Yu dɔn ɛva gɛt bak pen frɔm yu yɔŋ, ɔ yu dɔn fil bak we yu fɔs wek na mɔnin? I tan lɛk se di pen kin stɔp afta yu dɔn waka fɔ shɔt tɛm ɔ we yu bigin fɔ wok fɔ yu de? Yu go tink se dis na jɔs simpul bak-ak. Bɔt sɔmtɛm dɛn sayn ya kin bi di fɔs sayn fɔ wan sik we dɛn kɔl Ankylosing Spondylitis, we wi de tɔk bɔt tide. Nɔ wɔri, wi go tɔk bɔt dis klia wan ɛn simpul wan.
Wetin rili na Ankylosing Spondylitis (AS)?
Fɔ tɔk am simpul wan, Ankylosing Spondylitis (AS) na wan kayn at at sik. Bɔt i kin afɛkt di jɔyn dɛn na wi spayna spɛshal wan . Wi spayna gɛt bɔku smɔl smɔl bon dɛn we kin kam togɛda, ɛn di jɔyn dɛn we de bitwin dɛn bon dɛn ya kin inflam, swel, ɛn pen. as tεm de go, dis inflameshn kin mek di jכint dεm na di spayna fכ fכs tכgeda, we de mek di spayna nכ kin ebul fכ fכm.
De kɔmɔn sayn dɛm fɔ dis sik na:
- Bak pen ɛn stif: Dis kin fil mɔ we yu fɔs grap na mɔnin ɔ afta yu dɔn tinap fɔ lɔng tɛm.
- Di pen we yu de fil we yu de du ɛksɛsayz: I sɔprayz fɔ no se di pen kin bɔku we yu de rɛst ɛn i kin stɔp we yu de du tin, lɛk we yu de waka, rɔn, ɔ jomp.
- Pen na ɔda jɔyn dɛn: Sɔm pipul dɛn kin gɛt pen bak na dɛn jɔyn dɛn lɛk di hip, ni, ɛn il.
- Fɔ fil se yu taya bad bad wan.
Bɔrku tɛm dis sik kin bigin pan yɔŋ pipul dɛm wae ol bitwin 15 ɛn 30. Na dat mek bɔrku pipul kin mistek kɔl am simpul bak-ak.
So yu tink se sɔntin de we gɛt fɔ du wit dis?
Yɛs. Dis na di pɔynt we impɔtant pas ɔl na dis atikul. Ankylosing Spondylitis na sik we gɛt strɔng frut frɔm in mama ɛn papa, dat min se i gɛt sɔntin fɔ du wit in jɛnɛtiks . If pɔsin na yu famili, dat na, mama ɛn papa, brɔda ɛn sista, gɛt dis sik, dat min se yusɛf de pan ay risk fɔ gɛt dis sik pas ɔda pipul dɛn.
As sayɛnsman dɛn de du risach bɔt dis, dɛn dɔn put bɔku atɛnshɔn pan wan patikyula jin: di HLA-B27 jin.
Jɔs tink bɔt, dɛn dɔn si se pas 85% pan di sik pipul dɛn we dɛn no se gɛt Ankylosing Spondylitis gɛt dis jin we dɛn kɔl HLA-B27. Dat nɔ sho di strɔng link bitwin dis jin ɛn di sik?
Dis HLA-B27 jin de ɛp wi bɔdi in imyun sistɛm. Fɔ tɔk am simpul wan, i de no ɛn fɛt fɔrina dɛn lɛk vayrɔs ɛn baktri dɛm. bכt sכmtεm, bikoz fכ chenj dεm na dis jin, di imyun sistεm de go haywire εn bigin fכ atak hεlty pat dεm na wi כwn bכdi, insay dis kes, di jכint dεm na wi spayna. Sayɛnsman dɛn biliv se na dis kin mek dis inflamɛns.
Na HLA-B27 nɔmɔ gɛt fɔ du wit dis?
Nɔ, dat na kwɛstyɔn we rili impɔtant. Pan ɔl we HLA-B27 na di men pɔsin we de insay dis stori, sɔm ɔda sɔpɔt aktɔ dɛn de. Sayɛnsman dɛm se lɛk 30% pan di ɔl jɛnɛtik risk fɔ gɛt dis sik de kɔmɔt frɔm di HLA-B27 jin. Di ɔda wan dɛn we lɛf na bɔku ɔda smɔl smɔl jin dɛn kin afɛkt dɛn.
