Kan tih dan hian kan genes pawh a tidanglam thei em? Epigenetics chungchang hi a awlsam zawngin i zir dawn teh ang!

Kan genes hian kan natna leh kan hmel lan dan a nghawng tih i hre tawh ngei ang. Chu chu a dik a ni. Mahse, heng gene-te hnathawh dan hi kan nunphung, kan ei leh in leh kan chenna boruak ang chi thil hmangin kan thlak danglam thei bawk tih i hria em? Chu chu he topic Epigenetics tih hnuaia kan sawi tumte chu a ni. Hei hi thupui thar tak ni mahse, kan hriselna atan a pawimawh hle a, chuvangin i sawi dawn nia.

Chuti a nih chuan hei hi eng nge ni tak tak (Epigenetics)?

A awlsam zawngin, epigenetics chu kan gene-te’n kan chhehvel leh kan thil tihte a nghawng dan zir chianna a ni . Genes hi kan thunun theih loh, kan nu leh pate hnen atanga kan rochun angah kan ngai tlangpui. Dik tak chuan thil tam tak, kan mit rawng leh natna thenkhat kan neih theih dan te hi kan pian tirh atangin heng genes te hian a hril a ni. Chuvangin genes hi tihdanglam theih loh, lungah dah a ni tih i ngaihtuah mai thei. Mahse heng genes te hnathawh dan hi kan thlak danglam thei a, kan hriselna pawh kan tichangtlung thei a nih chuan han ngaihtuah teh ? Scientist-te chuan chu beiseina chu ngaihtuah chungin epigenetics an zirchiang mek a ni. Chuvangin he thupui, epigenetics hi nangmah ang mi tam takin an zir duh ber a lo ni ta a ni. Epigenetics hi zirchianna thar tak a ni. Kan taksa cell chhunga chemical thenkhatin kan gene hnathawh dan a thunun dan a en a ni. Scientist te chuan heng chemical te hi ‘epigenetic marks’ emaw ‘chemical signatures’ emaw an ti a. A chang chuan heng chemical mark te hian kan taksa hi chak zawk leh natna laka inven theihna turin a pui thin. Mahse a chang chuan kan hriselna a tichhe thei a ni. ‘Epigenetics’ tih thumal hi i thenfai chuan a then hnih a awm a, chungte chu ‘epi’ leh ‘genetics’ te an ni. ‘Epi’ tih hi Greek tawnga ‘a chung, pawn, a chhehvel’ tihna a ni. ‘Genetics’ hi genes chungchang a ni a, chu chu DNA (Deoxyribonucleic Acid) chi hrang hrang sang tam tak, danglam bikna siamtu che a ni. Chuvangin, ‘epigenetics’ kan sawi hian i genes chhehvel zawng zawng kan sawi a ni. Scientist te chuan i genes-a literally thut a, a chunga thil ti thin chemicals te chu an en mek a ni. Tin, kan ni tin nunah kan hmuh theih thilte, kan ei leh in te, exercise kan tih zat te, naupan laia kan enkawl dan te pawh an ngaihven hle bawk.

Engtin nge kan chhehvêl leh kan duhthlannate hian hei hi a nghawng?

Scientist-te chuan kan chhehvel leh kan mimal nungchang hian kan hriselna a siam tih hi hun rei tak atangin an lo hre tawh a. Entîr nân, hetiang hian ngaihtuah teh:

• Toxin thenkhat nena inzawmna hian cancer vei theihna a tipung a ni .
• Thli bawlhhlawh hian natna chi hrang hrang asthma ang chi a thlen thei a ni .
• Exercise hian i thinlung a tichak a .
• Chaw tha ei hi i thluak leh taksa tan a tha hle .

Chuvangin, i hriselna leh dam rei hi i genes emaw, i nature emaw atanga lo chhuak mai a ni lo. Hei hi nghawng nei thil dang tam tak a awm a, i hrethiam em?

