Ka pāngia te hinengaro wareware e ētahi rongoā? (Me ako tātou mō ngā rongoā ārai mate cholinergic).

He mataku kei roto i ō tātou ngākau katoa kei tīmata ō tātou mātua, o tātou rānei, ki te wareware i ngā mea i a tātou e pakeke haere ana. He tino whakamataku te whakaaro ki te ngaro o tō tātou mahara me te kaha ki te whakaaro mārama. Ahakoa ko te koroheketanga tetahi o ngā tino take o tēnei ngaronga mahara, te mate wareware rānei, kei te kōrerohia inaianei tētahi atu āhuatanga mōrearea. Arā, ko ētahi o ngā rongoā e whakamahia ana e tātou mō ngā momo mate.

He aha ēnei rongoā anticholinergic?

He māmā noa iho, he momo rongoā ngā rongoā ārai-kōriniki. He mea hanga ēnei mai i tētahi tipu e kiia nei ko Belladonna. Tērā pea he paitini tēnei tipu i roto i ētahi horopeta. Heoi, ka taea e ngā matū o tēnei tipu te whakahaere, te pehi rānei i te mahi a tō tātou pūnaha io ki tētahi taumata, nō reira ka whakamahia hei hanga rongoā whakahaeretia.

Whakaarohia, he rite tō tātou pūnaha io ki tētahi whatunga io e horapa ana puta noa i te tinana. Ko tō tātou roro te pokapū matua. Ko ngā whakahau e tukuna ana mai i reira ka haere ki te tinana katoa mā roto i ēnei pūtau io. Ko ngā mea katoa mai i tō tātou hikoi, te whakaaro, te manawa, te manawa, te moe, me te mahi a ō tātou mātakitaki e rima e whakahaeretia ana e tēnei pūnaha io.

He matū kei roto i tēnei pūnaha io e kawe ana i ngā karere. Ka kiia rātou he neurotransmitters. Ko te Acetylcholine tētahi o ngā karere tino nui. Nō reira, ko te mahi a ngā rongoā anticholinergic he aukati i tēnei karere e kiia nei ko te acetylcholine. Mā roto i tēnā, ka whakahaeretia ētahi o ngā mahi a te pūnaha io.

He maha ngā rongoā e whakamahia ana hei rongoā i ngā mate pāwera.

Ko ētahi rongoā e whakamahia whānuitia ana

Kei te wātea ēnei rongoā i roto i te ahua o ngā pire, ngā pata kanohi, me ngā werohanga. Ko ētahi tauira ko:

• Diphenhydramine: He momo rongoā tēnei e whakamahia ana hei rongoā i ngā mate pāwera. Kei roto i te rongoā Piriton o Sri Lanka tētahi matū rite tonu e kiia nei ko te chlorpheniramine. Kei roto hoki ēnei i te akomanga kotahi o ngā rongoā anti-cholinergic.
• Benztropine: Whakamahia mō ngā tohumate o te mate a Parkinson.
• Dicycloverine: Whakamahia mō te mamae o te puku, inā koa i roto i ngā āhuatanga pēnei i te Irritable Bowel Syndrome (IBS).
• Oxybutynin: He rongoā e hoatu ana ki te hunga e uaua ana ki te whakahaere i ō rātou mimi.
• Hyoscyamine: Whakamahia mō te mamae o te uaua o te puku me te pūkahukahu.

He aha te tikanga o te mate wareware?

Ko te mate wareware he kupu whānui e whakamahia ana mō ngā āhuatanga maha e pā ana ki te kaha o te tangata ki te whakaaro, ki te mahara, ki te whakatau rānei. He mea tino noa tēnei i waenga i te hunga kaumātua.

Ka pā pea tēnei āhuatanga ki te tangata:

• Te kaha ki te arotahi
• Te kōrero ki ētahi atu (te whakawhitiwhiti kōrero)
• Te kaha ki te whiriwhiri i te tika me te hē (te mātauranga ā-whakaaro)
• Mahara
• Te kaha ki te whakaaro arorau me te whakaoti rapanga

I ētahi wā, ka taea e ngā momo mate wareware pēnei i te mate a Alzheimer te whakaputa huringa ki te tuakiri me te whanonga o te tangata.

Ko wai kei te nui ake te mōrearea ki te mate wareware?

• Tau: Ko te koroheketanga te tino take mōrearea.
• Mate manawa: Ko te hunga he hītori o te toto toto tiketike, te cholesterol tiketike, me te whiu he nui ake te mōrearea ki te mate wareware.
• Ira: Mena kua pāngia tētahi o ngā mema o te whānau tata e te mate a Alzheimer, ka piki ake pea tō tupono ki te pangia e te mate mā te 10% - 30%.
• Whara Roro: Ka taea hoki e ngā whara upoko kino, roa rānei te whakanui ake i te mōrearea.

Engari i ētahi wā ka noho rangitahi tēnei ngaronga mahara. Ka taea hoki e ētahi rongoā, te korenga o ngā huaora, me te kore taurite o ngā homoni tairoi te whakararu i te mahara mō te wā poto.

Nō reira, he tino take tēnei rongoā mō te mate wareware?

I whakahaerehia e ngā kairangahau tētahi rangahau nui hei rapu i tēnei. He rangahau tekau tau te roa. Tata ki te 3,500 ngā tāngata neke atu i te 65 tau te pakeke i whai wāhi ki tēnei. Kāore tētahi o ēnei tāngata i pāngia e te mate wareware i te tīmatanga o te rangahau.

I puritia e ngā kairangahau ngā rēkoata o ngā rongoā katoa i tangohia e ngā kaiuru, arā, ko ngā rongoā i tohua e te tākuta me ngā rongoā e wātea ana mā te kore utu, pērā i te piridine. I whakamātauria e rātou te mahara me ngā pūkenga whakaaro o ngā kaiuru i ia rua tau.

I te mutunga o te rangahau, e 797 o ngā kaiuru kua pāngia e te mate wareware. I roto i a rātou, e 637 i pāngia e te mate a Alzheimer.

I te tātaritanga o ēnei raraunga, i kitea e ngā kairangahau tētahi kitenga whakamiharo. I kitea e rātou he hononga nui i waenga i te hunga i whakamahi i ngā rongoā anticholinergic me te hunga i pāngia e te mate wareware . I kitea anō hoki e rātou ko te roa o te whakamahinga o ēnei rongoā, ka nui ake te tūponotanga ki te pāngia e te mate wareware .

He aha tēnei e tupu nei?

Ko tētahi o ngā ariā matua ko tōna pānga ki te neurotransmitter acetylcholine, he iti noa iho i roto i ngā roro o te hunga e pāngia ana e te mate a Alzheimer. Inaa, ko ētahi rongoā e whakamahia ana hei rongoā i te mate a Alzheimer ka mahi mā te whakanui ake i te nui o te acetylcholine i roto i te roro.

Nō reira, ka āraihia e ngā rongoā anticholinergic te karere acetylcholine, nō reira e whakaaro ana ngā kairangahau koinei pea te take. Engari me nui ake ngā rangahau mō tēnei.