Ka tuyige ku biziyiza protease ebifuga yinfekisoni z’akawuka.

Ffenna tuwulidde ku bika by’eddagala eby’enjawulo eri endwadde ez’enjawulo, nedda? Leero tugenda kwogera ku kiraasi y'eddagala ery'enjawulo katono. Zino ziyitibwa ‘Protease Inhibitors’. Oyinza okuba nga towulirangako linnya lino, naye eddagala ery’ekika kino lyetaagisa nnyo mu kuziyiza endwadde ez’amaanyi ez’akawuka nga siriimu, Hepatitis C, ne COVID-19. Kale ka tulabe bino bye biruwa, engeri gye bikolamu, era ebintu ebikulu by’olina okumanya ku byo.

Mu ngeri ennyangu, bino ebiziyiza protease bye biruwa?

Mu ngeri ennyangu, eddagala eriziyiza protease kika kya ddagala erikozesebwa okujjanjaba yinfekisoni z’akawuka . Omulimu gwazo omukulu kwe kuyimiriza akawuka okwekolako kkopi nga kamaze okuyingira mu mubiri gwaffe, ekitegeeza nti tekasobola kwongera kusaasaana. Eddagala lino mu bukulu ‘liziyiza’ akawuka kano okusaasaana.

Eddagala lino lisinga kumanyibwa nga ddagala eriweweeza ku siriimu erikozesebwa okuddukanya akawuka ka siriimu. Era akozesebwa okujjanjaba obulwadde bw’ekibumba C ne COVID-19.

Oluusi eddagala lino eriziyiza protease liweebwa zokka (monotherapy). Naye emirundi egisinga, ziweebwa nga zigatta wamu n’eddagala eddala eritta akawuka. Kino kikolebwa okwongera ku bulung’amu bw’obujjanjabi. Mu mbeera eno, era ziyitibwa "booster".

Mbeera ki enkulu ezijjanjabwa n’eddagala lino?

Ekika ky’eddagala eriyitibwa protease inhibitors kikkirizibwa okujjanjaba obulwadde obutono obw’enjawulo obw’akawuka. Ka tulabe kiki kye bali.

Eddagala lino likola litya?

Okusobola okutegeera kino, ka tutwale ekyokulabirako ekitono. Teebereza nti akawuka kkolero erikola olujegere oluwanvu olwa puloteyina. Okusobola okukozesa olujegere luno oluwanvu okukola, kyetaaga okusalibwamu obutundutundu obutonotono obukola. ‘Essso’ ez’enjawulo akawuka ze kakozesa okusala kuno ze enzymes eziyitibwa ‘proteases’ .

Bika ki eby’ebiziyiza protease?

Olw’okuba buli kawuka kalina enziyiza yaako eya protease, ebika bya protease inhibitors eby’enjawulo bye bikozesebwa okujjanjaba siriimu, hepatitis C, ne COVID-19. Waliwo n’engeri ennyangu ey’okuzizuulamu.

• Amannya g'eddagala erikozesebwa okujjanjaba siriimu gatera okukoma mu "-navir" .
• Amannya g'eddagala erikozesebwa ku bulwadde bwa hepatitis C gatera okukoma mu "-previr."

Ebiziyiza ebirungo ebiziyiza akawuka ka siriimu

Bino biziyiza enziyiza ya protease eyitibwa HIV-PR, akawuka ka siriimu gye kakozesa okwekolera kkopi.

• Eddagala lya Atazanavir
• Eddagala lya Darunavir
• Eddagala lya Fosamprenavir
• Eddagala lya Indinavir
• Eddagala lya Lopinavir
• Eddagala lya Nelfinavir
• Eddagala lya Ritonavir
• Eddagala lya Saquinavir
• Eddagala lya Tipranavir

Ebiziyiza obutoffaali obukola omubiri (protease inhibitors) ku bulwadde bwa hepatitis C

Zino ziziyiza enzyme NS3/4A serine protease, akawuka ka hepatitis C ke kakozesa okwekolera kkopi.

