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Renal function (eGFR)
Measure kidney function based on creatinine value
He damdawi Jynarque hian engtin nge ADPKD vei te a puih?
A awlsam zawngin sawi ila, ADPKD hi genetic disease a ni a, thlah khat atanga thlah dangah a darh zel a ni . Hei hi kal (kidney)-ah hian fluid-filled cyst ) tam tak a lo awm thinna a ni. Hun a kal zel a, heng cyst te hi an lo thang lian a, kal (kidney) pianzia an thlak danglam a, a tlangpui aia lian zawk an ni. A tawpah chuan kal (kidney) te hian thisen filter tha taka an hna chu an thawk thei tawh lo. A tam zawkah chuan heng natna lan chhuah dan hi thalai zingah a lang lo va, kum 30 leh 50 inkar ah a lang thin a, a lan chhuah dan tlangpui chu thisen sang a ni . Kal natna pawh a awm thei bawk. Hei hi kal emaw, zun kawng emawa natna hrik awm vang te, ruptured cysts vang te, kal chhunga lung awm vang te pawh a ni thei. ADPKD vei zawng zawng deuhthaw hian a tawpah chuan chronic kidney disease (CKD) an nei vek a ni. Hei hi dinhmun a ni a, zawi zawiin a zual zel a ni. A stage te chu eng nge ni tih i en ang u.| CKD Stage a ni | Thil awmdan chu a awlsam hle. |
|---|---|
| Stage 1 leh 2-ah te | Hei hi a vawi khatna a ni. Kal (kidney) hian hna a la thawk tha hle a, chuvangin a tlangpuiin symptom a awm lo. |
| Stage 3 leh 4-naah te | Tunah chuan kal (kidney) hnathawh chu nasa takin a tlahniam tawh a ni. Thisen a filter tha thei loh avangin symptoms a lang tan thin. |
| Stage 5-na a ni | Hei hi a tawp ber a ni. Kidney te chu operation theih loh vek (Kidney Failure) a lo ni ta a ni. Dialysis emaw kidney transplant emaw tel lo chuan nunna atana hlauhawm tak a ni thei. |
Jynarque hian kawng danglam takin hna a thawk a. Kan taksa hian hormone (vasopressin) tih a nei a. ADPKD vei teah chuan he hormone hian kidney -ah signal a thawn a, cyst tam zawk siam rawh. Jynarque-a active ingredient, (tolvaptan), chuan chu signal chu kidney thleng turin a block a ni. Hei hian cyst thar siam a ti tlem a, cyst hlui a tipung bawk. Hei hian kal (kidney) te chu hrisel takin hun rei zawk a thawk thei a ni.
He damdawi hi mi zawng zawng tan a tha lo em ni?
Ni e, Jynarque hi damlo zawng zawng tan a tha lo. I doctor hnenah i damdawi lam dinhmun hmasa leh tuna i awm tawh zawng zawngte hrilh vek a pawimawh , a bik takin:- Liver lama harsatna i neih chuan.
- I thisenah sodium level hniam emaw sang emaw i neih chuan.
- Zun harsatna i neih chuan (e.g. kidney stones , urinary tract obstruction).
- Nilengin tuihal i neih loh emaw, tui in harsatna i neih loh chuan.
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Check Availability →Damdawi hi engtin nge hman ang?
Jynarque hi pill a ni a, ni khatah vawi hnih ei thin a ni. Chaw ei hma emaw ei zawhah emaw ei theih a ni. Hei hi ei hun tur hi a pawimawh hle.| Dose hman dan tur | Hun a la a |
|---|---|
| Dose hmasa ber (zing) . | Zing i thawh veleh ei nghal rawh. Hei hi dose sang ber a ni. |
| Dose pahnihna (chawhnu lam) . | Dose hmasa ber chu dose hnuhnung ber atanga darkar 8 chiah ah ei tur a ni. (Entirnan, zing dar 8-a i lak chuan a dawt leh chu tlai dar 4-ah la rawh). Hei hi dose hniam tak a ni. |
Pawimawh tak: He damdawi hi i ei lai hian i doctor chuan i liver hnathawh dan enfiah turin a hun takah thisen test (Liver function tests) neihpui turin a ti ang che Heng test-ah hian ni ruat saah i tel a pawimawh hle. Results a zirin i dose tihhniam a ngai mai thei a, ni engemaw zat tihtawp a ngai thei a, tihtawp vek a ngai mai thei bawk.Dose i miss a nih chuan ei suh. Missed dose chu skip la, i dose leh tur chu a hun ruatah ei rawh. Schedule dik taka zawm a pawimawh a, zing i thawh veleh leh darkar 8 hnuah. Dose pahnihna hriatreng nan phone-ah alarm set a tha.
