak insay sɔm dez afta yu dɔn stɔp fɔ gi yu di heparin. Te da tɛm de, yu dɔktɔ go mɔs gi yu ɔda mɛrɛsin fɔ ɛp fɔ mek blɔd nɔ klɔt. Bɔku mɛrɛsin dɛn de we yu kin yuz insted ɔf ɛparin:- Dayrekt trombin inhibito dεm'' (εgz. argatroban', bivalirudin')
- Fondaparinux
- Direct oral anticoagulants (mεdisin dεm we de mek blכd kכlכt we yu kin tek dairekt wit mכt)
Wi kin ebul fɔ mek HIT nɔ apin?
Natin nɔ rili de we yu go du fɔ mek yu nɔ gɛt HIT. Bɔt if yu dɔktɔ de wach yu pletlɛt lɛvɛl ɔltɛm, dat kin ɛp fɔ ridyus di prɔblɛm dɛn we kin kam wit ɛprin.Wetin fɔ ɛkspɛkt if yu gɛt HIT?
Heparin-Induced Thrombocytopenia (HIT) na siriɔs sik we kin kil pɔsin if dɛn nɔ trit am kwik. Big big blɔd we de na di an ɛn fut kin mek dɛn ɔgan dɛn de pwɛl fɔ lɔng tɛm. Blɔd we kin klɔt we kin afɛkt di men ɔgan dɛn kin kil pɔsin. Laki, wit di inkris awareness of HIT en beta tritment opshon, di savaiv ret don improv plenti. Fɔ no kwik kwik wan, bifo siriɔs blɔd klɔt, na di men tin fɔ mek yu gɛt gud tin fɔ du.Wae yu dɔktɔ si sayn dɛm fɔ HIT, lɛk fɔ gɛt smɔl pletlɛt, dɛn kin gi yu tritmɛnt fɔ ridyus di risk fɔ mek yu blɔd klɔt we denja.Aw a kin kia fɔ misɛf?
Yu go nid fɔ go to yu dɔktɔ ɔltɛm fɔ wach yu pletlɛt lɛvɛl ɛn mek shɔ se yu nɔ de divɛlɔp blɔd klɔt. Apat frɔm dat, yu dɔktɔ go no bɔt di sayd ɛfɛkt dɛn we pɔsin kin gɛt (lɛk we sɔm pipul dɛn kin blɔd) we i de chenj frɔm ɛparin to nyu antikɔagulant. Insay dis tɛm, i rili impɔtant fɔ tek yu mɛrɛsin lɛk aw dɛn tɛl yu fɔ tek am. Ivin if yu nɔ bin dɔn gɛt blɔd klɔt, yu go nid fɔ tek wan mɛrɛsin we nɔ gɛt ɛparin fɔ at le wan mɔnt. If yu dɔn gɛt blɔd klɔt, yu go nid fɔ tek am fɔ lɔng tɛm.Di bɛst we fɔ kia fɔ yusɛf na fɔ tɛl ɛni dɔktɔ we go trit yu tumara bambay se yu dɔn gɛt dis prɔblɛm. If yu dɔn gɛt HIT, yu nɔ fɔ ɛva tek heparin igen.If yu notis ɛni chenj na yu bɔdi we yu de tek ɛprin, go to dɔktɔ wantɛm wantɛm. Heparin-Induced Thrombocytopenia (HIT) na wan sik we nɔ kin apin so ɔltɛm, bɔt ɛni sayn we de sho se blɔd dɔn klɔt tu siriɔs fɔ ignore. If yu nɔ gɛt tritmɛnt, HIT kin kil pɔsin. We yu gɛt tritmɛnt, yu pletlɛt lɛvɛl fɔ kam bak to nɔmal ɛn di risk fɔ mek yu blɔd klɔt fɔ go dɔŋ. Tɔk to yu dɔktɔ bɔt di bɛst mɛrɛsin fɔ yuz instead fɔ heparin go bifo.
Faynal Mɛsej fɔ Tek-Hom
- pan ɔl we heparin na impɔtant mɛrɛsin we de mek blɔd nɔ klɔt, i nɔ kin rili mek pɔsin gɛt siriɔs sik we dɛn kɔl Heparin-Induced Thrombocytopenia (HIT).
- Wetin kin apin pan dis kes na dat, insted fכ mek blɔd kכlכt, di blɔd kכlכt fכmeshכn de bכku εn di nכmba fכ di pletlεt dεm de dכn.
- Yu fɔ de wach fɔ sɔm sayn dɛm lɛk fɔ swel na yu leg/an, pen, pen na yu chɛst, ɛn i nɔ izi fɔ blo. If yu notis dɛn tin ya, go to dɔktɔ wantɛm wantɛm.
- If dεn no se HIT, di fכs tin fכ du na fכ stכp di hεparin. Dɔn yu go nid fɔ yuz ɔda mɛrɛsin dɛn we de mek yu blɔd tan.
- If yu dɔn gɛt HIT, mek not pan am na ɔl yu mɛdikal rɛkɔd ɛn tɛl ɛni dɔktɔ we yu go si tumara bambay. Dɛn nɔ fɔ ɛva gi yu ɛprin igen.
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