Me ako tātou mō te GABA (gamma-aminobutyric acid), te mea ngaro o te roro e whakamarie ana i tō hinengaro.

Kei te pōuri koe i ētahi wā, kei te manukanuka, kei te mataku noa rānei? Kei te pāngia rānei koe e te kore moe i te pō? Kei muri i ēnei mea, tera pea he karere matū iti kei roto i tō tātou roro. Koinei te mea ka kōrerohia e tātou i tēnei rā. Ko GABA. He rite tana mahi ki te pātene 'whakamatao' i roto i tō tātou roro.

He aha te GABA (waikawa gamma-aminobutyric)?

He māmā noa iho, he matū te GABA e tuku karere ana i waenga i ngā pūtau io (ngā neuron) i roto i tō tātou roro. He rite ki te kaikawe mēra atamai i roto i tō tātou tinana. Engari ko te mea motuhake mōna ko tana "whakamarie" i te mahi koretake o te roro. Arā, ka aukati i ngā pūtau io o te roro kia kaua e tino whakaohokia, e tino ohooho hoki. Ka kiia ēnei momo matū e ngā kaipūtaiao he neurotransmitters. Whakaarohia te GABA he "pēhi" e whakahaere ana i te tere o tō tātou pūnaha io matua, tae atu ki tō tātou roro me te taurakira. Koinei te mea e āwhina ana i a tātou kia kaua e tino harikoa, e mataku rānei.

He aha te mahi a te GABA? He aha ngā mea e tupu ana i roto i tō tātou roro?

Tirohia te mahi a tēnei GABA i roto i tō tātou roro. He tikanga tino whakamiharo. E miriona, e piriona ngā pūtau io kei roto i tō tātou roro. Me tuku karere tātou mai i tētahi pūtau io ki tētahi atu. He āputa iti kei waenganui i ēnei pūtau io e rua. Ko te ingoa o tēnā he `(Synapse)`, he hononga io rānei.

Mā te `(Neurotransmitter)` pērā i a GABA ka taea tēnei mā te kawe i te karere puta noa i tēnei hononga ka hono atu ki ngā `(Recipients)` motuhake i te pūtau io e whai ake nei. He rite ki tētahi kī e uru ana ki roto i tētahi raka. Pērā i te kore e taea e ngā kī katoa te whakatuwhera i ngā raka katoa, kāore hoki e taea e ngā `(Neurotransmitter)` katoa te hono atu ki ngā `(Recipients)` katoa. E rua anō hoki ngā `(Recipients)` motuhake a GABA e mōhio ana ki a ia – ko te `(GABA-A)` me te `(GABA-B)`.

Nō reira, ina haere te GABA ka herea ki ēnei kaiwhakawhiwhi, ka whakaitihia te kaha o te pūtau io e whai ake nei ki te urupare. Arā, ka whakaitihia te tūponotanga o taua pūtau ki te tuku karere kore e hiahiatia, ki te tuku atu rānei ki tētahi atu. Koia te take i kiia ai te GABA he "kaiwhakawhitiwhiti aukati" he kaiwhakamarie rānei.

He aha ngā painga hauora e tukuna ana e te GABA?

Nā, he aha ngā painga hauora ka riro mai i a tātou mai i te GABA, e whakamarie ana i te roro i tēnei ara? He maha tonu. Whakaarohia, kei te tino "auaha" koe, arā, i te wā e tino taumaha ana koe, kāore tō hinengaro i te wāhi kotahi, kei te tino manukanuka koe, ā, e ahua pā ana tō uma. I tētahi wā pēnei, ki te tika te taumata GABA i roto i tō tinana, ka whakamarie i tō hinengaro, ka āwhina i a koe ki te whakaiti i tēnei ahotea .

He kaha whakamiharo anō hoki tō GABA ki te whakahaere i te manukanuka . Ka āwhina i te whakaiti i te wehi me te manukanuka koretake mō ngā mea katoa.

Ko tētahi atu mea, kāore e taea e ētahi te moe i te pō. Ka huri noa rātou ina haere ki te moenga, engari te āhua nei kāore rātou e moe ana. E ai ki ngā rangahau o nāianei, ka āwhina anō hoki te GABA i te moe pai, i te moe marino .

GABA me te Glutamate: Te Pātene 'Whakakā-Whakaweto' o te Roro

Haunga te GABA, kei reira tētahi atu '(Neurotransmitter)' tino nui i roto i tō tātou roro. Ko te '(Glutamate)'. He rite te mahi a ēnei mea e rua ki ngā taha e rua o te moni, ki ngā pana 'kā' me te 'weto' e rua rānei. Arā, kei ngā taha rerekē tetahi ki tetahi.

• GABA: 'Ka whakaweto' i te mahi a te roro, ā, ka whakamarie i a ia (ka ārai).
• Glutamate: 'Ka whakakā', ka whakaoho i te mahi a te roro (he mea whakaohooho).

