Tarpeyo, kal natna damdawi IgA Nephropathy tih hi i hre vek ang u.

Kan taksa peng pawimawh ber pakhat chu kal (kidney) hi a ni. Mahse a chang chuan kan taksa hriselna (immune system) inthlak danglamna hian kal (kidney) a tichhe thei a ni. Chutiang dinhmun pakhat chu primary immunoglobulin A nephropathy, a nih loh leh IgA nephropathy mai a ni. Hemiah hian antibody IgA an tih chu kal (kidney)-ah a awm khawm a, chu chuan a ti hring a, hna a thawk tha lo. Vawiin hian he natna chungchang leh a natna atana damdawi bik Tarpeyo an tih chu kan sawi dawn a ni.

Engtin nge damdawi Tarpeyo hian hna a thawh?

A awlsam zawngin sawi ila, IgA Nephropathy hi kan taksain IgA antibodies (IgA1) pangngai lo a siam tan atang hian a intan thin. A tlangpuiin antibodies hi kan immune system sentinels ang mai a ni. Bacteria leh virus ang chi thil lakah min venghim a ni. Mahse he natnaah hian IgA antibodies siamchhuahnaah hian chhiatna tenau tak a awm a. Heng antibody chhia te hi an inzawm khawm a, clump lian tak tak an siam thin. Kan immune system hian heng clump te hi hmelma ang maiin a en thin. Chuvangin, immune system chuan heng clumps te hi a do tan ta a ni. He indona hi kal chhungah a thleng thin. Hei hian kal chhunga filtering unit nalh tak tak, glomeruli an tihah inflammation a siam thin. Hun a kal zel a, he inflammation hian chutiang hmunah chuan hliam a siam a, kal (kidney) a tichhia a ni. He natna vei hian a tir lamah chuan lungawi lohna a nei tam lo mai thei. Mahse, hun kal zelah chuan kal (kidney) tihchhiat vangin heng natna lan chhuah dan hi a lo lang thei a ni. Doctor ten he natna hi an enkawl tlangpui a, thisen sang ang chi symptoms control-in, immune system control thei damdawi an pe bawk. Hei hian damdawi, immunosuppressant leh corticosteroid te pawh a huam tel a ni. Mahse, heng damdawi hman tlanglawn tak takte hian hun rei tak ei a nih chuan duh loh zawng tam tak a nei thei a ni. Hetah hian damdawi Tarpeyo hi a lo lut a, Tarpeyo pawh hi corticosteroid a ni a, mahse a specialty chu harsatna nei IgA antibodies siamna hmun ngeiah a kal a ni. Antibodies te hi kan intestine hmun bik ileum an tih ah siam a ni. Tarpeyo chu chutah chuan direct-in a kal a, he IgA1 dik lo siam chhuah hi a ti tlem a ni. Chuvangin, kal (kidney)-a inflammation leh tihchhiatna a tlahniam a, steroid damdawi hman tlanglawn tak takte hian hun rei tak chhunga nghawng a neih thinte pawh a tlahniam bawk.

He damdawi hi engtin nge ka hman ang?

Tarpeyo hi damdawi a ni a, capsule angin a awm a. Zing tin, chaw ei hma darkar khat tal ei tur a ni .

• Damdawi chu tikehsawm suh, chew suh, chil chhe suh. A pumin ei tur a ni.
• He damdawi hi ei lai hian grapefruit ei loh tur leh grapefruit tui in loh tur a ni. A chhan chu nakinah kan sawi leh ang.

Pawimawh tak: Doctor nen inbia lovin he damdawi hi ei khap suh. Tarpeyo ang chi corticosteroid i ei chhunzawm chuan i taksain a pianphung atanga a siam steroid hormone te chu a siam chhuak tawh lo. Damdawi i ei loh thut chuan i taksain steroid a mamawh zat a hloh ang a, withdrawal symptoms i nei thei bawk. Entîr nân, chau lutuk, taksa na, luak chhuak, thisen hniam, leh lu na i nei thei a. Chuvangin, damdawi i ei tawh loh chuan a dose tihtlem (tapering) hmangin zawi zawiin i ei tur a ni. I doctor chuan tih dan dik tak a hrilh ang che.

Engtin nge he damdawi hlawkna hi zirchian a nih?

Tarpeyo hi a him leh him loh enfiah tura zirchianna lian takah chuan placebo nen an khaikhin a. Placebo hi dummy pill a ni a, damdawi a awm lo. Hei hi damdawi tak tak ei leh dummy pill ei thinte inkara danglamna chu eng nge ni tih hriat nan a ni. He zirchiannaa tel zawng zawngte hian IgA nephropathy an nei vek a, an zun-ah protein extra an nei bawk. An vai hian thisen sang damdawi, ACE inhibitor emaw ARB emaw an ei vek bawk a, hei hian kal pressure a tihziaawm a ni. He huna tel turte hi tehfung pahnih hmanga thlan an ni a:

• Urine protein-to-creatinine ratio (UPCR): Hei hian darkar 24 chhunga zun atanga protein chhuak zat a tehna a ni.
• Estimated glomerular filtration rate (eGFR): Hei hian i kal (kidney) hnathawh that leh bawlhhlawh a filter that dan a teh a ni. He zirchiannaa telte hian an kal (kidney function) a tlahniam lo hle a, a tlahniam lo hle.

