Kei a koe anō tētahi āhuatanga e kore ai e mutu te toto ahakoa he motu iti? (Te Kore o te Take VII)

I ētahi wā, ka whakaaro koe he roa te wā ka mutu te toto ahakoa he motu iti noa iho? Kāore rānei, ka kikorangi noa iho tō kiri, ka maru? Tērā pea he take kei muri i ēnei mea kāore tātou e mōhio. Koia te korenga o te Tauwehe VII.

He aha te Kore o te Tauwehe VII?

He māmā noa iho, ko te korenga o te Factor VII he āhuatanga ira e kore ai e totoka tika tō toto, arā, kāore e mutu wawe te toto. He maha ngā momo pūmua i roto i ō tātou toto e kiia nei ko ngā 'blood clotting factors' me ngā 'coagulation factors' . Ko te Factor VII tētahi o aua pūmua. Ka mahi tahi ēnei pūmua katoa me ō pereti toto ki te hanga i tētahi totoka hei aukati i te toto ina whara koe. He rite tēnei tukanga ki te hanga i tētahi pakitara ki ngā pereki me te sima. Nō reira, ki te kore e nui te nui o tēnei pūmua nui e kiia nei ko te Factor VII i roto i tō tinana, ki te kore rānei e mahi tika, ka roa ake te totoka i te tikanga. Koinei te take e ngawari ake ai te maru me te toto i a koe i ētahi atu.

Ko ētahi atu ingoa mō tēnei ko te mate a Alexander me te ngoikore o te proconvertin .

He pēhea te auau o tēnei ngoikoretanga o te tauwehenga VII?

He mate onge tēnei. I te ao whānui, e pāngia ana e te kotahi i roto i te 500,000 tāngata . He maha ngā mate toto toto tuku iho e kiia ana e ngā tākuta he "onge." Ko te ngoikore o te Factor VII tētahi o ngā mate onge e tino kitea ana.

He aha ngā tohu o tēnei?

Ka taea e te korenga o te Factor VII te whakaroa i te toto me te ngawari o te marō. Ko ngā tohu matua ko:

• Ngā kapia toto.
• Te toto o te ihu (epistaxis) , me te uaua ki te whakamutu.
• Mō ngā wāhine, ka nui te toto i te wā paheketanga (menorrhagia).
• He toto kei roto i te mimi (hematuria) he toto rānei kei roto i te tūtae.
• Te toto tonu i muri i te whara, te pokanga, te whānautanga rānei.
• Te toto o roto i te tinana (hei tauira, i roto i te pūnaha gastrointestinal, ngā kiko, ngā uaua, ngā hononga).
• Tērā pea ka puta te toto i roto i te angaanga . He ahua kino ake tēnei.
• Ka puta te toto tūpono ina tīmata ohorere te toto, kāore he take e kitea ana.

He rerekē te kaha o ēnei tohu me te wā e puta mai ai i ia tangata, i ia tangata. Hei tauira, ka taea te tautuhi i tētahi pēpi he ngoikore nui te Factor VII i te whānautanga. Heoi, ko tētahi he ngawari ake ngā tohu, kāore pea e tautuhia kia pakeke rawa atu.

He aha te take o te korenga o te Tauwehe VII?

Ahakoa he mate tuku iho tēnei i te nuinga o te wā, tera anō tetahi ara ka puta ai tēnei āhuatanga i a ia e ora ana.

Mena i whānau mai koe me te ngoikore o te āhuatanga VII , ko te tikanga kua riro i a koe tētahi whakarerekētanga, he hapa rānei, i roto i tō ira F7 . Mā tēnei ira e whakahaere te hanga a tō tinana i te āhuatanga VII. Hei whakawhanake i te ngoikore o te āhuatanga VII, me riro i a koe tēnei whakarerekētanga ira mai i ngā mātua e rua . Ka kiia tēnei ko te tukunga iho autosomal recessive . Mena kei ngā mātua e rua tēnei whakarerekētanga, tata ki te 25% te tūponotanga ka whānau he tamaiti me te ngoikore o te āhuatanga VII.

