Lɛ wi lan bɔt dis spɛshal mɛrɛsin (Sacubitril; Valsartan) we dɛn kin gi fɔ at pwɛl.

Yu kin gɛt prɔblɛm bak fɔ blo, yu kin fil lɛk se yu go fɔdɔm ivin if yu tray smɔl? Ɔ yu dɔktɔ dɔn tɛl yu se yu gɛt sɔm kayn at prɔblɛm? If na so, sɔntɛm dɛn dɔn gi yu wan mɛrɛsin we dɛn kɔl Sacubitril; Valsartan (---‍; --) . I kin kam ɔnda di brand nem `Entresto`. So, tide wi go tɔk bɔt dis mɛrɛsin, aw fɔ yuz am, ɛn wetin fɔ tek tɛm. Jɔs lɛk aw yu go tɛl yu padi.

Us kayn mɛrɛsin dis? Wetin mek dɛn de gi dis?

Fɔ tɔk am simpul wan, dis `Sacubitril; Valsartan` na wan kɔmbaynshɔn fɔ tu mɛrɛsin dɛn. Wan na `Sacubitril` க்ய-஬ி-ட்ரில்),-க்ய-஬ி-ட்ரில் - க்ய-஬ி-ட்ரில்), dis na mεdisin we de insay di `(neprilysin inhibitor)` grup. Di ɔda wan na `Valsartan` கா-தன்),-வலஸாட் -ஸாட்ரில் - க்ய-஬ி-ட்ரில்), dis na mɛrɛsin fɔ in yon to di `(angiotensin II rεsεptכr blכk - ARB)` grup. Dɛn tu mɛrɛsin ya kin wok togɛda. Dɛn kin gi dis mɛrɛsin mɔ to pipul dɛn we gɛt at prɔblɛm . Hat fεil na wan kכndyushכn wae de hat nכ kin ebul fכ pכmp bכku bכdi to di bכdi. Tink bɔt am, di at tan lɛk wata pɔmp. If i nɔ de wok fayn, i kin tan lɛk se wata nɔ de flɔ ɔlsay na di bɔdi, ɛn blɔd nɔ de flɔ ɔlsay na di bɔdi. Na da tɛm de tin dɛn lɛk taya ɛn shɔt briz kin kam. So, wetin dis mεdisin de du na fכ εp di at in pכmp abiliti εn rεdכks di lod pan di at. Sɔntɛnde, dɔktɔ dɛn kin yuz dis mɛrɛsin fɔ ɔda sik dɛn bak. Dat na yu dɔktɔ fɔ disayd.

Wetin a fɔ tɛl mi dɔktɔ bifo a bigin dis mɛrɛsin?

Dis rili impɔtant. Bifo yu bigin fɔ tek dis mɛrɛsin `Sacubitril; Valsartan`, yu fɔ rili tɛl yu dɔktɔ ɔ nɔs bɔt dɛn tin ya. Nɔ ayd ɛnitin.

• Tɛl yu dɔktɔ if yu gɛt dayabitis ( Diabetes Mellitus) , mɔ if yu de tek di mɛrɛsin aliskiren.
• If yu no se yu blɔd potashɔm lɛvɛl bɔku .
• If yu gɛt ɛni sik na yu kidni .
• If yu gɛt ɛni sik na yu liva .
• If yu gɛt lɔw blɔd prɛshɔn (`lɔ blɔd prɛshɔn` ) .
• Dis na `Sacubitril; Valsartan`, ɔ `(If yu dɔn gɛt alɛji fɔ mɛrɛsin dɛn we dɛn kɔl ACE inhibitors (e.g., enalapril, lisinopril), mɛrɛsin dɛn we dɛn kɔl angiotensin II receptor blockers (ARBs) (e.g., losartan, telmisartan), ɛni ɔda mɛrɛsin, it, it day, ɔ prɛzɛvɛtiv .
• If yu gɛt bɛlɛ, ɔ yu de tray fɔ gɛt bɛlɛ . Dis na tin we rili impɔtant, wi go tɔk bɔt dis leta.
• If yu na mama we de gi pikin in bɛlɛ .

