Yu nos kin blok ɔltɛm, i nɔ kin izi fɔ blo, yu nɔ kin ebul fɔ smɛl ɔ test ɛnitin, yu kin de rɔn na yu nos ɔltɛm... Yu dɔn de sɔfa wit dɛn sik ya fɔ lɔng tɛm? Sɔntɛm di tin we kin mek dis apin na di raynosinusitis we nɔ de dɔn, we na wan inflamɛns we kin de fɔ lɔng tɛm na di sayn dɛn we kin kam wit smɔl smɔl tɔŋ dɛn (nasal polyps) we kin gro insay yu nos. Pan ɔl we bɔku pipul dɛn kin kɔntrol dis wit sprɛy ɛn pils na dɛn nos , sɔm pipul dɛn nɔ kin gɛt ful wɛlbɔdi ilɛksɛf dɛn tek dɛn tritmɛnt ya fɔ lɔng tɛm. Tide, wi go tɔk bɔt wan nyu tritmɛnt we go ɛp dɛn kayn pipul ya, ɛn i de wok difrɛn we. Dis na di injεkshכn tritmεnt we dεn kכl Xolair.
Fɔs, lɛ wi si wetin na saynsaytis wit nos pɔlip?
Fɔ tɔk am simpul wan, dɛn kɔl di say dɛn we ful-ɔp wit briz na di skel we de rawnd wi nos sayn. Krכnik raynosaynayt na we di sayn dεm εn di layn na di nos kin inflam εn swεla fכ lכng tεm, we kin te pas 3 mכnt. we dis inflameshn de kכntinyu, sכm sכft growth dεm ( polyps ) we lεk grep de bigin fכ gro frכm sכm pat dεm na di layn.
Bɔrku tɛm, dɛn polyp ya nɔr kin kɔz ɛni sayn. bכt sכmtεm, dεn kin gro εn bigin fכ blok di nos pasεj dεm εn di sayn dεm. Na da tɛm de di prɔblɛm dɛn kin bigin.
- Nasal congestion : Di nos kin fil se i dɔn blok ɔltɛm.
- Nɔs we de rɔn: Na di wata we de kɔmɔt na di bɔdi bɔku tɛm.
- Lɔs fɔ smɛl ɛn teist : Yu nɔ go ebul fɔ smɛl di fayn fayn it dɛn ɔ di sɛnt we flawa gɛt.
- Sayn pen : We di mכkus nכ kin kכmכt na di sayn kכva, i kin bכku, we kin mek yu fil pen εn prεshכn. Sɔntɛnde, dɛn wan ya kin gɛt di sik .
di men tin we de fכ trit dis kכndyushכn na fכ rεdכks di inflameshn na di nos εn di sayn dεm. Dɔn di polip dɛn go shrink ɛn di sayn dɛn go bigin fɔ stɔp.
Aw di Xolair vaysin de wok?
Dis mɛrɛsin we dɛn kɔl Xolair gɛt di aktif ingridiɛnt we dɛn kɔl omalizumab. Di tin we i de du rili spɛshal. I de tɔch wan pat pan wi bɔdi in imyun sistɛm dairekt wan.
Tink bɔt wi bɔdi lɛk fɔt. We alɛrjen go insay dis fɔt, wi bɔdi in "gad dɛm" kin spring insay akshɔn wantɛm wantɛm ɛn bigin fɔ fɛt am. wan pan dεn "gad" dεm ya na wan protin we dεn kכl Immunoglobulin E (IgE) . Na pipul dɛm wae gɛt dis sik, dis gad wae dɛn kɔl IgE kin tu aktif smɔl. I kin riak pasmak pan ivin di smɔl smɔl tin dɛn, ɛn i kin mek di nos swel ɛn inflamɛns we nɔ nid.
wetin di Xolair vaksin de du na fכ blok di akshכn fכ di ova aktiv IgE protin. I tan lɛk se yu de mek pɔsin we de gayd pɔsin we de wɔri, kol. We di IgE stɔp fɔ wok, dɛn kin kɔntrol di alɛji ɛn di swel, rɛd, ɛn mɔkus we i kin mek. Dis kin mek di nos polip dεm kin shrink εn di simptom dεm kin bigin fכ bεtεh.
Fɔ tɔk am simpul wan, Xolair na wan mɔdan drɔg we de tɔch di ɔndalayn imyun rispɔns we de mek pɔsin gɛt di sik, pas fɔ stɔp dɛn.
Udat dis tritmɛnt fayn fɔ?
Nɔto ɔlman we gɛt dis kɔndishɔn dɛn kin gi Xolair wan tɛm. Bɔku tɛm, dɛn kin du di tritmɛnt stɛp bay stɛp.
| Di stɛp dɛn fɔ trit | Tɔk bɔt |
|---|---|
| Step Wan: Intranasal Kɔtikosterɔyd | Bɔku pipul dɛn kin gi dɛn sprɛy ya fɔs. Dɛn kin ɛp fɔ ridyus di swɛlin na di nos. If dɛn nɔr kɔntrol di sayn dɛm afta sɔm mɔnt wae yu dɔn yuse dɛn tin ya, den go to di nɛks step. |
| Step Tu: Stɛroyd pils fɔ shɔt tɛm (Oral Corticosteroids) . | If yu gɛt siriɔs sik, yu dɔktɔ kin gi yu stɛroyd pils fɔ shɔt tɛm. |
| Ɔda tin dɛn we yu kin du: Ɔpreshɔn | Sɔm pipul dɛn kin ivin gɛt ɔpreshɔn fɔ pul di polip dɛn na dɛn nos. |
| We yu tink bɔt Xolair tritmɛnt | Di dɔktɔ de tink bɔt dis vaysin tritmɛnt we dɛn kɔl Xolair as ɔda gud opshɔn fɔ di wan dɛn we stil de sɔfa wit siriɔs sik ivin afta di tritmɛnt dɛn we wi dɔn tɔk bɔt. |
Yu tink se dis mɛrɛsin rili de wok?
