Jynarque (Tolvaptan) hian ADPKD, kal natna, kal chhunga cyst lo awm thin tan a tidam a ni

I doctor hian nangmah emaw, i chhungte tu emaw hnenah i kal (kidney)-ah tuiin a khat cyst a siam theihna tur natna i nei tih a hrilh ngai em? Hei hi damdawi lam chuan ‘Autosomal Dominant Polycystic kidney disease ’, a tawi zawngin ADPKD tia hriat a ni. He thu i hriat hian tlem a hlauhthawn hi thil pangngai a ni a, a chhan chu hun kal zelah hei hian kal (kidney failure) a thlen thei a ni. Mahse, lungngai suh. He natna kal zel tur tikhawtlai thei leh i kal venhimna atana pui thei enkawlna a awm. Vawiin hian Jynarque , he natna atana damdawi phalsak awmchhun chungchang kan sawi dawn a ni.

He damdawi Jynarque hian engtin nge ADPKD vei te a puih?

A awlsam zawngin sawi ila, ADPKD hi genetic disease a ni a, thlah khat atanga thlah dangah a darh zel a ni . Hei hi kal (kidney)-ah hian fluid-filled cyst (cyst) tam tak a lo awm thinna a ni. Hun a kal zel a, heng cyst te hi an lo thang lian a, kal (kidney) pianzia an thlak danglam a, a tlangpui aia lian zawk an ni. A tawpah chuan kal (kidney) te hian thisen filter tha taka an hna chu an thawk thei tawh lo. A tam zawkah chuan heng natna lan chhuah dan hi thalai zingah a lang lo va, kum 30 leh 50 inkar ah a lang thin a, a lan chhuah dan tlangpui chu thisen sang a ni . Kal natna pawh a awm thei bawk. Hei hi kal emaw, zun kawng emawa natna hrik awm vang te, ruptured cysts vang te, kal chhunga lung awm vang te pawh a ni thei. ADPKD vei zawng zawng deuhthaw hian a tawpah chuan chronic kidney disease (CKD) an nei vek a ni. Hei hi dinhmun a ni a, zawi zawiin a zual zel a ni. A stage te chu eng nge ni tih i en ang u. ADPKD enkawlna tum ber chu kal (kidney) a tihchhiatna chu a theih ang anga tihziaawm a ni. Chutianga tih theih dan pakhat chu i thisen sang control hi a ni. A dang chu nitin tui tam tak in a, caffeine (tea, coffee) ei tlem hi a ni. Chu bâkah, i doctor chuan nun dân thlak danglam tûrin a rawt thei bawk a, chu chu exercise lak te, i ei leh in-a chi (salt) tihtlem te, leh zu in bânsan te hi a ni.

He damdawi hi mi zawng zawng tan a tha lo em ni?

Ni e, Jynarque hi damlo zawng zawng tan a tha lo. I doctor hnenah i damdawi lam dinhmun hmasa leh tuna i awm tawh zawng zawngte hrilh vek a pawimawh , a bik takin:

• Liver lama harsatna i neih chuan.
• I thisenah sodium level hniam emaw sang emaw i neih chuan.
• Zun harsatna i neih chuan (e.g. kidney stones , urinary tract obstruction).
• Nilengin tuihal i neih loh emaw, tui in harsatna i neih loh chuan.

Hetiang thil chungchanga doctor nena inbiakna hi i himna atan a pawimawh hle.

Damdawi hi engtin nge hman ang?

Jynarque hi pill a ni a, ni khatah vawi hnih ei thin a ni. Chaw ei hma emaw ei zawhah emaw ei theih a ni. Hei hi ei hun tur hi a pawimawh hle. Damdawi i ei tan chuan i doctor chuan dose tlem a pe ang che. Kar 1-2 chhung harsatna lian tham i neih loh chuan tlemin an tipung ang. Chumi hnuah chuan harsatna i la nei lo a nih chuan a dose hi i tipung leh thei a ni. Dose i miss a nih chuan ei suh. Missed dose chu skip la, i dose leh tur chu a hun ruatah ei rawh. Schedule dik taka zawm a pawimawh a, zing i thawh veleh leh darkar 8 hnuah. Dose pahnihna hriatreng nan phone-ah alarm set a tha.

