Nangmah emaw, i hriat mi emaw doctor-in ‘Givosiran’ an tih damdawi a lo pe tawh em? Chu hming i hriat chuan tlem chuan hriat loh, chu chu hriat loh, leh hlauthawng deuh pawh a ni mai thei. Chutianga inhriat chu thil pangngai a ni. A chhan chu hengte hi nitin damdawi chi hrang hrang kan hriatte an nih loh vang a ni. Chuvangin vawiin hian he damdawi Givosiran an tih hi, eng atan nge a nih, engtin nge i hman ang, eng fimkhur tur nge i tih tur tih hi, awlsam takin i hriatthiam theih tur angin i sawi dawn nia.
He Givosiran hi eng nge ni?
A awlsam zawngin Givosiran hi vaccine a ni. Brand name ``(GIVLAARI)`` tia hriat lar a ni. He damdawi hi natna hmuh tur awm lo tak ``Acute Hepatic Porphyria`` tih enkawlna atan hman a ni ber.
Tunah chuan ‘Acute Hepatic Porphyria’ tih hi eng nge ni tih i ngaihtuah mai thei. Hei hi kan thin (liver)-a lo awm thin, genetic disease a ni. Kan taksa hian thisenah hemoglobin siam turin ‘porphyrin’ an tih chemical a mamawh a. Mahse, he natna vei teah chuan chutiang kalphung dik lo a awm avangin he chemical porphyrin an tih hi a tul lovah taksaah a pung khawm thin. Hei hian symptom na tak tak, pum na tak, luak chhuak, taksa ruh chak lohna, leh rilru lama harsatna te a thlen thei a ni.
He vaccine, Givosiran an tih hi a danglam bik hle. Technology hmasawn tak tak ‘small interfering RNA’ (siRNA) hmanga siam a ni. Chumi awmzia chu he damdawi hi kan cell-ah direct-in a lut a, porphyrin chhiatna thlentu genetic message chu a titawp tihna a ni. Thurawn dik lo petu che chu tihtawp ang mai a ni.
Hei hi natna tidamtu pangngai ang a ni lo. Damdawi targeted tak a ni a, natna bulpui ber thlengin a kal a, a tidam thei a ni.
Damdawi ei hmaa doctor hnena i hrilh tur thilte
Givosiran i hman tan hmain i doctor nen i hriselna chanchin kimchang chungchang zalen taka inbiakna neih a pawimawh hle. A hnuaia mite hi hrilh ngei ang che:
- Kidney disease: Kidney nena inzawm natna i neih chuan.
- Liver disease: I porphyria condition awmsa bakah liver natna dang i neih chuan.
- Allergies: Givosiran chauh ni lovin, damdawi dang, ei tur, dye emaw, preservative dang emaw allergy i neih chuan i doctor hnenah hrilh rawh.
- Naupai: Naupai emaw, nau neih thuai tur emaw i nih chuan.
- Nu hnute petu i nih chuan: Naute hnute i pe a nih chuan.
Heng thute a\ang hian doctor chuan he enkawlna hi i tan a tha em tih leh engtin nge i tih ang tih a rel ang.
Damdawi hmuh dan leh fimkhur tur
Hei hi damdawi in lama hruai leh hman theih a ni lo.
- Administration: Hei hi vun hnuaia injection a ni .
- Hmun: He vaccine hi damdawi in, damdawi in emaw, damdawi in emaw-ah chauh healthcare professional trained-in a pe thin.
- Naupang tan: He damdawi hi naupang tê tête tana hman a nih chuan naupang enkawltu doctor thurawn angin a bik taka enkawl a ngai a ni.
- Dose i miss a nih chuan: I doctor chuan i vaccine lak hun leh hun a pe ang che. A hun taka inenkawlna neih a pawimawh hle. Eng emaw chhan vanga chu ni chuan i kal thei lo a nih chuan i doctor emaw clinic emaw ko nghal la, hriattir nghal rawh.
