Kan thinlungah khawi emaw laiah hlauhna kan nei vek a, kan nu leh pate, emaw, keimahni ngei pawhin kan upat deuh deuh chuan thil kan theihnghilh tan ang. Kan hriatrengna leh ngaihtuahna fim tak neih theihna hloh tur ngaihtuahna hi a hlauhawm tak zet a ni. Tar hi he hriatrengna hloh, a nih loh leh dementia thlentu lian ber a nih laiin, tunah chuan risk factor dang sawi a ni ta. Chu chu natna chi hrang hrang atana kan hman damdawi thenkhatte hi a ni.
Heng anticholinergic damdawi te hi engte nge ni?
A awlsam zawngin anticholinergics hi damdawi chi khat a ni. Belladonna an tih thing atanga siam an ni. He thlai hi a takah chuan dose engemaw zatah toxic a ni thei. Mahse, he thlai chhunga compound te hian kan nervous system hnathawh chu eng emaw chen chu a control thei a, a titawp thei bawk a, chuvangin controlled damdawi siam nan an hmang thin.
Ngaihtuah teh, kan nervous system hi taksa pum puia darh nerve network ang mai a ni. Kan thluak hi a bulpui ber a ni. Chuta tang chuan thupek pekte chu heng nerve cell kaltlangin taksa pum puiah a kal a ni. Kan kalna, ngaihtuahna, thinlung na, thawk, mut leh kan hriatna panga hnathawh dan atanga engkim hi he nervous system hian a thunun vek a ni.
He nervous system kaltlangin thuchah kengtu chemical messenger an awm a. Neurotransmitter kan ti a. Chutiang thuchah pawimawh tak pakhat chu acetylcholine hi a ni. Chuvangin, anticholinergic damdawi te hian an tih chu he messenger acetylcholine an tih hi a block hi a ni. Chumi hmang chuan nervous system hnathawh thenkhat chu control a ni.
Heng damdawi tam tak hi damdawi lam dinhmun enkawlna atan hman a ni.
| Anticholinergic damdawi hman hun tur | |
|---|---|
| Damdawi lam dinhmun tlanglawn tak tak tan | |
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| Surgery neih lai hian | |
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| Poisoning damdawi atan | |
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Damdawi hman tlanglawn thenkhat
Heng damdawi te hi pill, mittui tlakna leh injection angin a awm thin. Entirna thenkhat chu:
- Diphenhydramine: Hei hi allergy enkawlna atana hman thin damdawi chi khat a ni. Sri Lanka damdawi Piriton-ah hian hetiang chiah hian compound chlorpheniramine an ti a. Hengte pawh hi anti-cholinergics class khatah an tel ve bawk.
- Benztropine: Parkinson natna lan chhuahna atan hman a ni.
- Dicycloverine: Pum natna atan hman a ni a, a bik takin Irritable Bowel Syndrome (IBS) ang chi natnaah te hman a ni.
- Oxybutynin: Zun thunun harsa ti thinte hnena damdawi pek thin a ni.
- Hyoscyamine: Pum leh zun ruh natna atan hman a ni.
A awlsam zawngin, dementia chu eng nge ni?
Dementia hi mi pakhat ngaihtuahna, hriatrengna leh thutlukna siam theihna tichhe thei dinhmun hrang hrang sawina hmanraw tlangpui a ni. Kum upa lam zingah a tam ber.
Dementia chi hrang hrang awm mahse, 60% - 80% chu Alzheimer natna vang a ni .
Hetiang dinhmun hian mi pakhat chu a nghawng thei a ni:
- Thil ngaihtuah thiam
- Midang nena inbiakna (inbiakpawhna) .
- Thil dik leh dik lo thlan thiamna (discretionary intelligence) .
- Hriatrengna
- Thil ngaihtuah thiam leh harsatna chinfel thiam
A châng chuan Alzheimer’s ang chi dementia chi hrang hrang hian mi mizia leh nungchangah pawh danglamna a thlen thei a ni.
Tute nge dementia vei theihna sang zawk?
