I vunah hliam na tak tak i nei em? Calciphylaxis a ni thei!

Natna Calciphylaxis tih hi i hre tawh em? A hming hi a mak deuhin a ri mai thei. Mahse thil awm lo tak, hrehawm tak, a chang chuan nunna atana hlauhawm tak a ni. Thil thleng chu i taksa chhunga thisen kalna kawng te tak te chhungah hian calcium deposit a awm a, chu chuan a block ta a ni. Chutiang a nih chuan thisen kal chu a titawp a, i vun leh a hnuaia tissue te chu a thi tan ta a ni. Tui tlem a hmuh loh laia thlai a lo hring chhuak ang mai a ni.

Calciphylaxis hi eng nge ni? A awlsam zawngin i hrethiam ang u!

A awlsam zawngin sawi ila, Calciphylaxis hi i thisen kalna kawngah calcium awmkhawmna a ni a, thisen kal dan a tikhawlo a, vun leh a hnuaia tissue te chu a thi a ni. Tui pipe chu bawlhhlawhin a khuh a, tui a luang chhuak tawh lo ang bawkin, kan taksaa thisen kalna kawng te tak teah calcium a awm khawm a ni.

A tam zawkah chuan heng calcium deposit te hi vun leh vun hnuaia tissue te thisen petu thisen kalna kawngah a awm thin. Mahse, a tlem hle a, heng calcium deposit te hi taksa chhunga taksa peng hrang hrang, mit, lung, thluak, ruh leh intestines-ah te pawh a awm thei a ni.

Hetiang dinhmun hian vun a nghawng hian rin loh takin a na thei . A natna hmun pawh a inhawng thei a, hliam a siam thei bawk a, khumah hliam ang chiah a ni. A natna chhehvel vun leh tissue te a thih chuan a chhiatna chu a darh thei a ni. Calciphylaxis natna hi a dam theih nan hun rei tak a ngai a, harsatna lian tham a thlen thei bawk.

He hliam hi a kai chuan taksa pum puiah natna hi a darh a, kan immune system hian a overreact tan ta a ni. Hei hi sepsis kan ti a ni . Hei hi Calciphylaxis natna hlauhawm ber leh thihna thlen thei ber a ni.

Calciphylaxis chi hrang hrang a awm em?

Ni e, calciphylaxis hi chi hnih lian tak a awm a, chu chu a lo awm dan azirin a ni.

1. Uremic calciphylaxis hmanga tihdam theih a ni

Hei hi a tam ber chi a ni . End-stage kidney disease (ESKD) avanga dialysis nei mekte zingah a awm fo thin. Chumi awmzia chu an kal (kidney) te hian hna a thawk tha lo a, an thisen atanga bawlhhlawh paih chhuah nan dialysis machine nena inzawm tir a ngai tihna a ni.

2. Uremic ni lo calciphylaxis

Hetiang chi hi a tlem hle . Kidney natna hmasa berteah te, tun hnaia kal pakhat emaw, a pahnih emaw chhiatna nei tawhteah emaw, (a tlem hle) kidney lama harsatna nei loteah emaw a thleng thei a ni.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Calciphylaxis hi a awm lo hle a ni.. Dialysis hmang mek zingah hian mi 10,000 zinga 35 vel (1% hmun thuma ṭhena hmun khat vel)-ah a thleng ṭhin. Entirnan, United States-ah chuan dialysis hmang mi maktaduai 1.5 chuang an awm a, chuvangin kum tin calciphylaxis vei mi 2,000 vel an awm thin. He natna hi kal natna vei tlemna ramteah chuan a tlem zawk hle.

Mahse, mak tak maiin hmeichhiate hian he natna hi an vei theihna chance a sang zawk a ni . Hmeichhiain mipa aiin a let hnih zetin an nei tam zawk.

Hei hi eng symptoms nge ni?

Calciphylaxis natna lan chhuah dan chu:

