I doctor hian hnute cancer enkawlna atana damdawi chi khat SERMs emaw SERDs emaw tih chu a hrilh tawh che em? Ngaihtuah buai suh, heng hmingte hi a buaithlak deuhin a lang thei. Vawiin hian an nihna, an hnathawh dan leh an chungchanga i hriat tur te chu thu awlsam takin kan sawi dawn a ni. Heng damdawi chi hnih pawimawh tak tak te hian hnute cancer dona kawngah min pui thei a ni .
SERM te hi eng nge ni? Engtin nge hna an thawh?
A awlsam zawngin sawi ila, SERMs (Selective Estrogen Receptor Modulators) hi hnute cancer cells thanna titawptu damdawi chi khat a ni. Mahse, cancer chi khat bik chauh an thawk a ni. Chu chu cancer chi khat Estrogen Receptor-Positive tia hriat chu a ni. Kan rama hnute cancer hmuh chhuah zinga 75% chauh hi he chi hi an ni.
Ngaihtuah teh, heng cancer cell te hian an chung lamah "antenna" tlemte chauh an nei a. Damdawi lamah chuan heng receptor te hi kan ti a ni. Kan taksaa hormone estrogen chu heng antenna-ah hian a inzawm chuan cancer cell hian "inthen darh leh thang zual" turin signal a dawng a ni.
Hei hi SERM-te tih dan chu a ni:
An kal a, chu antenna, chu chu receptor te chu an block ta a ni. Tichuan estrogen hormone hian khawiah mah lo kal a, a inzawm khawmna tur a nei tawh lo. Signal a dawn loh avangin cancer cells te thanna chu a tawp emaw, a tam zawkah chuan control a ni emaw.
A pawimawh ber chu, ‘selective’ an tih chhan a awm. Heng damdawi te hian hnute chhunga estrogen hnathawh a tikhawlo laiin, taksa peng dang, ruh leh nausen pumah te hormone chu a thawk tha thei a ni. Chu chu an danglam bikna chu a ni.
SERM chi hrang hrang leh a hman dan
Breast cancer atana SERM pawmpui chi hrang hrang a awm a.
| Damdawi hming | A hman dan tlangpui |
|---|---|
| Tamoxifen a ni |
|
| Toremifene a ni | |
| Raloxifene a ni |
Chuti a nih chuan SERD te hi eng nge ni?
SERDs (Selective Estrogen Receptor Downregulators) hi damdawi chi khat a ni a, SERM aiin a thawk chak zawk deuh a ni. SERMs ang bawkin estrogen receptor te pawh an block bawk. Mahse chu bakah chuan SERDs hian receptor zat a tihtlem (downregulate) a , receptor la awmte hnathawh pawh a thlak danglam a, chu chuan a tichak lo hle.
Tunah hian SERD pawmpui chi hnih a awm a:
- Fulvestrant a ni
- Elacestrant a ni
Hengte hi hnute cancer hmasawn, hormone receptor-positive leh HER2-negative te tan pek a ni ber. HER2-negative tih awmzia chu cancer cell-te hian an chung lamah protein HER2 an tih, an thanlenna tura puitu an nei lo tihna a ni.
He damdawi hi engtin nge kan hman ang?
- SERMs: Heng zinga a tam zawk hi pill angin a lo thleng thin. I doctor chuan ni khatah 20mg atanga 40mg ei turin a hrilh ang che. Cancer lo let leh tur venna atana heng damdawi te hi i ei a nih chuan kum 5 atanga kum 10 chhung i ei chhunzawm a ngai tlangpui ang.
- SERDs: Entirnan, Fulvestrant hi injection angin a lo thleng thin.Pahnih. Heng injection pahnih hi hnute chhunga muscle pakhatah pek a ni. Thla khatnaah vawi thum pek thin a ni a, chumi hnuah thla khatah vawi khat pek thin a ni.
Eng dinhmunah nge SERM leh SERD hi pek a nih?
I doctor-in heng enkawlnate hi a pek theihna tur dinhmun engemaw zat a awm.
| Huntha | Hrilhfiahna |
|---|---|
| Operation hma (Neoadjuvant Therapy) tih a ni. | I tumor a lian a nih chuan he damdawi hi operation hmain pek theih a ni a, a tihtlem nan leh lakchhuah awlsam zawk nan. |
| Operation hnuah (Adjuvant Therapy) tih a ni. | He enkawlna hi operation hnua cancer cell te tak te awm thei zawng zawng tihchhiat nan leh cancer lo kir leh tawh lo turin pek a ni. |
| Late-Stage Cancer tan chuan | Cancer hi hnute pawn lama taksa peng dang dangah a darh tawh a nih chuan heng damdawi te hian a thanna control emaw, a ti hniam emaw thei a ni. |
| Invenna atan | Breast cancer i la nei lo a nih pawhin, genetics ang chi thil avanga i vei theihna chance chu a tlangpui aia sang a nih chuan, chu risk tihtlem nan SERMs pek theih a ni. |
Heng enkawlnate hian eng side effect leh risk nge a neih?
Damdawi dang ang bawkin hengte hian side effect a nei thei a ni. Mahse, mi zawng zawngin an hmu vek lo. Side effect awm thei te hriat a pawimawh.
SERMs te hian side effect a nei thei
Side effect hmuh fo thin hi menopause lai a kan tawn thin nen a inang tlangpui.
- Hot flash a rawn chhuak ta
- Vaginal dryness, discharge emaw, thisen chhuah tlem emaw
- Zan a thawk hah
- Luhai
- Mood a inthlak danglam thin
Side effects awm lo mahse na tak:
- Uterine cancer vei theihna a tipung tlem hle
- Kea thisen zam (Deep Vein Thrombosis, or DVT) emaw, lung chhunga thisen zam (Pulmonary Embolism) .
- Mit (cataract) a awm
- Hmeichhia menopause hmaa ruh thim
SERDs te hian side effect a nei thei
- Injection na hmuna natna rei lo te
- Luhai
- Ruh, ruh, ruh natna
- Lu na
- Labouriousness a ni
- Hot flash a rawn chhuak ta
Pawimawh tak: SERD hian platelet a tihtlem thei a, chu chuan thisen a tikhawlo thei a ni. Hei hian thisen chhuah theihna a tipung deuh thei a ni. Tin, naupai lai emaw, naupai tum emaw a nih chuan heng damdawi pahnih hi hman tur a ni ngai lo . Heng damdawi ei lai leh enkawlna tihtawp hnu kum khat tal hman a pawimawh hle.
I doctor-in he enkawlna hi a rawt a nih chuan, a chungchang hi sawipui rawh. "He damdawi hian eng hlawkna nge min pek ang?", "Eng side effect nge ka beisei theih ang?", leh "He damdawi hi eng chen nge ka ei a ngai dawn?"
Take-Home Thuchah a ni
- SERM leh SERD te hi estrogen receptor-positive hnute cancer enkawlna tha tak a ni. Cancer cells te thanna atana pawimawh hormone estrogen hnathawh chu an block a ni.
- Heng damdawi zawng zawng hi mi zawng zawng tan a tha vek lo. I doctor chauh hian cancer chi, i kum leh i hriselna a zirin i tana enkawlna tha ber tur a ruat thei a ni.
- Side effect a awm thei a, mahse a tam zawk chu enkawl theih a ni. I harsatna eng pawh, eng ang pawhin tenau pawh ni se, i doctor nen sawiho rawh.
- He damdawi ei lai hian naupai loh a pawimawh hle. Naupai ven dan tur dik tak chu doctor rawn hmasa phawt ang che.
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