I thisen hi a inzawm thei em? (Prothrombin Gene Mutation) A chungchang hi awlsam takin i zir ang u

Mi pakhatin rang takin a ke a hring a, a na a, doctor-in a keah thisen a zam tih a hrilh tih i hre ngai em? A nih loh leh, mipa naupang, hrisel tak, thawk harsa leh rilru natna leh damdawi ina dah nghal mai? Hetiang thil kan hriat hian eng thil nge thleng tih kan ngaihtuah mai thei. A tam zawkah chuan tar leh thau lutuk ang chi hi hei hi a thlentuah kan ngai a. Mahse, a châng chuan a chhan chu kan mit rawng, kan sam hring, a nih loh leh kan nu leh pate aṭanga kan rochun gene ang chi emaw a ni thei. Vawiin hian hetiang genetic condition, thisen zam hlauhawmna tipungtu chungchang kan sawi dawn a ni. Hei hi Prothrombin Gene Mutation an ti a .

A awlsam zawngin, he Prothrombin Gene Mutation hi eng nge ni?

Hei hi scientific hming ang maiin a lang thei a, mahse a thawnthu erawh a awlsam hle. Kan taksaah hian a tlangpuiin thisen zam (blood clotting) a awm dan hi han en hmasa ila. Hliam tenau i neih chuan thisen tlem a luang a, rei vak lo hnuah a tawp ta a ni lawm ni? Chu chu kan taksaa thisen zam (blood clotting system) a thawk chhuak vang a ni. Protein chi tam takin hei hi a pui a ni. Heng protein te hi Clotting Factors kan ti a. Chutiang protein pakhat chu Prothrombin hi a ni. Hei hi a hming dang chu Factor II a ni. A tlangpuiin kan taksa hian Prothrombin a mamawh zat chauh a siam thin. Mahse, Prothrombin Gene Mutation tih hming pu genetic mutation nei taksaah chuan he protein Prothrombin an tih hi a mamawh aia tam zawkin a siam chhuak thin Ngaihtuah teh, mi pakhatin tea no khatah sugar spoon hnih aiah sugar spoon nga emaw, spoon paruk emaw a dah chuan eng nge thleng ang? Tea a thlum lutuk ang bawkin, prothrombin level a san chuan kan thisen chu tlem a "sticky," a nih loh leh clotting a awlsam zawk. Hei hian thisen zam (veins)-ah thisen zam a siam theihna a tipung a , hliam awm lo pawhin a tipung a ni. Heng thisen zamte hi ke ruh thuk takah a lo awm a. Hetiang dinhmun hi Deep Vein Thrombosis (DVT) kan ti a. A châng chuan, he thisen zam hi a chhe thei a, lung chhunga vein pakhat a tikhawlo thei bawk. Hei hi natna hlauhawm tak a ni a, Pulmonary Embolism (PE) an ti a ni.

Engtin nge he gene hi kan neih theih ang? Homozygous leh heterozygous te hi eng nge ni?

Hei hi hriatthiam a awlsam hle. Gene eng pawh hi kan nu hnen atangin copy khat leh kan pa hnen atangin copy khat angin kan hmu thin. He Prothrombin siamtu gene hi han ngaihtuah teh. 1. Heterozygous: He gene chhia hi i nu emaw i pa emaw hnen atangin i hmu a, chu chu i nu leh pa pakhat chauh hnen atangin i dawng tihna a ni. Mi dang chuan gene hrisel, pangngai tak chu a hmu ta a ni. Sri Lanka leh khawvel hmun hrang hrangah mi tam takin he natna hi an nei a ni. Hetiang a nih chuan thisen zam (blood clots) hi mi pangngai aiin a sang deuh a ni. A tlangpuiin hetiang natna vei mi 1,000 zinga pahnih emaw pathum emaw hian thisen zam (blood clot) an nei thei a ni. 2. 2. A rilru a hah lutuk chuan a rilru a buai em em a.Homozygous: Hei hi a tlem deuh. Heta thil thleng chu i nu leh i pa hnen atangin gene chhia chu i hmu a ni. Hei hian a awmzia chu nu leh pa pahnih hnen atangin gene chhia copy pahnih i dawng tihna a ni . Hetiang a nih chuan `Heterozygous` te aiin thisen zam vei theihna hi a let tam takin a sang zawk a ni.

Ka fate hian hei hi ka hnen atangin an rochun dawn em ni?

Hei hi nu leh pa tam takin harsatna an neih chu a ni.

• Homozygous condition i neih chuan (gene copy pahnih a chhia tihna a ni), i fate pakhat zel hnenah gene chhia pakhat i pe chhuak ngei ang
• Heterozygous i nih chuan (gene chhia pakhat chauh i nei tihna a ni) i fate zinga pakhatin chu gene chu a rochun theihna chance 50% a awm. Coin flipping ang mai a ni; i hmu thei a, i hmu lo thei bawk.

Hetiang natna lan chhuah dan hi engte nge ni?

Hetah hian a pawimawh ber. Prothrombin Gene Mutation tih hming pu genetic mutation chungchangah hian symptom bik a awm lo. Chu chu i taksaah he gene hi nei mah la, danglamna leh harsatna i nei lovang tihna a ni. Mi tam tak chuan he gene hi an nei tih pawh an hre lo va, an dam chhung zawng thisen zam siam lovin an hmang thin. Chuti a nih chuan khawiah nge buaina chu? He gene avanga thisen zam (blood clot) a lo awm chauhvin buaina hi a lo awm thin. Tichuan chu thisen zam nena inzawm symptoms te chu kan hmu ta a ni.

