Kerendia hian zunthlum leh kal natna (CKD) nei te tan hahdamna a pe thin

Zunthlum vei te hi hriselna lama harsatna dang engemaw zat nei thei tura hlauhawm an ni tih kan hria a, chung zingah chuan kal leh thinlung lama harsatna te pawh a tel. Hetiang hlauhawmna tihziaawmna tur hian damdawi chi hrang hrang awm mah se, zunthlum vei tam tak chuan hun kal zelah chronic kidney disease (CKD) an nei thei a ni. Zunthlum leh CKD i neih chuan hriselna lama harsatna lian tham i neih a rinawm. Mahse, kum 2021-a pawm tawh Kerendia tih hming pu damdawi hian mi ṭhenkhat tan heng hlauhawmnate hi a tihziaawm thei a ni.

Kerendia hian engtin nge zunthlum leh kal natna nei te chu a puih?

Type 2 Diabetes i vei chuan hun kal zelah thisen sugar level sang chuan taksa peng hrang hrang a tichhe thei a ni. A bik takin hei hian mi tam tak kal (kidney) a nghawng a ni. Hetianga kal chhia te hian hna a thawk tha thei lo. Hetiang dinhmun hi Chronic Kidney Disease (CKD) an ti a. Hun a kal zel a, he natna hi a zual zauh zauh a, kal (kidney failure) a thlen thei a ni. Thisen thlum sang hian thinlung leh thisen kalna kawng (cardiovascular system) a tichhe bawk. Hei hian natna khirh tak tak, stroke, heart attack, leh heart failure te a thlen theihna a tipung a ni. Kal (kidney) hian hna a thawk tha tawk lo a, CKD vei te pawhin thinlung natna an vei tam zawk bawk. Chuvangin, zunthlum, CKD, leh thinlung natna vei zawng zawng chu thihna hlauhawmna a sang zawk a ni. I thisen thlum leh thisen sang control-na hmang hian i thinlung, thisen kalna kawng leh kal (kidney) tihchhiatna chu i tihtlem thei a ni. Mahse i awm lai hian i kal (kidney) chu chhiatna nasa zawk laka humhim thei damdawi a awm. Kerendia hi chutiang damdawi bik pakhat chu a ni. Kerendia hian i thinlung leh kal a tihchhiat loh nan kawng danglam deuhin hna a thawk a ni. He pill a active ingredient chu finerenone a ni . I kal, thinlung leh thisen kalna kawnga mineralocorticoid receptor (MR) an tih receptor block-in hna a thawk a ni. He MR receptor hi zunthlum vei tan chuan a thawk nasa lutuk thei a ni. He receptor hi a block avangin Kerendia hian i kal (kidney) te chu i thisen atanga sodium (salt) lakchhuah nan a pui thin. Tin, i thinlung leh thisen kalna kawnga inflammation leh scarring (fibrosis) te a tihziaawm bawk. Hun rei tak i ei chuan hriselna lama harsatna lian tham i neih theihna chu i ti tlem thei a ni.

He damdawi hi engtin nge ka hman ang?

Kerendia hi tablet a ni a, ni khatah vawi khat ei theih a ni a, ei tur nen emaw ei loh pawhin ei theih a ni. Tablet pum pui ei harsa i tih chuan i chil a, tui tlem emaw, ei tur nem tak, applesauce ang chi emaw nen i pawlh thei bawk. Mahse, i chawhpawlh hnuah i ei nghal tur a ni . Kerendia i ei tan hnuah i doctor chuan i thisen potassium level a enfiah fo ang. Chuvangin, i doctor-in a tih angin nitin thisen test turin i kal ngei ngei tur a ni. I thisen potassium level a zirin i doctor chuan damdawi dose tihpun emaw tihhniam emaw, a nih loh leh ni engemaw zat damdawi ei kha chawlhsan emaw turin a fuih thei che a ni. Dose i miss a nih chuan i hriatreng veleh ei nghal rawh. Mahse a dose hloh ni chhunga a nih chauhvin. A tuk i hriatreng chuan missed dose kha ei suh. Double dose ei hian side effect a thlen theihna a tipung thei a ni.

He damdawi hi eng test nge tih a nih?

Tunah chuan he damdawi hi engtiang chiahin nge a rintlak tih leh tuin nge hmang tawh tih i ngaihtuah mai thei. Chumi chungchanga zirchianna an neih tawhte han thlir ila. Kerendia hi zunthlum leh CKD vei puitlingte tan eng ang taka him leh tangkai nge a nih tih hriat nan trial lian pahnih neih a ni tawh bawk. Heng trial-a telte kum zat chu kum 64 vel a ni.

Test-a telte chanchin pawimawh tak tak:

• An vai hian type 2 diabetes leh CKD an nei vek a ni .
• Ṭhenkhat chu a hmain thinlung natna vei nia hriat ni mah se, test an neih lai hian tumahin symptoms an nei lo.
• Mi zawng zawng hian kal venhimna tur damdawi engemaw zat an hmang vek a .
• 97% chuan thisen sugar control nan damdawi an hmang a .
• Kerendia damdawi hi placebo , dummy pill, nghawng nei lo nen an khaikhin a. Ruihhlo tak tak nge dummy pill an dawng tih chu tumahin an hre lo.

Heng trial pakhatah hian damdawi ei laiin kal lama harsatna lian tham engzat nge awm tih a teh a ni. Chu chu:

• Kidney natna khirh tak nei te.
• Kidney failure nei te.
• Kidney lama harsatna vanga thite.

Test dang chuan cardiovascular event na tak engzat nge thleng tih a teh a ni. Chu chu:

• Mite chu stroke emaw heart attack emaw vei tawhte .
• Lung lam natna avanga damdawi ina awmte.
• Lung lam harsatna vanga thite.

Test result te chu eng nge ni?

Kidney lama harsatna: Kum 2.5 vel a awh zirchiannaah hian Kerendia ei thinte hian placebo ei thinte aiin kal lama harsatna lian tham an nei tlem zawk a ni. Chumi awmzia chu mi thenkhat chu kal lama harsatna lian tham, kal tha lo, kal tha lo, kal natna avanga thihna te an nei tlem zawk tihna a ni. Lung lam harsatna: Kum 3.5 vel a awh zirchiannaah hian Kerendia ei thinte pawhin placebo ei thinte aiin thinlung lama harsatna lian tham an nei tlem zawk bawk. Chumi awmzia chu mi ṭhenkhat chuan thinlung lama harsatna lian tak tak, stroke, heart attack, heart disease avanga damdawi ina awm, emaw thihna emaw an nei tlem zawk tihna a ni.

Side effects leh engtin nge kan enkawl ang?

Damdawi dang ang bawkin Kerendia hian side effect engemaw zat a nei thei a ni. A bulpui ber chu thisena potassium level a san vang a ni. Chuvang chuan i doctor chuan i thisen a check fo ang. He damdawi hi i hman hian danglamna lian tham i nei lo mai thei. Hei hi a chhan chu a hnathawh ber chu chhungril lama chhiatna rate tihhniam a nih vang a ni. Chuvangin, i rilru a hahdam a nih pawhin doctor thurawn tel lo chuan damdawi ei kha bansan suh. Kerendia, finerenone, zunthlum, kal natna, kal natna rei tak, CKD, thinlung natna, Sri Lanka