SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion) tih hi eng nge ni? A awlsam zawngin sawi ila!

Kan taksaa tui awm zat hi a thunun mai ni lovin, hormone bik pakhatin a pui tih i ngaihtuah ngai em? Dik tak chuan kan taksaa tui leh chi (i.e. sodium) awm zat dik taka awm theihna tura puitu mechanism mak tak a awm a. Hemi atana puitu ber chu hormone `ADH` a ni. Mahse, a chang chuan he `ADH` hormone hi kan taksaah a lo pung tam lutuk tan chuan harsatna tenau te a lo awm thei a ni. Chu chu vawiin a kan sawi tur dinhmun chu a ni, `SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion)`. A hming hi sei deuhin lang mahse, awlsam takin i hrethiam ang u.

SIADH hi eng nge ni tak tak?

A awlsam zawngin sawi ila, SIADH hi i taksain hormone `Antidiuretic Hormone (ADH) a siam tam lutuk, a nih loh leh a dik lo taka a siam chhuah theihna a ni. He `ADH` hormone hi `Vasopressin` an ti bawk. He `ADH` hormone hi kan thluaka hypothalamus ah siam a ni. Chumi hnuah chuan posterior pituitary gland -ah dahin, a tul hunah taksaah a chhuak leh thin. Tunah chuan he `ADH` hormone hian kan taksaah eng thil pawimawh nge a puih tih hi han en ila:

• Kan thisena tui leh sodium ( chi ) awm zat inthlauhna vawng reng.
• Thisen sang control nan a pui thin .
• Kidney hnathawh thatna tur a pui thin.

A awlsam zawka sawi chuan hormone `ADH` hian i kal (kidney)-in i zun atanga tui a paih chhuah zat a control a ni. `SIADH` chungchangah chuan he `ADH` hormone tam lutuk avang hian i taksa hian tui a vawng tam tan thin. Chumi rah chhuah ber chu i thisenah sodium (salt) level a tlahniam a ni. Damdawi lam hawi chuan hei hi `Hyponatremia` kan ti a.

SIADH hian tute nge a nghawng tam ber?

Dik tak chuan tu pawhin `SIADH` an nei thei. Mahse, kum upat deuh deuh hian he natna hi a vei theihna a sang chho zel a ni. A tlangpuiin, he `SIADH` an tih hi a tam ber chu:

• Damdawi in-a zai atanga dam lehte zingah hian operation hnua tui pek te, damdawi thenkhat, leh taksain natna leh lungkhamna a dawn dan avang te hian a thleng thei a ni.
• Lung cancer vei zingah, a bik takin ``Small Cell Lung Cancer ( SCLC )'' tih chi khat nei zingah.

Hetiang dinhmun hi engtiang chiahin nge SIADH tia koh a nih?

`SIADH` hi a awm fo thin. A hmaa kan sawi tawh `Hyponatremia` (thisenah sodium tlem) hi damdawi ina awm damlote zingah `Electrolyte` imbalance hmuh tam ber a ni. `SIADH` hi `Hyponatremia` thlentu ber a ni.

Engtin nge SIADH hian hyponatremia a thlen?

I tuihal hle tih han ngaihtuah teh. I taksa hian eng nge a tih? Taksa chu hormone `ADH` chhuah tir turin signal a pe a ni. Tichuan, kal (kidney) hian zun atanga tui chhuak chu a ti tlem a, chu tui chu taksa chuan a vawng reng a ni. Tui i in hian i tuihalna a reh chuan taksain `ADH` a chhuah tawh lo va, kal (kidney) chuan zunah tui a chhuah leh tan a, a pangngaiin a chhuak leh ta a ni. Hei hi thil kalphung pangngai a ni. Amaherawhchu `SIADH` vei tam takah chuan tui in hnuah pawh hormone `ADH` tihchhuah hi a tlahniam tha tawk lo. Chuvangin an zun chu a concentrate hle (tui tlem leh bawlhhlawh tam tihna a ni). Hei hian taksaah tui a khawlkhawm thin. He tui hi a lo awm khawm chuan thisena sodium ang chi thilte chu a diluted ta a ni. Chu chu thisenah sodium level a tlahniam a, chu chu `Hyponatremia` an ti a ni. `SIADH` thenkhatah chuan taksain tui a tam lutuk chuan kal (kidney) te chu zun atanga chi (sodium) tam lutuk chhuah tir turin signal a awm thin. Hei hi `hyponatremia` thlentu dang a ni bawk.

SIADH natna lan chhuah dante chu engte nge ni?