He zirchiannaah hian group pakhat chu thla 9 chhung Tarpeyo pek an ni a, group dang chu placebo pek an ni bawk. Thla 9 hnuah enkawl an chawlhsan a, thla 15 dang enkawl leh an ni.

Zirna hrang hrangah eng hlawkna nge hmuh chhuah?

He zirchiannaah hian Tarpeyo ei thinte hian placebo ei thinte aiin an kal (kidney damage) an nei tlem zawk tih hmuhchhuah a ni. He hlawkna hi thla 9 chhung damdawi ei hnuah pawh a chhunzawm zel a ni.

Zun chhunga protein level tlahniam

Thla 9 hnuah Tarpeyo ei thinte zun-ah protein level chu 35% in a tlahniam a, placebo ei thinte chu 5% chauh a ni thung. He tihtlem hi thla 24 chhung zet chu an vawng reng a ni.

Kidney hnathawh (eGFR) 1.1.

Thla 24 tawp lamah chuan Tarpeyo ei thinte hian placebo ei thinte aiin an kal hnathawh a tlahniam tlem zawk hle. Positive (+) value chuan kal hnathawh a titha tihna a ni a, negative (-) value chuan a chhe zawk tihna a ni. He zirchianna hian Tarpeyo thla 9 chhung ei hian kal chhiatna a ti hniam thei tih a tarlang. Hei hian symptoms control nan a pui thei a, kidney failure a tikhawtlai thei bawk. Mahse, heng result te hi mi tin a inang lo thei tih hre reng ang che.

Side effects te hi engtin nge kan ven ang leh kan enkawl ang?

Tarpeyo hi damdawi a ni a, immune system a titawp a, chuvangin natna hrik i kai tam zawk. Khawsik, flu, leh zun kawng infection te i vei fo thei. Natna hrik kai theih chickenpox leh measles nei te lakah inthiarfihlim rawh. Infection laka invenna tha ber chu kut sil fo a, damlote laka inthiarfihlim hi a ni. Vaccine lak chungchang hi doctor nen sawiho rawh. Heng natna lanchhuahna te hi i neih chuan doctor ko nghal rawh:

• Khawsik emaw, khawsik emaw
• Taksa natna
• Khuh
• Chauhna nasa tak a awm
• Lu na reng reng
• Mit a inthlak emaw, hriatrengna a tlahniam emaw
• A vuakna hrehawm tak

Tarpeyo hian a hring emaw thisen sang emaw a thlen thei . I doctor nen nunphung hrisel chungchang sawipui la, ei leh in leh exercise te pawh a tel. I ei leh in-a chi (salt) tihtlem te, tui in tam te, leh kea kal ang chi exercise light tak tak tih te hian swelling tihziaawmna leh thisen sang control-na kawngah a pui thei a ni. Side effect langsar dangte chu rilru hahna, pum na, taksa ruh natna, hmai vun, leh lu na te hi a ni . Acne i neih chuan vun enkawl dan tha tak zawm la, chu chu gentler cleanser leh oil-free moisturizer te hi a ni. Hengte hi a side effect awm thei zawng zawng a ni lo. I rilru tibuaitu symptom i neih chuan i doctor nen sawiho rawh.

Damdawi ei lai hian eng test nge tih tur?

I doctor chuan i taksain damdawi a dawn dan tur test hrang hrang a ti ang. Hengte hi a bulpui berte chu an ni:

• Thisen sang tehna a ni
• Urinalysis hmanga zun chhunga protein awm zat enfiah thin
• Kidney function endik nan thisen test neih thin a ni
• Thisen test a, hepatitis B virus a awm leh awm loh enfiah a ni

He damdawi nen hian eng thil dang nge inzawm thei?

Damdawi leh ei tur thenkhat hian Tarpeyo hnathawh dan a nghawng thei a ni. Chuvangin, i damdawi ei zawng zawng (vitamin leh herbal products te pawh tel) doctor hnenah hrilh a pawimawh hle A bik takin a hnuaia mite hi fimkhur hle ang che:

• Antifungal leh antibiotic damdawi thenkhat (e.g., clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral))
• HIV damdawi hman \henkhat
• Grapefruit emaw grapefruit tui emaw

Hei hi list kimchang a nih loh avangin i ei zawng zawng chu doctor hnenah hrilh vek ang che.

He damdawi hi engtin nge i hmuh theih ang tih zawng rawh.

Tarpeyo hi damdawi bik a ni. Hei hian a man a to tihna a ni a, damdawi lam harsatna bik atan hman a ni. Chuvangin damdawi dawr zawng zawngah a awm lo mai thei. A tlangpuiin, he damdawi chi hi damdawi in damdawi dawr emaw, damdawi dawr bik emaw-ah emaw lei theih a ni. I doctor chuan he damdawi hi i hmuh dan tur leh khawi atanga i hmuh dan tur nge a kaihruai ang che. IgA nephropathy, Tarpeyo, kal natna, zun a protein, eGFR, corticosteroid, immune system