Yu de gɛt lumps nia yu jɔyn dɛn? Mek wi tɔk bɔt Tumoral Calcinosis!

Sɔntɛnde yu kin fil lɛk se yu gɛt wan lump ɔ had say ɔnda yu skin nia wan jɔyn lɛk yu ɛlb, yu sholda, ɔ yu ni? Sɔntɛm i nɔ go at we yu prɛs am, bɔt i kin big smɔl. Na nɔmal tin fɔ mek yu fred smɔl we yu si sɔntin lɛk dis. Bɔt nɔto ɔl dɛn lumps ya na kansa we denja. Tide wi go tɔk bɔt wan sik we de sho dɛn kayn sik ya, bɔt nɔto kansa, ɛn i nɔ kin apin smɔl bɔt i impɔtant fɔ no bɔt. Dat na ‘Tɔmɔral Kalsinɔsis’ .

Wetin na Tumɔral Kalsinɔs?

Fɔ tɔk am simpul wan, tumoral calcinosis na wan sik we pɔsin kin gɛt frɔm in jɛnɛtiks . Dis na we yu blɔd lɛvɛl fɔ wan kemikal we dɛn kɔl fɔsfɛt tu bɔku. Fɔsfɛt na wan patikyula ɔ ayɔn we gɛt ilɛktrik chaj we gɛt di minral fɔsfɔr. So, pan pɔsin we gɛt tumoral calcinosis, ɔl tu di fɔsfɔr ɛn kalsiɔm kin gɛda na di bɔdi, we kin mek lump dɛn fɔm ɔnda di skin, mɔ rawnd di jɔyn dɛn.

Fɔsfɔr ɛn kalsiɔm ɔl tu impɔtant fɔ mek wi bɔdi gɛt wɛlbɔdi, strɔng tit ɛn bon dɛn. bכt we dεn gεt tu hכy, nכn kεnsar (benign) growth dεm, dat na, nכ denja, bכt we lεk tכmכro, kin bigin fכ fכm na di tisu dεm. Dis na wetin wi kin kɔl tumoral calcinosis.

Yu tink se ɔda nem de fɔ dis?

Yes, di ful mεdikal nem fכ dis kכndyushכn na ‘Hyperphosphatemic Familial Tumoral Calcinosis’ (HFTC) . Na bit of a long nem, no bi so? Sɔm dɔktɔ dɛn kin kɔl am bak ‘Teutschlaender disease’. Dat na fɔ mɛmba Otto Teutschlaender, wan Jaman dɔktɔ we bin stɔdi dis sik frɔm di 1930s to di 1950s.

Wetin dis lɔng mɛrɛsin nem min?

Wi go brok dis nem to pat ɛn ɔndastand am? Dat go izi fɔ am.

• Hyperphosphatemic: Dis min se di fosfet lεvεl na di bכdi de hכy.
• Famili: Dis min se dis na kɔndishɔn we de rɔn na famili ɛn i kɔmɔt frɔm dɛn mama ɛn papa.
• Tumoral: Dɛn kin yuz dis wɔd bikɔs dɛn tin ya we de gro lɛk tumor kin tan lɛk kansa tumor.
• kalsinosis: Dis min se di kalsiכm de dכn insay di tisu dεm na yu mכsul dεm εn di mכsul εn skel sistεm.

Yu ɔndastand wetin da lɔng nem de min naw?

Aw ɛksaktɔli Tumoral Calcinosis de afɛkt di bɔdi?

