Wetin na SIADH (Syndrome of Inappropriate Antidiuretic Hormone Sekreshɔn)? Lɛ wi tɔk bɔt am simpul wan!

Yu dɔn ɛva tink se di wata we de na wi bɔdi nɔ jɔs de kɔntrol insɛf, bɔt wan spɛshal ɔmon de ɛp wit am? fכ tru, wan amazing mεkanism de we de εp fכ kip di כmכnt כf wata εn sכlt (i.e. sodium) na wi bכdi jכs rayt. di men wan we de εp wit dis na di כmon `ADH`. כltu, sכmtεm we dis `ADH` כmon bigin fכ bכku pasmak na wi bכdi, sכm sכm prכblεm dεm kin kam. Dat na di kɔndishɔn we wi go tɔk bɔt tide, `SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion)`. Pan ɔl we i go tan lɛk se di nem lɔng smɔl, lɛ wi ɔndastand am simpul wan.

Wetin rili na SIADH?

Fɔ tɔk am simpul wan, SIADH na wan kɔndishɔn we yu bɔdi de mek tumɔs, ɔ we nɔ fayn, di ɔmon `Antidiuretic Hormone (ADH). dis `ADH` כmon dεn kכl am bak `Vasopressin`. dis `ADH` כmon de prodyuz na di haypothalamus na wi bren. afta dat, i de stכr na di posita pituitary gland εn i de kכmכt na di bכdi we nid de. Naw, lɛ wi si us impɔtant tin dɛn dis `ADH` ɔmon de ɛp na wi bɔdi:

• Fɔ mek wi gɛt balans bitwin di wata ɛn sɔdiɔm ( sɔl ) we de na wi blɔd.
• I de ɛp fɔ kɔntrol blɔd prɛshɔn .
• I de ɛp di kidni dɛn fɔ wok fayn fayn wan.

fכ put am mכr simpul, di כmon `ADH` de kכntro di כmכnt כf wata we yu kidni dεm de pul na yu urine. insay di kes fכ `SIADH`, biכs fכ di εksyכs fכ dis `ADH` כmon, yu bכdi de stat fכ kip mכr wata. di men tin we kin mek yu du dis na dat di sodium (sכlt) lεvεl na yu bכdi de dכn. We wi de tɔk bɔt mɛrɛsin, wi kin kɔl dis `Hyponatremia`.

Udat dɛn kin gɛt mɔ prɔblɛm wit SIADH?

Infakt, ɛnibɔdi kin gɛt `SIADH`. Bɔt di risk fɔ gɛt dis sik kin bɔku wit di ej. in jεnarכl, dis kכndyushכn we dεn kכl `SIADH` de mכst kכmכn pan:

• Na pipul dɛm wae de wɛl frɔm ɔpreshɔn na ɔspitul, dis kin apin bikɔs ɔf di wata we dɛn kin gi afta dɛn du ɔpreshɔn, sɔm mɛrɛsin dɛm, ɛn di bɔdi in ansa to pen ɛn strɛs.
• pan pipul dεm we gεt lכng kεnsar, spεshal wan dεm we gεt wan kayn we dεn kכl ``Smכl Sεl Lכng Kεnsar ( SCLC )''.

Aw kכmכn dεn kכl dis kכndyushכn SIADH?

`SIADH` na wan fayn kɔmɔn kɔndishɔn. `Hyponatremia` (low sodium in di bכdi) we wi bin dכn tכk bכt na di mכst kכmכn `Electrolyte` imbalans we dεn kin si pan כspitul pasεnshכn dεm. `SIADH` na di men tin we de mek yu gɛt `Hyponatremia`.

Aw SIADH kin mek pɔsin gɛt hayponatremia?