A hmasain, gene leh DNA chungchang tlem han zir ila, kan zir dawn em ni?

Genes hi DNA unit bulpui ber a ni. I DNA sequence zawng zawng hi gardening book emaw instruction manual emaw nen an khaikhin fo thin. Chu chu DNA hian i taksaa cell tinte chu a hnathawh dan pangngaia an thawh theih nan an mamawh tur thupek a pe a ni. I cell te hian he DNA hi an chhiar a, eng nge tih tur leh tih dan tur an hre thei a ni.

Tichuan gene chu eng nge ni?

I taksaah hian engtik lai pawhin cell trillion tam tak a awm a. Heng cell te hi an inthen darh reng a, cell thar siam (mahni copy siam) chu a thi tawhte thlak turin an inthen darh zel a ni. Chu chu cell inang chiah hian i dam chhung zawng a daih a ngai lo - an thi a, a thar siam a ni. Hei hi i taksaa thil awm dan pangngai a ni. Hêng cell tluklehdingawn tam takte hian i DNA-ah an innghat a, chu chu a ṭhan chhoh dân te, engtikah nge copy siam tûr te, leh engtikah nge inṭhen darh loh tûr tih te a ni.

Engtin nge cell-te hian he DNA hi an hman?

Taksa chhunga cell tin hian an hna an thawk vek a. Chutianga tih theih nân chuan i DNA hmun ṭhenkhat chu an chhiar a. Chu hmunte chu i mimal gene an ti a. Heng genes te hi instruction manual-a bung angin i ngaihtuah thei a, chaw siamna bu-a recipe angin i ngaihtuah thei bawk. Genes chu i gene set zawng zawng, a nih loh leh genome -a siam tûra thu tê tête chu a ni. Mahse cell tin hian instruction set pumpui (i DNA sequence, emaw genome zawng zawng) chu an chhiar vek lo. Chu chu cell tin hian instruction set pumpui an mamawh vek lo - part thenkhat chauh an mamawh vang a ni. Cell te hian taksaah hna bik an nei a, an hna bik an thawh a ngai chauh a ni. Hetiang hian han ngaihtuah teh: cake i siam dawn hian tomato sauce siam dan tur recipe i mamawh lo. I thil siam tur recipe kha i mamawh chauh a ni.

Chuti a nih chuan he epigenome hi eng nge ni?

I epigenome hi i gene zawng zawng leh i hman dan tur tidanglamtu zawng zawng a ni . A pawimawh ber chu i epigenome hi dynamic a ni . Hun kal zelah a danglam thin. Hei hi a tha emaw, a chhe emaw pawh a ni thei. A tha a ni, a chhan chu thil tha tak tak, exercise, leh stress level tlemte ang chi thilte hian epigenetic changes a thlen thei a, chu chuan hriselna atan a hlawkpui thei a ni. Mahse processed foods, meizuk, leh stress lutuk ang chi thilte hian epigenetic changes a thlen thei a, chu chuan hriselna atan a tichhe thei a ni. Chuti a nih chuan, eng thilin nge i epigenome hi a nghawng? Engtin nge i tih theih ang? A nihna takah chuan kan la hriat loh tam tak a awm. Mahse finfiahna chuan kan taksaa kan dah thilte leh kan chhehvela khawvel nena kan inpawh dan hian kan epigenome-ah nghawng thui tak a nei thei tih a tilang.Heng thilte hi kan thunun theih reng loh laiin, a chang chuan kan enkawl thei - chu chu kan rochun gene chungchanga kan sawi theih aiin a tha zawk hle a ni lawm ni?

Eng natna nge epigenetics nena inzawm?