Dɛn lumps ya we dɛn kɔl tumoral calcinosis , kin apin bɔku tɛm ɔnda di skin, nia di jɔyn dɛn . Dɛn kin divɛlɔp na mɔ pas wan jɔyn, bɔt dɛn kin divɛlɔp bak na bɔku jɔyn dɛn. Di say dɛn we dɛn kin yuz mɔ na:

• Hip jɔyn dɛn
• Ɛlbɔ dɛn
• Sholda dɛn
• Bɔtɔm
• Di jɔyn dɛn na di an
• Spinal kɔd we gɛt fɔ du wit am
• Jaw eria

Aw dis sik kin kɔmɔn?

di mεdikal masta sabi pipul dεm nכ sכri εksεkt כl di pipul dεm gεt dis tumoral calcinosis. Bikɔs na wan sik we nɔ kin bɔku , i kin bɔku pan pipul dɛn we kɔmɔt na Afrika ɛn di Midul Is. I kin afɛkt man ɛn uman.

Wetin na di men kayn Tumoral Calcinosis?

Di kayn we we kin apin pas ɔl na Hyperphosphatemic Familial Tumoral Calcinosis, we wi bin dɔn tɔk bɔt. Apat frɔm dat, ɔda kayn dɛn de we nɔ kin bɔku:

• Hyperphosphatemia-hyperostosis syndrome (HHS): Dis na wan kכndyushכn we de mek di bon dεm de gro pasmak εn di divεlכpmεnt fכ di bon lεsin dεm we nכ de fכ kansa.
• Normophosphatemic tumoral calcinosis: Dɛn kin si dis kayn tin pan pipul dɛn we gɛt kidni we nɔ de wok fayn. I kin mek pɔsin gɛt wan sik we dɛn kɔl haypaparatayroydism, we na paratayroyd gland we de wok pasmak.

Wetin kin mek pɔsin gɛt Tumoral Calcinosis?

Tumor calcinosis na wan mεtabolik dizכrd we dεn kin gεt . Na lɛk wan pat pan tri pipul dɛm we gɛt dis sik gɛt chenj ɔ muteshon na dɛn FGF23 jin. di FGF23 jin de εp wi bon sεl dεm fכ mek wan protin we dεn kכl fibroblast growth factor (FGF) 23. sכm pipul dεm gεt di kכndyushכn bak biכs fכ chenj dεm na di GALNT3 εn KL jin dεm. dis jin dεm de kכntro di prodakshכn fכ FGF23. Pipul dεm we gεt nomophosphatemic tumor calcinosis gεt mכtεshכn na di SAMD9 jin.

nכmal wan, di protin `FGF23` de tεl wi kidni dεm aw mכch fכsfεt fכ riabsכp frכm di bכdi. Bɔt we wan chenj de na di jɛnɛtiks, dis prɔses nɔ kin go fayn. Dɔn di kidni dɛn kin tek mɔ fɔsfɛt bak pas aw dɛn fɔ tek am. nכmal wan, di kidni dεm de pul di fכsfεt we pasmak na di urine. bכt insay tכmכro kalsinosis, dis fכsfεt de tay pan kalsiכm εn fכm tכmכro dεm na di sכft tisu dεm.

Udat de pan denja fɔ gɛt dis sik?

Tumorous calcinosis na wan sik we de mek pɔsin nɔ ebul fɔ du am . Dis kin at fɔ ɔndastand smɔl, bɔt fɔ tɔk am simpul wan, fɔ mek yu gɛt di sik, yu fɔ gɛt di jin muteshɔn frɔm yu mama ɛn papa ɔl tu. Yu mama ɛn papa kin bi pipul dɛn we gɛt di muteshon, bɔt dɛn nɔ kin gɛt di sik.

If mama ɛn papa dɛn ɔl tu na pɔsin we de kɛr pikin dɛn, ɛni wan pan dɛn pikin dɛn gɛt dɛn chans ya:

• 1 pan 4 chans de fכ nכ gεt di mutated jin (no risk fכ divεlכp di sik).
• 1 pan 4 chans de fɔ mek yu gɛt tumoral calcinosis.
• 1 pan 2 chans de fɔ bi pɔrsin wae gɛt dis sik.

