I thisenah platelet i nei tam lutuk em? Essential Thrombocythemia chungchang hi han sawi ila!

Thisen report i en a, i platelet count a sang hle tih i hmu ngai em? A nih loh leh, chhan awm lovin i taksa hmun hrang hrangah thisen zam (blood clots) lo awm, emaw, thisen chhuak mai mai ang chi thil i tawng tawh em? Heng thilte hi i ngaihven vak lo mai thei. Amaherawhchu, heng thil hnuaia awm thei, tunlaia kan sawi tur, Essential Thrombocythemia an tih, thil awmdan tlemte hi hriat a pawimawh hle.

Essential Thrombocythemia tih hi eng nge ni? A awlsam zawngin i hrethiam ang u.

A awlsam zawngin, essential thrombocythemia chu kan ruhro, thisen siamtu factory lian ber chuan a mamawh aia tam thisen cell chi khat, platelet an tih chu a siam chhuak a ni. Tunah chuan, "Heng platelet te hi eng nge ni ?" Platelets hi kan thisena cell chi hrang hrang te te ber a ni. Sipai te tak te ang mai an ni. Khawi emaw laiah hliam a awm a, thisen a chhuak tan chuan heng platelet te hi chutah chuan an tlan lut hmasa ber a, an inzawm khawm a, thisen zam an siam a, thisen chhuah chu an titawp ta a ni. Ngaihtuah teh, ruhro, platelet siamtu factory-ah thil dik lo a awm a, heng platelet te hi a tam lutuk a nih chuan eng nge thleng ang? Chutah chuan buaina chu a intan ta a ni. Hetiang dinhmun hi kan taksaa gene thenkhat, chu chu mutations . Hei hi pianpui thil a ni lo va, dam chhunga lo thanglian zel a ni. Chuvangin ``acquired genetic condition'' an ti a ni.A tam zawkah chuan chhan dang avanga thisen test an tih laiin accident-a hmuhchhuah a ni. Mi thenkhat chuan symptom engmah an nei lo mai thei. Tin, mi zawng zawng hian enkawlna an mamawh nghal vek dawn lo bawk. Dam kim theih ni lo mah se, enkawl dan dik chuan harsatna lian tham a thlen theihna chu nasa takin a tihziaawm thei a ni.

Hei hian engtin nge ka taksa a nghawng?

Tunah chuan ruhro hian platelet a siam tam lutuk chuan eng nge thleng tih i hrethiam ta. Heng extra platelet te hi platelet pangngai ang an ni lo va, a then chu a tlangpui aia lian zawk an ni a, an pianzia pawh a danglam deuh hlek bawk. Factory pakhatin thil tlawm zawk batch khat a siam chhuak ang mai a ni. Heng platelet pangngai lo, extra platelet te hian thisen kalna kawngah thisen zam a siam thin. Heng thisen zamte hian thisen kalna chu a tikhawlo a, kawngpuiah lirthei a jam ang maiin. Heng thisen zamte hi taksa khawi hmunah pawh a lo awm thei a ni. Mahse thluak, kut leh keah an lang tam ber.

Hetiang dinhmun hian a bik takin nu naupai tan chuan thisen zam a tipung a ni .

Thil mak dang chu he natna hian a chang chuan thisen chhuah tam lutuk a thlen thei a ni.I ngaihtuah mai thei, "Thisen hi thil thleng a ni a, chuti a nih chuan engtin nge thisen hi a kal?" A chhan chu thisen zam a tam lutuk hian taksaa platelet zawng zawng a hmang zo vek a ni. Tichuan, hliam a awm chuan thisen chhuah kha titawp tak tak thei tur platelet a tling lo. Hmu? Chuvang chuan essential thrombocythemia vei te chu heart attack emaw stroke emaw ang chi natna khirh tak tak an vei theihna a sang zawk a ni.

Hei hi cancer a ni em? Leukemia nen a inzawm em?

Ni e, essential thrombocythemia hi thisen cancer chi khat a ni. Doctor-te chuan myeloproliferative neoplasm an ti a. A awlsam zawngin, thisen cell chi khat (he thu-ah hian platelet) siam chhuah tam lutukna dinhmun a ni. Mahse, thisen cancer chi khat leukemia an tih chiah a ni lo. Mahse, a tlem berah chuan he natna hi mi thenkhatah chuan leukemia-ah a chang thei a ni. Chuvang chuan doctor-te chuan an lo thlir reng a ni.

Essential thrombocythemia leh thrombocytosis hi thil inang an ni em?

Heng hming pahnihte hi eng emaw chen an inang a, chuvangin an inthlau thei hle. Mahse, an pahnih inkarah hian danglamna a awm.