Genes bakah hian thisen zam theihna tipungtu thil dang a awm em?

Ni e, a dik tak zet. He gene nei zawng zawng hian thisen zam an nei vek dawn lo kan ti a. Mahse, a hnuaia thil pakhat emaw a aia tam emaw a awm chuan a hlauhawmna a sang thei hle. Mei chunga gasoline leih ang mai a ni.

• Meizial zuk: Meizial hian thisen kalna kawng a tichhia a, thisen zam a tipung bawk .
• Surgery neih: Surgery lian tak hnuah ni eng emaw zat khumah i mu thei a, chu chuan thisen kal a ti tlem thei a, thisen a tikhawlo thei bawk.
• Obesity : Taksa rihna a san chuan thisen zam (veins)-a pressure tam zawk dah a nih chuan he hlauhawmna hi a sang chho zel a ni.
• Naupai: Naupai lai hian taksaa hormone inthlak danglamna leh naute lo thang lianin thisen zam a tihbuai vangin thisen zam hi a pianphungah a pung a ni.
• Birth control pill emaw hormone therapy emaw ei: Naupai venna pill leh hormone therapy thenkhata estrogen hormone awm hian a hlauhawmna a tipung thei a ni.
• Tar: Kum upat deuh deuh hian thisen zam hi a pianphungah a pung a.
• Hmun khata rei tak awm reng:
• Damdawi inah ni tam tak khumah mut a ni.
• Ke i tihchhiat hunah cast ha.
• Vanlawng, bus emaw, motor emawa darkar tam tak a vawi khata zin.

Engtin nge he natna hi i neih leh neih loh i hriat theih ang?

Hei hi thisen test mumal (full blood count ang chi) hmanga hriat theih a ni lo. Chumi atan chuan genetic test bik neih a ngai a ni. Hei hi thisen sample lak atanga tih a ni. Amaherawhchu, doctor pakhatin he test hi ti turin mi zawng zawng a hrilh lo. A tlangpuiin doctor chuan hei hi a ringhlel a, a hnuaia thil awmte hi test turin a ti thin:

• Thisen zam vawi khat aia tam i neih tawh chuan.
• Naupan laia thisen zam i neih chuan, i hrisel a, natna dang i neih loh chuan.
• I chhungte zinga i chhungte hnai tak (nu, pa, unau) hian hetiang thisen zam harsatna hi a neih chuan.

Engtin nge enkawl a nih?

Hetah hian point chiang tak pahnih kan sawi a ngai a ni. 1. Genetic mutations enkawl dan: Tuna medical science atanga kan hmuh dan chuan kan genes enkawl dan tur leh tihdanglam dan tur a awm lo. Chumi awmzia chu Prothrombin Gene Mutation chu i dam chhung zawng i bulah a awm dawn tihna a ni. 2. Thisen zam enkawlna: Mahse, he gene avanga thisen zam awm theihna hi kan thunun thei a, thisen zam lo awm tawh chu kan enkawl thei a ni DVT emaw PE emaw i neih chuan i doctor chuan thisen zam (blood thinners kan tih tlangpui) venna damdawi chi khat pein enkawlna a tan fo ang. Damdawi lam hawi chuan hengte hi anticoagulants an ti a. Emergency dinhmun thenkhatah chuan thrombolytics an tih damdawi chu injection hmangin thisen zam chu a tithianghlim a, a paih chhuak thin. A tlem hle a, catheter emaw surgery emaw hmangin thisen zam chu lakchhuah theih a ni. Enkawl hun chhung hi mi hrang hrangah a inang lo. Mi thenkhat tan chuan thla thum vel damdawi ei hi a tawk. Mi dangte chuan an dam chhung zawng thisen tithianghlimtu damdawi an ei a ngai mai thei. I doctor chuan i dinhmun leh i risk factors a zirin chu thutlukna chu a siam ang.

Hetiang dinhmun hian naupai hi engtin nge a nghawng?

Hei hi hmeichhe tam tak tan chuan thil pawimawh tak a ni.

• If you have this Prothrombin Gene Mutation and have had a blood clot in the past , i doctor chuan i naupai chhung zawng leh i naute pian hnu kar engemaw zat chhung chu nitin thisen tithianghlimtu (heparin ang chi) dose tlem (preventive) ei turin a rawt thei ang. Heng injection chi hrang hrang hi i naute tan a pawi lo.
• Mahse, he gene hi nei mah la, i nunah thisen zam i la nei ngai lo a nih chuan , naupai lai hian enkawlna engmah i mamawh lo tlangpui.

Engtikah nge doctor i hmuh ang?

Hei hi a pawimawh hle. A natna lan chhuah dan hriat a, hma lak hmasak hian natna khirh tak tak a veng thei a ni. A tawp berah chuan Prothrombin Gene Mutation i nei tih i hriat chuan hlauthawng suh. He gene nei mi tam zawk hian harsatna nei lovin nun hrisel tak an hmang thei tih hre reng ang che. A pawimawh ber chu hei hi hriat chian a, risk factors (zuk leh hmuam, thau lutuk ang chi) laka inthiarfihlim a, nun hrisel taka nun a, thisen zam chhinchhiahna i neih chuan damdawi lam thurawn la nghal a ni. Prothrombin Gene Mutation, Factor II mutation, Thisen zam, Deep Vein Thrombosis, Pulmonary Embolism, DVT, PE, Genetic natna, Thisen tithianghlimtu, Anticoagulants