Ko te ngoikore o te Tauwehe VII e puta ake ana i roto i te wā ka kiia ko te 'korenga o te Tauwehe VII kua whiwhi' . He maha ngā take pea:

• Mate ate: Ka hangaia e tō ate te pūmua Factor VII. Mena he mate ate kino tōu, tērā pea kāore e taea e tō ate te mahi tika i tēnei mahi.
• Te korenga o te huaora K: He mea nui te huaora K mā te tinana hei hanga i te Tauwehe VII. Ki te kore e nui te huaora K e whiwhihia ana, ka pāngia koe e te korenga o te Tauwehe VII.
• Ngā rongoā whakaiti toto: Ka puta anō hoki tēnei āhuatanga ina whakamahia ngā rongoā whakaiti toto pēnei i te Warfarin (Coumadin®) .
• Ngā mate toto me te mate pukupuku: Kua pūrongohia te korenga o te Factor VII i roto i te hunga whai mate pēnei i te aplastic anemia me te leukemia .

He aha ngā raruraru o te korenga o te Factor VII?

I ngā wā tino kino, ka taea e te korenga o te Factor VII te arahi ki ētahi atu raruraru hauora mēnā kāore e rongoatia. Hei tauira:

• Te mate toto kore toto: Ina nui rawa te toto e ngaro ana i te tinana, ka tino heke te maha o ngā toto whero.
• Te kino o te hononga: Ina toto te hononga, ka memeha pea te kiko o te hononga, ā, kāore e taea e te hononga te piko, te whakatika tika rānei.
• Ngā toto totoka: He kohinga toto totoka te toto totoka i raro i tō kiri. Mēnā ka puta he toto totoka nui, ka taea e ia te pēhi i ngā whekau tata, ā, ka puta he tohu mamae.

Ko te mea nui, ka taea e te toto nui te whakararu i te ora mēnā kāore e rongoatia. Koia te mea nui kia rapu tohutohu hauora mēnā kāore te toto e mutu.

Me pēhea te tātaritanga o te ngoikore o te Tauwehe VII?

Ka pātai atu tō tākuta ki a koe mō ō tohumate, me te mea kei roto i tō whānau tētahi hītori o ngā mate toto. Ka kitea te korenga o te Tauwehe VII mā roto i ngā whakamātautau toto e aromatawai ana i te pai o te totoka o tō toto.

Kei roto i ēnei whakamātautau:

• Whakamātautau wā prothrombin (PT/INR): Ka ine tēnei i te roa o te toto e totoka ana i runga i te mahi a te matū totoka e kiia nei ko te prothrombin. Mena he ngoikore tō matū VII, ka roa ake te toto e totoka ana i te mea noa.
• Whakamātautau wā thromboplastin wāhanga (PTT): Ka ine tēnei i te wā e totoka ai te toto i runga i te mahi a ngā mea totoka ehara i te prothrombin. He noa ngā hua o tēnei whakamātautau i te nuinga o te wā mō te tangata he ngoikore te mea totoka VII.
• Whakamātautau Tauwehe VII: E whakaatu ana tēnei whakamātautau i te mahi a te pūmua Tauwehe VII.

Me pēhea te rongoā mō te korenga o te tauwehenga VII?

Ko te tikanga, ko te tāpiri i te matū VII e mahi tika ana ki roto i tō toto te tikanga maimoatanga. Tērā pea ka mahi tahi koe me tētahi tākuta tohunga ki ngā mate toto, e kiia nei ko te tohunga toto , māna e whakatau ko tēhea maimoatanga e hiahiatia ana e koe me te roa o te wā e hiahiatia ana.

He maha ngā tikanga maimoatanga matua:

• Te rongoā tauhohenga VIIa (NovoSeven®): Kua whakaaetia tēnei rongoā e te US Food and Drug Administration (FDA) hei rongoā mō te korenga o te tauhohenga VII. He mea hanga tēnei e ngā kaipūtaiao i roto i te taiwhanga. Ko te tikanga, kāore i rite ki ētahi atu rongoā whakakapinga tauhohenga VII, he mea hanga mai i te toto i kohaina mai i te tangata.
• Ngā matū matatini prothrombin (PCC): Kei roto i tēnei maimoatanga he kukū tiketike o ngā matū toto e whā, tae atu ki te matū VII, i tangohia mai i te toto i kohaina.
• Plasma hou tio (FFP): Tērā pea ka hoatuhia he plasma ki a koe mā te uaua hei āwhina i te hanga anō i ō toa Factor VII.

