Yu kin bigin yu de bak wit bak stiffness ɛn pen we yu wek na mɔnin? Dis pen kin go dɔŋ we yu waka smɔl, du sɔm wok, ɛn bɔku bak we yu stil de? Dɛn tin ya kin bi kɔmɔn sayn dɛm fɔ wan sik we dɛn kɔl Ankylosing Spondylitis (AS). Dis na tin we kin rili mek pɔsin vɛks ɛn we kin ambɔg di layf we pɔsin kin liv ɛvride. As tritmɛnt fɔ dis, dɔktɔ dɛn fɔs kin gi dɛn mɛrɛsin fɔ mɛn pen (NSAID). If dɛn tin ya nɔr de kɔntrol di sik, dɛn kin rifer yu to injɛkshɔn we dɛn kɔl biologics. Bɔt sɔm pipul dɛn nɔ kin gɛt fridɔm frɔm dɛn tritmɛnt ya, ɔ i nɔ kin izi fɔ bia wit di bad tin dɛn we kin apin to dɛn. Yu tink se yu de gɛt di sem tin? If na so i bi, nɔ wɔri. We di sayɛns bɔt mɛrɛsin dɔn go bifo, wan ɔda nyu tritmɛnt we dɔn wok fayn dɔn kam na do naw. Dat na di wan dɛn we de stɔp Janus Kinase (JAK) . Lɛ wi tɔk bɔt dis tide.
Wetin na JAK Inhibitors?
JAK inhibito na nyu klas fɔ drɔgs fɔ trit ankylosing spondylitis. Lɛk bayolojikal drɔgs, dɛn de pan wan klas ɔf drɔgs we dɛn kɔl disease-modifying antirheumatic drugs (DMARDs). "Disease-modifying" min se dɛn drɔgs ya nɔr de jɔs ridyus pen. Dɛn kin kɔntrol bak di damej we di spayna ɛn ɔda jɔyn dɛn kin gɛt, ɛn dis kin mek di sik nɔ go bifo kwik kwik wan.
Bɔt dɛn nɔ jɔs de yuz dɛn tin ya fɔ Ankylosing Spondylitis. Dɛn dɔn gri fɔ dis kayn mɛrɛsin bak fɔ sɔm ɔda sik dɛn we pɔsin kin gɛt we i de fɛt insɛf. Dat min se sik dɛn we di bɔdi in imyun sistɛm kin atak in yon sɛl dɛn.
- Rimatɔyd at at sik
- Polyartikul kɔs juvenail idiopatik atraytis (JIA) .
- Psoriatic arthritis we pɔsin kin gɛt
- Ɔlsɛrativ kɔlaytis
Di spɛshal tin na dat yu kin tek dɛn tin ya as pils instead fɔ gɛt injɛkshɔn lɛk bayolojikal. So dis na big rilif fɔ di wan dɛn we de fred fɔ injɛkshɔn.
Us kayn dɛn kin yuse fɔ Ankylosing Spondylitis?
Naw, dɛn dɔn gri fɔ tu kayn JAK inhibito fɔ di tritmɛnt fɔ Ankylosing Spondylitis.
- Tofacitinib (nem fɔ di brand: Xeljanz, Xeljanz-XR) .
- Upadacitinib (nem fɔ di brand: Rinvoq) .
Dɛn kin gi dɛn tin ya to pasɛnt dɛn we dɛn nɔ bin dɔn kɔntrol dɛn sik wit wan ɔ mɔ bayolojikal mɛrɛsin we dɛn kɔl TNF inhibitor, ɔ we nɔ ebul fɔ bia wit di sayd ifɛkt dɛn we dɛn mɛrɛsin dɛn de gɛt. So, yu dɔktɔ go tek tɛm luk yu kɔmplit mɛdikal istri bifo yu gi yu dis mɛrɛsin.
Aw dis mɛrɛsin de wok?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin se di imyun sistɛm na wi bɔdi na big ami. Insay sik lɛk Ankylosing Spondylitis, dis ami kin gɛt di rɔng mɛsej ɛn bigin fɔ atak in yon kɔntri (wi yon bɔdi) jɔyn dɛn. Dis atak na in de mek yu fil pen ɛn swel (inflammation).