Wetin na di sayn dɛm fɔ Tumoral Calcinosis?

dis kכndyushכn de mek lכmp dεm we difrεn saiz fכm nia wan כ mכr joyn dεm. Dɛn lumps ya kin apin bɔku tɛm we dɛn smɔl ɔ we dɛn yɔŋ . Bɔt dɛn kin divɛlɔp bak pan bebi ɛn big pipul dɛn. Sɔntɛnde, na wan wan lumps nɔmɔ kin kam insay wan layf. Ɔ, bɔku bɔku lumps kin kam wan tɛm.

Yu kin gɛt sɔm kayn sik lɛk dis:

• I nɔ izi fɔ muv ɔ bɛn di jɔyn we dɔn afɛkt fayn fayn wan.
• Lump dεm we at, we nכ de mek yu fil pen (sכm lumps kin pen sכm we yu tכch).
• Di pen we de na di mɔskul ɛn skel.

Aw dɛn kin no se pɔsin gɛt Tumoral Calcinosis?

Ɔtpidist na dɔktɔ we spɛshal pan bon ɛn jɔyn prɔblɛm dɛn. I go chɛk yu ɛn aks yu bɔt di sayn dɛn we yu gɛt. Dɔn i kin du wan ɔ mɔ pan dɛn ɛkstrem rayt ya fɔ luk fɔ dɛn tumbu ya ɛn ɔda prɔblɛm dɛn we gɛt fɔ du wit in bon dɛn:

• X-ray egzamin `(X-ray)`
• CT skan we dɛn kin du
• MRI skan `(MRI)`

Us ɔda kɔndishɔn dɛn de sho di sem kayn sayn dɛm fɔ Tumoral Calcinosis?

Dis rili impɔtant. Na bikɔs i impɔtant fɔ mek dɛn no di sik kɔrɛkt wan . De rizin na dat ɔda kayn sik de wae de sho dis kayn sik, bɔt dɛn kin siriɔs pasmak. Sɔm pan dɛn tin ya na:

• Benign sכft tisu tכmכro dεm εn malign sכft tisu tכmכro dεm
• Calcific myonecrosis (na wan tumbu we de mek di kalsiɔm we de na di leg mɔsul dɛn) .
• Kalsifik tεndonayt (kalsiכm dεposit wit tεndonayt) .
• Calcinosis circumscripta (di dipɔsit dɛm na di skin ɛn di tisu dɛm na di an ɛn fut) .
• Calcinosis fכ krכnik kidni (rεnal) fεil (kalsiכm dεposit na pipul dεm we de pan dayalysis) .
• Calcinosis universalis (diposishכn fכ di kalsiכm sכlt dεm na di skin, di tisu dεm, di tεndon dεm, εn di mכsul dεm) .
• Kɔnɛktif tisu sik dɛn
• Gout we pɔsin kin gɛt
• Myositis ossificans (di mכsul we de tכn to bon) .
• Osteosarcoma ɛn sarkoma (bɔn kansa) .
• di sinovial kכndrכmatosis (di kכtilaj nכdul dεm na di jכint dεm) .

Si? Pan ɔl we de sayn dɛn kin fiba, di tin we kin mek pɔsin gɛt dis sik kin rili difrɛn. Na dat mek i impɔtant fɔ no di rayt tin we de apin.

Wetin na di tritmɛnt dɛn we nɔto ɔpreshɔn?

Yu dɔktɔ kin mek di fɔstɛm we de na yu blɔd nɔ bɔku.Dɛn kin gi yu mɛrɛsin dɛn we de mek pɔsin gɛt fosfɛt. We dɛn miks dɛn mɛrɛsin ya we de tay fɔsfɛt wit wan mɛrɛsin we dɛn kɔl asetazɔlamid (we dɛn kin yuz fɔ ɛpilepsi ɛn glaukoma), dɛn kin mek di bɔdi nɔ ebul fɔ tek fɔsfɔr. Yu kin nid bak fɔ it it we nɔ gɛt bɔku fosfɔr .