- I overdose chuan: Hei hi medical professional-in a pek avangin overdose chance a tlem hle. Mahse, thil thleng nia i rinhlelh chuan Colombo National Hospital-a National Poisons Information Center -ah i call nghal tur a ni a, a nih loh leh damdawi in hnai ber Emergency Treatment Unit (ETU)-ah kal nghal tur a ni.
Damdawi avanga side effect awm thei te
Damdawi dang ang bawkin Givosiran hian mi thenkhatah side effect a nei thei a ni. Hengte hi fimkhur a pawimawh hle. Hengte hi hmun hnih ah then ila.
| Side effects leh symptoms te | Hrilhfiahna |
|---|---|
| Side effect na tak tak, damdawi lam pan vat ngai | |
| Allergic Reaction awm thei te | Skin rash, eczema ang chi, hnim hring, hmai, hmui emaw lei emaw a hring, thawk harsa. Chung zinga pakhat tal a lo awm chuan emergency a ni. |
| Liver Injury natna lan chhuah dan | Zun dum emaw, sen emaw, mit emaw vun emaw a sen (jaundice), pum dinglam chunglam na, rilru hah, ei duh lohna, rilru hah, leh khawsik. |
| Kidney Injury natna lan chhuah dan | Zun harsatna emaw, i zun chhuah zat a inthlak danglam nasa emaw ( zun chhuah tlem lutuk emaw, zun chhuah loh emaw). |
| Thil pawi lo tlangpui, mahse a awm reng chuan doctor hnenah hriattir tur a ni | |
| Luhai | I pum a churn emaw, i luak ang emaw tih hian. |
| Injection na hmuna natna | Injection na hmuna a sen, a hring deuh emaw, a na emaw. |
| Chau lutuk | A hma aia chau zawka inhriatna. |
Damdawi dangah harsatna a awm thei em?
Ni e, a ti thei ngei ang. Chu chu ‘Drug Interactions’ kan ti a. Givosiran vaccine hian damdawi dang thenkhat nen a inzawm thei a ni.
Chuvangin, i hman zawng zawng chu i doctor hnenah hrilh rawh . Chumi awmzia chu:
- Natna dang doctor ten damdawi an pek.
- Damdawi dawr atanga lei theih damdawi (e.g. painkillers, cold medicine) te.
- Vitamin, mineral emaw thil dang emaw ei tur a ni.
- Ayurvedic, local emaw traditional herbs emaw a ni.
- Zu i in emaw, zu i in emaw chuan min hrilh teh.
A bik takin, rilru lam damdawi thioridazine hi he vaccine nen hian hman loh tur a ni lo. Tin, caffeine awmna thil leh khuh damdawi dextromethorphan te hian hei hi harsatna a thlen thei bawk.
He list hi a kim lo a, chuvangin i ei tur zawng zawng hi doctor hnenah chiang taka sawi a tha ber.
Take-Home Thuchah a ni
- Givosiran hi thin natna hmuh tur awm lo, ‘Acute Hepatic Porphyria’ an tih tan vun hnuaia injection bik pek thin a ni.
- He damdawi hi damdawi in emaw clinic emaw-ah chauh damdawi lam thiam trained-in a pe thin. In lama hman tur a ni lo.
- Enkawlna i tan hmain i damdawi lam dinhmun zawng zawng, allergy zawng zawng, leh damdawi leh supplement dang i ei zawng zawngte chu i doctor hnenah hriattir hmasak a pawimawh hle.
- Side effect na tak tak, allergy emaw, liver emaw kidney emaw chhiatna chhinchhiahna emaw awm thei te chu fimkhur reng ang che. Chung zinga pakhat tal i hriat chuan doctor hnenah hriattir nghal rawh.
- I doctor-in thisen test leh enkawlna appointment a pekte chu tlawh loh ngai suh.
- He damdawi chungchanga zawhna leh ngaihtuahna i neih chuan a enkawltu doctor hi a ni.
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