Wae yu dɔn gɛt dɛn tin ya na yu maynd, yu dɔktɔ kin disayd if dis mɛrɛsin fayn fɔ yu ɔ nɔr fayn fɔ yu, ɛn aw fɔ gi am.

Aw yu kin yuz dis mɛrɛsin kɔrɛkt wan?

We yu de tek mɛrɛsin, di tin we impɔtant pas ɔl na fɔ yuz am di rayt we. If nɔto dat, i nɔ go wok fayn.

• Aw fɔ tek: Dis kin kam insay pil fɔm. Na fɔ tek am wit mɔt. Tray fɔ tek di doz we dɛn tɛl yu fɔ tek, jɔs lɛk aw yu dɔktɔ dɔn tɛl yu, di sem tɛm ɛvride . Da we de, di mɛrɛsin go wok di sem we.
• Wit ɔ atɔl it?: Yu kin tek dis pil wit it ɔ atɔl it. Bɔt sɔm pipul dɛn kin gɛt bɛlɛ at if dɛn tek am we dɛn nɔ it. If na so i bi, i bɛtɛ fɔ tek am wit it.
• Fɔ stɔp: Kɔntinyu fɔ yuz dis mɛrɛsin te yu dɔktɔ tɛl yu fɔ du am. Nɔ stɔp wantɛm wantɛm. If yu nid fɔ stɔp, tɔk to yu dɔktɔ ɛn fala wetin i tɛl yu fɔ du.
• Yu tink se dɛn kin gi pikin dɛn dis mɛrɛsin?: Yɛs, sɔntɛnde dɛn kin gi dis mɛrɛsin to pikin dɛn we yɔŋ lɛk wan ia fɔ sɔm kayn at sik dɛn we dɛn dɔn pik. Bɔt i rili nid spɛshal kia ɛn dɔktɔ fɔ kia fɔ am.
• Wetin fɔ du if yu tek tumɔs: If yu tink se yu dɔn tek tumɔs pan dis mɛrɛsin, ɔ if yu aksidɛntli tek tumɔs pils, go na di ɔspitul imejensi rum we de nia yu ɔ kɔl pɔyzin kɔntrol sɛnta wantɛm wantɛm. Nɔ west tɛm.
• Nɔ sheb: Dis na sɔntin bak we wi fɔ mɛmba. Dɛn dɔn gi yu dis mɛrɛsin fɔ yu nɔmɔ, fɔ trit yu sik. So, nɔ ɛva gi dis mɛrɛsin to yu padi, fambul, ɔ ɔda pipul dɛn na yu fambul, ilɛksɛf dɛn se dɛn gɛt di sem prɔblɛm we yu gɛt.

Wetin yu kin du if yu mis apɔntinmɛnt fɔ tek mɛrɛsin?

Sɔntɛnde wi kin fɔgɛt fɔ tek wi mɛrɛsin. If dat apin, nɔ wɔri.

• Tek yu mɛrɛsin jɔs lɛk aw yu mɛmba.
• Bɔt if i dɔn lɛf smɔl fɔ lɛ yu tek yu nɛks doz we yu mɛmba, skip di doz we yu mis ɛn jɔs tek di nɛks doz na di tɛm we yu dɔn sɛtul.
• Nɔ ɛva tek dɛbul doz fɔ mek di doz we yu mis.If yu du dat, dat kin mek yu gɛt bad bad tin dɛn.

Us ɔda mɛrɛsin dɛn we yu nɔ fɔ yuz wit dis mɛrɛsin, ɔ we kin mek yu gɛt sayd ɛfɛkt?