Wetin na it we nɔ gɛt bɔku fɔsfɔr?

If yu gɛt tumoral calcinosis, yu dɔktɔ kin tɛl yu fɔ it tin dɛn we nɔ gɛt bɔku fosfɔr. Fɔsfɔrɔs de insay mit, fish, ɛn tin dɛn we dɛn mek wit milk. Dɛn kin ad fɔsfɔs bak to sɔm ɔda it dɛn as tin fɔ mek tin nɔ pwɛl ɔ fɔ mek i gɛt flawa.

Tray fɔ ridyus di it ɛn drink dɛn we gɛt bɔku fɔsfɔr, lɛk:

• Bia, kola, ays ti ɛn chɔklɛt drink dɛn.
• Chokolat ɛn karamel difrɛn kayn dɛn.
• Di it dɛn we dɛn mek wit milk (milk, chiz, ayskrim, yogɔt we nɔto Grik, sup dɛn we gɛt krim).
• Sifud lɛk ɔysta ɛn sadin, ɛn ɔgan dɛn we de insay lɛk bif ɛn chukchuk liva.
• Mit dɛn we dɛn dɔn prosɛs (ɔt dɔg, lanch mit, bekin, sosish).
• Prodakt dɛn we dɛn mek wit oat bran.

I bεst fɔ tɔk to yu dɔktɔ ɔr nyutrishɔnist bɔt dis fɔ no mɔr.

Wetin na di tritmɛnt dɛn we dɛn kin du fɔ ɔpreshɔn?

Yu kin nid fɔ du ɔpreshɔn fɔ pul di tumbu dɛn we tu big fɔ mek dɛn ebul fɔ wok fayn. Bɔt dɛn tumbu ya kin gro bak . Yu dɔktɔ kin tek sɛmpul bak pan di tisu we dɛn pul ɛn du bayɔpsi fɔ kɔnfirm di sik.

Wetin na di prɔblɛm dɛn we kin kam wit Tumoral Calcinosis?

Na smɔl tɛm nɔmɔ, dis sik kin afɛkt yu blɔd vesel ɔr bren, ɛn dis kin mek yu gɛt siriɔs wɛl bɔdi prɔblɛm lɛk at atak ɛn strok.

Apat frɔm dat, dis sik kin mek bak dɛn tin ya:

• di kכnia kalsifikכshכn כ angioid strik (rεd strik) na di kכnia na di yay.
• Prɔblɛm dɛn we gɛt fɔ du wit dɛn tit.
• di bon dεm we de gro pasmak (hyperostosis).
• Inflameshɔn na di lɔng bon dɛm (diaphysis) na yu leg ɔ yu an.

Yu tink se dɛn kin ebul fɔ protɛkt di Tumoral Calcinosis?

If yu ɛn yu patna ɔl tu gɛt di jin muteshon we de mek yu gɛt tumoral calcinosis, yu kin tɔk to wan jenɛtik kɔlnɔ bɔt aw fɔ ridyus di risk fɔ mek yu pikin dɛn gɛt di mutation. Sɔm pipul dɛn kin pik wan we we dɛn kɔl Preimplantation Genetic Diagnosis (PGD) . dis involv fכ no di εmbrayo dεm we nכ gεt di mכtεshכn. Dɔn yu dɔktɔ kin yuz wan tin we dɛn kɔl In Vitro Fertilization (IVF) fɔ transfa di wɛlbɔdi embryo dɛn to di uman in riprodaktiv sistɛm. If yu du dis, yu pikin nɔ go gɛt di jin we de mek pɔsin gɛt di sik.

Wetin na de luk fɔ pɔrsin wae gɛt Tumoral Calcinosis?

Bɔrku pipul dɛm wae gɛt tumoral calcinosis de liv ful, aktif layf . Dis sik nɔ kin kam wit siriɔs wɛlbɔdi prɔblɛm. Bɔt yu go nid fɔ go to yu dɔktɔ ɔltɛm fɔ chɛk fɔ si if i gɛt di sik bak.