Nō reira, kia ora ai, kia tika ai te mahi a tō tātou roro, me whai taurite ngawari i waenganui i te mana whakamarie o te GABA me te mana whakaoho o te `(Glutamate) . Pērā i te whakateretere me te parai o te motuka. Mā te mahi tika me te wā tika anake ka taea ai e tātou te haere maeneene me te haumaru. Ki te ngaro tēnei taurite, ka puta he maha ngā raruraru. He mea whakamiharo, ko tēnei kaiwhakamarie e kiia nei ko te GABA ka puta mai i te whakaoho `(Glutamate). Kei roto i tēnei he `(enzyme)` motuhake, arā, he enzyme (`glutamic acid decarboxylase`).

Ka mahi tahi anō hoki a GABA me tētahi atu neurotransmitter, te serotonin. Inaa, he maha ngā neurotransmitter e mahi tahi ana, i ētahi wā he rerekē tetahi ki tetahi, kia pai ai te mahi a ō tātou tinana me ō tātou roro.

Ngā mate ka puta mai i ngā taumata GABA iti

Whakaarohia te mea ka tupu mēnā kāore tēnei whakawhitiwhiti karere GABA e mahi tika ana, arā, he iti ngā taumata GABA i roto i te roro? Tērā pea ka ara ake he maha ngā raruraru hauora io me te hinengaro. Kua kitea e ngā rangahau ko te iti o te mahi GABA ka whai wāhi atu ki ngā āhuatanga pēnei i:

• Te manukanuka me ngā mate hinengaro: Te mataku tonu, te manukanuka, te ngaro o te harikoa, me te kore e taea te arotahi.
Te Hauāwhiowhio : He mate hinengaro uaua e tohuhia ana e te ngaronga o te hononga ki te ao tūturu me te kite, te rongo, me te whakaaro ki ngā mea ehara i te mea tūturu.
• Mate autism: He mate whanaketanga e tohuhia ana e ngā ngoikoretanga i roto i ngā taunekeneke pāpori me te whakawhitiwhiti kōrero.
• Te Pouri: He kare ā-roto pouri mō te wā roa, te ngaronga o te hiahia ki tetahi mea, me te kare ā-roto hoha ki te ao.
• Te mate haurangi me ngā hopuhopu: Ko ngā āhuatanga pēnei i te wiri me te hopuhopu e puta ana i roto i te tinana nā te mahi ohorere, kore e taea te whakahaere i ngā pūtau io i roto i te roro.

Haunga ēnei āhuatanga nui, he maha atu anō ngā mate e whakaarohia ana e pā ana ki te kore taurite o te GABA:

• Te korenga o te piridoksini:He mate onge tēnei. Nā te korenga o te huaora B6 (pyridoxine) i puta ai, he mea nui mō te hanga GABA. He maha ngā wā ka puta he hopuhopu i roto i ngā tamariki nohinohi. He uaua ki te whakahaere i ēnei hopuhopu mā te whakamahi i ngā rongoā anti-hypoglycemic paerewa, engari ka taea te whakaora mā te whakamahi i ngā tāpiringa huaora.
• Te mate ate nui: He mate kino ki te ate e pā ana ki te mahi a te roro.
• Te mate a Huntington: He mate tuku iho e whakangaro haere ana i ngā pūtau roro.
• Dystonia me te spasticity: Ngā āhuatanga e tohuhia ana e te pakari o te uaua me te wiriwiri rerekē.
• Hypersomnia: Te hiamoe nui, te nui rawa rānei o te moe i te awatea.

He pai te hauora o te whakanui ake i ngā taumata GABA?

Kei te rangahau tonu ngā kairangahau i ngā pānga o te pikinga o ngā taumata GABA. Ahakoa kāore anō kia tino mārama ngā taunakitanga, kei te tirotirohia mēnā ka āwhina te GABA ki te rongoā, ki te ārai rānei i ētahi āhuatanga hauora. Hei tauira:

• toto toto tiketike
• Te kore moe
• Mate huka

Me whakahaere tonu he rangahau mō ēnei.

Ngā momo rongoā e aro ana ki te GABA

Nā te hiranga o te GABA, kua whakawhanakehia e ngā kaihanga rongoā he maha ngā rongoā e aro ana ki ngā "kaiwhakawhiwhi" GABA. Ka mahi ēnei mā te āwhina, mā te whakarei ake rānei i ngā pānga marino ā-taiao o te GABA. Kua rongo pea koe i ēnei:

• Benzodiazepines: Kei roto i tēnei akomanga rongoā ko te diazepam (e mōhiotia ana ko Valium) me te alprazolam (e mōhiotia ana ko Xanax) ā, e whakamahia ana hei rongoā i te manukanuka, te kore moe, te haurangi, me te tango waipiro. E whakamahia ana hoki ēnei hei rongoā whakamoe i te wā e pokanga ana.
• Barbiturates: He momo rongoā whakamoe hoki ēnei e whakararuraru ana i te hiamoe. Heoi, kua iti ake te whakamahinga i ēnei rā.
• Vigabatrin (Sabril®): He rongoā e whakamahia ana hei rongoā i ngā haurangi me ngā mamae o ngā uaua i roto i ngā tamariki nohinohi.
• Flumazenil (Romazicon®): Hei rongoā i te nui rawa o te benzodiazepine. Ka whakamahia hoki hei whakapai ake i te āhua hinengaro i roto i te mate ate encephalopathy, he mate e puta mai ana i te mate ate.
• Waikawa Valproic: He rongoā whakaū wairua tēnei e whakahaere ana i ngā hopukanga haurangi.
• Zolpidem (e mōhiotia ana ko Ambien®, ko Edluar® rānei): He rongoā nui tēnei mō te kore moe.
• Propofol (e mōhiotia ana ko Diprivan®): He rongoā e whakamahia ana hei whakamarie me te whakamoe i te tūroro i te wā e rongoā ana i te mate whakamoe whānui.
• Baclofen (`Baclofen (Lioresal®, Gablofen®)`): He whakangawari uaua.

Kia maumahara: Me whakamahi noa i ēnei me ētahi atu rongoā rite i raro i te tirotiro a te rata. Mā te whakamahi i a koe anō, nā te mea rānei i tohutohuhia koe e tētahi atu i tō taha, ka pā he kino kino. Nō reira, kia tūpato.

He whai hua ngā tāpiringa GABA?

Inaianei, tera pea ētahi e pātai, 'He aha rā e kore ai e taea e tātou te hoko i te GABA hei tāpiringa?' Ae, kei te wātea te GABA hei tāpiringa kai. Engari he raruraru iti kei konei. Kāore anō kia mārama te nui o te GABA e tangohia ana e tātou, e uru ana ki roto i ō tātou roro.

Nā te mea, kei roto i tō tātou roro tētahi kiriuhi tiaki tino motuhake e kiia nei ko te "arai toto-roro". He rite tēnei ki tētahi kēti, kāore e whakaaetia kia uru ngāwari ngā matū katoa ki roto i te roro, engari ko ētahi kua tohua anake e whakaaetia ana. Nō reira, kāore anō kia nui ngā taunakitanga pūtaiao pakari hei kī mēnā he pānga pono ēnei tāpiringa GABA ki te roro. Nō reira, me nui ake ngā rangahau mō tēnei mea mā te whakamahi i tētahi rōpū nui ake o te iwi. I runga i te āhuatanga o nāianei, ehara i te mea whakaaro nui te whakamahi i ngā tāpiringa GABA me te kore e kōrero ki tētahi tākuta.

He kai kei roto he GABA?

Kei roto hoki i ētahi kai te GABA. Hei tauira:

• Ngā kai kua whakapūkaratia: ngā mea pēnei i te kimchi (he pīkara Kōrea), te miso (he whakapiri pīni Hapanihi), me te tempeh (he hua pīni Initonīhia).
• Ngā momo tī: Kei roto hoki i te tī matomato, te tī pango, me te tī oolong te GABA.
• Ētahi atu kai: Kei roto hoki i ngā kai pēnei i te raihi parauri, te pīni soya, te pī, te nati (he momo pīnati), te harore, te tōmato, te pīnihi, te pūrokoro, te kāpeti, te kūmara, te pihi o te paraka (he momo kāpeti iti), ngā witi kua pihi (hei tauira, ngā pīni matomato ina pihi), me te kūmara, te GABA, te āwhina rānei i te tinana ki te whakaputa GABA.

Engari e ai ki ngā kōrero mō ngā tāpiringa, kāore anō kia mārama te whakamārama mō te nui o te GABA mai i ēnei kai e tae atu ana ki te roro. He pai te whakauru i ēnei hei wāhanga o tētahi kai hauora, engari kāore i te tūtohutia kia whakawhirinaki noa ki ēnei kai hei rongoā motuhake mō tētahi mate motuhake. Me rapu tohutohu hauora hoki mō tēnei.

Hei whakamutunga, ngā mea hei maumahara (Karere hei tango ki te kāinga)

Nō reira, kua mārama pea koe ināianei ko te GABA (gamma-aminobutyric acid) i kōrerohia e tātou i tēnei rā he neurotransmitter e whakamarie ana i te roro, ā, he mea tino nui mō te hauora hinengaro, te moe, me te mahi a te tinana whānui.

Ka āwhina i te whakahaere i te manukanuka, te ahotea, me te kore moe. Ka taea e ngā taumata GABA iti te arahi ki ngā mate pūnaha io me ngā mate hinengaro. Ka mahi ētahi rongoā mā te aro ki te pūnaha GABA.

Me nui ake ngā rangahau pūtaiao mō ngā painga o ngā tāpiringa GABA me ngā kai kei roto he GABA. Nō reira, ki te mea he āwangawanga, he ruarua, he pātai rānei āu mō te GABA, ko te mea pai me te mea haumaru ko te toro atu ki tō tākuta whānau, te kōrero mō tō āhuatanga, me te tiki i ngā tohutohu tika.Kaua e haere ki te mahi i runga i ngā whakapae, i ngā kōrero noa rānei. He mea nui tō hauora ki a koe.

` GABA, waikawa gamma-aminobutyric, neurotransmitter, roro, hauora hinengaro, manukanuka, moe