Scientist-te chuan epigenetic changes hian kan taksa a nghawng dan leh natna lo awm dan hi an la zirchiang mek a ni. Taksa inthlak danglamna leh natna dinhmun thenkhat pawhin i epigenome a tidanglam thei tih an ring bawk. Tun hnaia zirchianna hrang hrangah chuan epigenetic changes hi:

• I taksa metabolism hnathawh dan.
• Tar dan leh tar chakna nena inzawm natna te .
• I thluak nghawng thei natna, Parkinson natna , Alzheimer natna , leh rilru lama harsatna thlen thei syndrome te ang chi te .
• Cancer vei tur chuan .
• Substance hmansualna (substance hmansualna) .
• Inflammation leh a kaihhnawih natna hrang hrang asthma leh autoimmune diseases te .

Research a kal zel avangin scientist-te chuan:

• Epigenetic changes hian natna chi hrang hrang a thlen dan emaw, a inzawm dan emaw hriatthiamna thar nei rawh.
• Natna thenkhat kan vei theihna tur tihziaawmna tura kan nitin nunah eng nge kan tih theih tih zir rawh.
• Epigenome target tur natna enkawlna thar siam chhuah.

Eng thilin nge kan epigenome hi a thlak danglam thei tak tak?

I epigenome hi chakna chhiar sen lohin a siam a ni. Ṭhenkhat chuan i pian hma pawhin an nghawng ṭan che a ni. Entirna tlemte chu hetiang hi a ni:

• I nuin a pum chhunga a phurh lai che ei tur (pregnancy diet) .
• Naupai laiin i nu hriselna zawng zawng leh rilru hriselna .
• Nausen leh naupang tê i nih laia i ei leh in tur i dawn kha .
• Naupan laia thil tha lo thleng thin .
• Naupan laia zirlai i tawn te leh puitling nena in inpawhna te .
• Thli bawlhhlawh, diesel meikhu, leh cigarette meikhu ang chi thil tha lo tak takte nena inzawmna .
• Chemical plastic, BPA, leh heavy metals lead emaw cadmium ang chi te nena inzawmna.
• Damdawi thenkhat prescription hmanga pek chhuah .
• Zu, zuk leh hmuam leh intihhlimna atana ruihhlo dangte hman .
• Puitling anga i ei tur ei tur .
• I taksa tihchakna level .
• Nitin nunah i stress level .
• I inlaichinna leh inpawh tawnna te .
• I chenna khawtlang leh chuta tang chuan tanpuina i dawn (a nih loh leh i dawn loh) te .
• I hriselna mamawh phuhrukna tur hriselna lama service leh resources hmuh theihna .

Engtin nge heng inthlâk danglamnate hi a lo awm?

Scientist-te chuan heng exposure leh experience-te hian i cell-a inthlak danglamna a thlen dan hi an la chhui chhuak zel a ni. A tlangpuiin heng thilte hian i DNA-ah epigenetic mark a siam a, chu chuan i cell-te hnathawh dan a nghawng a ni. Entirnan, epigenetic marks hian i genome hmun thenkhat chu cell-te’n an chhiar theih loh nan a veng thei a ni. Chu chu gene active nia ngaih chu silenced, a nih loh leh off a ni tihna a ni. Chuvang chuan i cell te chuan chu genes (recipe) te chu an chhiar thei lo va, i hriselna atana an mamawh thenkhat, cancer cell te lo thang lian zel tur tihtawp ang chi te chu an ti thei lo bawk. Epigenetic inthlak danglamna tha lo thenkhat chu hun rei lote chhung atan a ni a, tihdanglam theih a ni. Mahse, a dangte chu rei tak an daih a, a châng chuan damchhung an daih.

Hêng inthlâk danglamnate hi a ṭha zâwk thei ang em?

Ni e, a dik tak zet. Epigenetic marks hi a hlawkpui thei a, a venghim thei bawk. Entîr nân, naute chu zir theihna hun remchâng tam tak pêk chuan kum tam tak chhûnga an rilru leh taksa hrisêlna ṭanpuitu epigenetic change ṭha tak a thlen thei a ni I nu leh pa hnen atanga i rochun genes chu i thlang thei lo. Tin, i chhehvel khawvel hi i thunun thei lo. Mahse heng thil zawng zawng, nangmah - leh i fate 'chawm'tu zawng zawngte hi hriat chian hian epigenome hrisel siam turin i theihtawp chhuah turin a pui thei che a ni.