Yɛs. Tu big klinik trial, POLYP 1 ɛn POLYP 2, dɔn du fɔ kɔnfɔm se dis mɛrɛsin de wok fayn. Ɔl di wan dɛn we tek pat pan dɛn trayal ya na bin pipul dɛn we bin de yuz di nos sprɛy ɛvride bɔt stil de sɔfa wit di sayn dɛn.
di risal sho se di wan dεm we gεt di Xolair vaysin bin gεt bכku rεdukshכn pan di nכmba כf di nos polyp dεm . Dɛn nos kɔnjɛshɔn simptom dɛnsɛf bin go dɔŋ bad bad wan.
Aw dɛn kin yuz Xolair? Ɛn aw i go wɛl kwik kwik wan?
Xolair na wan likwid injεkshכn. Dɛn kin injɛkt am ɔnda di bɔdi . Dɛn kin gi am ɛvri 2 to 4 wik . Aw ɔltɛm ɛn aw bɔku yu nid, na yu dɔktɔ go disayd bay yu wet ɛn di IgE lɛvɛl na yu blɔd.
- Di fɔs fɔs dos dɛm: Dɛn go gi yu di fɔs dos dɛm fɔ dis mɛrɛsin ɔnda dɔktɔ in sɔpɔtishɔn na ɔspitul ɔ klinik. Dis na fɔ wach fɔ ɛni alɛji we kin apin to sɔm pipul dɛn.
- Dɔn na os: If yu nɔ gɛt prɔblɛm, wit yu dɔktɔ in aprɔval, dɛn kin tren yu fɔ gi yusɛf dis vaysin na os. wan divays de we izi fכ yuz, we dεn fulכp bifo tεm we dεn kכl ``autoinjector'' fכ dis.
- Rizult: Bɔku tɛm yu go si sɔm impɔtant tin dɛn pan yu sik dɛn insay di fɔs mɔnt we yu bigin fɔ tek tritmɛnt. Di sayn dɛm kin kɔntinyu fɔ bɛtɛ insay di nɛks sɔm mɔnt dɛm.
Di tin we impɔtant pas ɔl na fɔ nɔ ɛva stɔp fɔ tek dis mɛrɛsin ɔ ɛni ɔda mɛrɛsin we dɛn gi yu we yu nɔ tɔk to yu dɔktɔ, ilɛksɛf yu sik de go bifo. If yu du dat, yu sik kin kam bak.
Lɛ wi lan bɔt di sayd ɛfɛkt ɛn sef.
Lɛk ɔl di mɛrɛsin dɛn, chans de fɔ mek yu gɛt sayd ɛfɛkt. Bɔt, siriɔs sayd ɛfɛkt dɛn nɔ kin apin so ɔltɛm.
Di tin we impɔtant pas ɔl na dat, sɔm pipul dɛn kin gɛt siriɔs alɛji (anaphylaxis) afta di fɔs doz.Dis kin mek i nɔ izi fɔ blo wantɛm wantɛm, i kin swel, ɛn in ed kin tɔn. Dis na imejensi.
Na dat mek yu kin gɛt yu fɔs doz ɔltɛm na ɔspitul ɔ klinik bikɔs ɔf da risk de. Dɔn, if prɔblɛm de, dɛn gɛt trenin mɛdikal wokman dɛn fɔ trit am. So yu nɔ nid fɔ wɔri bɔt am.
Apat frɔm dis, smɔl smɔl sayd ɛfɛkt dɛn lɛk fɔ rɛd, it, ɛn pen kin apin na di say we dɛn injɛkshɔn. If yu gɛt ɛnitin we nɔ kɔmɔn, tɛl yu dɔktɔ wantɛm wantɛm.
Mɛsej we dɛn kin kɛr go na os
- Krεse saynayz wit nos polip (CRSwNP) nכto kכmכn kol, bכt na kכndyushכn we de tek lכng tεm.
- Xolair na wan mɔdan injɛkshɔn tritmɛnt we dɛn kin tink bɔt fɔ pipul dɛn we nɔ de ansa standad tritmɛnt (nasal spray, steroid pills).
- dis de blok di akshכn fכ wan protin we dεn kכl IgE, we de involv insay di bכdi in alerjik rispכns, εn i de ridyus di nos swεla εn polyp.
- Dis na vaysin we dɛn kin gi ɔnda di skin ɛvri 2-4 wik. Di fɔs doz fɔ de ɔnda di dɔktɔ in sɔpɔtishɔn.
- If yu gɛt dɛn kayn sik ya ɔr yu want fɔ no mɔ bɔt dis tritmɛnt, i rili impɔtant fɔ tɔk to yu dɔktɔ.
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