Imajin se yu tɔsti bad bad wan. Wetin yu bɔdi de du? i de gi signal fכ di bכdi fכ rilis di כmon `ADH`. Dɔn di kidni dɛn kin ridyus di wata we de kɔmɔt na di urine, ɛn di bɔdi kin kip da wata de. we yu drink wata, we yu tɔsti dכn, di bכdi de stכp fכ rilis `ADH`, εn di kidni dεm de bigin fכ pul wata na di urine nכmal wan bak. Dis na di nɔmal tin we kin apin. כltu, pan bכku pipul dεm we gεt `SIADH`, di rilis fכ di כmon `ADH` nכ de dכn fayn fayn wan ivin afta dεn dכn drink wata. fכ dat, dεn urine de bכku bכku wan (we min se dεn nכ de bכku wata εn dεn de west mכr). Dis kin mek wata gɛda na di bɔdi. We dis wata gɛda, tin dɛn lɛk sɔdiɔm we de na di blɔd kin dil. na we di sodium lεvεl na di bכdi de dכn, we dεn kכl `Hyponatremia`. insay sכm kes dεm fכ `SIADH`, we di bכdi gεt tu mכch wata, dεn kin gi signal fכ di kidni dεm fכ kכl tu mכch sכlt (sכdiכm) insay di urine. Dis na ɔda tin we kin mek pɔsin gɛt `hayponatremia`.

Wetin na di sayn dɛm fɔ SIADH?

We yu gɛt `SIADH`, yu urine kin rili kɔnsɛntret. Dat min se bɔku bɔku dɔti tin dɛn de ɛn wata smɔl. Bikɔs yu bɔdi nɔ kin pul wata wit urine, di wata we de na yu blɔd kin bɔku. Dis kin mek tin dɛn lɛk sɔdiɔm we de na yu blɔd nɔ bɔku.

di lכw sodium lεvεl na di bכdi (hyponatremia) na di men tin we de mek di simptom dεm f כ SIADH .

Bɔrku tɛm, ivin if yu gɛt smɔl smɔl sodium nɔr kin mek yu gɛt ɛni big big sayn. Bɔt if di sɔdiɔm lɛvɛl smɔl ɔ i rili smɔl, sɔm sayn dɛn lɛk dis kin apin:

• Mɔsul dɛn de twitch ɔ wik. Imajin se yu de fil lɛk se yu leg dɛn jɔs de shek shek.
• Nɔs ɛn vɔmit .
• Ed de at .
• Prɔblɛm wit balans, we kin mek pɔsin fɔdɔm sɔntɛnde.
• Di chenj dɛm na yu maynd, lɛk fɔ gɛt prɔblɛm fɔ pe atɛnshɔn, fɔ mɛmba tin dɛm, ɛn/ɔ fɔ biev strenj.
• If i siriɔs, yu kin gɛt sik ɔ kɔma .

Wetin na di tin dɛn we kin mek pɔsin gɛt SIADH?

Bɔrku tɛm, na ɔda mɛrɛsin sik kin kam wit SIADH. Hɛridit SIADH (we min se dɛn kin pas am tru jɛnɛreshɔn) nɔ kin bɔku.i de kכz fכ wan jin mכtεshכn na di `Vasopressin 2 (V2) rεsεpכta dεm` na di kidni dεm. Na sɔm pan di kɔndishɔn ɛn kɔz dɛm we kin mek bɔku tɛm `SIADH` apin:

• Sɔm kayn kansa: Sɔm tumbu kin mek dɛn yon ADH ɔmon. dis kin mek di ADH pasmak na di bכdi, we kin mek i gεt SIADH. Smɔl sɛl lɔng kansa (SCLC) na di kayn kansa we kin mek ADH dis kayn we. pan tap dat, kansa lεk sכm sכm sεl kansa we de divεlכp ausayd di lכng, ed εn nεk kεnsar, εn olfaktכri nyuroblastoma kin mek SIADH bak.
• Sεntri Nεv sεstem (CNS) Prכblεm dεm: Wi sεntri nεv sεstem na di bren εn di spεnal kכd. Eni abnכmal tin na dis sistεm, lεk strok, blɔd na di bren, infεkshכn, injuri, כ, rεli, saykosis, kin mek SIADH.
• sכm mεdikeshכn dεm: sכm mεdikeshכn kin inkrεs di rilis כ aktiviti fכ di כmon `ADH`. So, `SIADH` kin apin. Fɔ ɛgzampul, sɔm mɛrɛsin fɔ ɛpilepshi, mɛrɛsin fɔ pwɛl hat, mɛrɛsin fɔ kansa, ɛn sɔm mɛrɛsin fɔ at sik, dayabitis, ɛn ay blɔd prɛshɔn.
• Ɔpreshɔn ɔnda anestezi: SIADH kin gɛt fɔ du wit ɔpreshɔn. Dis kin bi bikɔs ɔf di strɛs we di bɔdi kin gɛt na in maynd ɛn bɔdi.
• Lɔng sik: Lɔng sik, mɔ nyumonia (we vayrɔs, baktri, ɔ TB kin kam wit), kin mek pɔsin gɛt SIADH. Risach pipul dɛn nɔ shɔ yet wetin mek dis kin apin.
• di כmon dεm we nכ de: כl tu di kכndyushכn dεm we dεn kכl `Hypopituitarism` (underactive pituitary gland) εn `Hypothyroidism` (underactive thyroid gland) kin mek `SIADH`.

Aw dɛn kin no se pɔsin gɛt SIADH?

If yu gɛt sayn dɛn fɔ hyponatremia (we sodium nɔ bɔku na yu blɔd), yu dɔktɔ go du wan kɔmplit ɛgzam fɔ yu bɔdi. Dɛn go chɛk yu fluid stetɔs bak. Dis impɔtant fɔ mek dɛn no di sik kɔrɛkt wan. Dɛn go chɛk if yu nɔ gɛt wata na yu bɔdi, yu gɛt wata pasmak, ɔ yu jɔs rayt. No wan bɛst tɛst nɔ de fɔ no if yu gɛt SIADH. Pan ɔl we tɛst dɛn de we kin chɛk di lɛvɛl we ADH de na yu blɔd, i kin tek tu wiks fɔ mek di rizɔlt kam bak. So, yu dɔktɔ go mɔs tɛl yu fɔ du ɔda tɛst fɔ chɛk if yu gɛt hayponatremia, lɛk:

• Komprεhεnsiv Mεtabolik Panεl (CMP).
• Blɔd osmolaliti tɛst.
• Yurin Osmolality Tɛst fɔ yu.
• Yurin sɔdiɔm ɛn potashɔm tɛst.
• Toxicology Skrin fɔ sɔm drɔgs.

If yu pikin gɛt simptom dɛm fɔ SIADH, di dɔktɔ kin ɔda fɔ mek dɛn tek imej tɛst (e.g., skan) fɔ di lɔng ɛn bren.

Aw dɛn kin trit SIADH?

Di tritmɛnt fɔ SIADH dipen pan di kɔz. Fɔ ɛgzampul, if yu gɛt tumbu we de mek ADH, yu dɔktɔ go tɛl yu fɔ du ɔpreshɔn fɔ pul am. If na mɛrɛsin mek yu gɛt di sik, yu dɔktɔ kin chenj di doz fɔ di mɛrɛsin ɔ gi yu ɔda mɛrɛsin. Insay ɔl di kes dɛm fɔ SIADH, di fɔs tin we yu fɔ du na fɔ stɔp di wata we yu de drink. Dis kin ɛp fɔ mek yu bɔdi nɔ gɛt bɔku wata. Yu dɔktɔ go tɛl yu ɔmɔs wata yu fɔ drink ɛvride (inklud wata, kɔfi, ti, ɛn drink dɛn we gɛt shuga). If yu gɛt siriɔs sayn dɛm fɔ hayponatremia (lɛk fɔ kɔnfyus, fɔ gɛt sik), na mɛdikal imejensi. Dɛn kin trit dis na ɔspitul wit salin (sɔl sɔlvushɔn we dɛn kin gi tru IV) we dɛn kin gi insay wan vein. Yu kin nid mɛrɛsin bak fɔ blok di ifɛkt dɛm we di ADH ɔmon gɛt pan yu kidni dɛm. afta dat di kidni dεm de gεt signal dεm εn bigin fכ pul di wata we pasmak na di bכdi tru di urine.

