"Aw, chu tlangval chuan thisen a chhuak nghal a ni," tih hi i hre tawh ngei ang. A nih loh leh nangmah ngei pawh i ke chu a lo hring chhuak nghal a, i na tawh ngai em? Vawiin hian ‘Thrombophilia’ tih natna pakhat, a chang chuan hetiang thil hi a thlen thei tih kan sawi dawn a ni. He hming i hriat hian hlau suh, hei hi mi tam takin an neih theih tur condition a ni. Chuvang chuan fimkhur a pawimawh hle.
A awlsam zawngin, Thrombophilia hi eng nge ni?
Thrombophilia hi thisen pangngai aia awlsam zawk leh rang zawka i thisen a inzawm khawmna a ni. Hei hi Doctor-te chuan ‘hypercoagulable’ condition an ti a. Chumi awmzia chu i thisen hian clot theihna a tipung tihna a ni. Hei hi genetic emaw acquired emaw pawh a ni thei. Tunah chuan chemte hmanga i kut i tan chuan eng nge thleng tih han ngaihtuah teh? Thisen tlem a bo a, rei vak lo hnuah chu hmunah chuan thisen zam a lo awm a, thisen chhuah chu a reh ta a ni. A nihna takah chuan kan taksaah hian venhimna a ni. Hliam a dam hnuah taksain thisen zam chu a tithianghlim leh a, a paih chhuak leh thin. Mahse Thrombophilia vei chungah thil dang a thleng leh thin. Taksain a mamawh loh lai pawhin thisen zam chu thisen zam (veins) ah a lo awm thin. A nih loh leh, thisen zam lo awmte chu a hmin lo va, a chhuak tha lo. Buaina lian tak chu heng thisen zamte hi thisen kalna kawng hrang hranga kal a, taksa peng pawimawh tak panna thisen kalna kawng pakhat a tihkhawtlai hian a ni. A chhan chu kan taksaa cell tin hian thisen a\angin an mamawh oxygen an hmu \hin. Artery pakhat a block chuan oxygen a phur thei lo. Hei hian
heart attack leh stroke ang chi natna khirh tak tak a thlen thei a ni .
Thrombophilia hi chi hnih a awm a, chungte chu:
Kan sawi tawh ang khan he dinhmun hi a lo awm dan a zirin chi hnih lian takah then theih a ni. 1.
Acquired Thrombophilia: Hei hi a tam ber a ni. Rochun thil a ni lo. Damdawi thenkhat kan ei vang te, kan nun dan te, natna dang vang te pawh a ni thei. Heng zinga a tam ber leh na ber chu
Antiphospholipid Syndrome a ni . 2.
Inherited Thrombophilia (Genetic/Inherited Thrombophilia): Hei hi i nu, i pa emaw, an pahnih atanga i hmuh thin genetic condition a ni. Kan taksaah hian thisen zam control tu protein a awm a. Heng genetic changes avang hian chu protein te chuan hna a thawk tha lo mai thei. A nih loh leh taksain thisen zam titawptu protein a siam tlem thei bawk.
Kum 40 i tlin hmaa thisen zam i nei tawh a, nau pai vawi engemaw zat i nei tawh a nih chuan , emaw, i chhungte zinga mi pakhatin thisen zam a neih tawh chuan, he inherited thrombophilia hi i nei ve thei bawk.
Congenital thrombophilia hi eng subtype nge awm?
He genetic condition hi chi hrang hrang a awm a. A chi hrang hrang thenkhat han thlir ila.
| Genetic Thrombophilia chi hrang hrang | A chungchang sawifiahna awlsam tak |
|---|
| Factor V Leiden Thrombophilia natna a ni | Hei hi genetic variant zingah chuan a tam ber a ni. Mipui 1% atanga 5% vel a nghawng a ni. Ke ruh thuk takah thisen zam (Deep Vein Thrombosis - DVT) a vawi khatna atan thisen zam a awm theihna a tipung a ni. |
| Prothrombin Thrombophilia natna a awm | Hei hi chi hnihna a ni. Pulmonary embolism, DVT, leh nau pai theihna a sang zawk. |
| Protein C tlakchhamna | Hei hi a tlem deuh. Thisen zam nawn leh theihna a sang hle. Hetiang dinhmun hi nu leh pa pahnih atanga rochun a nih chuan nunna atana hlauhawm pawh a ni thei. |
| Protein S tlakchhamna | Hei pawh hi a tlem hle. A tlem zawk (nu leh pa pahnih atanga rochun) chuan nau piang tharte thisen zam (blood clotting problem) nunna atana hlauhawm tak a thlen thei a ni. |
| Antithrombin tlakchhamna a awm | Hei hi a tlem hle bawk (mi 500 atanga 5,000 zinga 1-ah a thleng thin). Mahse he natna vei te hi genetic condition dang nei te aiin thisen zam (blood clots) an neih theihna chance a sang zawk hle. Hetiang natna vei zinga 80% aia tam chuan kum 50 an tlin chuan thisen zam vawi khat tal an nei ang. |
Thisen zam natna lanchhuahna chu engte nge ni?