Ustɛm a fɔ go to dɔktɔ?

Si dɔktɔ if yu gɛt dɛn sayn ya:

• Di rεnj fכ muvmεnt na wan jכint de dכn.
• Jɔyn pen, bon pen, ɔ mɔsul pen.
• Di we aw tumbu ɔ lump de apin ɔnda di skin.

Wetin a fɔ aks mi dɔktɔ?

Yu kin aks di dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Wetin mek a bin gɛt tumoral calcinosis?
• Wetin na di bɛst tritmɛnt fɔ mi?
• Yu tink se a nid ɔpreshɔn?
• Us kayn it dɛn a fɔ stɔp fɔ it?
• A fɔ wɔri bɔt di prɔblɛm dɛn we kin apin?
• Yu tink se dɛn fɔ du di ɔda pipul dɛn na mi famili fɔ tɛst dɛn jɛnɛtiks?

Yu tink se Tumoral Calcinosis kin bi Kansa?

pan ɔl we di wɔd "tumoral" de na di nem, di tכmכro dεm we de divεlכp bikoz fכ tumoral calcinosis nכto rili kεnsar . No risk nɔ de fɔ mek dɛn tumbu ya bi bad bad tin. So nɔ wɔri bɔt am.

na tru se di tכmכro dεm we de כnda di skin bikoz fכ di tכmכro kalsinosis kin mek yu nכ fil fayn sכmtεm εn i kin mek yu fred. Bɔt fɔ bɔku pipul dɛn, dɛn tumbu ya nɔ kin mek dɛn gɛt ɛni big prɔblɛm. Mεdikeshכn kin lכs di fכsfכr lεvεl na di bכdi. Yu dɔktɔ kin tɛl yu bak fɔ go to pɔsin we sabi bɔt it fɔ ɛp yu fɔ it tin dɛn we nɔ gɛt bɔku fosfɔr. If yu gɛt pen na yu jɔyn, bon, ɔ mɔsul dɛn we de mek yu nɔ ebul fɔ muv, tɛl yu dɔktɔ. Pan ɔl we dɛn kin pul di tumbu dɛn we dɛn du ɔpreshɔn, mɛmba se dɛn kin kam bak.

Mesej we yu kin kɛr go na os (Tin dɛn we yu fɔ mɛmba) .

Okay, so lɛ wi rikap di impɔtant pɔynt dɛm we wi tɔk bɔt tide bɔt Tumoral Calcinosis:

• Dis na wan sik we nɔ kin apin so ɔltɛm, we pɔsin kin gɛt frɔm in mama ɛn papa. di lεvεl dεm we di fכsfεt de go כp na di bכdi de mek dεn kכmbayn wit kalsiכm fכ fכm lכmp nia di jכint dεm.
• Dɛn tumbu ya nɔto kansa .
• Bɔku tɛm dɛn tin ya nɔ kin mek pɔsin fil pen, bɔt dɛn kin ambɔg di jɔyn dɛn we de muv.
• Di tritmɛnt na fɔ tek mɛrɛsin fɔ mek yu nɔ gɛt bɔku fosfɛt, fɔ it tin we nɔ gɛt bɔku fosfɔr, ɛn if nid de, yu fɔ du ɔpreshɔn.
• If yu si wan lump lɛk dis, nɔ panik ɛn go to dɔktɔ. Fɔ no di sik kɔrɛkt wan rili impɔtant.
• Bɔrku pipul dɛn kin liv nɔrmal, aktif layf wit dis sik.

So, if yu ɔ pɔsin we yu sabi gɛt dɛn sik ya, i go fayn fɔ mek yu go to dɔktɔ fɔ advays.

` Tumorous calcinosis, joyn sist, fכsfεt, kalsiכm, jεnεtik sik dεm, skin nodul dεm, bon sik dεm