He aha te Renin? He aha tōna pānga ki tō toto toto?

Kua whakaaro koe he aha te mahi whakamiharo a te tikanga i roto i tō tinana hei pupuri i tō toto toto, arā, te toto toto, ki te taumata tika? He rite ki te karaka e kore e kitea e mahi ana me te tino ātaahua. Nō reira, ko tētahi o ngā tino tangata o tēnei tukanga nui ko 'Renin'. Kāore pea koe i rongo i tēnei ingoa, engari he tino rawe te ratonga e tukuna ana e ia ki tō hauora. Me kōrero tātou mō tēnei renin i roto i ngā kupu māmā i tēnei rā.

He aha te tikanga o Renin?

Āe, me tīmata tātou i te tīmatanga. Ko te renin he whākōkī e hangaia ana e tētahi momo pūtau motuhake i roto i ō whatukuhu. Ko te whākōkī he pūmua e tere ake ai ngā tukanga matū i roto i ō tātou tinana.

Ehara tēnei renin i te mea kotahi. He wāhanga ia o tētahi pūnaha tino nui. Ka kiia e mātou ko te 'pūnaha renin-angiotensin-aldosterone'. Kaua e manukanuka, tera pea he roa te ingoa. He mekameka o ngā tukanga e hono tahi ana. Ko te kaupapa matua o tēnei pūnaha katoa ko te pupuri i tō toto toto kia mau tonu.

He pēhea te mahi a te renin i roto i te tinana? Koinei te āhua o tēnei tukanga!

Hei mārama ki tēnei, me tango he tauira iti. Whakaarohia he tāone tō tinana, ko ngā uaua toto ko ngā paipa wai o taua tāone, ā, ko te toto ko te wai e rere ana i roto i aua paipa. Kātahi ko te toto toto ko te pēhanga i roto i aua paipa wai.

Whakaarohia inaianei, mō tētahi take, ka heke te pēhanga wai (te pēhanga toto). Ka ahatia i muri mai? Ka rongo te tari wai o te tāone (arā, ō whatukuhu) i tēnei. I taua wā tonu, ka tukuna e ngā whatukuhu he karere. Ko taua karere ko te renin.

Kia tāpirihia te renin ki te toto, koinei te mea ka tupu:

1. Te taahiraa tuatahi: Ka kimi tuatahi a Renin i tētahi pūmua moe e kiia nei ko te angiotensinogen, e hangaia ana i roto i te ate. Ka whakahohehia e Renin tēnei pūmua, ka hurihia hei angiotensin I.

2. Hipanga 2: Kāore anō kia tino kaha te 'angiotensin I'. Ina haere mā roto i te toto ki ngā pukahukahu, ka hurihia e tētahi atu whākōkī i reira hei 'angiotensin II' kaha ake.

3. Hipanga Tuatoru: Inaianei ka puta te mahi tuturu. E rua ngā mahi a tēnei matū kaha e kiia nei ko te 'angiotensin II'.

• Ko tētahi, ka haere, ka whakawhāiti i ō tātou uaua toto (aua paipa wai). Ka aha rā? Ina whakawhāitihia ngā paipa, ka piki te pēhanga, ka piki hoki te toto toto.
• Tuarua, ka tukuna he tohu ki ngā repe adrenal (e rua ngā repe iti kei runga ake i ngā whatukuhu) kia whakaputa i tētahi homoni e kiia nei ko te aldosterone.

4. Te taahiraa whakamutunga:Ko tēnei homoni, arā, ko te aldosterone, e kī ana ki ngā whatukuhu kia "kati te tuku i te tote (konutai) me te wai mai i te tinana mō tētahi wā." Ka whakanuia e tēnei te nui o te wai i roto i te tinana. Ka whakanuia hoki e tēnei te toto toto.

