Kan taksa thisen sang control tu super system (Renin-Angiotensin-Aldosterone System - RAAS) .

I doctor-in i thisen sang chungchang a sawi tawh a, emaw, i thisen sang damdawi i ei dan a sawifiah tawh chuan ACE inhibitor leh ARB tih ang chi hming i hre tawh mai thei. Vawiin hian heng zawng zawng hnuaia system awm, kan thisen sang tidanglam rengtu, kan taksa chhunga super management team ang maia awm chu kan sawi dawn a ni. Hei hi Renin-Angiotensin-Aldosterone System, a tawi zawngin RAAS kan ti a. A hming hi a buaithlak deuhin a lang thei a, mahse a hnathawh hi a awlsam hle a, a pawimawh hle bawk.

A awlsam zawngin RAAS chu eng nge ni?

I taksa hian i thisen sang enkawl rengtu leh a hniam lutuk chuan rang taka chhang let thei tur defense system a nei ang tih han ngaihtuah teh. Chu chu RAAS chu a ni. Hormone, enzyme leh protein te inzawmkhawm a ni. He system hian a tum ber chu hun rei tak chhunga kan thisen sang leh thisen volume control a nih theih nan a ni.

He system hian kan pressure tihpunna kawngah kawng pawimawh pathum a pui a:

• Kidney-in sodium (salt) a reabsorption tihpun: Taksa chhunga chi (salt) a san chuan tui pawh taksaah a awm reng bawk.
• Tui reabsorption (retention) tihpun): Hei hian taksaa thisen volume a tipung a.
• Vascular tone: Kan thisen kalna kawng a tihkhauh . Tui pipe hrual hian tui a luang chak zawk ang bawkin thisen kalna kawng a inzawm chuan pressure a sang chho thin.

He super team-ah hian player pawimawh pathum an awm. Anmahni hi i hrechiang ang u.

He RAAS system hian engtin nge hna a thawh?

Hei hi chain reaction ang mai a ni. Thil pakhat a lo thlen chuan thil dang a tichhuak leh thin. Heng step te hi thawnthu awlsam tak angin i hrethiam ang u.

Eng emaw chhan vangin (entir nan, i taksa atanga tui tam tak i hloh tawh - dehydration, emaw, accident tenau takah thisen engemaw zat i hloh tawh emaw) i thisen sang a tlahniam tih han ngaihtuah teh.

1. A chhinchhiahna hmasa ber: I kal (kidney) hi sensor ang mai a ni. Hetianga pressure tlahniam hi an hriat chuan an phur a, thisenah renin an tih enzyme an chhuah tir thin.

2. Lehlin hmasa ber: He renin hian thisen a kal kual rual hian protein pakhat angiotensinogen a tawk a, chu chu kan thin (liver)-ah siamin thisenah a chhuak a ni. Renin hian he protein hi a tichhia a, hormone angiotensin I an siam nan a hmang a, mahse he angiotensin I hi inactive a ni a, chu chu hna tam tak a thawk thei lo tihna a ni.

3. Hruaitu Pian: Tunah chuan he dormant angiotensin I hian thisenah a kal a, a bik takin kan lung chhungah a kal zel a, chutah chuan enzyme bik a awm a. Chu chu Angiotensin-Converting Enzyme (ACE) a ni. He ACE enzyme hian a tih chu chu dormant angiotensin I chu la in, chak tak, active angiotensin II ah a chantir a ni. Tunah chuan hruaitu tak tak a lo piang ta.

4. Hruaitu thupek: Tunah chuan he angiotensin II chak tak hian vawi khatah hna tam tak a thawk mek a ni:

• Kan taksa chhunga thisen kalna kawng te tak te bangah a kal nghal a, tui pipe hrual ang maiin a tikhawtlai a ni . Hei hian thisen sang a tisang nghal vek a ni.
• Kidney chung lama awm adrenal glands-ah a kal nghal a, aldosterone tih hormone siam turin a hrilh a ni.
• Tin, thluaka pituitary gland chu Antidiuretic Hormone (ADH) siam turin signal a pe bawk.