Dis na pɔynt bak we rili impɔtant. Dis mɛrɛsin we dɛn kɔl `Sacubitril; Valsartan` kin mek prɔblɛm we dɛn tek am wit sɔm ɔda mɛrɛsin dɛn. Dat min se, ɔl tu di wok we dis mɛrɛsin de du kin ridyus, ɔ i kin go ɔp, ɔ nyu sayd ɛfɛkt kin apin.

Nɔ tek `Sacubitril; Valsartan` togɛda wit dɛn mɛrɛsin ya:

* If yu gɛt dayabitis, wit di mɛrɛsin `(aliskiren)`.

* Wit mεdisin dεm we dεn kכl `(Angiotensin-converting enzyme - ACE inhibitors)`. Fɔ ɛgzampul, mɛrɛsin dɛn lɛk `benazepril`, `kaptopril`, `enalapril`, `fosinopril`, `lisinopril`, `ramipril`. Ivin if yu stɔp fɔ tek dis kayn mɛrɛsin fɔ sɔm dez, i nɔ fayn fɔ bigin `Sacubitril; Valsartan`. Tɔk to yu dɔktɔ bɔt am.

* Wit di mɛrɛsin `(tranylcypromine)`.

di mεdikeshכn dεm we de kam biεn kin intarakt wit `Sacubitril; Valsartan`. So, tɛl yu dɔktɔ bɔt dɛn tin ya bak:

• כda kayn Angiotensin II rεsεptכr blכk dεm (ARB dεm). Ɛgzampul dɛn: azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, ɔ valsartan (if yu de tek valsartan apat frɔm di valsartan we de insay dis mɛrɛsin).
• Mɛrɛsin dɛn lɛk `(celecoxib)`.
• `(lithium)` (na mεdisin we dεn kin gi fכ mental sik).
• `(NSAID)` - Dis na mεdisin wae dεn kin yuse fכ trit pen εn inflameshn. Ɛgzampul dɛn: `ibuprofen`, `naproxen`. Bɔku tɛm, yu kin bay dɛn tin ya na kɔwnta na famasi dɛn, so if yu de yuz dɛn, tɔk bɔt dɛn.
• Diuretik dɛn we nɔ de mek pɔsin nɔ gɛt potashɔm. Ɛgzampul dɛn: amilorid, spironolactone, triamterene.
• Potashכm supliment כ potashכm-rich salt substitutes.

Dis list nɔ kin gɛt ɔl di mɛrɛsin dɛn. So, i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, lɛk vaytamɛn, ɛbul mɛrɛsin, mɛrɛsin dɛn we yu nɔ de bay, ɛn tradishɔnal mɛrɛsin. Dɔn bak, tɔk tru to yu dɔktɔ bɔt ɛni mɛrɛsin we yu de tek, lɛk di mɛrɛsin dɛn we yu de smok, rɔm, ɔ ɔda drɔgs we nɔ rayt. Dɛn tin ya kin afɛkt aw dis mɛrɛsin de wok fayn.

Wetin a fɔ tek tɛm mɔ we a de tek dis mɛrɛsin?

Duya pe atɛnshɔn to dɛn pɔynt ya we yu de yuz dis mɛrɛsin fɔ mek shɔ se yu sef ɛn fɔ gɛt di bɛst bɛnifit frɔm di mɛrɛsin.

• Wach fɔ di sayn dɛm: If yu at sik simptom dɛm (lɛk fɔ blo shɔt, taya, swel na yu leg) nɔr bɛtɛ afta yu dɔn bigin dis mɛrɛsin, ɔr if i tan lɛk se i de wɔs, tɛl yu dɔktɔ wantɛm wantɛm.
• Bɛlɛ (dis rili impɔtant!):

Nɔ gɛt bɛlɛ we yu de tek Sacubitril; Valsartan we dɛn kɔl Valsartan. Dis mɛrɛsin kin ambɔg di pikin we nɔ bɔn yet, ɛn i kin ivin put in layf pan denja. So, if yu de plan fɔ gɛt bɛlɛ, ɔ if yu tink se yu go gɛt bɛlɛ, stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm ɛn tɛl yu dɔktɔ. Yu dɔktɔ go gi yu di rayt advays. Aks yu dɔktɔ fɔ no mɔ.