Ki te kī ngāwari, ina heke te toto toto, ka puta mai he karere e kīia nei ko te renin, ka tīmata i tēnei tauhohenga mekameka katoa e whakahoki ai i te toto toto ki te noho noa. Kei te mārama koe?

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Āhea ka tukuna te renin mai i te tinana?

He maha ngā take matua e tukuna ai te renin e ngā whatukuhu. Arā, kei te tino aro turuki te tinana i ēnei mea.

• Te toto toto iti: Ina rongo ngā pūoko pēhanga (ngā baroreceptor) i roto i ngā oko toto kua heke te toto toto, ka tukuna atu ngā tohu ki ngā whatukuhu.
• Te iti o te tote (konutai) i roto i te tinana: Ka taea e ngā whatukuhu te kite i te wā kua heke te nui o te konutai i roto i te toto. Mēnā ka heke, ka tukuna e rātou te renin.
• Te mahi a te pūnaha io: Ka whakaohokia tō tātou pūnaha io ina mataku tātou, ina ngenge, ina whakakori tinana rānei. Ka puta hoki te tukunga o te renin i ēnei wā.

He whakamātautau hei tirotiro i ngā taumata renin?

Āe, tino tika. Ki te hiahia tō tākuta, ka taea e ia te whakahaere i tētahi whakamātautau toto hei ine i ō taumata renin. I te nuinga o te wā ka inehia tēnei mā te whakamātautau e kīia nei ko te 'Plasma Renin Activity' (PRA). I ​​te nuinga o te wā ka inehia hoki e tēnei whakamātautau ō taumata aldosterone.

Tērā pea kei te whakaaro koe, "He aha ahau i hiahia ai ki tēnei whakamātautau?" Ko te take matua e tono ai te tākuta i tēnei whakamātautau he mea kei a koe te toto toto tiketike e uaua ana ki te whakahaere mā te whakamahi i ngā rongoā noa.

I ētahi wā, ka puta te toto toto tiketike i tētahi āhuatanga e kiia nei ko te 'primary aldosteronism', e mōhiotia ana ko te 'Conn's syndrome'. I roto i tēnei āhuatanga, ka nui rawa te homoni aldosterone e whakaputaina ana e te tinana. Nō reira, mā te whakamātautau i ō taumata renin me te aldosterone ka āwhina i tō tākuta ki te kimi i te tino take o tō toto toto tiketike.

He aha te tohu o te taumata renin kua piki ake?

Mena kei roto i tō pūrongo he nui ngā taumata renin, tera pea he tohu tēnei mō ētahi āhuatanga hauora kei raro. Ehara tēnei i te mate, engari he tohu noa iho.

He aha ngā take o te iti o ngā taumata renin?

Waihoki, ko ngā taumata renin tino iti ka puta mai i ētahi āhuatanga.

Me pēhea te pupuri i te hauora o ngā taumata renin?

Koinei te mea tino nui. Kāore e taea e koe te "rongo" i tō taumata renin anake. Ehara te nui, te iti rānei o te taumata renin i te mate, engari he tohu nō tētahi atu mate.

Nō reira, ko tō tākuta te tangata tika hei whakarato i te otinga mō tēnei. Ka arotakehia e ia tō pūrongo, ka whakahaerehia ētahi atu whakamātautau mēnā e tika ana, ā, ka kitea te tino take o te taumata renin rerekē. Ka ahu mai te maimoatanga i taua take.

Hei tauira, ki te mea he toto toto tiketike tōu, ā, he nui hoki ngā taumata renin, ka tohua pea e tō tākuta he rongoā whakaheke toto, pērā i ngā beta-blockers. Ki te mea ko te matewai te take, ka tohutohu pea ia kia nui te wai e inumia e koe.

Kia maumahara, he uaua ngā taumata o te renin. Kaua e manukanuka ki ēnei mea. Mena he āwangawanga āu, me kōrero ki tō tākuta. Māna e hoatu ki a koe te tohutohu me te maimoatanga pai rawa atu.