He damdawi hlawhtlinna chungchangah hian test-te hian eng nge a sawi?

Jynarque damdawi hi a him leh him loh enfiah nan zirchianna lian tak pahnih neih a ni tawh bawk.

CKD natna vei hmasa ber (stage 1 emaw 2 emaw) .

He zirchiannaah hian Jynarque ei thinte chu placebo ei thinte nen khaikhin chuan an kal (kidney lian tham) rate chu a tlahniam hle a ni. A dik tak chuan Jynarque ei thinte zingah hian placebo ei thinte nen khaikhin chuan 49% velin an kal a lian zawk a ni . Hei hian a awmzia chu kal chhiatna chu nasa takin a thunun tihna a ni. Hei bakah hian Jynarque eitute pawhin kal (kidney) nena inzawm natna an nei tlem zawk bawk.

Late-stage CKD vei (stage 3 emaw 4 emaw) .

He damlo pawlah hian Jynarque eitute zingah hian kal (kidney function) a tlahniam nasa zawk a, midang aiin a hniam deuh hlek a ni. Chumi awmzia chu he damdawi hian an kal hnathawh chu rei zawk a humhim thei tihna a ni a, natna khirh tak nei tawhte tan pawh a pui thei tihna a ni.

Side effects leh engtin nge kan enkawl ang?

Jynarque hman hian side effect a awm thei a, chu chu hriat reng a pawimawh.

• Zun tam: Hei hi a side effect tam ber a ni. Hei hian nitin leh zan lamah pawh toilet pan fo a ngai thei a ni. Zan lama harsatna tihziaawmna tur chuan a rualin a vawi hnihna ei tur a ni a, tlai lamah ei tur a ni lo.
• Dehydration: Taksain tui a hloh tam lutuk avangin tui tlakchhamna a awm thei. Chutiang laka inven nan nitin tui tam tak in la, tuihal i neih hma chu nghak ngai lovin . Tuihâl i hriat hunah tui in nghal rawh. Dehydration hian thisenah sodium level a tisang thei a ni. Luak chhuak, chak lohna , hah lutuk, rilru hahna, emaw thinlung thawk mumal lo ang chi symptoms i neih chuan i doctor hnenah hriattir nghal rawh.

Hengte chauh ni lovin, side effect dang pawh a awm thei bawk. I doctor nen in tibuai thei symptoms eng pawh sawipui rawh.

Damdawi dang emaw, ei tur dang emaw-ah harsatna a awm thei em?

Ni e, hei pawh hi thil pawimawh tak a ni.

• Damdawi dang: Jynarque hian damdawi dang thenkhat nen a inzawm thei. Damdawi thenkhat chuan Jynarque side effects a tipung thei a, thenkhat erawh chuan Jynarque thatna a ti tlem thei thung. Chuvangin, i damdawi ei zawng zawng (vitamin leh herbal remedies te pawh tel) i doctor hnenah hrilh ngei ang che.
• Chaw: He damdawi hi ei lai hian grapefruit ei loh tur leh grapefruit tui in loh tur a ni . Grapefruit hian taksaa Jynarque level a tisang a, side effect a awm theihna a tipung a ni. He effect hi ni khata hun dangah grapefruit ei pawhin a awm thei a, damdawi ei lai ni lovin, chuvangin grapefruit hi pumpelh vek rawh.

He damdawi hi hmuh theih dan bik a awm em?

Jynarque hi damdawi a ni a, liver tihchhiat theihna a nei tlem hle. Hetiang hlauhawmna avang hian he damdawi hi REMS Program tih hming pu program bik hnuaiah chauh hman theih a ni. Damdawi i ei tan hmain he program-ah hian i inziak lut hmasa tur a ni. Tin, i thin (liver) hnathawh dan enfiah nan thisen test i neih a ngai bawk ang. Damdawi i ei tan hnuah pawh heng thisen test te hi a hun takah i neih chhunzawm zel a ngai dawn a ni. Damdawi i ei chhunzawm duh chuan heng test te hi i tih chhunzawm zel a pawimawh hle. Hemi chungchang hi i doctor chuan a sawifiah belh ang. Jynarque, Tolvaptan, ADPKD, Polycystic Kidney Disease, Kidney Disease, Kidney Cysts, CKD, Kidney Failure, Chronic Kidney Disease, Jambola te a ni