A tam zawkah chuan thrombophilia i vei tih pawh i hre lo mai thei. Buaina hi thisen zam (blood clot) a lo awm a, symptoms a lo lang chauhvin a lo awm thin. Heng symptoms te hi clot siamna hmun a zirin a inang lo.
| Taksa peng pakhat | Symptoms beisei tur a awm |
|---|
| Thluak | |
| Thinlung | |
| Chuap | |
| Ke emaw Arm emaw | - A lo hring chhuak nghal
- Natna nasa tak a nei
- A khawih pawhin a lum tih hriat
|
| Dul | |
Thrombophilia vei chhan leh a hlauhawmna te chu engte nge ni?
Genetic cause bakah hian chhan dang tam tak leh risk factor tam tak hian thrombophilia a thlen thei a, thisen zam a tipung thei bawk.
A chhan ber chu:
- Antiphospholipid Syndrome natna a ni
- Thisen natna hmuh tur awm lo, Disseminated Intravascular Coagulation (DIC) a ni
- Hepatitis natna a ni
- HIV hrik kai
- Liver natna
Risk tipungtu thilte:
- Thau lutuk: Thau lutuk hi thisen zam thlentu lian ber a ni.
- Naupai: Naupai laiin taksaa hormone inthlak danglamna hian a pianphungah thisen a tikhawlo duhna a tipung a ni.
- Zuk leh hmuam hman dan: Meizial zuk hian thisen kalna kawng a tichhe a, thisen zam a siam awlsam phah bawk.
- Natna dang: Diabetes, cancer, thinlung natna, leh atherosclerosis ang chi dinhmun.
- Hun rei tak dinhmun inang reng reng: Operation hnua damdawi ina kan awm lai te, thlawhna emaw bus-a rei tak kan kal lai te, hnathawhna hmuna ṭhut lai te hian kea thisen kal dan a tlahniam thei a, thisen zam a lo awm thei bawk.
- Surgery neih mek a ni.
- Naupai venna pill emaw hormone replacement therapy (HRT) hormone estrogen awmna ei.
- Chhungkaw history-a thisen zam nei.
- Kum upa lam.
- Nau pai chhan hmuh theih loh.
- Kum 40 an tlin hmaa thisen zam vawi khat aia tam neih.
Heng risk factor pakhat emaw a aia tam emaw i neih vang mai mai hian thisen zam i nei dawn tihna a ni lo tih hre reng ang che. Mahse, anmahni hriat chian a, doctor thurawn zawm a pawimawh.
Engtin nge he natna hi ka neih leh neih loh ka hriat theih ang?
Thisen zam i neih a, enkawl mek i nih chuan i doctor chuan thrombophilia a ringhlel mai thei. Hemi hnu hian test eng emaw zat an kalpui ang a, an dinhmun an finfiah ang.
- I damdawi lam chanchin: Tun hmaa thisen zam awm tawhte, i chhungte zingah tu emaw chuan an nei tawh em tih emaw, nau pai tawh em tih emaw zawhna i dawng ang.
- Physical Exam: Thisen zam vanga a hring leh na a awm leh awm loh enfiah thin.
- Thisen Test: Thisen test bik hi genetic condition emaw, protein tlakchhamna dang emaw, thrombophilia thlentu te enfiah nan an ti thin.
- Test dang: Thisen zam awmna hmun dik tak hriat tumin ultrasound scan, CT scan , emaw angiogram ang chi test te pawh tih theih a ni.
He test hi tute nge ti tur?
Heng test te hi mi zawng zawng tan tih a ni tlangpui lo. I doctor chuan a hnuaia thil awm danah hian heng test te hi a order thei ang:
- Kum 50 i tlin hmaa thisen zam i neih chuan.
- I chhungkuaa mi engemaw zatin thisen zam an neih tawh chuan.
- Risk factor chiang tak awm lovin thisen zam a lo awm a nih chuan.
- Hmun danglam tak (e.g., kut, pum)-ah thisen zam a lo awm chuan.
- Nau pai fo thin i nih chuan.
- I chhungte chu hlauhawmah an awm em tih hriat i duh chuan.
Thrombophilia enkawl dan tur chu engte nge ni?
Congenital thrombophilia hi damdawi a awm lo. Mahse
a enkawl tha thei a, thisen zam a veng thei a, nun pangngai a hmang thei bawk. Enkawl dan tur chu thrombophilia i neih chi hrang hrang, thisen zam a lo awm leh awm loh leh i natna nasat danah a innghat a ni.
