Hairy Cell Leukemia chungchang pawh hriat i duh em? Kan sawi dun teh ang!

I chau reng reng em? A nih loh leh khawsik leh natna hrik i vei reng em? A chang chuan heng thilte hi thil pangngai anga ngaih a ni a, mahse thil dang chhinchhiahna a ni thei lo. Vawiin hian thisen cancer hmuh tur awm lo mahse pawimawh tak, fimkhur a pawimawh em em chungchang kan sawi dawn a ni. "Hairy Cell Leukemia" tih a ni.

He "Hairy Cell Leukemia" hi eng nge ni?

A awlsam zawngin sawi ila, hei hi thisen atanga intan cancer chi khat a ni. Kan taksa peng pakhat bone marrow an tih kan nei a. Chu ruhro atang chuan kan thisena cell chi hrang hrang siam a ni. Chung zingah chuan B-cells (`B lymphocytes` an tih bawk) hi thisen var chi khat a ni. An hnathawh ber chu kan taksaa hrik lutte do a, natna laka min venhim hi a ni.

Chuvangin, he `Hairy Cell Leukemia` an tih dinhmunah hian thil thleng chu i ruhro hian B-cells pangngai lo a siam chhuak thin . Heng cell pangngai lo tak takte hi microscope hmanga i en chuan sam ang maia rawn chhuak te tak te an nei tih i hmu thei a ni. Chuvangin he natna hi chu ``hairy'' hmel avang chuan ``hairy cell leukemia'' an ti a ni. Pathologist te chuan microscope hmanga cell te an enfiah thin te hian an hmuchhuak thin.

Engvangin nge hetiang hi a lo awm? Taksa chu eng nge thleng?

Hetiang thil hi a thlen chhan chiang taka hriat ni lo mah se, he natna hi a lo awm hian taksaah thil engemaw zat a thleng thin. Thlai huan i nei ang tih han ngaihtuah teh, buh chite chu thunun theih lohvin a lo thang lian a nih chuan eng nge thleng ang? Thlai tha te hian hmun an hloh a, an thang tha lo a ni lawm ni? Hetah pawh hi chutiang chu a ni.

• Bone marrow effects: Chu B-cells pangngai lo chu bone marrow-ah, weeds ang maiin a lo awm tan thin. Chu chuan thisen var hrisel, thisen sen, leh platelet (thisen tichhe thei cell) siam chhuah theihna a ti tlem a ni.
• Lymph nodes leh spleen swelling: Kan lymph node leh spleen-a heng cell pangngai lo te hi an inthen darh a, an pung chho tan a, chu chuan chu taksa pengte chu a ti hring chhuak thin.
• Liver effects: A chang chuan heng cell pangngai lo te hi thisen kaltlangin liver-ah a darh thei a, a tichhe thei bawk. Hei hian pum chhungah tui a awm khawm thei a (`ascites` an tih condition).

Hei hi a awm fo em?

`Hairy Cell Leukemia` tih hi a tlem hle . America ang ramah pawh hian mi sang za zinga pakhat vel ah a awm thin. Hetiang dinhmun hi hnam dang aiin mipa hring zingah a tam zawk niin an sawi bawk.

Eng nge a lan chhuah dan?

A chang chuan Hairy Cell Leukemia vei te hian symptom an nei lo thei bawk . Mahse, symptoms a lan tak tak chuan, chungte chu:

• Fatigue: Hetiang hahna hi thisen sen (red blood cell level) tlahniam (anemia) vang a ni thei.
• Khawsik leh natna hrik kai fo thin: 1.1.Infection dotu thisen var hrisel tak tak a tlem avangin khawsik leh natna khirh tak tak a awm tam zawk.
• Left lower abdominal pain: Spleen-a cell pangngai lo tak takte an lo pungkhawm a, spleen a ti na a nih chuan veilam lower abdominal area-ah natna i nei thei a ni. Spleen chu a lian thei a, i chawm thei a, ei tlemte i ei hnuah pawh i khat thei bawk. I tum lo pawhin i thau i tihtlem thei bawk.
• Pum dinglam hnuai lam na: Thin a lo lian chuan dinglam a na thei.
• Thâwk harsa: Hei hi thisen tlakchhamna chhinchhiahna dang a ni.
• Swollen lymph nodes: Kawr, kawr leh pumah natna nei lo hrui a lo lang thei.
• Hriselna danglam tak emaw thisen chhuak emaw: Ruhro hian platelet a siam tling lo a, chu chuan thisen a tikhawlo thei a, hliam tenau ber pawh nise, thisen chhuak pawh a awm thei.