• Dɛn kin slip ɔr diziz: Sɔm pipul kin fil smɔl fɔ slip ɔr diziz we dɛn de tek dis mɛrɛsin. So, nɔ drayv, yuz ebi ebi mashin, ɔ du ɛnitin we nid fɔ pe atɛnshɔn ɛn wach te yu no gud gud wan aw dis mɛrɛsin de afɛkt yu. Nɔ grap frɔm we yu sidɔm ɔ sidɔm frɔm we yu tinap wantɛm wantɛm. Tek tɛm mɔ if yu dɔn ol. If yu chenj yu pozishɔn ɔltɛm, dat kin mek yu nɔ gɛt diziz ɛn fɔdɔm.
• Rɔm: Nɔ drink rɔm as yu ebul we yu de tek dis mɛrɛsin. Alkol kin ambɔg di wok we dis mɛrɛsin de du ɛn i kin mek di sayd ɛfɛkt dɛn bɔku.
• Sɔl we dɛn kin yuz fɔ mek sɔl: Sɔm tin dɛn we dɛn kin yuz fɔ mek sɔl gɛt potashɔm. Yu fɔ tek tɛm wit di potashɔm lɛvɛl we yu de tek dis mɛrɛsin, so nɔ yuz sɔl sɔlt pas yu dɔktɔ tɛl yu fɔ du am.

Wetin na di sayd ɛfɛkt dɛm we dis mɛrɛsin kin gɛt?

Lɛk ɔl di mɛrɛsin dɛn, Sacubitril; Valsartan kin mek sɔm pipul dɛn gɛt sayd ɛfɛkt. Nɔto ɔlman kin gɛt dɛn, bɔt i fayn fɔ no bɔt dɛn. If yu gɛt ɛni wan pan dɛn bad bad tin ya, tɛl yu dɔktɔ ɔ ɔspitul kwik kwik wan:

• Di tin dɛn we kin mek pɔsin gɛt alɛji:
• Skin lɛsin, lɛk ɛkzema, it, ayv.
• Fɔ swel na yu fes, yu lip, yu tɔŋ, ɔ yu trot (dis kin rili denja bikɔs i kin mek i nɔ izi fɔ blo).
• Di ay potashɔm lɛvɛl na di blɔd:
• Fɔ fil lɛk se yu de fil pen na yu chɛst.
• Di at kin bit kwik kwik wan ɛn i nɔ kin bit ɔltɛm.
• Fɔ fil se yu wik ɛn yu gɛt swɛt na yu mɔsul dɛm.
• Kidni injuri:
• Fɔ fil se i nɔ izi fɔ yu fɔ pis.
• Fɔ pas smɔl ɔ mɔ urine pas aw i kin pas.
• Chenj in kɔlɔ na di urine.
• Lɔw blɔd prɛshɔn:
• Fɔ fil diziz, mɔ we yu tinap.
• I de fil fɔdɔm, in yay dɛn de tɔn blu.
• Fɔ fil lɛk se yu go fɔdɔm we yu tinap.
• Fɔ fil wik ɛn taya we nɔ kɔmɔn.

Bɔrku tɛm, de sayd ɛfɛkt dɛm wae de dɔŋ ya nɔr kin bi tin wae yu fɔ wɔri bɔt. Bɔt if dɛn kɔntinyu ɔ de mɔna yu, tɛl yu dɔktɔ se:

• Kɔf: Sɔm pipul dɛn kin gɛt dray kɔf we dɛn de tek dis mɛrɛsin.