- Kum: Kum upa lam hi a hlauhawm ber a ni.
- Lung natna: Thisen sang, cholesterol sang, leh stroke nei tawhte chu dementia vei an tam zawk.
- Genetics: Chhungkaw hnai tak pakhatin Alzheimer natna a vei tawh a nih chuan i vei theihna chance chu 10% - 30% velin a pung thei.
- Traumatic Brain Injury: Lu hliam na tak emaw, a awm reng emaw pawh hian a hlauhawmna a tipung thei bawk.
Mahse a chang chuan he hriatrengna hloh hi rei lo te chhung atan a ni thei. Damdawi thenkhat, vitamin tlakchhamna leh thyroid hormone inthlauhna te hian hun eng emaw chen hriatrengna a hloh thei bawk.
Chuti a nih chuan he damdawi hian dementia a thlen tak tak em?
Hemi chungchang hi zirchiangtute chuan zirchianna lian tak an nei a. Hei hi kum sawm chhung zet zirchianna a ni. Hemiah hian kum 65 chunglam mi 3,500 vel an tel a ni. Heng mite zingah hian zirchianna an neih tan tirh khan dementia nei an awm lo.
Hrilhfiahtute hian he huna telte damdawi ei zawng zawng, doctor-in a pek leh over-the-counter-a lei theih, piridine ang chi te chu record an vawng vek a ni. Kum hnih danah telte hriatrengna leh ngaihtuahna thiamna an test thin.
Zirna tawp lamah chuan mi 797 chuan dementia an vei tawh a ni. Chung zinga mi 637 chu Alzheimer natna vei an ni.
He data hi an zirchian hian zirchiangtute chuan mak tak maiin thil an hmuchhuak a ni. Anticholinergic damdawi hmangtute leh dementia vei te inkarah inzawmna nasa tak a awm tih an hmuchhuak a ni . Tin, mi pakhatin heng damdawite hi a hman rei poh leh dementia vei theihna a sang zawk tih an hmuchhuak bawk .
Entirnan, exposure sang ber, nitin dose pangngaia kum thum vel zet he damdawi hmang chhunzawm zelte ang chi te hian he damdawi hmang lote aiin dementia leh Alzheimer natna vei an tam zawk tih hmuhchhuah a ni.
Engvangin nge hetiang hi a lo awm?
Theory lian ber pakhat chu neurotransmitter acetylcholine nen a inzawm tih hi a ni a, chu chu Alzheimer natna vei thluaka a pianphungah a hniam hle a ni. Dik tak chuan Alzheimer natna enkawlna atana hman damdawi thenkhat chuan thluaka acetylcholine awm zat a tipung a ni.
Chuvangin, anticholinergic damdawi hian acetylcholine messenger chu a block a, chuvangin zirchiangtute chuan chu chu a chhan pawh a ni mai thei niin an ngai. Mahse hemi chungchangah hian zirchianna tam zawk neih a ngai a ni.
Take-Home Thuchah a ni
- Natna tlanglawn tak tak, allergy, depression, urinary incontinence, leh pum na tan damdawi pek thin thenkhat chu anticholinergic category-ah a tel thei.
- Zirna hrang hrangah chuan heng damdawi te hi hun rei tak chhunga hman tam hian dementia vei theihna a tipung a, a bik takin kum upa lam tan chuan a tipung a ni.
- He damdawi ei zawng zawng hian dementia an nei vek dawn tihna a ni lo. Risk factor mai a ni.
- I doctor-in damdawi a pek zawng zawng chu nangmah chauhin ei kha bansan ngai suh. Chutianga tih chuan i dinhmun a tichhe thei a ni.
- I damdawi ei tur chungchangah ngaihtuahna emaw zawhna emaw i neih chuan, a bik takin he damdawi ang chi hi hun rei tak chhunga hman tur damdawi chungchangah hian i chhungkaw doctor nen inbia ngei ang che. I mimal hlauhawmnate chu a zir chiang thei a, a tul chuan i tana ṭha tur kawng dang a rawt thei bawk.
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