I hnute cancer hi HER2-Negative a ni em? Hemi chungchang hi awlsam takin han sawi ila! (HER2-Negative hnute cancer) a ni.

I doctor-in hnute cancer i vei tih a hrilh che chuan i rilru put hmang chu thuin sawi chhuah a harsa tih ka hria. Zawhna leh hlauhna tam tak i rilruah a lo lut hi thil pangngai a ni. Mahse he zinkawng harsa tak karah hian i tanpui theitu tur pawimawh tak pakhat chu i cancer awm dan dik tak hriatthiam hi a ni. Cancer stage, a chi, a lian leh te, leh i cancer cell-a protein thenkhat hriat hi enkawl dan tur thutlukna siam nan a pawimawh hle.

A awlsam zawngin, HER2-Negative hi eng nge ni?

Hetiang hian i hrethiam ang u. Kan taksa chhunga cell awmte hi in te tak te ang mai an ni. Heng in te hian ‘antenna’ bik an nei a, pawn lam atanga thuchah an dawng thin. Damdawi lamah chuan heng receptor te hi kan ti a. Heng antenna atang hian cell pakhat hian ‘to thanglian’ leh ‘to divide’ tih ang chi thuchah a dawng thin.

Chutiang antenna bik pakhat chu HER2 (Human Epidermal Growth Factor Receptor 2) hi a ni. HER2 hian cell hrisel te than dan a thunun thei a ni. Mahse, cancer cell te hian a chang chuan he HER2 antenna hi an siam tam lutuk a, a tlangpui aia tam an siam thin. Tichuan cancer chuan ‘thang’ turin thuchah a dawng fo a, cancer chu a darh chak hle a ni. He dinhmun hi HER2-Positive kan ti a.

Chuvangin, i doctor chuan i hnute cancer chu HER2-negative a ni a tih chuan, chu chu i cancer cell-te hian he extra HER2 antenna hi an nei lo tihna a ni. A awlsam zawngin, i cancer hian a lo thang chak zawkna tur thil lian tak a nei lo.

Engtin nge i cancer HER2 dinhmun dik tak i hriat theih ang?

HER2-negative leh HER2-positive cancer pahnih symptoms hi a inang vek a ni. I doctor chuan eng type nge i neih tih chu a enfiah mai mai hian a hrilh thei lo che. I tumor (biopsy) sample tlemte a lak a ngai dawn a, test tir a ngai dawn a ni. He test hian cancer cell-a HER2 protein awm zat chiang takin a hriat theih ang.

HER2 chauh ni lovin thil dang kan en a ngai!

HER2 chauh hi cancer thanna tichhe theitu a ni lo. Kan taksaah hian hormone laka sensitive tak tak receptor chi hnih dang ( hormone receptor - HR) a awm bawk.

• Estrogen Receptor (ER) te hi a tha hle.
• Progesterone dawngtu (PR) te hi 1.1.

Heng receptor te hi cancer cell-ah a awm a nih chuan hormone estrogen leh progesterone te hian cancer hi a tipung thei a ni. Doctor-te chuan heng receptor zawng zawng hi an sawi dun vek a. Hei hian i HER2-negative cancer chu chi hnih ah then belh theih a ni tihna a ni:

1. HR-Positive / HER2-Negative: Chumi awmzia chu cancer hian HER2 a sensitive lo va, hormone a sensitive zawk tihna a ni. Hei hi hnute cancer chi khat a ni ber .

2. HR-Negative / HER2-Negative: Hei hian cancer hian HER2 emaw hormone emaw a sensitive lo tihna a ni. Heng receptor pathum (HER2, ER, PR) te hi a awm loh avangin he chi hi Triple Negative an ti bawk.

Heng zawng zawng hriat hian nang leh i doctor te chu i cancer biological behavior chiang zawka hriat theih nan a pui ang a, chu chuan i tana enkawlna tur tha ber leh tangkai ber i thlan theih nan a pui ang che.

HER2-negative cancer enkawlna tur engte nge ni?

I cancer hi HER2-negative a nih avangin targeted therapy pek i ni dawn lo a, chu chuan HER2 protein a target a ni. Chu chu damdawi te hian hna an thawh theih nan cancer cell-ah HER2 antenna an neih a ngai a ni. Chu ai chuan i cancer stage leh hormone laka sensitive a nih leh nih loh a zirin enkawlna dang i thlang zawk ang.

• Surgery leh radiation: Cancer hi a hmaa hriatchhuah a nih chuan surgery hmangin a bo vek thei a ni. Operation hma emaw, operation hnuah emaw pawh radiation therapy hman a tha thei bawk.

• Endocrine/ Hormone therapy: I cancer hi HR-Positive/HER2-Negative a nih chuan he enkawlna hi a pawimawh hle. Taksa chhunga estrogen ang chi hormone level tihhniamna hmangin hna a thawk a ni. Hormone te a bo chuan cancer cell te hian thanlenna tur thuchah an hloh a, cancer chu a tlem emaw, a lo thang chak tawh lo emaw thei bawk.

• Chemotherapy: Chemotherapy hi a chang chuan HR-positive / HER2-negative cancer tan hormone therapy nen a rualin pek theih a ni. Hei hi cancer stage leh grade, i kum leh i hriselna zawng zawngah a innghat a ni. A chang chuan chemotherapy hian a thatna a phak lo thei a, chuvangin i tana tha ber tur chu i doctor nen inbiakna neih a pawimawh hle.

• Immunotherapy: I cancer hi triple negative leh advanced a nih a, protein dang PD-L1 tih a neih chuan he enkawlna hi duhthlan tur a ni thei. Cancer do turin nangmah ngeiin immune system a tichak a, a thawk a ni.

Outlook leh Prognosis te

Hnute cancer chungchanga thil pawimawh ber chu taksa peng dangah a darh hmaa zawn chhuah hi a ni. I HER2-negative cancer hi hnuteah a awm a nih chuan kum 5 chhunga dam rei zat chu a sang hle. Hei hi i cancer chu HR-positive a nih chuan a dik hle.

Triple-negative cancer hi enkawl a harsa deuh a, a chhan chu hormonal therapy emaw HER2-targeted therapies emaw an dawn loh vang a ni. An chetsual lehzual thei bawk.

A hnuaia tarlan te hi cancer stage atanga kum 5 chhunga relative survival rates te an ni. Hengte hi averages chauh a ni a, i mimal dinhmun chu a danglam thei tih hre reng ang che.

Heng number te hian hlauthawng suh. Hengte hi mi sang tam tak atanga averages chauh a ni. I mimal ngaihdan chu thil tam takah a innghat ang a, chutah chuan i taksain enkawlna a dawn dan leh i hriselna zawng zawng pawh a tel ang. Chuvangin, i dinhmun leh test dang i mamawh theih apiang chu i doctor hnenah inhawng takin sawi rawh.