• Essential Thrombocythemia: Hetah hian natna dang vang ni lovin, ruhroah ngei pawh harsatna a awm avangin platelet count a pung a ni.
• Reactive Thrombocytosis: Hetah hian damdawi lam thil dang (e.g., infection, iron deficiency , operation hnua) avanga platelet count hi a pung a ni.

An pahnih zingah hian essential thrombocythemia aiin thrombocytosis an tih hi a tam zawk a ni.

He natna hi tuin nge vei tam zawk?

Essential thrombocythemia hi a awm ve lo hle. United States-a statistics-a a lan dan chuan mi 100,000 zingah mi pahnih vel a nghawng a ni. Hmeichhiain mipa aiin a let hnih zetin an nei tam zawk. He natna hian kum 60 leh 80 inkar mi a vei tlangpui a, mahse, a vei zinga 20% vel chu kum 40 hnuai lam an ni a, naupangte tan chuan a vei hi a tlem hle. An tih chuan an nu leh pate hnen atanga genetically rochun a nih a rinawm ber.

Hei hi eng symptoms nge ni? Engtin nge i hriat chian?

Mi zawng zawng hian symptoms inang an nei vek lo. Mi thenkhat chu kum tam tak chhung chu symptom nei lovin an kal thei. Platelet count a san zauh zauh chauhvin symptoms a lang tan thin. A lan chhuah dan ber chu thisen zam avanga lo awmte hi a ni. Chungte chu thluak, kut leh ke ang hmunah te a thleng thei a ni. Thisen zam avanga natna lanchhuahna awm thei te chu:

• Lu na rei tak .
• Luak chhuak .
• Ke kutphah leh kephah ah kang emaw, throbbing emaw feeling .
• Kut leh ke hring emaw sen emaw .
• Thusawi dan inthlak danglamna .
• Migraine a awm thin .
• Seizures a awm thin .
• A rilru, kut, hnungzang, kawr, hmui, pum chhunga natna emaw, nuam lo emaw.
• Luhai .
• Thâwk harsa (dyspnea).
• A rilru a na .
• Chaklohna .
• Enlarged spleen - pum veilam chunglam a awm organ pakhat.
• Hnar thisen chhuak (epistaxis).
• Gums thisen chhuak.
• Thisen chu stool ah a awm.
• Zun chhunga thisen (hematuria) a awm.
• Bruising awlsam tak a ni.
• Hmeichhia hian thlasik hun na tak an nei thin .

Hei hian naupai hi engtin nge a nghawng?

Naupai lai hian hmeichhe taksaah thisen zam (blood clots) a lo awm theihna a awm fo. Hetiang hlauhawmna hi nu naupai, essential thrombocythemia nei tan chuan a sang zawk a ni. Tin, he natna enkawlna thenkhat hi naupai emaw, naupai tum emaw tan pawh a tha lo hle bawk. Chuvangin he natna hi i vei a nih chuan fa neih dan tur ngaihtuah hmain doctor nen sawiho hmasak a pawimawh hle.

I theihnghilh suh, he natna hian heart attack leh stroke a thlen thei a ni. Hetiang natna i neih chuan heart attack emaw stroke emaw symptoms i neih chuan 1990 ah i call nghal tur a ni.

Engvangin nge hetiang dinhmun hi a lo awm? A chhan engte nge ni?

Kan sawi tawh ang khan hei hi genes inthlak danglamna (mutations) avanga lo awm a ni. Chûngte chu pian tirh laia awm reng reng ni lovin, dam chhûnga inthlâk danglam ṭhin gene an ni. A bik takin, thisen cell siamtu kan ruhroa stem cells tichhe thei gene pathum mutations hi a chhan ber a ni. Heng genes te hi:

• (JAK2) gene: He gene hian protein pakhat ``(JAK2)`` tih code a siam a. He protein hian thisen cell siamchhuahna control nan a pui thin.
• (CALR) gene: He gene hian protein pakhat ``calreticulin'' tih code a siam a. Zirchiangtute chuan hei hian cell thanna, inthen darh leh thihna thununna kawngah chanvo a nei niin an ngai.
• (MPL) Gene: He gene hi ``oncogene'' tia hriat a ni bawk a, hei hi cancer thlentu gene a ni.

Heng genes te hi an inthlak chuan ruhro (bone marrow)-a platelet siam dan chu thunun theih loh leh rang lutuk a lo ni ta a ni. Accelerator-in a rawn deng ang mai a ni! Chu chu taksain a tih theih aia tam platelet a siam chhuah hun a ni.

Engtin nge doctor-te hian hei hi an hriat chian? (Diagnosis) tih a ni.