`SIADH` i neih chuan i zun chu a concentrate hle. Chumi awmzia chu bawlhhlawh a tam lutuk a, tui a tlem lutuk tihna a ni. I taksain a tlangpuiin zun hmanga tui a paih chhuah loh avangin i thisena tui awm zat chu a pung zel a ni. Hei hian i thisenah sodium ang chi thil a ti dilute a ni.

Thisena sodium level hniam (hyponatremia) hi SIADH natna lan chhuah chhan ber a ni.

A tam zawkah chuan sodium level hniam deuh pawhin symptom lian tham a thlen lo. Mahse, sodium level a hniam lutuk emaw, a hniam lutuk emaw a nih chuan heng ang symptoms hi a awm thei a ni:

• Muscle twitching emaw chak lohna emaw. I ke chu a hrual mai mai ang maia i hriat kha han mitthla teh.
• Nausea leh luak chhuak .
• Lu na .
• Balance lama harsatna, a chang chuan tlu thei.
• Rilru lama inthlak danglamna, ngaihtuahna seng harsa, hriatrengna hloh, leh/ emaw nungchang mak tak tak te.
• A nasat chuan seizure emaw coma emaw a awm thei.

SIADH awm chhante chu engte nge ni?

A tam zawkah chuan SIADH hi damdawi lam thil dang vang a ni. Hereditary SIADH (chu chu thlah kal zelah a kal zel tihna) hi a tlem hle.Kidney-a `Vasopressin 2 (V2) receptor`-a gene mutation vang a ni. `SIADH` lo awm chhan fotu dinhmun leh chhan thenkhat chu hetiang hi a ni:

• Cancer chi thenkhat: Tumor thenkhat chuan anmahni ADH hormone an siam chhuak thei. Hei hian taksaah ADH tam lutuk a thlen thei a, SIADH a thlen thei a ni. Small cell lung cancer (SCLC) hi cancer chi hrang hrang zingah hetianga ADH siam chhuaktu tam ber a ni. Tin, cancer te, lung pawn lama lo awm small cell carcinoma te, lu leh kawng cancer te, olfactory neuroblastomas te pawh hian SIADH a thlen thei bawk.
• Central Nervous System (CNS) lama harsatna: Kan central nervous system hi thluak leh ruhro atanga siam a ni. He system-a thil dik lo eng pawh, stroke, thluaka thisen chhuah, natna kai, hliam, emaw, a tlem berah chuan rilru lam natna (psychosis) te hi SIADH a thlen thei a ni.
• Damdawi thenkhat: Damdawi thenkhat hian hormone `ADH` release emaw activity emaw a tipung thei. Chuvangin `SIADH` a lo thleng thei a ni. Entîr nân, epilepsy damdawi ṭhenkhat, lungngaihna damdawi, cancer damdawi, leh lung natna, zunthlum, leh thisen sang damdawi ṭhenkhat.
• Anesthesia hnuaia surgery: SIADH hi surgery nen a inzawm thei. Hei hi taksain rilru leh taksa lama harsatna a tawh vang pawh a ni thei.
• Lung natna: Lung natna, a bik takin pneumonia (virus, bacteria, tuberculosis avanga lo awm) hian SIADH a thlen thei. Zirchiangtute chuan hetiang thil hi a thlen chhan an la hre chiang lo.
• Hormone tlakchhamna: `Hypopituitarism` (underactive pituitary gland) leh `Hypothyroidism` (underactive thyroid gland) an tih hian `SIADH` a thlen thei a ni.

Engtin nge SIADH hi hmuhchhuah a nih?

Hyponatremia (thisenah sodium tlem) symptom i neih chuan i doctor chuan taksa enfiahna kimchang a ti ang. I fluid status pawh an check bawk ang. Hei hi diagnosis dik tak siam nan a pawimawh hle. I dehydrated, overhydrated, a dik chiah em tih an enfiah ang. SIADH hriat theihna tur test tha ber pakhat mah a awm lo. I thisena ADH level enfiah thei test awm mahse, result a lo chhuah leh theih nan kar hnih vel a ngai thei. Chuvangin, i doctor chuan hyponatremia enfiah nan test dang a ti mai thei a, chu chu:

• Metabolic Panel (CMP) hmanga siam a ni.
• Thisen osmolality test a ni.
• Zun Osmolality Test a ni.
• Zun sodium leh potassium test.
• Damdawi thenkhat tan Toxicology Screens a awm.