• Natna nasa tak: Hei hi natna khirh tak a ni fo. Hliam emaw, chhiatna dang emaw hmuh theih a awm hmain natna hi a intan thei a ni. A natna hmun chu pressure emaw khawih emaw a sensitive thei a, chu chuan a natna chu a tizual thei a ni.
• Vun inthlak danglamna (early stages): Hengte hi vun chhunga hmun sen, sen, sen, emaw dum emaw a lo awm thinte a ni. Heng inthlak danglamna te hi mesh ang maiin a lang tlangpui. Blisters a awm thei a, a natna vun chu a thim a, savun ang maiin a awm thei bawk.
• Hliam leh ulcer (late stage): Vun inthlak danglamna hi hliam ah a chang tlangpui a, arsi ang maiin a darh thin. Heng hliamte hian rimchhia an nei fo thin. Vun leh sa thi chu a dum thei a, a hring chhuak thei a, a hring chhuak thei bawk.
• Mit lama harsatna, chhungril thisen chhuak, leh taksa ruh chhiatna: A tlem hle a, vun hnuaiah chauh ni lovin, taksa chhungah pawh calcium deposit a awm thei a, harsatna dang a thlen thei bawk. Mit-ah calcium deposit a awm chuan mit a tichhe thei a ni. Internal organs-ah an awm chuan thisen a chhuah thei a, taksa ruh a tichhe thei bawk.
• Thisen kalna kawng lian leh thinlunga calcium awm zat: End-stage kidney disease-a harsatna awm fo chu thisen kalna kawng lian leh thinlung valve-a calcium awm hi a ni. Hei hi calciphylaxis a lo awm chuan a lo awm theihna a sang hle.

Calciphylaxis natna chi hnih a awm a, chungte chu:

Hliam a awm hian kawng hnih zinga pakhatah a thleng fo thin:

• Central distribution: Heng lesions te hi pum leh kawr chhungah a awm tam ber. Body Mass Index (BMI) sang zawk nei leh hmeichhiaah an tam zawk. Uremic calciphylaxis vei zinga 70% vel chuan heng central distribution lesions te hi an nei a ni. Non-uremic case-ah chuan 50% vel a ni. Heng central lesions tam zawkna hmunah chuan thihna a sang zawk.
• Peripheral distribution: Hengte hi kut leh ke tawp lam, a bik takin kut zungtang tawp lama awm te an ni. Peripheral lesions a nasat chuan doctor chuan a kut zungtang, ke ruh, a nih loh leh a ke ruh thenkhat a tan a ngai thei a, chu chuan chhiatna chu a darh zel loh nan leh nunna atana hlauhawm harsatna a thlen loh nan a titawp thei a ni.

Engvangin nge calciphylaxis hi a lo awm? A chhante chu engte nge ni?

Calciphylaxis hi a chhan dik tak hi hriat a la ni lo , mahse zirchianna atanga a lan dan chuan thil pakhat aia tam vang a ni. Heng thilte hi an inzawm khawm a, Calciphylaxis a thlen thin.

Chûng thilte chu:

• Parathyroid hormone tam lutuk: Kidney lama harsatna i neih hian i parathyroid glands te hian i thisen calcium level chu a nghet thei ang bera awm tir an tum thin. Chutianga an tih chuan i taksa mamawh hormone an siam tam zawk a ni. Hei hi hyperparathyroidism an ti a . Hei hi i taksain vitamin D emaw calcium emaw a hmuh tlem chuan a thleng thei bawk.
• Kidney failure: Kal a thawk tha lo chuan taksaa calcium leh phosphorus control tu chemical balance a tibuai a.
• Phosphorus tam lutuk: Kan taksa hian phosphorus hi chemical process hrang hrang atan a hmang a, kal hian phosphorus level control nan a pui bawk.
• Cancer chi hrang hrang: Hei hi kal natna nena inzawm lo calciphylaxis-ah a lang tam ber.
• Trauma: Hei hi hliam vang emaw, damdawi lam thila operation ang chi emaw, intravenous (IV) line emaw avanga lo awm thei a ni.

Hemi atan hian tute nge hlauhawm ber? (Risk Factor hrang hrang) 1.1.

Calciphylaxis nen hian risk factor leh medical condition engemaw zat a awm thei. Anni chu:

• Kidney lama harsatna: Calciphylaxis vei tam zawk hi chu kidney failure hnuhnung ber an ni a, dialysis hmang mekte pawh an awm bawk.
• Obesity: Hetiang dinhmun hian calciphylaxis vei theihna a tipung a ni.
• Diabetes: Nitin insulin i inject hian injection na hmuna vun a chhe thei.
• Autoimmune natna: Entirnan, Lupus, Ulcerative Colitis, leh Rheumatoid Arthritis ang chi natna te.
• Liver natna: Zu in vanga hepatitis, zu in vanga natna awm hi a hlauhawmna a ni thei bawk.
• Warfarin: He thisen tithianghlimtu damdawi hian taksain vitamin K a hman loh nan a veng a, thisen zam nan Vitamin K hi a pawimawh hle. Vitamin K hian calcium awm zat control tu protein a tichak bawk. End-stage kidney disease nei tam tak chuan vitamin K an nei tlem hle a, hei hian calcium deposit a siam awlsam phah a ni.
• Corticosteroids: Heng damdawi te hi swelling leh inflammation tihziaawmna atana pek thin a ni. Calciphylaxis vei te hian tun hnaiah corticosteroid an ei fo thin.