Yu tink se dɛn kin ebul fɔ stɔp SIADH?

Bikɔs bɔku tin dɛn de we kin mek pɔsin gɛt `SIADH`, i kin at fɔ mek i nɔ apin. If yu de wɔri se yu kin gɛt `SIADH` ɔ `hyponatremia`, tɔk to yu dɔktɔ.

Wetin na di prɔgnosis fɔ SIADH?

Di luk fɔ SIADH dipen pan di ɔndalayn kɔz. Di gud nyus na dat bɔku pan di tin dɛn we kin mek pɔsin gɛt SIADH kin chenj ɛn/ɔ dɛn kin trit am. Akyu hayponatremia, we kin apin kwik kwik wan, insay lɛs dan 48 awa, kin denja pas hayponatremia we kin kam smɔl smɔl as tɛm de go. Krכnik hayponatremia de sho se yu gεt nyurolכjik prכblεm dεm (e.g., lכs fכ bεlε, mεmכri lכs). If SIADH rili bad ɛn di sodium lɛvɛl na di blɔd drɔp tumɔs, dɛn tin ya kin apin:

• I nɔ kin no natin, i kin si tin dɛn we i de tink bɔt, ɔ i kin kam na kɔma.
• Bren Ɛnieshɔn.
• Day.

Ustɛm yu fɔ go to dɔktɔ bɔt SIADH?

If yu gɛt sɔm sayn dɛm fɔ hyponatremia, lɛk fɔ gɛt mɔsul kramp ɛn fɔ gɛt prɔblɛm wit yu balans, tɔk to yu dɔktɔ. Bikɔs bɔku tin dɛn kin de we kin mek yu gɛt dɛn sik ya, i go mɔs bi se yu dɔktɔ go du difrɛn tɛst dɛn.

If yu gɛt sɔm sayn dɛm fɔ siriɔs hayponatremia, lɛk fɔ kɔnfyus, fɔ delirium, ɔ fɔ gɛt sik, go na di ɔspitul we de nia yu kwik kwik wan.

SIADH na wan sik wae kin pasmak wae kin gɛt bɔrku tin wae kin mek pɔrsin gɛt dis sik. Bɔrku tɛm e kin afɛkt pipul dɛm wae dɔn ɔlrɛdi de na ɔspitul. Bɔt if yu gɛt sɔm sayn dɛm fɔ SIADH, lɛk fɔ nɔs ɔr yu maynd chenj, i impɔtant fɔ tɔk to dɔktɔ.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

Okay, so a op se yu naw get beta andastan fo di `SIADH` we wi tok abaut tide.

• `SIADH` na wan kכndyushכn we di bכdi de kip wata εn de ridyus sכdiכm na di bכdi bikoz fכ di כmon `ADH` we de prodyuz pasmak.
• Bɔku rizin dɛn kin de fɔ dis; tin dεm lεk kεnsar, sכm mεdikeshכn dεm, כpεrayshכn, lכng sik, εtk.
• Di sayn dɛm kin bi fɔ nɔs, fɔ vɔmit, fɔ gɛt diziz, ɛn fɔ chenj yu maynd . If i siriɔs, yu kin gɛt sik ɛn nɔ kin no natin.
• Di tritmɛnt kin inklud fɔ kɔntrol wata, fɔ trit di tin we mek i gɛt am, ɛn fɔ gi salin ɔ mɛrɛsin if nid de .
• De tin wae impɔtant pas ɔl na, if yu gɛt dɛn kayn sik ya, nɔr panik ɛn go to dɔktɔ kwik kwik wan. Da we de, yu kin no di rayt tin ɛn bigin di tritmɛnt we yu nid.

Fɔ kia fɔ yu wɛlbɔdi na di tin we impɔtant pas ɔl. Na dat mek i rili impɔtant fɔ no bɔt tin dɛn lɛk dis. SIADH, Antidayuretik Ɔmon, ADH, Hayponatremia, Vasopresin, Sɔdiɔm, Ɔmon Imbalans