Sɔm "mɛsenja" dɛn de we kin sɛn dɛn rɔng mɛsej ya. Dɛn kɔl dɛn JAK ɛnzaym dɛn . dis εnzym dεm na dεn wan dεm we de gi signal fכ di imyun sεl dεm fכ "go εn atak," di kεmikכl dεm we dεn kכl saytokεn dεm.
wetin dכg dεm we dεn kכl JAK inhibito dεn de du na fכ blכk dεn mεsenja dεm (JAK εnzym dεm). dis kin mek dεn rכng mεsej dεm de fכ fכlכ εn i de rεdכks di imyun sistεm in ebul fכ atak di jכint dεm.
Bayolojikal drɔgs kin wok difrɛn smɔl. bayolojikal de tכk εn blכk wan spεsifi k saytokכn, lεk TNF כ IL-17. JAK inhibito dεm de blכk di prodakshכn fכ mכltipכl saytokεn dεm wan tεm. Fɔ tɔk am simpul wan, dɛn kin blok di prɔblɛm fɔs.
Ɛni bad bad tin dɛn de we kin apin to am?
Jɔs lɛk ɛni mɛrɛsin, chans de fɔ mek yu gɛt sayd ɛfɛkt. Bɔt fɔ bɔku pipul dɛn, dɛn nɔ gɛt wan prɔblɛm. Yu dɔktɔ go wach yu gud gud wan bifo yu bigin fɔ tek dis mɛrɛsin ɛn we yu de tek am.
| Tayp fɔ di sayd ɛfɛkt | Tɔk bɔt |
|---|---|
| Kɔmɔn (bɔku tɛm nɔto siriɔs) sayd ɛfɛkt dɛm |
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| Siriɔs sayd ɛfɛkt dɛn we nɔ kin apin so ɔltɛm (Boxed Warning) . |
Smɔl mɔ bɔt siriɔs sayd ɛfɛkt dɛn
Bikɔs dɛn mɛrɛsin ya de stɔp di imyun sistɛm, di bɔdi in ebul fɔ fɛt jem lɛk baktri ɛn vayrɔs kin ridyus smɔl. Dis kin mek di risk fɔ gɛt infɛkshɔn bɔku.
Tubakulosis (TB) tɛst: Bifo yu bigin dis mɛrɛsin, yu dɔktɔ go mɔs tɛst yu fɔ TB. Sɔm pipul dɛn kin gɛt layt TB baktri na dɛn bɔdi. we yu yuz JAK inhibito, dis dormant baktri kin bi aktif. So, yu dɔktɔ go de wach yu fɔ dis we yu de trit yu.
Impɔtant: We yu de tek dis mɛrɛsin, yu fɔ avɔyd fɔ gɛt layf vaysin. Sɔm ɛgzampul dɛn na mizɛl, mɔmp, rubɛla (MMR), ɛn rotavayrɔs. Dɛn vaysin ya kin mek yu sik bikɔs yu imyun sistɛm kin wik da tɛm de. Mek shɔ se yu tɔk to yu dɔktɔ bifo yu gɛt ɛni vaysin.
Wetin a fɔ ɛkspɛkt we a de bigin fɔ tek mɛrɛsin?
Sɔm pipul dɛn kin bigin fɔ fil fri frɔm dɛn sik insay lɛk tu wiks afta dɛn bigin dis mɛrɛsin. Bɔt i kin tek 6 mɔnt fɔ mek sɔm pipul dɛn fil fridɔm. Dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin.
If yu nɔr fil fayn afta yu dɔn tek mɛrɛsin fɔ sɔm mɔnt, nɔr panik ɛn tɔk to yu dɔktɔ bɔt am ɛn gɛt advays bɔt wetin fɔ du nɛks.
Mɛsej we dɛn kin kɛr go na os
- JAK inhibito na nyu klas fɔ drɔgs we de as pils fɔ ankylosing spondylitis. Dɛn kin gi dɛn to pipul dɛm wae nɔr dɔn du ɔda tritmɛnt.
- Dɛn mɛrɛsin ya nɔr kin jɔs ridyus di pen, bɔt dɛn kin kɔntrol bak di pwɛl hat we di jɔyn dɛn kin pwɛl.
- Dɛn tin ya rili izi fɔ yuz bikɔs dɛn nɔ nid injɛkshɔn lɛk bayolojikal.
- Lɛk ɔl di mɛrɛsin dɛn, dis wan kin gɛt sayd ɛfɛkt. So, i impɔtant fɔ mek dɛn de du blɔd tɛst ɔltɛm ɔnda dɔktɔ in sɔpɔtishɔn.
- Nɔ ɛva bigin, stɔp, ɔ chenj di doz fɔ dis mɛrɛsin if yu dɔktɔ nɔ advays yu.
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