Calciphylaxis natna hian eng harsatna nge a thlen?

Calciphylaxis hian harsatna a thlen thei a, chungte chu:

• Mu thei lo
• Chaw ei chakna hloh
• Lungngaihna
• Ulcer na tak tak a awm
• Infection awm thei te
• Amputation tih a ni
• Sepsis natna (Sepsis) a awm

Engtin nge doctor-te hian hei hi an hriat chian?

Doctor chuan i dinhmun, i natna lan chhuah dan leh i taksa enfiahna a enfiah hnuah calciphylaxis a ringhlel thei a ni. He taksa enfiahnaah hian i vun emaw, i vun hnuai lam emaw en a, a danglamna eng emaw hriatna a tel thei. I medical history pawh an zawt ang a, calciphylaxis hmuhchhuah an tum bawk ang. Doctor-in hei hi a rinhlelh hnuah chuan hriat belh tumin medical test an ti ang.

Eng test nge tih a nih?

Doctor chuan heng test te hi a order thei ang:

• Vun biopsy hmanga tihchhuah: 1.1.

Calciphylaxis hriat theihna rintlak ber chu vun leh a hnuaia tissue awm sample te tak te (a tlangpuiin millimeter 4 atanga 5 vel a thuk) lak hi a ni. Doctor chuan hliam emaw vun natna emaw kil khatah sample a la tlangpui ang. He sample hi microscope hmanga enfiah a ni a, thil thenkhat hmangin a rawng thlak danglam emaw, chemical tihdanglam emaw a awm a, chu chuan a natna hmuhchhuah chu a nemnghet thei a ni.

End-stage kidney disease i neih tawh a, black crust neia hliam na tak i neih chuan biopsy lak a ngai lo mai thei.

• Lab testing neih a ni:

Thisen leh zun test hian natna chi hrang hrang a hriat theih nan a pui a, natna a nasat dan a teh a, a enkawl dan tha ber tur a hriat theih bawk. Doctor-te’n test an hman tam berte chu:

• Kidney function tests: Heng test te hian zun an zirchiang a, i kidney te hnathawh that dan an enfiah thin.
• Mineral leh ruh parameters: Calcium, phosphorus, parathyroid hormone, leh vitamin D te thlirletna hian natna nasat dan a hriat theih.
• Liver function tests: I kal (kidney) atanga filter chhuak damdawi i ei theih loh chuan a dawt leh tur chu i liver-in a filter chhuah damdawi ei hi a ni. Liver function test hian doctor-te chu liver-a innghat damdawi pek che hi a him em tih a hriat theih nan a pui a ni.
• Immune system chhinchhiahna: 1.1.He test hian i taksain natna hrik a do tih chhinchhiahna a zawng thin. Autoimmune natna hriatchhuahna kawngah pawh a pui thei bawk.
• Blood coagulation markers: I thisen zam (a khap loh) dan thlirlet hi a \angkai a, chu chuan chhungril thisen chhuak emaw, harsatna dang emaw a awm theih thu a hriat theih avangin.

• Imaging test hrang hrang:

Doctor chuan imaging test, X-ray emaw, ruh density scan emaw a ti thei a, mahse hengte hi a awm lo. Imaging test hi test dangin diagnosis-a pui thei tur chhanna a pek loh hunah tih a nih a rinawm ber.

Hei hi engtin nge enkawl a nih? (Tihdamna)

Researcher-te hian calciphylaxis hi an la hrethiam tawk lo a, enkawlna tha ber tur kaihhruaina a tlem hle. Tunah hian he natna hi damdawi a la awm lo a , mahse enkawlna a hlawhtlin chuan i natna lan chhuah dan chu a reh thei.