Kan epigenome hi a tha zawngin kan nghawng thei ang em? Awle! Engtin?

Ni e, a ti thei ngei ang. Engtin nge kan tih ang tih hi roadmap chiang tak pakhat mah a awm lo nain, scientist-te chuan kan thutlukna siam ṭhenkhat hian epigenetic change ṭha tak a thlawp thei a, negative change awm theihna a ti tlem thei niin an ngai. Ṭanpui theih tur tips ṭhenkhat chu hetiang hi a ni:

• Chaw tha tak tak ei rawh. I hriselna mamawh leh nunphung nena inmil ei tur ruahmanna siam turin nutritionist hnen atangin tanpuina i dil thei a ni.
• I ni khatah taksa tihchakna belhchhah rawh.Exercise plan thar i tan hmain i doctor nen inbiakna neih hmasak phawt ang che. Eng exercise nge i tan a him tih an hrilh ang che.
• Zu khap la, zuk leh hmuam hman kha bansan vek rawh.
• Stress control turin a theih ang anga chawlh hahdam tum ang che.

Heng zawng zawng hi nangmah tan i tih theih zawng zawng a ni. Mahse, zirchianna chuan kan epigenome hi kan dam chhung kum engemaw zat chhungin a inthlak danglam awlsam ber tih a tarlang . Chuvangin, nu leh pa emaw, enkawltu emaw i nih chuan hengte hi ngaihven a pawimawh hle:

• I fa hian ei leh in dik tak a dawng tih hria ang che. Hetiang tih dan tur hi i pediatrician hnenah thurawn i dil thei ang.
• I fate chu a naupan lai aṭanga zir theihna hun remchang siamsak rawh. Chutah chuan an zir leh hriat reng theihna tûr infiamna pêk te, anmahni biak te, lehkhabu chhiar te, leh thumal thar zirtîr te pawh a tel thei a ni.
• I fate chu an hlim theihna tur, him taka an awm theihna tur leh hmangaihna nei tak, thlawptu mite’n an hual velna hmun siam rawh.
• Ei leh in lama harsatna, in lama harsatna, emaw, chhungkaw tihduhdahna ang chi harsatna i tawk a nih chuan doctor hnenah tanpuina zawng rawh. Nangmah leh i fate humhimna tur leh puihna i hmuh theih nan i mamawh tur resources zawng turin an pui thei che a ni.

A tawp berah chuan kan hriat reng tur thil (Take-Home Message) .

Epigenetics concept hi i tan chuan mak leh hlauhawm deuhin a ri a nih chuan nangmah chauh i ni lo. Kan taksa chhunga thil thleng ngaihtuah hi a hlimawm thei a, a chang chuan a buaithlak thei bawk. Kan tanpui theih loh leh thiltihtheihna nei lo ang maiin a lang thei bawk. Thil tam tak chu kan thunun theih loh ang maiin a lang. Mahse epigenetics hian kan taksa chhunga thil awm danah nghawng engemaw zat kan nei thei tih beiseina min pe a ni .

Epigenetics hi zirchianna field dang nena khaikhin chuan a la thar hle. Kan hriat loh tam tak a la awm. Mahse, chu chuan thil tam tak hmuhchhuah tur a awm tihna chauh a ni! I doctor chuan i gene leh epigenome-in i hriselna a nghawng dan a hrilh belh thei che a ni. Thu belhchian dawl zawk i hmuh theihna tur hmun a hrilh thei bawk.

Chuvangin, a awlsam zawngin kan genes hi kan thawnthua thil pakhat chauh a ni. Kan nun dan te, kan duhthlanna te, hmangaihna leh ngaihsakna kan dawn te hian chu thawnthu ziah danah nghawng lian tak a nei vek a ni. Chu chu epigenetics-in min zirtirna hlu ber a ni.