If yu gɛt ɛni ɔda kayn sik ɔr sayd ɛfɛkt wae nɔr de ya, tɔk to yu dɔktɔ bɔt am. Nɔ wɔri, yu kin ebul fɔ kɔntrol bɔku pan dɛn tin ya.

Aw yu kin kip dis mɛrɛsin sef?

I rili impɔtant bak fɔ kip di mɛrɛsin dɛn we nɔ gɛt wan prɔblɛm.

• Kip am usay pikin ɛn animal dɛn we yu lɛk nɔ go ebul fɔ rich. Dis na tin we kɔmɔn fɔ ɔl di mɛrɛsin dɛn.
• Stɔr am na rum tɛmpracha (bitwin 20 ɛn 25 digri sɛlshiɔs, bitwin 68 ɛn 77 digri Fahrenheit). Protɛkt frɔm ɔt, layt, ɛn mɔs we pasmak. Dis min se yu nɔ fɔ kip am na say dɛn lɛk di bafa.
• Kip di bɔtul ɔ paket we gɛt di mɛrɛsin tayt tayt wan.
• Nɔ yuz mɛrɛsin we dɔn pas. Dɛn rayt di de we i fɔ dɔn na di paket.

Aw yu kin trowe mɛrɛsin dɛn we yu nɔ yuz ɔ we dɔn pas?

• Di bɛst tin fɔ du na fɔ gi di mɛrɛsin to ``tek-bak program.'' Chɛk wit yu famasi ɔ di polis steshɔn we de nia yu fɔ si if dɛn gɛt dɛn kayn program ya.
• If dat nɔ pɔsibul, chɛk di mɛrɛsin lɛbl ɔ paket fɔ si if instrɔkshɔn de bɔt aw fɔ trowe di mɛrɛsin na di dɔti ɔ flɔsh am dɔŋ di tɔylɛt.
• If yu nɔ shɔ, aks yu dɔktɔ ɔ fama.
• If na mɛrɛsin we dɛn kin trowe na di dɔti, pul am na di kɔntena, miks am wit yuz pusi dɔti, dɔti, ɔ kɔfi grɔn, put am insay bag ɔ kɔntena we dɛn kin sial, ɛn trowe am na di dɔti. Dis na fɔ mek smɔl pikin ɔ animal nɔ go insay am ɛn mek aksidɛnt.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

Okay, so wi don tok plenti abaut dis drug `Sacubitril; Valsartan` (Entresto), nɔto so? Fɔ dɔn, na di impɔtant tin dɛn we yu fɔ mɛmba:

• Dis mɛrɛsin na impɔtant mɛrɛsin wae de ɛp fɔ kɔntrol yu at pwɛl hat.
• Ɔltɛm tek di doz we dɛn tɛl yu fɔ tek di tɛm we dɛn tɛl yu fɔ tek, lɛk aw yu dɔktɔ tɛl yu. Nɔ skip fɔ it ɔ tek mɔ pas wetin yu nid.
• Mek shɔ se yu tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin we yu de tek ɛn ɛni ɔda sik we yu gɛt.
• Nɔ tek dis mɛrɛsin if yu gɛt bɛlɛ ɔ yu de tray fɔ gɛt bɛlɛ. Tek tɛm mɔ.
• Yu fɔ no bɔt di bad tin dɛn we kin apin to yu. Tɛl yu dɔktɔ if yu notis ɛnitin we nɔ kɔmɔn.
• If yu gɛt ɛni kwɛstyɔn ɔ dawt, nɔ shem fɔ aks yu dɔktɔ ɔ fama.

If yu fala dɛn step ya kɔrɛkt wan, dis mɛrɛsin go ebul fɔ gi yu gud rizulyt fɔ yu at wɛlbɔdi. A de wish yu fɔ wɛl kwik kwik wan! Sacubitril, Valsartan, Entresto, At Fail, At Sik, At Mɛdisin, Blɔd Prɛshɔn