5. A tawpah chuan: Tunah chuan aldosterone leh ADH te hian an thawk dun a, kal te hnenah, " Sodium (salt) leh tui taksa atang hian paih chhuak suh, taksa chhungah dah rawh Chutih rual chuan aldosterone hian taksain a mamawh loh potassium chu zun atangin a paih chhuak thin.

• Taksaah chi a awm reng chuan tui pawh a awm reng bawk.
• Kan taksaa tui a pun chuan kan thisen kalna kawng chhunga thisen awm zawng zawng (thisen volume) a pung a ni.
• Thisen volume a san a, thisen kalna kawng a constrict chuan thisen sang chu automatic-in a normal level-ah a sang leh ta a ni.

He RAAS system leh heart failure hi eng nge inzawmna?

Hei hi thil pawimawh tak a ni. Thil awmdan pangngaiah chuan RAAS system hian kan nunna chhanhim turin a pui thin. Mahse, hun rei tak chhunga heart failure ang chi dinhmunah chuan he system tha tak hian kan chungah hna a thawk tan thin.

Mi pakhat thinlung chu a chak lo va, taksaah thisen a pump tling thei lo ang tih han ngaihtuah teh. Hei hi heart failure kan tih chu a ni.

• Thinlung pump theihna a tlahniam chuan thisen kal (kidney) ang chi taksa peng pawimawh tak takte a thlen zat a tlahniam a ni.
• Kidney-a thisen supply a tlahniam chuan, "Aw, pressure a hniam, buaina lian tak!" Chuvangin kidney te hian rang takin RAAS system chu full capacity ah an activate thin.
• Tichuan taksa chuan angiotensin II leh aldosterone a siam tam lutuk a . Chungte chuan thisen sang a tisang a, taksaah chi leh tui a vawng reng thin.
• Mahse hetah hian buaina chu he pressure sang leh thisen volume sang hi thinlung chak lo leh chak lo tawh chungah phurrit lian zawk a lo ni ta a ni. Bungraw rit phur thei lo chunga rit dang dah ang mai a ni.
• Hun kal zelah he extra strain hnuaia thinlung hi dah a nih chuan thinlung chu a chak lo va, thinlung ruh chu a thim a, thinlung chu a lian ta a ni. Hei hian heart failure a tizual a ni.

RAAS system tichhe thei damdawi te

Thisen sang leh thinlung natna damdawi lian engemaw zat chuan he RAAS system-a step hrang hrangte hi a tikhawlo a ni.

RAAS leh Baroreceptor Reflex hi eng nge an danglamna?

Thisen sang control tu system dang chu Baroreceptor reflex a ni . An pahnih inthlauhna hi i hrethiam mai ang u.

• Baroreceptor Reflex: Hei hi system a ni a , second tlemte chhungin a thawk nghal vek a ni . I ṭhu a, chutah rang takin i ding chhuak ang tih han ngaihtuah teh. Tichuan pressure a tlahniam deuh a. Chutih lai chuan lu-a thisen kal chu a tlahniam a, i luak chhuak thei bawk. Mahse, chutiang chu a thleng lo a ni lawm ni? A chhan chu Baroreceptor reflex vang a ni. Second tlemte chhung chu heart rate a tisang a, thisen kalna kawng a tikhawlo deuh a, pressure a siamrem bawk. Car shock absorber ang mai a ni a, thil danglam nghal mai chu a thunun thei a ni.
• RAAS system: Hei hi hun rei tak chhunga hman theih , eng emaw chen slow system a ni. Hnathawh tur hian darkar tam tak, ni tam tak pawh a ngai a ni. Taksa chhunga tui leh chi awm zat thlak danglamin hun rei tak chhung thisen sang a control thin. Car chhunga engine management system ang mai a ni a, hun rei tak chhunga performance enin a awm.

Heng system pahnih hian kan thisen sang chu hrisel taka a awm theih nan an thawk dun a ni.