Neurofibromatosis Type 1 (NF1) tana beiseina thar: Gomekli (mirdametinib) damdawi chungchang zir rawh

I chhungte zingah, i fa pawh ni thei, Neurofibromatosis Type 1 (NF1) tih natna nei an awm em? He natna nena lo awm, natna, lak chhuah harsa, plexiform neurofibromas (PN) te hi i ngaihtuah mai thei. Mahse vawiin hian damdawi thar, beisei awm tak, tunah chuan puitling leh naupangte tana hman phalsak a nih tawh thu kan sawi dawn a ni. Gomekli (mirdametinib) tih a ni.

Gomekli chu eng nge ni? Engtin nge a thawh?

Ngaihtuah teh, kan taksa hian cell te thanlenna tur signaling pathway hrang hrang a nei a. NF1-ah chuan heng signaling pathway zinga pakhat hi a overactive a, chu chuan nerve vel ah tumor a siam thin. Heng tumor te hi a chang chuan hmun pawimawh tak tak, nerve, thisen kalna, leh chhungril lam taksa peng hrang hrangah an lo thang lian a, surgery hmanga lakchhuah a harsa hle a, a chang chuan tihchhuah theih loh a ni bawk.

Hei hi Gomekli tih dan a ni. Kan taksaa enzyme pahnih MEK1 leh MEK2 tih te a block thin. Heng enzyme te hian tumor te hi an lo thang lian zel theih nan signal an thawn thin a ni. Chuvângin, Gomekli-a’n chu signal pathway chu a tihtawp chuan, tumor-te chu a ṭhang tlem a, a châng chuan tumor-te chu a lo tlem a, a lo tlem ṭan bawk . A awlsam zawngin, hei hi surgery nei thei lo tan chuan enkawlna dang tha tak a ni.

He damdawi hi engtin nge i hman?

I doctor chuan nangmah emaw i fa emaw tan Gomekli dose dik tak chu a ruat ang a, i san zawng leh i rih zawng a zirin .

He enkawlna hi ni 28 chhunga tih thin a ni tlangpui.

• He damdawi hi ni khatah vawi hnih, darkar 12 danah i ei tur a ni .
• Hetiang hian damdawi hi ni 21 chhung a zawnin i ei a ngai a ni .
• Tichuan ni 7 chhung damdawi chu i ei tur a ni .
• Ni 28 a zawh chuan cycle thar a intan leh ta a ni.

Gomekli hi capsule-ah a rawn thleng a. Amaherawhchu, capsule ei harsatna nei tan chuan grape thlum tablet tuiah a hmin a, ei theih a awm bawk. A siam dan tur chu hetiang hi a ni:

1. Doctor-in pill a pek zat zat chu damdawi tehna noah dah la.

2. Tui mililitre 5 emaw 10 emaw dah la.

3. Cup chu minute hnih atanga minute li vel vel chu tablets te chu a hmin vek thlengin swirl rawh. Vawikhat a hmin chuan liquid chu a var ang a, milky deuhin a lang ang.

4. No atang chuan in nghal rawh. A nih loh leh oral syringe hmangin i suck up thei bawk .

5. I in zawh chuan chu cup khatah chuan tui 5-10 ml dang dah leh la, hrual la, chu pawh chu in rawh. Hei hian damdawi la awmte chu taksaah a luh theih nan a pui ang.

6. A siam atanga minute 30 chhunga i in loh chuan a tui la awm chu paih mai tur a ni.

Gomekli damdawi hlawhtlinna chungchangah hian zirchianna eng nge a sawi?

He damdawi hi a thatzia leh a himzia hi clinical study ReNeu study tih hmangin an finfiah tawh a ni. Naupang leh puitling kum 2 leh a chunglam 111, inoperable PN tumor nei te an tel a ni.

A rah chhuah chu a fuh tak zet a ni.

Mahse, heng zirchianna result hi mi zawng zawng tan a inang vek lo tih hre reng ang che . I dinhmun azirin a rah chhuah a inang lo thei.

Engtin nge damdawi hian hna a thawk em tih i hriat theih ang?

Hei hi hriat theih dan ber chu i doctor-in a order tur MRI scan hmangin a ni. Hengte hian tumor te hi a lian lo deuh em tih an enfiah thei a ni.

Plus, nangmah ngei pawhin a danglamna chu i hre tan ang.

• Pain reduction: Tumor avanga natna hi nasa takin a tlahniam a.
• I che thei zawk: Tumor avanga che harsa i neih chuan hengte hi a tlahniam ang a, nitin hna thawh a awlsam phah ang.
• Nunphung tihchangtlun: 1.1.A pum puiin a hma aiin ka rilru a hahdam tan ta.

He zirchiannaah hian thla 3 vel enkawl hnuah pawh result tha tak, natna tihziaawmna ang chi hmuh a ni.

Side effects awm tam ber chu engte nge ni?

Damdawi dang ang bawkin Gomekli hian side effect engemaw zat a nei thei a ni. Mahse, heng zinga a tam zawk hi chu enkawl theih a ni.

He damdawi chungchanga hriat tur bik dang

Gomekli tan hma leh enkawl lai hian ngaihtuah tur engemaw zat a awm.

1. Mit hmuh dan: He damdawi hian a chang chuan mit a tichhe thei. Chuvangin, enkawl tan hmain, .Mit enfiahna kimchang i nei tur a ni. Tin, enkawl laiin doctor-in a tih angin i mit i enfiah tur a ni bawk. Mit hmuh lohna ang chi symptom i neih chuan report nghal rawh.

2. Heart function: Damdawi ei tan hmain echocardiogram tih a ni a, chu chuan heart function a teh thin. Hei hi enkawl kum khatna atan thla 3 danah tih leh thin a ni.

3. Naupai: He damdawi hian nausen tan a tichhe thei .

• Hmeichhia fa neih theihna nei i nih chuan enkawlna i tan hmain naupai test an pe ang che. Enkawl lai leh damdawi i chawlhsan hnu kar 6 chhung chu naupai venna hmanraw tangkai tak i hmang tur a ni.
• Mipa i nih chuan enkawl lai leh damdawi i chawlhsan hnu thla 3 chhung chu naupai venna tha tak i hmang tur a ni. Hemi chungchang hi i doctor nen inhawng takin sawi rawh.