- Anticoagulants: Hengte hi a enkawlna ber a ni. Heng damdawi te hian thisen zam thar lo awm tur venna leh thisen zam awm tawhte lo thang chak lohna hmangin hna an thawk a ni. Heparin leh Warfarin te hi damdawi hlui zawk an ni. Tunah chuan damdawi thar zawk, ei awlsam zawk a awm ta. Mi thenkhat chuan dam chhung zawngin heng damdawi te hi an ei a ngai mai thei.
- Thrombolytics: Hengte hi emergency leh case na tak takah chauh hman a ni. Entirnan, lung chhunga thisen zam lian tak chu nunna atana hlauhawm a nih chuan, heng damdawi te hi thisen zam chu rang taka tihthianghlim nan thisen kaltlangin pek theih a ni.
- Compression Stockings: I doctor chuan heng stocking chi hrang hrangte hi vuah turin a fuih mai thei che a, chu chuan a hring tihziaawmna tur leh thisen kal tha a neih theih nan a ti thei a, a bik takin an kea thisen zam nei tan chuan.
- Surgery: A tlem hle a, thisen zam lian tak chu damdawi hmanga tihthianghlim theih a nih loh chuan paih chhuah nan operation neih a ngai mai thei.
Risk tihtlem nan thil kan tih theihte
Thrombophilia i vei tih i hriat chuan, emaw thisen zam vei theihna i nei a nih chuan i nunphung thlak danglam a pawimawh hle.
- Meizial zuk loh vek tur a ni.
- Taksa rihna hrisel tak vawng reng rawh.
- Exercise neih fo thin ang che. Kea kal ang chi thil awlsam tak pawh hi nitin tih tur tha tak a ni.
- Khualzin thui takah: Vanlawng emaw bus emaw-a rei tak i zin chuan darkar hnih emaw darkar hnih emaw danah tho la, tlem tal kal kual la, i ke kha ti nghing rawh.
- Operation zawhah: Khum atangin tho la, doctor-in a phal veleh kal tan rawh.
- Estrogen awmna damdawi: Estrogen awmna damdawi, naupai venna pill ang chi i ei a nih chuan he hlauhawmna hi i doctor nen sawiho rawh. I tan a danglamna tur remchang tak a rawn rawt thei ang che.
- Doctor thurawn: Thisen tihthianghlimna damdawi i ei a nih chuan a hun takah leh a dose dik takah ei thin ang che. Doctor rawn hmasa lovin damdawi ei kha bansan ngai suh.
Doctor hmuh hun tur
Thrombophilia i vei a nih chuan doctor nena inbiak reng a pawimawh a, symptom a lo lang a nih chuan rang taka hmalak a pawimawh bawk.
Damdawi lam thurawn lak hun: Doctor hmu emaw,
damdawi in Emergency Treatment Unit (ETU) pan nghal emaw. - Ke emaw kut emaw a hring thar, na emaw, a sen emaw.
- Thisen chhuah dan pangngai lo, hnar thisen chhuak, zun emaw ek emaw a thisen chhuak, thisen tithianghlimtu damdawi avanga thisen chhuak.
- I dinhmun chungchangah rinhlelhna emaw zawhna emaw i neih chuan.
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- Thinlung natna nasa tak emaw thawk harsat thut (hengte hi heart attack emaw pulmonary embolism emaw chhinchhiahna a ni thei).
- Lu na tak tak, tawng harsa, taksa sir khata chak lohna (hengte hi stroke chhinchhiahna a ni thei).
- Cut avanga thisen chhuak rit tak, chhunzawm zel.
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Take-Home Thuchah a ni
- Thrombophilia hi a tlangpui aia awlsam leh rang zawka thisen zam a ni. Hei hi pian tirh laia awm emaw, nakin lawka lo thanglian zel emaw pawh a ni thei.
- Hetiang natna vei tam tak hi thisen zam engmah nei lovin an nung thin. Vein chhungah thisen zam a lo awm a, thisen kal a tikhawlo a nih chauhvin symptoms a awm thin.
- Thisen zam hi thluak, thinlung, lung, ke-ah a lo awm a nih chuan a na hle thei a, chuvangin a natna lan chhuah dan hriat a pawimawh hle.
- He natna hi tihdam kim theih ni lo mah se, doctor-in a tih angin damdawi ei leh nunphung hrisel tak zawm hian a enkawl tha thei a, a hlauhawmna pawh a ti tlem thei bawk.
Thrombophilia, thisen zam, DVT, pulmonary embolism, thrombosis, thisen zam, thisen tithianghlimtu
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