A tlangpuiin doctor-te chuan heng thilte hi an ngaihtuah ber a ni:

Hliam enkawlna

A bulpui ber chu natna hrik laka invenna leh hliam damna tura puih a ni. Hei hian enkawlna hmasawn tak tak engemaw zat a huam thei a, entirnan:

• Hyperbaric oxygen therapy: Hei hi airtight chamber-ah dah che a ni a, chutah chuan oxygen 100% (oxygen concentration pangngai 20% vel ni lovin) a awm a ni. Chamber chhunga pressure pawh a pangngai aia sang deuh a ni. Hei hi hliam damna tichaktu tha tak a ni.
• Debridement: Hei hi hliam atanga tissue thi emaw thi emaw lakchhuahna a ni. Hei hian natna hrik a veng thei a, hliam chu a dam theih nan a fuih bawk. A nasat chuan hei hi operation a ngai mai thei.
• Skin and tissue grafting: Tissue tam tak a bo tawhna hmunah chuan i taksa hmun dang atanga lak chhuah grafts te hian hliam siamthat leh tihdam nan a pui thei a ni.
• Antibiotics: Heng damdawi te hian bacteria infection tihtawp nan a pui thin.

Natna control

Calciphylaxis hi natna khirh tak a ni . I tan chawlh hahdam a harsat thei a, i taksa chu a dam tir thei bawk. Doctor-te chuan Calciphylaxis tan hian opioid painkiller an pe tlangpui.

Sodium thiosulfate hmanga siam a ni

He damdawi hi vein (IV) hmanga pek che a ni. I thisen kalna kawng emaw, tissue dang emaw atanga calcium awm zat paih chhuahna kawngah a pui thei a ni.

Ruh leh mineral lama harsatna awmte enkawl dan

I thisen minerals level dik tak leh balance dik taka dah hi harsatna leh harsatna awm lo turin a pawimawh hle. Hei hian i parathyroid hormone level a hniam lutuk emaw, a sang lutuk emaw loh nan ven a huam a ni. Thil engemaw takah chuan i parathyroid gland pakhat emaw, a aia tam emaw lak chhuah nan operation neih a ngai thei bawk.

Dialysis tih a ni

Hei hi i kal (kidney) a thawk tha lo a nih chuan thisen atanga bawlhhlawh paih chhuak thei damdawi a ni.

Ei leh in lama enkawl dan

Kidney lama harsatna leh a kaihhnawih thilte nena lo awm thei ei leh in lama harsatna emaw, ei leh in lama harsatna emaw ven a pawimawh hle.

Damdawi enkawl dan tur

Damdawi i ei zawng zawngte chu a side effect leh harsatna awm thei lo turin enfiah vek a pawimawh. Hei hi warfarin emaw, calciphylaxis vei theihna tipung thei damdawi dang emaw i ei a nih chuan a pawimawh hle.

Enkawlna hian side effect a nei em?

I doctor chuan harsatna awm thei leh a nghawng tha lo awm thei te chu a sawifiah thei ber ang. Calciphylaxis hi hriat chian loh a nih avangin, a harsatna leh a nghawng dan tur chu sawi lawk theih loh a ni thei a, mi hrang hrangah a inang lo hle.

Side effect leh complication awm thei thenkhat chu:

• Infection: Hei hian damdawi lam thil, dialysis emaw, surgery emaw nena inzawm infection a kawk a, calciphylaxis vanga hliam atanga infection a ni lo.
• Sodium thiosulfate side effects: Chung zingah chuan luak chhuak, luak chhuak, fluid balance lama harsatna, thisen sang hniam, leh thisen acidity lama harsatna te a tel. Doctor ten heng harsatnate hi an fimkhur a ngai a, a bik takin thinlung natna nei te tan chuan a pawimawh ber a ni. Thil tam takah chuan hengte hi he damdawi hi a dose thlak danglam emaw, a side effects enkawl emaw hmanga enkawl theih a ni.

Hei hi a veng thei lo em ni?

A chhan chu zirchiangtute hian calciphylaxis awm chhan hi an hre chiang tawk lo a, chuvang chuan he natna hi ven a harsa hle. Mahse, doctor-te chuan risk factors, calcium leh phosphate level pangngaia awmtir ang chite chu tihtlem an rawt fo thin.

Calciphylaxis ka neih chuan eng nge thleng ang? Nakin hun chu eng nge ni?

Vanduaithlak takin natna hi hriatthiam loh vangin Calciphylaxis chungchanga hmalam hun chu a tlangpuiin a tha lo hle. Calciphylaxis vei tam tak chuan kea kal theihna an hloh a, an hun tam zawk chu wheelchair emaw khumah emaw an hmang thin.

Calciphylaxis vei zinga a chanve vel chu kum khat aia rei an dam lo. Sepsis hi thihna thlentu lian ber a ni.