Doctor chuan he natna hi i nei nia a rinhlelh chuan taksa enfiahna an nei hmasa ang . I natna lan chhuah dan leh i chhungte zingah hetiang harsatna nei an awm em tih te an zawt bawk ang. Tichuan, test ṭhenkhat an ti thei a, chu chu:

• Complete Blood Count (CBC): Hei hian i thisena cell chi hrang hrang, a bik takin platelet awm zat a enfiah thin.
• Peripheral Blood Smear: Hei hian thisen sample lak a, microscope hmanga platelet te en a, a pianzia leh a lian zawngah a pangngai em tih enfiah a ni. Platelet pangngai lo chu a lian zawk thei a, a pianzia pawh a inang lo thei bawk.
• Bone marrow test: A chang chuan bone marrow sample tlem te chu test nan lak theih a ni (Bone Marrow Aspiration emaw Bone Marrow Biopsy). Hei hian ruhro (bone marrow) dinhmun dik taka tehna atan a pui thei a ni.
• Genetic testing: Heng test te hi kan sawi tawh genes, (JAK2), (CALR), leh (MPL) te ah hian mutations a awm em tih hriat nan kan ti thin.

Heng test result hian i doctor chuan i risk a teh ang a, enkawlna tur ruahmanna a siam ang. A tlangpuiin, he natna vei theihna tur risk factors te chu:

• Kum 60 chunglam a nih avangin.
• Hmeichhia nih hi.
• Tun hmaa thisen zam nei tawh.
• A chunga kan sawi tawh ang khan taksaa genetic mutations awm dan.

Hemi atan hian mi zawng zawngin damdawi an mamawh em? Enkawlnate chu engte nge ni?

Hei hi mi zawng zawng tan a inang lo. Mi thenkhat tan chuan symptom an neih loh chuan doctor-te chuan "watchful waiting" tih strategy an rawt mai thei. Hei hian chhinchhiahna leh natna lan chhuah dan enfiah tihna a ni. Mite chu symptom nei emaw, thisen zam vei theihna sang tak nei emaw chuan enkawl an ngai dawn a ni. Enkawlna hian thisen zam venna leh/ emaw platelet level tihhniam hi a tum ber a ni. Hemi atan hian damdawi chi hrang hrang hman a ni a:

• Aspirin: Hei hian thisen zam a siam loh nan a veng a ni. Mahse, doctor-te chuan platelet count sang tak tak nei te hnenah aspirin pek hi an fimkhur hle a, acquired Von Willebrand syndrome an tih natna vei te thisen chhuahna a tipung thei a ni.
• Hydroxyurea: Hei hi chemotherapy damdawi a ni. Platelet level a tihniam a ni. Thisen zam hlauhawmna sang tak nei tan aspirin nen pek theih a ni.
• Anagrelide: Hydroxyurea ang bawkin hei hian platelet level leh heart attack leh stroke hlauhawmna a tihziaawm bawk.
• Interferon alfa chu a awm a:Hei hi immunotherapy a ni. Platelet pangngai lote chu a inthen darh a, a lo thang lian thei lo.
• Busulfan: Hei hi cancer dona damdawi a ni bawk. Hydroxyurea vei lo emaw, hmang thei lo emaw tan pek thin a ni.
• Ruxolitinib: He damdawi hi damdawi dang ei lo leh natna lanchhuahna nei te tan pawh hman a ni a, chu chu a natna, a ei tlem hnuah pawh a khat, leh hah lutuk te a ni.

A châng chuan i platelet level a san lutuk thut chuan plateletpheresis an tih chu hman a ni. Hetah hian i thisen chu machine bik nen a inzawm a, chu chuan platelet tam lutuk thenkhat chu a paih chhuak thin.

Hetiang thil thleng tur ven dan tur a awm em?

Dik tak chuan, ni lo. Hei hi genes inthlak danglamna avanga lo awm a ni a, chutiang inthlak danglamna lo thleng tur venna tur engmah kan ti thei lo. Heng genes te hi engvangin nge an inthlak tih hi zirchiangtute chuan an la hre chiang lo.

Hetiang dinhmun nen hian nun pangngaia nun theih a ni em? A dam rei zawng chu engzat nge ni?

I ti thei ngei ang! Symptoms i nei a nih pawhin doctor-te chuan harsatna lian tak tak, heart attack leh stroke ang chi te ven nan an enkawl thei che a ni. Chuvang chuan hlauthawng lova, doctor thupek zawm fimkhur a pawimawh. Nun rei zawng chungchang sawi dawn chuan hetiang natna vei te hian dam rei lote aiin an dam rei zawk thei niin an sawi. Mahse, hei hi mi hrang hrangah a inang lo. Thil tam tak, i dinhmun leh i hriselna kalphung te hian hei hi a nghawng a ni. Chuvangin, hemi chungchang hi i hriat chian theih dan tha ber chu i doctor zawh hi a ni.