Ētahi atu maimoatanga:

• Ngā rongoā ārai-fibrinolytic: Ka mahi ēnei rongoā mā te aukati i te memeha o ngā toto toto e puta ana i roto i tō tinana. Ka āwhina i te aukati i te toto nui mā te tiaki i ngā toto toto kua noho kē i roto i tō tinana. Ko ētahi tauira ko ngā rongoā e kiia nei ko te waikawa aminocaproic me te waikawa tranexamic .
• Ngā pire ārai whānau:Ka ārai ētahi momo pire ārai whānau i te toto nui i te wā paheketanga.
• Ngā tāpiringa huaora K, ngā werohanga rānei: Mena he ngoikore te huaora K i puta mai i tō mate, mā te nui ake o te huaora K ka taea e tō tinana te hanga i te tauwehe VII.

He aha ngā raruraru/ngā pānga taha o te maimoatanga?

Ka pā mai pea ngā raruraru i ētahi wā i ngā maimoatanga e tāpiri ana i te tauwehenga VII ki te toto. Heoi, he mea nui kia mahara kei te mōhio tō tākuta ki ēnei tūponotanga, ā, kei te mahi ia i ngā mahi hei ārai i aua tūponotanga.

Ko ngā raruraru pea o te rongoā Factor VII ko:

• Ngā toto toto kino: Mā te tāpiri i te tauwehenga VII ka piki ake te mōrearea o ngā toto toto ka ārai i ngā oko toto. Ka aroturukihia e tō tākuta te horopeta o tō rongoā hei whakaiti i tēnei mōrearea.
• Te pānga ki ngā mate urutā: Ina whiwhi toto i te toto i kohaina mai, kei reira tonu te tūponotanga o te pānga ki ngā mate urutā kino (hei tauira, ngā huaketo , ngā huakita rānei) i roto i te toto. Ka āta tirotirohia e ngā tākuta ngā hua toto hei ārai i tēnei.
• Ngā tauhohenga whakawhiti toto: Tērā pea he mate pāwera tōu ki te toto toto i tukuna mai.
• Te nui rawa o te toto: Ka tere rawa te pakaru o te Tauwehe VII, ā, ka tangohia mai i roto i ō toto. Hei ārai i tēnei, me nui pea te toto hei pupuri i te nui o te Tauwehe VII i roto i tō tinana. Ka piki ake pea te toto i roto i tō pūnaha. Ko ngā pānga o te nui rawa o te toto ko te toto toto tiketike me te pupuhi o ngā pukahukahu (te edema pūkahukahu) .

He aha ngā mea ka taea e au te tumanako mēnā he ngoikore tōku i te Factor VII?

He mate mō te wā roa te korenga o te Tauwehe VII. Ahakoa kāore he rongoā, ka taea e koe te mahi tahi me tō tākuta ki te whakahaere.

Ko tētahi o ngā wero nui ki te whakatau i te kaha o te mate, ko te kore e taea te matapae i te kaha o ngā tohu i runga i te iti o ō taumata Factor VII. Engari, ka mahi tahi ngā tākuta me te hunga whai ngoikoretanga nei i runga i te kaupapa takitahi. Ka whakawhirinaki tō tirohanga ki ngā āhuatanga motuhake ki a koe, pēnei i tō wheako, te take o te ngoikoretanga, te āhua o tō urupare ki te maimoatanga, me te kaha o tō toto i te nuinga o te wā.

Me pēhea taku tiaki i ahau anō?

He mea nui kia kōrerotia tō āhua ki ngā kaiwhakarato hauora katoa e rongoā ana i a koe. Mēnā he ngoikore te whārite VII o tāu tamaiti, kōrerotia ki tētahi e tiaki ana i a ia (tae atu ki ngā kaiako me ngā kaimahi tiaki tamariki).