Amaherawhchu, natna awm dan azirin kum khat dam theihna chance a pung emaw, a tlahniam emaw thei a ni. Condition leh chance te chu hetiang hi a ni:

• Non-uremic calciphylaxis (end-stage renal disease nena inzawm lo):End-stage kidney disease nei lo calciphylaxis vei te chu kum khat chhungin an thihpui tlem hle. Non-uremic calciphylaxis-ah chuan kum khat chhunga thihna hlauhawmna chu 25% leh 45% inkar a ni. Uremic calciphylaxis veiah chuan thihna hlauhawmna hi 45% leh 80% inkar a ni.
• Ulcer leh sores: Calciphylaxis hnuhnung ber ah chuan vun inthlak danglamna chu ulcer leh sores ah a lo chang thin. Diagnosis a tlai poh leh outlook a chhe zawk thin. Ulcer emaw, hliam emaw nei zinga 20% vel chauh hi thla ruk aia rei an dam thei.
• Hliam debridement (tissue thi lakchhuah): Hetiang hliam enkawl hian dam rei theihna a tipung tih finfiahna a awm. Debridement nei tawhte kum khat chhunga damchhuah zat chu 61% aia tlem a ni a, ti lote chu 27% vel a ni thung.

Hetiang dinhmun hi eng chen nge a awm tawh?

Calciphylaxis hi dam chhung zawnga natna rei tak a ni a, tunah hian damdawi a la nei lo . Mahse, a then phei chuan natna hi enkawl hnuah remission-ah a kal thei a ni. Remission-ah eng chen nge a awm theih tih zirchiangtute chuan an hre lo.

Engtin nge ka in enkawl ang?

Calciphylaxis chungchangah hian doctor thupek a theih ang anga zawm a pawimawh hle. A bik takin hliam enkawl danah fimkhur tur a ni a, hliam emaw, hliam emaw awm zawng zawng chu thianghlim taka vawn tur leh natna hrik laka venhim tur a ni. I ei leh in te, damdawi i ei te, leh supplement thar emaw, in lama damdawi thar emaw i ngaihtuah mek te pawh i doctor nen inbia tur a ni.

Engtikah nge Doctor ka hmuh ang?

Heng thil thlengah hian i doctor nen inbia ang che:

• Calciphylaxis vei theihna tur i ngaihtuah emaw i hriat emaw chuan a tha.
• He natna hi i vei tih i hriat tawh chuan.
• Hmun thar emaw hmun dang emaw i hriat chuan.
• I vun rawng inthlak danglam i hmuh chuan.
• I vun emaw i vun hnuaiah emaw inthlak danglamna i hmuh chuan.

I doctor hi i risk factors te, eng symptoms nge i fimkhur tur tih te, engtikah nge doctor thurawn i lak tur tih te hriatna tha ber a ni. Calciphylaxis hi an hre hmasa thei a, chu chuan i enkawlnaah a pui thei a ni.

Engtikah nge emergency room-ah ka kal ang?

Calciphylaxis i vei chuan i doctor chuan hliam enkawlna chungchangah an office biak hun tur emaw, damdawi lam pan vat tur emaw a kaihruai ang che. En tur pawimawh ber chu natna hrik emaw, hliam chhehvela harsatna awm emaw a ni. Chung zingah chuan:

• Hliam vel a hring emaw, a sen emaw chuan a pawi lo.
• Hliam chhehvel i khawih hian lumna i hriat chuan.
• Hliam atanga tui lo chhuak leh/ emaw rimchhia a awm chuan.
• Hliam chungah hian black crust a lo awm a nih chuan.

Doctor hnenah eng zawhna nge ka zawh ang?

I doctor zawh tur zawhna thenkhat chu:

• Eng ang Calciphylaxis nge ka neih?
• Ka tan enge inenkawlna tha ber?
• Ka damloh chhunga min pui thei tur resources te nen min inzawm tir thei ang em?
• Ka dinhmunah hian mi pakhat tan eng thlirna nge ni ang?

Take-Home Thuchah a ni

Calciphylaxis hi hriatthiam a harsa thei hle a, a chungchang zirchianna leh hriat tur a tlem avangin. I doctor nena inbiakna chuan a hriatthiamna a pe thei che a, i beisei tur pawh a hre thei bawk. Calciphylaxis hi natna khirh tak, enkawl harsa tak a ni thei a, mahse enkawlna kawng hrang hrang a awm a, chu chuan a pui thei a ni. Chumi chungchangah chuan i lungkham a nih chuan, counselor nena inbiakna chuan i rilru put hmang chu i thunun thei a ni. Nangmah chauh i ni lo tih hre reng la, damdawi lam thurawn leh puihna dik tak dawn a pawimawh hle.

` Calciphylaxis, kal natna, vun natna, thisen kalna kawng, calcium, dialysis, hliam