Engtin nge ka in enkawl ang? (Mahni inenkawlna) .

Essential thrombocythemia vei te hi thisen zam leh/ emaw thisen chhuah dan pangngai lo an awm theihna a sang hle. Hetiang hlauhawmna tihtlem nan hian thil engemaw zat tih theih a awm a:

• Meizial zu hi pumpelh vek rawh: Meizial zu mite hian thisen zam (blood clots) an neih theihna a sang zawk. Meizial zu mi i nih chuan bânsan tûrin ṭanpuina zawng rawh.
• Rihna hrisel tak vawng reng rawh: Mi thau lutuk te chu thisen zam (blood clots) an neih theihna a sang zawk. Nutritionist hnen atangin thurawn la la, ei leh in hrisel tak hmang rawh.
• Exercise neih fo: Exercise hian thisen zam a ti tlem.
• Thisen zam hlauhawmna tipungtu natna dang control: Diabetes mellitus emaw thisen sang emaw ang chi natna i neih chuan control tha rawh.
• I hriselna zawng zawng kha fimkhur rawh: A châng chuan he natna hi a lan chhuahna awm lovin a awm thei a, chuvangin i doctor hnenah eng natna lan chhuahna nge fimkhur tur tih zawt rawh.

Engtikah nge Doctor ka hmuh ang? Engtikah nge emergency room-ah ka kal ang?

Hetiang dinhmun hi i neih chuan checkup neih reng a pawimawh hle. Hei hian i doctor chuan i dinhmun a enfiah thei ang a, i platelet level a enfiah thei ang a, enkawlna a tul apiang a thlak danglam thei bawk ang. Emergency-ah chuan chu chu a awmzia a niHeart attack emaw stroke emaw symptom i neih chuan 911 call nghal tur a ni a, damdawi in pan tur a ni. Heart attack chhinchhiahna hrang hrangte chu:

• Chest na emaw tightness (angina) emaw a awm thei.
• Thâwk harsa.
• Nausen emaw, pum na emaw nei.
• Lung natna (palpitations) chak tak.
• Thil tha lo thleng tur ang maia lungawi lohna emaw.
• Thawmhnaw hak.
• Luak chhuak (vertigo), mit hmuh lohna emaw, hriatna hloh emaw.

Hmeichhia hian symptom hrang hrang an nei thei a:

• Chauh lutuk leh mut theih lohna.
• Thâwk harsa (dyspnea).
• Hnunglam, kekawrte, kawr, kut leh pum emaw a na.
• Luak chhuak.

Stroke natna lan chhuah dan chu:

• Taksa sir khat (hmai, kut)-ah rang taka rilru hah emaw, chak lohna emaw a awm.
• Thusawi harsa thut.
• Mit pakhat emaw, mit pahnih emawa hmuh harsat thut.
• Luak na tak, kal harsa, balance hloh.
• Lu natna nasa tak, chhan awm lova lo thleng nghal mai.

Doctor hnenah eng zawhna nge i zawh tur?

Essential thrombocythemia hi natna awm lo tak a nih avangin zawhna tam tak i nei mai thei. Doctor i hmuh hunah hetiang zawhna hi zawt hreh suh:

• Engvangin nge hetiang hian ka chungah a lo thlen?
• Tunah hian symptom ka nei lo. Engtikah nge symptoms a lo lang ang?
• "Watchful waiting" tih hian eng nge a awmzia?
• Eng damdawi nge min recommend?
• Ka dam chhung zawng damdawi ka ei a ngai dawn em ni?

Take-Home Thuchah a ni

Okay, chuvangin kan sawi tawh atanga thu pawimawh tak tak i hriat reng theih nan hei hi ka hrilh ang che.

Essential Thrombocythemia hi thisen lama harsatna awm lo, genetic blood disorder a ni a, ruhro hian thisen cell tam lutuk platelet an tih chu a siam chhuak nasa lutuk a ni. Hei hian thisen zam, heart attack leh stroke te a tipung a ni.

Dam vek theih ni lo mah se, damdawi lam enkawlna dik leh i puihna chuan he natna hi i thunun ṭha thei a, harsatna awmte chu i ti tlem thei a, nun pangngaiin i hmang thei bawk. Chuvangin, hemi chungchangah hian rinhlelhna i neih chuan, a nih loh leh natna lan chhuah dan danglam tak i neih chuan damdawi lam thurawn la nghal rawh. Nangmah chauh i ni lo va, he zinkawng zawh tura puitu tur doctor an awm bawk. Essential Thrombocythemia, Platelets, Thisen zam, Ruhro, Thisen Natna, Genetic Mutations, Cancer