Cholesterol control nana vaccine thar ber (PCSK9 Inhibitors) chungchanga i hriat tur te

Cholesterol pawh i buaipui em ? I doctor-in damdawi a pek chu i ei a, i ei leh in i thunun a, exercise i ti a ni mai thei. Mahse i cholesterol level tihhniam chu a la harsa hle a ni lawm ni? A châng chuan engtiang pawhin bei mah la, i taksaa cholesterol ṭha lo chu a sang reng thei a ni. He thuziak ah hian chutiang mite tanpui thei tur damdawi chi thar tak tak kan sawi dawn a ni.

A awlsam zawngin, heng PCSK9 Inhibitor te hi engte nge ni?

Hei hi hming buaithlak tak angin a lang thei a, mahse a thawk awlsam hle. PCSK9 inhibitor hi cholesterol tihhniamtu damdawi chi khat a ni. A bik takin, LDL (Low-Density Lipoprotein) cholesterol , kan taksa tana hlauhawm “cholesterol tha lo” chu an target a ni. Mi thenkhat chuan an dam chhungin cholesterol level sang tak an nei thin. Chutiang mite tan chuan he damdawi chi hi a \angkai hle thei a ni.

Okay, tunah chuan `PCSK9` tih hming awmzia hi han en ila. `PCSK9` hi kan thin (liver) atanga siam protein chi khat bik a ni. He protein hming hi `proprotein convertase subtilisin/kexin type 9` tih a ni. A tih chu kan taksaa `LDL receptor` an tihte control hi a ni. Medical study-ah chuan mi taksain a pianphungah `PCSK9` protein a siam tam zawk chuan chu mi chuan cholesterol sang a nei tam zawk tih hmuhchhuah a ni .

He damdawi hi tute nge mamawh?

Hei hi zawhna pawimawh tak a ni. A chhan chu he damdawi hi cholesterol sang zawng zawng tan pek a ni lo. A tlangpuiin i doctor-in he `PCSK9 inhibitor` damdawi hi a pek theihna tur dinhmun lian tak pahnih a awm a:

1. Damdawi dangin cholesterol a thunun loh hunah: Cholesterol tihhniamna damdawi dang, `(statins),` te i hmang tawh a, mahse i cholesterol level a la sang reng a nih chuan he damdawi hi a dawt leh tur atan i ngai mai thei.

2. Genetic condition thenkhatah: Mi thenkhat chuan hereditary, congenital condition, cholesterol sang an nei a. Hei hi medical science-ah chuan ``familial hypercholesterolemia`` an ti a.He damdawi hi he natna vei tan pawh a \angkai hle.

He damdawi hian taksa chhungah engtin nge hna a thawh?

Hei hi hrethiam tur chuan entirnan tlem han la ila.

I taksain “cholesterol mantu kut” a nei niin han ngaihtuah teh. Hengte hi “LDL receptor” kan ti a. Heng “receptor” te hi kan liver cells chung lamah an awm tam ber. Heng “kut” te hian thisena cholesterol tha lo (LDL cholesterol) luang chhuak chu an man a, liver-ah an hruai lut ta a ni. Chumi hnuah chuan liver chuan chu cholesterol chu a tichhia a, taksa atangin a paih chhuak ta a ni. Hei hi thil kalphung pangngai a ni.

Mahse hetah hian villain tlem a awm. Chu chu a hmaa kan sawi tawh `(PCSK9)` protein kha a ni. He `PCSK9` protein hian `scissors` angin hna a thawk a. A tih chu chu cholesterol mantu kut, chu chu `LDL receptor` tihna a ni a, an hnathawh a tihtlem phah a ni. Taksaah `PCSK9` protein a pun chuan cholesterol mantu `kut` a tlahniam a. Tichuan thisena cholesterol tha lo chu thinin a paih chhuak thei lo va, thisenah a khawl khawm ta a ni.

Tunah chuan `PCSK9 inhibitor` damdawi hian eng nge a tih tih i hrethiam tawh mai thei. A dik tak chuan he damdawi hian scissor ang maia hnathawk `PCSK9` protein chu a titawp a ni. Chumi awmzia chu, he damdawi hi ei a nih chuan `PCSK9` protein hian chu cholesterol mantu kut (LDL receptor) te chu a tichhia thei lo tihna a ni.

Chuti a nih chuan eng nge thleng?

• LDL receptor active zawk an awm bawk.
• Heng active ‘kut’ te hian thisen a cholesterol tha lo tam tak chu an man a, liver ah an thlen thin.
• Liver hian chu cholesterol chu taksa atangin a paih chhuak thin.

A tawpah chuan i thisenah cholesterol tha lo level nasa takin a tlahniam a ni.

He damdawi hi engtiang chiahin nge a thawh? Tin, eng chi nge a nih?

PCSK9 inhibitor hi damdawi chi khat a ni a, mi thenkhat tan chuan a tangkai hle tih hmuhchhuah a ni. Zirna thenkhatah chuan heng damdawi te hian bad cholesterol (LDL cholesterol) level 70% thlengin a tihniam thei a, heart attack hlauhawmna pawh hmun thuma ṭhena hmun khat velin a tihniam thei bawk.

Tuna Sri Lanka leh khawvela hman tam ber `PCSK9 inhibitor` chi hnih a awm a, chungte chu:

• `Alirocumab` (brand hming: Praluent®) tih a ni.
• `Evolocumab` (brand hming: Repatha®) tih a ni.

Engtin nge damdawi i ei ang?

Hei hi nitin ei tur pill a ni lo. `PCSK9 inhibitors` hi injection angin pek thin a ni.He vaccine hi i doctor-in a ruat angin kar tlemte danah emaw, thla engemaw zat danah emaw i lak a ngai tlangpui ang.

He damdawi hi i ei lai hian i doctor chuan thisen test a nei fo ang a, damdawi hian a hnathawh that dan a enfiah ang. A châng chuan he damdawi hi amah chauhin pek a ni thei a, a châng chuan damdawi i ei tawh, statin ang chi nên a inkawp theih bawk.

A hlawkna leh a side effect awm thei te chu engte nge ni?

Damdawi dang ang bawkin he damdawi hian hlawkna leh nghawng tenau te a nei thei bawk. Mahse, mi tam zawk chuan side effect na tak an tawk lo.

Damdawi ringawt pawh a tawk em? Ni lo, hei hi ruahmanna lian zawka tel a ni.

Hei hi a pawimawh hle. PCSK9 inhibitor emaw, cholesterol tihhniamna damdawi dang emaw i ei emaw, i enkawlna ruahmanna pum puia a tel ve chauh a ni. Damdawi chauh rinchhan lovin, i thinlung hriselna humhim nan thil dang tam tak i tih theih a awm bawk.

• Ei leh in tha: Oil, sugar leh chi ei tlem la, thlai, thei, green leh fiber tamna ei tur tam zawk ei bawk ang che.
• Exercise: Kar khatah ni engemaw zat tal chu thinlung hriselna atana tha exercise, kea kal chak tak, tlan, a nih loh leh cycle khalh ang chi ti rawh.
• Stress management: Meditation leh yoga ang chi thil hmanga i rilru tih hahdam.
• Mut tha: Zan tin darkar 7-8 tal mut thin ang che.
• Meizial in loh tur: Meizial i zuk chuan titawp vek tur a ni.

Heng nunphung inthlak danglamna te hi damdawi nena i inzawmkhawm hian result tha ber i hmu ang.

PCSK9 inhibitor, cholesterol, cholesterol, LDL cholesterol, heart attack, stroke, chhungkaw hypercholesterolemia, statin, Alirocumab, Evolocumab te a awm bawk