Ankylosing Spondylitis enkawlna atana hman thin DMARDs chungchang hi han zir chiang ila.

Zing lamah a chang chuan i harh a, i rilru a hah a, i rilru a na em? Hun engemaw chen chu ben a harsa em? Hei hi Ankylosing Spondylitis , ruhro (spine) ruh (spine) tichhe thei natna vang pawh a ni thei. Over-the-counter pain reliever ( NSAIDs ) i ei tawh a, i natna leh i hliam a reh lo a nih chuan i doctor chuan DMARD i hman a rawt thei ang. Chuvangin he thu bulpui ber hi han sawi ila.

DMARD hi eng nge ni a, engtin nge an hnathawh?

Ankylosing Spondylitis ah hian kan taksa invenna system, immune system , chu a thawk nasa lutuk a, kan ruhro (spinal joint) te chu a rawn bei tan ta a ni. Hei hian inflammation , natna, leh stiffness a thlen a, chu chuan ruhro chu a tiche tha thei lo.

DMARD hi ‘Disease-Modifying Antirheumatic Drug’ tih tawifel a ni. A awlsam zawngin ‘natna tidanglam thei arthritis damdawi’ tihna a ni. Heng damdawi te hian overactive immune system chu a ti reh thei a ni. Regular painkiller (NSAIDs) ang lo takin, hengte hian natna a tihziaawm mai bakah, natna kal zel dan tur control-na leh ruhkawr tihchhiat belh zel tur venna kawngah a pui bawk. Chuvangin "natna tidanglam thei" damdawi an ti a ni.

Ankylosing Spondylitis tan hian eng DMARD chi nge pek thin?

He natna atana DMARD pek hi chi hrang hrangah then theih a ni. Biologics leh traditional DMARD an ti a. Heng chi hrang hrangte hi han thlir ila.

Biologics: Target khata thawk damdawi

Biologics te hi sniper ang mai an ni. Anni hian direct-a harsatna thlentu protein chauh an target a, an bei bawk.

• TNF inhibitors: Hengte hi ankylosing spondylitis atana biologic drugs class hmasa ber pawm a ni. Anni hian protein pakhat Tumor Necrosis Factor (TNF) an tih chu block-in hna an thawk a, chu chuan inflammation a siam a ni. Anni hian ruh leh ruh dangte arthritis te, natna nena lo awm thei dinhmun te, uveitis , mit natna, leh Inflammatory Bowel Disease (IBD) ( Crohn’s disease leh ulcerative colitis) te pawh an pui thei a ni. I doctor chuan hengte hi pain reliever (NSAID) chi hnih tal i lo enchhin tawh a, engmah a nghawng lo a nih chuan a pe tlangpui ang.
• Adalimumab (Humira) te hi a awm a.
• Certolizumab (Cimzia) a awm bawk.
• Etanercept (Enbrel) chuan a rawn ti a.
• Infliximab (Remicade) hmanga tihdam theih a ni.
• Golimumab (Simponi) te hi a awm a.

• IL-17 inhibitors: Hengte hian inflammatory protein dang Interleukin-17 (IL-17) an tih chu block-in hna an thawk a ni. TNF inhibitor dawng lo emaw, thinlung natna emaw multiple sclerosis (MS) ang chi natna avanga TNF inhibitor ei thei lo tan chuan duhthlan tur tha tak an ni.
• Ixekizumab (Taltz) tih hi a awm a.
• Secukinumab (Cosentyx) tih hi a tha hle.

JAK inhibitors: Damdawi thar, pill anga ei theih

Hengte hi biologics nen a danglam a ni. Injection duh lo tan chuan solution tha tak an ni a, a chhan chu pill form-a awm an nih vang a ni. Anni hian enzyme system Janus Kinase (JAK) an tih chu target-in hna an thawk a, chu chuan inflammation a thlen a ni.

• Tofacitinib (Xeljanz) te hi a tha hle a ni.
• Upadacitinib (Rinvoq) a awm bawk.

Traditional DMARDs: Peripheral joint atana damdawi hman tlanglawn ber

Hengte hi ruhro natna aiin, kut, ke, hip, leh khup ang chi ruh natna leh hliam vangin pek a ni ber.

• Methotrexate: Hei hi pill emaw injection emaw angin a lo thleng thin. A ruh (joint) a chhiat loh nan a pui thin.
• Sulfasalazine (Azulfidine): Hei hi peripheral joint leh IBD te tan pawh a ni. Pill angin a ei thin.

Engtin nge doctor hian i tan DMARD dik tak a thlan theih ang?

I doctor chuan damdawi i thlan dawnin thil engemaw zat a ngaihtuah thin.

• I symptoms te hi a nasat zia.
• Tun hmaa damdawi i hman tawhte leh a rah i hmuh tawhte.
• Damdawi sawi tur hian side effect a neih dan leh i hriselna a nghawng dan te.

He damdawi hian eng side effect nge a neih?

Damdawi zawng zawng ang bawkin DMARD hian side effect a nei thei a ni. Ṭhenkhat chu minor an ni a, ṭhenkhat erawh chu serious tak an ni thei thung. Chuvangin damdawi i ei tan hmain hengte hi i doctor nen sawiho rawh.

• Biologics leh JAK inhibitors: Hengte hian immune system a ti slow a, infection a do thei lo. Chuvangin, heng damdawi ei tan hma hian i vaccine pek zawng zawng hi i update hmasak phawt a pawimawh.
• Tuberculosis (TB) Test: TNF inhibitor i hman tan hmain tuberculosis (TB) test hmasak a pawimawh a, heng damdawi te hian i taksaa TB hrik muhil te chu a tichak leh thei a ni.
• Side effect dang: Injection na hmuna sen, lu na, vun na te a awm thei. IL-17 inhibitor hian IBD hi a ti na zual thei bawk.

Traditional DMARD hmanga side effect awm thei

• Methotrexate: Pum natna, hmui na, leh thisen cell count tlem hian natna hrik, khawsik, leh hliam a thlen thei. Chungte tihtlem nan i doctor chuan folic acid tablet a pe ang che. While taking this medication , i kal leh thin hnathawh enfiah nan thla 1-3 danah thisen test i neih a ngai ang. He damdawi hi naupai lai hian a tha lo.
• Sulfasalazine: Luak chhuak, luak chhuak, ni êng laka sensitivity, vun vun rawng, leh lu na a awm thei. He damdawi hian i zun, i thawmhnaw leh i mittui chu yellow-orange color-ah a chantir thei a ni. A hlauhawm lo nain thawmhnaw a tibawlhhlawh thei.

Enkawl tan tirh hian eng nge beisei tur?

Heng damdawi te hian mi zawng zawng tan hna a thawk inang vek lo. Results hmu rawhKar tlemte emaw thla khat emaw thla hnih emaw vel a ni thei. Chuvangin dawhtheih a pawimawh. Damdawi hi a dam leh dawn lo nia i ngaih avangin rang takin chawlhsan suh.

Tin, i natna lan chhuah dan chu a reh vek tawh a nih pawhin doctor-in a tih chhung chu i damdawi ei chhunzawm zel a pawimawh hle. I chawlhsan chuan natna hi a lo chhuak leh thei a ni.