Bikɔs di tin dɛn we dɛn jin ya kin du smɔl, i nɔ kin izi fɔ no dɛn wan bay wan. Bɔt dɛn dɔn no bɔku ɔda jin dɛn tru risach we sayɛnsman dɛn ɔlsay na di wɔl dɔn du we dɔn wok togɛda ɛn sheb infɔmeshɔn.
| Jin | Simpul ɛksplen |
|---|---|
| HLA-B27 we dɛn kɔl HLA-B27 | Dis na di men jin. I gɛt fɔ du wit di imyun sistɛm. di mכtalman in AS pasεnshכn gεt dis jin. |
| ERAP1 | dis na jin bak we de involv fכ mek di imyun sistεm wok. I de mek di risk fɔ gɛt sik bɔku we dɛn kam togɛda wit HLA-B27. |
| IL23R ɛn IL1A | dis na jin dεm bak we de involv fכ divεlכp εn kכntrכl inflameshn na di bכdi. di vεryushכn dεm na dεn jin dεm ya kin inkrεs di risk fכ AS bak. |
Risach pipul dɛn stil de luk fɔ ɔda jin dɛn we dɛn nɔ no, we kin afɛkt dis bak.
Yu tink se ɔlman kin gɛt di sik jɔs bikɔs dɛn gɛt di jin?
Nɔ. Fɔ tru, nɔto so.Dis na sɔntin we yu nid fɔ mɛmba. If yu gɛt di HLA-B27 jin na yu bɔdi, dat nɔ min se yu go gɛt Ankylosing Spondylitis. I jɔs min se yu de pan smɔl risk fɔ gɛt dis sik pas ɔda pipul dɛn.
Tink bɔt am dis we. Wan stɔdi dɔn sho se 75% pan di pikin dɛn we gɛt di HLA-B27 jin frɔm dɛn mama ɛn papa we gɛt Ankylosing Spondylitis, ɔ tri pan 4, nɔ go ɛva gɛt dis sik.
Dis min se di jin dɛn nɔmɔ nɔ go du fɔ mek pɔsin gɛt dis sik. Apat frɔm di tin dɛn we de apin na di jɛnɛtiks , tin dɛn we de apin na di envayrɔmɛnt fɔ de bak. Pan ɔl we dɛn nɔ no yet bɛtɛ bɛtɛ wan wetin na dɛn tin ya, dɛn biliv se sɔm tin dɛn lɛk sɔm infɛkshɔn dɛn kin gɛt sɔntin fɔ du wit am. Fɔ tɔk am simpul wan, di jin dɛn tan lɛk gɔnpawda we rɛdi fɔ bɔn, ɛn i nid spak fɔ mek i bɔn.
So wetin a fɔ du?
If yu gɛt sayn dɛm lɛk di wan dɛm wae wi bin dɔn tɔk bɔt na dis atikul (bak pen wae kin bigin wae yu yɔŋ, kin wɔs na mɔnin, ɛn yu kin gɛt sɔm kayn sik wae yu de du fɔ ɛksesaiz), ɔr if pɔrsin na yu famili gɛt Ankylosing Spondylitis, yu nɔr nid fɔ wɔri.
Di bɛst tin we yu kin du na fɔ go to dɔktɔ we sabi du di wok, we na yu GP, wantɛm wantɛm . I go lisin to yu sayn dɛm, chɛk yu, ɛn if nid de, ɔda fɔ mek dɛn tek yu blɔd tɛst ɛn ɛkstrem rayt. Dɛn kin se bak fɔ du tɛst fɔ si if yu gɛt di HLA-B27 jin.
Mɛmba se di tin we impɔtant pas ɔl na fɔ no ɛn mɛn dɛn tin ya kwik kwik wan . If yu du dat, yu go ebul fɔ kɔntrol di pen, mek yu nɔ gɛt bak pen, ɛn liv nɔmal layf ɛn gladi at.
Mɛsej we dɛn kin kɛr go na os
- Ankylosing Spondylitis (AS) na wan kayn at at sik we kin afɛkt di spayna mɔ. I kin apin mɔ pan yɔŋ pipul dɛn.
- dis sik gεt wan rili strכng jεnεtik link, wit di jin HLA-B27 spεshal wan we na wan mεjכr fכs tin.
- Bɔt jɔs fɔ gɛt di HLA-B27 jin na yu bɔdi nɔ min se yu go gɛt di sik. Na jɔs wan tin we kin mek pɔsin gɛt prɔblɛm.
- Apat frɔm di jin dɛm, di tin dɛm we de na di envayrɔmɛnt kin afɛkt bak aw dis sik kin apin.
- If yu gɛt bak pen fɔ lɔng tɛm, yu gɛt stiff na mɔnin, ɔ yu famili histri bɔt sik, nɔ panik ɛn go to yu dɔktɔ fɔ gɛt di rayt advays.
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