Pawimawh: Heng symptoms pakhat emaw a aia tam emaw i neih hian Hairy Cell Leukemia i vei tihna a ni hauh lo. Mahse, heng symptoms te hi a la awm reng a nih chuan doctor thurawn lak a tha ber.

A chhante chu engte nge ni? Risk factors a awm em?

Mithiamte chuan Hairy Cell Leukemia awm chhan dik tak hi an la hre lo . Mahse, zirchiannaah chuan he natna vei zinga 90% vel hian genetic mutation an nei tih hmuhchhuah a ni. BRAF an tih gene a nghawng a ni. He gene hian cell te chu a ti thang lian thei a ni. Chuvangin, a inthlak chuan cell pangngai lote chu an lo thang lian tan a, thunun theih lohvin an pung chho ta a ni. He genetic change hi kan pian hnuah a thleng thin. Mahse, chu inthlâk danglamna thlentu chu eng nge ni tih erawh hriat chian a la ni lo.

Mahse, he natna vei theihna tipungtu risk factor thenkhat hmuhchhuah a ni a:

• Kum: He natna hian kum 40 leh 70 inkar mi a vei tlangpui a, a natna hmuhchhuah a nih lai hian kum zatve chu kum 58 vel a ni.
• Gender: He natna hi hmeichhia aiin mipaah ​​a tam zawk.
• Agent Orange exposure: Zirchiangtute chuan he chemical leh chronic B-cell leukemia leh lymphoma (hairy cell leukemia pawh tel) te hi inzawmna a awm niin an ngai.

Hei hian eng harsatna nge a thlen theih?

Hairy Cell Leukemia hian i taksaa thisen var, natna dotu chu nasa takin a tihtlem a, chu chuan natna kai theihna a tipung a ni Chungte chu bacteria, viral, fungal infection a ni thei. A châng chuan, heng hri kai te hi nunna atana hlauhawm tak a ni thei.

Cancer chi hnihna hi hriatchhuah leh enkawl a nih atanga kum tam tak hnuah pawh a vei theihna chance tlemte a awm bawk. Entirnan, kum 10-20 chhung zet Hairy Cell Leukemia hlawhtling taka enkawl tawhte zirchiannaah chuan mi thenkhatin cancer dang an vei tih hmuhchhuah a ni.

He natna hi engtin nge an hriat chhuah?

Doctor i hmuh chuan i natna lan chhuah tirh leh natna i vei fo leh vei fo loh ang chi thilte a zawt ang che. I medical history pawh a zawt ang. Tichuan, taksa enfiahna an nei ang. I lymph nodes, spleen leh liver te pawh a hring em tih an enfiah thei bawk.

Tichuan, i natna hriat chian nan hematologist emaw medical oncologist emaw hnenah test dang neih belh turin refer i ni thei bawk. Heng test-ah hian:

• Complete blood count (CBC) leh differential: Hei hian thisen cell sen leh var awm zat a teh a, chubakah platelet awm zat a teh bawk. Differential hian thisen var chi hrang hrang awm zat a teh a ni.
• Peripheral blood smear: Pathologist te chuan thisen sample chu microscope hmangin an en a, "sam" ang chi protrusions nei cell pangngai lo an zawng thin.
• Bone marrow aspiration leh bone marrow biopsy: Heng test te hian ruhro chhunga cell pangngai lo awmte chu a hmuchhuak thei a ni.
• CT scan (Computed tomography - `CT` scan): `CT` scan hmangin taksa chhung lam chipchiar takin thlalak a la thei. Hei hi spleen, liver leh lymph node lian tham tak hriatna atan emaw, pum ultrasound hmanga enfiah nan emaw hman theih a ni.
• Flow cytometry: Hei hian thisen leh ruhroah cell pangngai lo, sam cell ang chi a awm leh awm loh a enfiah thin. Tin, cell lian leh te, a pianzia leh tumor marker awm leh awm loh a enfiah bawk. Tumor marker hi cancer cell siam protein a ni thei.