Pātai atu ki tō tākuta mō ngā mea ka taea e koe te mahi hei tiaki i a koe anō i ia rā. Tērā pea ka tūtohu ia i ētahi mea pēnei i:

• Āta karohia ngā mahi mōrearea nui:Akene me karo koe i ngā mahi ka whakanui ake i te mōrearea o te whara (hei tauira, ngā hākinakina pā).
• Āraia ētahi rongoā: Me karo pea koe i ngā rongoā e whakangawari ana i tō toto (hei tauira, te aspirin , ngā NSAID , ngā rongoā ārai pouri SSRI ). Me karo hoki koe i ngā tāpiringa kei roto ko te hinu ika, te huaora E, me te turmeric, nā te mea ka taea hoki e ēnei te whakanui ake i te toto.
• Puritia he kape o tō mahere maimoatanga: He mea nui kia puritia ngā tuhinga mai i tō tākuta toto mō te āhua o te maimoatanga a ngā tohunga hauora ki a koe mēnā ka puta he āhuatanga ohorere.
• Rapua he tohutohu ira, he whakamātautau rānei: I mua i te whakamātau ki te whānau pēpi, ka taea e koe te kōrero ki tētahi kaitohutohu ira hei aromatawai i te tūponotanga o tāu tamaiti ki te whiwhi i te ngoikore o te tauwehenga VII.

Āhea ahau me toro atu ki taku tākuta?

Ki te kite koe, tāu tamaiti rānei i ētahi tohu o te toto tonu, te kikorangi auau rānei, me toro atu ki tō tākuta. He mea noa te toto ihu me te kikorangi i ētahi wā. Engari ki te nui ake i te wā noa, he tohu pea tēnei nō te raruraru toto.

Āhea ahau me haere ki te Wāhanga Maimoatanga Ohotata (ETU) ?

Mena he tūmomo mōrearea tō toto ki tō hauora, haere ki te rūma whawhati tata. Rapua ngā tohu pēnei i ēnei:

• Te toto o te ihu e roa ana mō te haora, neke atu rānei.
• Te mākū i te neke atu i te rua ngā papa, ngā tampon rānei i te hāora mō ngā hāora e rua, neke atu rānei (mō ngā wāhine).

He aha ngā pātai me pātai atu e au ki taku tākuta?

Anei ētahi pātai ka taea e koe te pātai atu ki tō tākuta:

• He uri tuku iho taku ngoikore o te Factor VII, i puta mai rānei i muri mai?
• He aha te momo maimoatanga e hiahiatia ana e au?
• Kia pēhea te roa o taku maimoatanga?
• He aha ngā pānga taha me mōhio ahau i te wā e rongoatia ana?
• He aha ngā huringa āhua noho me mahi e au hei whakahaere i tōku āhua?

He rite tonu te korenga o te Factor VII ki te 'hemophilia'?

Ko te korenga o te Factor VII me te hemophilia he mate toto tuku iho e rua e pā ana, engari he rerekē. Ko te korenga o te Factor VII ka puta mai i te korenga o te pūmua Factor VII (7), ko te hemophilia A ia, te momo hemophilia tino noa, ka puta mai i te korenga o te pūmua Factor VIII (8).

He nui ake te kitea o te hemophilia A i te korenga o te factor VII, e pā ana ki te kotahi i roto i te 100,000 tāngata. He nui ake hoki te kitea o tēnei i roto i ngā tāne .

Engari ko te mea nui, ka taea e ēnei āhuatanga e rua te whakaputa toto nui rawa, nō reira me whakahaere pai mā te awhina a te tākuta.

Ngā mea tino nui hei maumahara

Kāore he huarahi hei ārai i te whānautanga mai me te ngoikore o te toto toto, arā, te factor VII. Engari, ehara i te mea kāore e taea e koe (e tō pēpi rānei) te noho ora, ora hoki me tēnei mate. Ka taea e tō tākuta toto te āwhina i a koe ki te ārai me te whakahaere i te toto. Ka taea hoki e ia te āwhina i a koe ki te whakawhanake i tētahi mahere mō te aha me mahi mēnā ka nui rawa tō toto. Kaua e manukanuka, ka taea e koe te noho angitu me tēnei mate.

Te Kore o te Take VII, Te Pupuri Toto, Te Toto, Ngā Mate Tuku Iho, Te Mate a Alexander, Te Tohunga Toto, Ngā Mate Toto