He damdawi hlawhtlinna chungchangah hian test-te hian eng nge a sawi?
Jynarque damdawi hi a him leh him loh enfiah nan zirchianna lian tak pahnih neih a ni tawh bawk.CKD natna vei hmasa ber (stage 1 emaw 2 emaw) .
He zirchiannaah hian Jynarque ei thinte chu placebo ei thinte nen khaikhin chuan an kal (kidney lian tham) rate chu a tlahniam hle a ni. A dik tak chuan Jynarque ei thinte zingah hian placebo ei thinte nen khaikhin chuan 49% velin an kal a lian zawk a ni . Hei hian a awmzia chu kal chhiatna chu nasa takin a thunun tihna a ni. Hei bakah hian Jynarque eitute pawhin kal (kidney) nena inzawm natna an nei tlem zawk bawk.Late-stage CKD vei (stage 3 emaw 4 emaw) .
He damlo pawlah hian Jynarque eitute zingah hian kal (kidney function) a tlahniam nasa zawk a, midang aiin a hniam deuh hlek a ni. Chumi awmzia chu he damdawi hian an kal hnathawh chu rei zawk a humhim thei tihna a ni a, natna khirh tak nei tawhte tan pawh a pui thei tihna a ni.Side effects leh engtin nge kan enkawl ang?
Jynarque hman hian side effect a awm thei a, chu chu hriat reng a pawimawh.- Zun tam: Hei hi a side effect tam ber a ni. Hei hian nitin leh zan lamah pawh toilet pan fo a ngai thei a ni. Zan lama harsatna tihziaawmna tur chuan a rualin a vawi hnihna ei tur a ni a, tlai lamah ei tur a ni lo.
- Dehydration: Taksain tui a hloh tam lutuk avangin tui tlakchhamna a awm thei. Chutiang laka inven nan nitin tui tam tak in la, tuihal i neih hma chu nghak ngai lovin . Tuihâl i hriat hunah tui in nghal rawh. Dehydration hian thisenah sodium level a tisang thei a ni. Luak chhuak, chak lohna , hah lutuk, rilru hahna, emaw thinlung thawk mumal lo ang chi symptoms i neih chuan i doctor hnenah hriattir nghal rawh.
Damdawi dang emaw, ei tur dang emaw-ah harsatna a awm thei em?
Ni e, hei pawh hi thil pawimawh tak a ni.- Damdawi dang: Jynarque hian damdawi dang thenkhat nen a inzawm thei. Damdawi thenkhat chuan Jynarque side effects a tipung thei a, thenkhat erawh chuan Jynarque thatna a ti tlem thei thung. Chuvangin, i damdawi ei zawng zawng (vitamin leh herbal remedies te pawh tel) i doctor hnenah hrilh ngei ang che.
- Chaw: He damdawi hi ei lai hian grapefruit ei loh tur leh grapefruit tui in loh tur a ni . Grapefruit hian taksaa Jynarque level a tisang a, side effect a awm theihna a tipung a ni. He effect hi ni khata hun dangah grapefruit ei pawhin a awm thei a, damdawi ei lai ni lovin, chuvangin grapefruit hi pumpelh vek rawh.
He damdawi hi hmuh theih dan bik a awm em?
Jynarque hi damdawi a ni a, liver tihchhiat theihna a nei tlem hle. Hetiang hlauhawmna avang hian he damdawi hi REMS Program tih hming pu program bik hnuaiah chauh hman theih a ni. Damdawi i ei tan hmain he program-ah hian i inziak lut hmasa tur a ni. Tin, i thin (liver) hnathawh dan enfiah nan thisen test i neih a ngai bawk ang. Damdawi i ei tan hnuah pawh heng thisen test te hi a hun takah i neih chhunzawm zel a ngai dawn a ni. Damdawi i ei chhunzawm duh chuan heng test te hi i tih chhunzawm zel a pawimawh hle. Hemi chungchang hi i doctor chuan a sawifiah belh ang.Take-Home Thuchah a ni
- ADPKD hi thlahtu natna a ni a, kal (kidney stone) a siam a, chu chuan a tawpah chuan kal (kidney) a tichhe thei a ni.
- Jynarque (Tolvaptan) hi damdawi bik a ni a, heng kidney tumor te hi a lo thang chak lo hle.
- He damdawi hi mi zawng zawng tan a tha lo. I damdawi lam dinhmun zawng zawng doctor hnenah hrilh rawh.
- Damdawi hi a hun takah, a dose dik takah ei tur a ni. I liver function enfiah nan thisen test hi skip suh.
- Nilengin tui tam tak in thin ang che. Grapefruit ei leh in loh vek tur a ni.
- Danglamna i hre lo a nih pawhin he damdawi emaw, damdawi dang emaw hi doctor thurawn tel lova chawlhsan loh tur a ni.
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