Engtin nge enkawl a nih?

Infection i neih chuan enkawl hmasak a ngai dawn a ni. Tichuan, `Hairy Cell Leukemia` symptoms control nan enkawlna dang tan a ni ang. Mahse, a hmaa kan sawi tawh ang khan mi zawng zawngin symptom an nei vek dawn lo. Chutiang mite tân chuan i hematologist emaw, oncologist emaw chuan active surveillance tih dân chu a rawn rawt thei a ni. Symptoms a awm chuan damdawi an pe thei bawk.

Active Surveillance neih a ni

Hairy Cell Leukemia hi a lo thang chak lo hle a . Symptoms a lan theih nan kum tam tak a ngai thei. Cancer enkawlna hian side effect leh complication a thlen theih avangin, symptomatic i nih chuan i doctor chuan symptoms a lan hma loh chuan enkawlna tan hun sawn a rel thei a ni.

Active surveillance neih chhung hian thla thum atanga thla ruk danah doctor i hmu ang. Chutiang tlawhnaah chuan:

• I hriselna tlangpui an zawt ang a, a bik takin a hma aia chau zawka i hriat chuan.
• Taksa enfiahna (physical examination) neih a ni ang a, liver leh spleen a hring em tih enfiah a ni ang.
• Thisen test tura tih a ni a, thisen cell leh platelet awm zat enfiah a ni.

Enkawl tan hmaa natna lan chhuah hun nghah chu rilru lamah a harsa deuh thei. Mahse i doctor chuan i rilru put hmang chu a hrethiam ang a, active surveillance neih a tha chhan a sawifiah ang.

Damdawi ei tur

Hairy cell leukemia vei tan chuan enkawlna bulpui ber chu chemotherapy a ni . Cancer dona damdawi hman tlanglawn ber chu Cladribine (Leustatin®) emaw Pentostatin (Nipent®) emaw an ni.

Chemotherapy hian hna a thawk lo a nih chuan, emaw, natna a lo lang leh a nih chuan, enkawlna dang a awm:

• Immunotherapy: `Rituximab (Rituxan®)` hi `Hairy Cell Leukemia` enkawlna atana hman thin `monoclonal antibody` a ni. Chemotherapy hmanga enkawlna hmasa atan emaw, natna a lo awm leh chuan pek theih a ni. Immunotherapy dang chu `Recombinant Interferon Alfa-2b (Intron A®)` a ni.
• Targeted therapy: Relapsed Hairy Cell Leukemia tan chuan damdawi Rituximab leh Moxetumomab pasudotox (Lumoxiti®) (hei hi antibody-drug conjugate chi khat a ni) tih te hman theih a ni.
• Splenectomy: A tlem hle a, damdawi hmanga enkawlna chemotherapy te hian a puih loh a, spleen chhunga cell pangngai lo avanga spleen a lo hring chhunzawm zel chuan he surgery hi tih a tha thei.

Enkawlna hian side effect a nei em?

Cancer enkawlna dang ang bawkin side effect a nei thei bawk. A bîk takin, hairy cell leukemia damdawi chemotherapy chuan nunna atana hlauhawm natna kai theihna a tipung a ni . I doctor chuan natna hrik laka invenna atana i tih theih dan tur leh i taksaa inthlak danglamna te chu hri kai chhinchhiahna a nih theih dan tur a hrilhfiah ang che.

He natna nena nung chung hian eng nge i beisei theih ang?

Tunah hian Hairy Cell Leukemia hi damdawi a la awm lo . Mahse, zirchianna chuan chemotherapy telin enkawlna hian kum 10 emaw a aia rei emaw chhung chu natna chu a reh thei tih a tarlang . Remission tih awmzia chu symptoms nei lo leh test-ah natna chhinchhiahna hmuh tur a awm lo tihna a ni. Hairy Cell Leukemia vei te thil tawn thlirletna zirchiannaah chuan enkawl an nih hnuah he natna nei lote ang bawkin an dam rei thei tih an hmuchhuak.