I fain SIADH symptoms a neih chuan doctor chuan lung leh thluak imaging test (e.g., scan) neih a ti thei ang.

SIADH hi engtin nge enkawl a nih?

SIADH enkawl dan chu a chhanah a innghat. Entirnan, ADH siamtu tumor i neih chuan i doctor chuan operation tihchhuah a rawt thei ang. He natna hi damdawi avanga lo awm a nih chuan i doctor chuan damdawi dose a thlak thei a, damdawi dang a pe thei bawk. SIADH vei zawng zawngah hian a hmasa ber chu tui i in zat tihtlem hi a ni. Hei hian i taksain tui a vawn tam lutuk loh nan a pui a ni. I doctor chuan nitin tui i in tur zat (tui, coffee, tea leh sugary drinks te pawh tel) a hrilh ang che. Hyponatremia symptom na tak tak (confusion, seizures ang chi) i neih chuan medical emergency a ni. Hei hi damdawi inah saline (IV hmanga pek chhuah chi solution) vein-a pek hmanga enkawl a ni tlangpui. I kal (kidney)-a ADH hormone-in nghawng a neih loh nan damdawi i mamawh thei bawk. Tichuan kidney te hian signal an dawng a, taksaa tui tam lutuk chu zun hmangin an paih chhuak tan ta a ni.

SIADH hi ven theih a ni em?

`SIADH` awm chhan tam tak a awm avangin ven a harsa tlangpui. `SIADH` emaw `hyponatremia` emaw i vei thei tih i ngaihtuah chuan doctor nen inbia ang che.

SIADH hi eng prognosis nge ni?

SIADH hmalam hun chu a chhan bulpuiah a innghat a ni. Thu lawmawm tak chu SIADH thlentu tam tak hi tihdanglam theih leh/ emaw enkawl theih a ni. Acute hyponatremia, darkar 48 aia rei lova lo awm hi a hlauhawm zawk a, hun kal zelah zawi zawia lo awm thin hyponatremia aiin a hlauhawm zawk. Chronic hyponatremia hi thluak lam harsatna (e.g., balance hloh, hriatrengna hloh) nen a inzawm a ni. SIADH a nasat a, thisena sodium level a tlahniam lutuk chuan a hnuaia mi hi a thleng thei a ni:

• Thil hriatna hloh, hallucinations, emaw coma emaw.
• Thluak Herniation a awm.
• Thihna.

SIADH chungchangah engtikah nge doctor i hmuh ang?

Hyponatremia symptoms, muscle cramps leh balance problems te i neih chuan doctor nen inbia ang che. Heng symptoms te hi chhan hrang hrang a awm theih avangin i doctor hian test hrang hrang a nei ngei ang.

Hyponatremia na tak symptoms, confusion, delirium, seizures i neih chuan a rang thei ang bera damdawi in hnai ber pan rawh.

SIADH hi natna tlanglawn tak a ni a, a chhan hrang hrang a nei thei bawk. Damdawi ina awm tawhte a nghawng fo thin. Amaherawhchu, SIADH natna lanchhuahna, rilru hahna emaw, rilru lam inthlak danglamna emaw i neih chuan doctor nena inbiakna neih a pawimawh.

Thil pawimawh tak tak hriat reng tur (Take-Home Message) .

Okay, chuvangin tunah chuan vawiin a kan sawi `SIADH` hi in hriatthiam ka beisei.

• `SIADH` hi taksain tui a vawng reng a, hormone `ADH` a siam chhuah tam lutuk avangin thisenah sodium a tihtlem phah a ni.
• Hei hi chhan tam tak a awm thei a; thil cancer, damdawi thenkhat, surgery, lung natna, etc. ang chi te.
• A lan chhuah dan chu rilru hahna, luak chhuak, luak chhuak, leh rilru lam inthlak danglamna te a ni thei . A nasat chuan seizure leh hriatna hloh a awm thei.
• Enkawlnaah chuan tui control te, a chhan enkawl te, leh a tul chuan saline emaw damdawi emaw pek te pawh a tel thei .
• A pawimawh ber chu, heng symptoms te hi i neih chuan hlauthawng suh la, doctor thurawn la nghal rawh. Chutiang chuan thil dik lo dik tak chu i hre thei ang a, a tul anga enkawlna chu i tan thei ang.

I hriselna enkawl hi a pawimawh ber a ni. Chuvang chuan hetiang thil hi fimkhur a pawimawh em em a ni. SIADH, Antidiuretic Hormone, ADH, Hyponatremia, Vasopressin, Sodium, Hormone inthlauhna te a ni