• Eddagala lya Boceprevir
• Eddagala lya Glecaprevir
• Eddagala lya Grazoprevir
• Eddagala lya Paritaprevir
• Simeprevir eddagala eriyitibwa Simeprevir
• Eddagala lya Telaprevir

Ebiziyiza ebirungo ebiziyiza obulwadde bwa COVID-19

Paxlovid® kirungo kya protease inhibitors bibiri okuli nirmatrelvir ne ritonavir, ebikozesebwa okujjanjaba COVID-19.

Nlonda ntya eddagala erisaanira?

Kati oyinza okuba nga weebuuza eddagala lino kye liyinza okunkolera.Omusawo wo yekka y’asobola okusalawo. Ajja kulowooza ku bintu ebiwerako ng’alonda eddagala erisinga okukusaanira.

• Obulwadde ki obw’enjawulo obw’akawuka bw’olina?
• Obulamu bwo okutwaliza awamu n‟embeera endala zonna ez‟obujjanjabi z‟oyinza okuba nazo (e.g. ssukaali, obulwadde bw‟omutima).
• Eddagala ki eddala ly’omira mu kiseera kino (nga bwe wayinza okubaawo enkolagana wakati wa zino).
• Edda obadde omira eddagala eddala eriwonya embeera eno?
• Obuwanguzi bw’eddagala lino businziira ku kika ky’akawuka k’olina.
• Ebikwata ku bizibu ebiyinza okuva mu ddagala.

Biki ebiva mu ddagala lino n’emigaso ki?

Okufaananako n’eddagala lyonna, eddagala eriziyiza protease lirina emigaso n’ebizibu.

Ebirungi ebikulu

• Ng’ekimu ku bitundu by’obujjanjabi bwa ART eri omuntu alina akawuka ka siriimu, kiyamba okukuuma obungi bw’akawuka ka siriimu mu mubiri ku mutendera ogutazuulibwa.
• Ayamba okuwonya obulwadde bwa Hepatitis C.
• Ayamba okutangira obulwadde bwa COVID-19 obutaba bwa maanyi.

Ebiyinza okuvaamu ebizibu

Ebizibu ebivaamu bisinziira ku ddagala ly’omira, eddagala eddala ly’omira n’embeera y’obulamu bwo. Kikulu okwogera n’omusawo wo ku nsonga eno n’osigala ng’omanyi.

Kiki kye nnyinza okukola okusobola okwanguyiza obujjanjabi?

Nga okola obujjanjabi buno, waliwo ebintu ebiwerako by’osobola okukola okukendeeza ku bimu ku bizibu ebivaamu n’okwanguyira obujjanjabi.

• Eddagala lyo limira ddala nga bwe likulagidde omusawo, mu kiseera ekituufu, mu ddoozi entuufu. Tobuuka ddoozi emu.
• Nywa amazzi mangi. Kino kiyinza okukendeeza ku buzibu obukwata ku nsigo.
• Weewale okumira eddagala eddala eriyinza okukwatagana n’eddagala lyo. Buuza omusawo wo ku nsonga eno.
• Eddagala erimu likola bulungi nga limira n'emmere . Ebimu byetaaga emmere erimu amasavu. Buuza omusawo wo engeri gy’omira eddagala lyo era ogoberere amagezi ago.

Ddi lwe nnina okulaba omusawo?

Bw’ofuna ebizibu byonna by’otosuubira ng’ojjanjabibwa oba ng’olina ekikweraliikiriza ku bujjanjabi, tuukirira omusawo wo mu bwangu.

Okusingira ddala, bw’ofuna ekimu ku bizibu bino wammanga eby’amaanyi, funa amagezi mu basawo amangu ddala awatali kulwa oba genda mu kitongole ky’eddwaaliro eky’amangu (ETU) ekikuli okumpi.

• Omusujja
• Okutabulwa oba enkyukakyuka mu birowoozo
• Okufuuka okwa kyenvu kw’olususu oba amaaso (jaundice) .
• Ebizimba ebizimba, ebiruma oba ebibunye wonna
• Obulumi obw’amaanyi mu lubuto
• Okusesema okw’amaanyi