Mahse, hairy cell leukemia hi enkawl hmasak atanga kum engemaw zat hnuah a lo lang leh thei a ni. Mahse, chutiang a nih chuan natna chu remission-a dah leh thei tur enkawlna a awm.

Mi tam tak chuan dam chhung zawnga damdawi lam enkawlna leh puihna an mamawh a, doctor-te chuan a lo lang leh leh awm loh an enfiah a ngai a ni. Natna nei mah la, a lan chhuahna nei lo mah la, i hriat chhuah hnu thla thum atanga thla ruk danah test leh follow-up appointment neih a ngai ang.

Recovery rate chu engzat nge ni?

Leukemia and Lymphoma Society chhinchhiah danin, Chemotherapy damdawi Cladribine hmanga enkawl zinga 90% chu enkawl a nih atanga kum nga hnuah an dam tawh a ni. Mahse, i prognosis — enkawlna hnua thil thleng tur — chu thil tam takah a innghat a ni . I kum, i hriselna zawng zawng, i natna lan chhuah dan leh i taksain enkawlna a dawn dan te hian hmun a chang vek a ni. Hemi chungchanga zawhna i neih chuan doctor zawt la.

Engtin nge ka hriselna ka enkawl ang?

Hairy Cell Leukemia hian nunna atana hlauhawm natna kai theihna a tipung a ni. I immune system i tichak thei a , natna hrik lakah i inveng thei bawk . Rawtna thenkhat chu hetiang hi a ni:

• Ei leh in hrisel ei: Thlai, thlai, protein tha lo, leh buh chi hrang hrang ang chi thilte hian immune system hnathawh a pui thin.
• Nitin exercise la: Nitin active taka awm hi i hriselna kawng tam takah a tha a, i immune system pawh a tha hle.
• Mut tam: Mut tam loh hian i taksa hriselna a tichak lo thei a ni.
• I vaccine te chu a hun takah la rawh: Vaccine hian i taksa chu natna thlentu hrik do turin a zirtir thin. Eng vaccine nge i mamawh tih leh engtikah nge i lak dawn tih i doctor nen sawiho rawh.

Engtikah nge doctor i hmuh ang?

Hairy Cell Leukemia leh a enkawlna hian natna khirh tak tak, a chang chuan nunna atana hlauhawm tak i vei theihna a tipung thei a ni. Heng symptoms te hi i neih chuan doctor pan nghal rawh:

• Khawsik chu 38 degree Celsius (100.4 degree Fahrenheit) aia sang a, a tlahniam lo.
• Ni engemaw zat aia rei emaw, a zual zel emaw, rilru natna.
• Pum natna a reh lo emaw, a zual zel emaw.

Thupui leh A tawp berah (Take-Home Message) .

Chhan awm lovin a hma aia nasa zawkin i chau tawh pawh a ni mai thei. A nih loh leh damdawi i ei tam tawh zawng zawng pawh nise, thawkna lam natna, a bo lo tih i ngaihtuah tawh pawh a ni thei. Tunah chuan test-naah chuan thisen cancer hmuh tur awm lo `Hairy Cell Leukemia` tih i nei tih hmuhchhuah a ni a, chu chu enkawlna nen chuan tihdam theih loh tak a ni.

Mahse, lungngai suh . Kum tam tak chhung chu natna lan chhuahna awm lovin a thunun thei enkawlna a awm. Hun rei tak chhunga `remission` tih awmzia chu i healthcare team chuan i dam chhung zawngin i hriselna an enfiah ang. Tin, Hairy Cell Leukemia hi a lo kir leh tak tak a nih chuan zirchiangtute chuan he natna hi `remission`-a dah leh theih dan tur an zawng chhunzawm zel bawk.

I lam atanga i tih theih tur a awm. Entirnan, cancer enkawlna hian natna kai theihna a tipung thei a ni. I doctor hnenah vaccine pek dan tur leh natna kai theihna tihziaawmna tura i tih theih dangte zawt rawh.Nangmah chauh i ni lo, he zinkawng zawh tura pui turin doctor leh healthcare worker an awm bawk.

` Hairy Cell Leukemia, leukemia, thisen cancer, B cells, ruhro, spleen, symptoms te