Ma SERM ndi ma SERD a khansa ya m'mawere? Tiyeni tikambirane za mankhwala awa mwachidule (ma SERM ndi ma SERD a khansa ya m'mawere)

Kodi dokotala wanu wakuuzanipo za mtundu wa mankhwala otchedwa SERMs kapena SERDs ochizira khansa ya m'mawere? Musadandaule, mayina awa angamveke ovuta pang'ono. Lero, tikambirana mwachidule za zomwe ali, momwe amagwirira ntchito, komanso zomwe muyenera kudziwa za iwo. Awa ndi mitundu iwiri yofunika kwambiri ya mankhwala yomwe ingatithandize kulimbana ndi khansa ya m'mawere .

Kodi ma SERM ndi chiyani? Amagwira ntchito bwanji?

Mwachidule, ma SERM (Selective Estrogen Receptor Modulators) ndi mtundu wa mankhwala omwe amaletsa kukula kwa maselo a khansa ya m'mawere. Komabe, amagwira ntchito pa mtundu winawake wa khansa. Umenewo ndi mtundu wa khansa wotchedwa Estrogen Receptor-Positive . 75% yokha ya khansa ya m'mawere yomwe imapezeka m'dziko lathu ndi ya mtundu uwu.

Tangoganizirani, maselo a khansa awa ali ndi "ma antenna" ochepa pamwamba pawo. Mu zamankhwala, timatcha ma receptor awa. Pamene hormone ya estrogen m'thupi lathu imamatira ku ma antenna awa, selo la khansa limalandira chizindikiro choti "ligawane ndikukula kwambiri."

Izi ndi zomwe SERMs amachita:

Amapita ndikutseka ma antenna amenewo, kutanthauza ma receptor. Kenako hormone ya estrogen siitha kudziphatika yokha. Chifukwa chakuti silandira chizindikiro, kukula kwa maselo a khansa kumayima kapena kumalamulidwa kwambiri.

Mitundu ya ma SERM ndi momwe amagwiritsidwira ntchito

Pali mitundu ingapo yayikulu ya ma SERM ovomerezeka ku khansa ya m'mawere .

Ndiye kodi ma SERD ndi chiyani?

Ma SERD (Selective Estrogen Receptor Downregulators) ndi mtundu wa mankhwala omwe amagwira ntchito mwamphamvu pang'ono kuposa ma SERM. Monga ma SERM, amaletsanso ma estrogen receptors. Koma kuwonjezera apo, ma SERD amachepetsa chiwerengero cha ma receptor (kuchepetsa) komanso amasintha ntchito ya ma receptor otsala, zomwe zimapangitsa kuti asagwire bwino ntchito.

Pakadali pano pali mitundu iwiri ya ma SERD ovomerezeka:

• Fulvestrant
• Elastrant

Izi zimaperekedwa makamaka kwa khansa ya m'mawere yapamwamba, yokhala ndi mahomoni olandirira komanso khansa ya m'mawere yopanda HER2 . HER2-negative imatanthauza kuti maselo a khansa alibe puloteni yotchedwa HER2 pamwamba pawo yomwe imawathandiza kukula.

Kodi mankhwalawa angagwiritsidwe ntchito bwanji?

• Ma seramu: Ambiri mwa awa amapezeka mu mawonekedwe a mapiritsi . Dokotala wanu adzakuuzani kuti mumwe 20mg mpaka 40mg patsiku. Ngati mukumwa mankhwalawa kuti mupewe khansa kubwereranso, nthawi zambiri muyenera kupitiriza kuwamwa kwa zaka 5 mpaka 10.
• SERDs: Mwachitsanzo, Fulvestrant imabwera ngati jakisoni.Awiri. Jakisoni awiriwa amaperekedwa mu minofu ya m'matako. Amaperekedwa katatu pamwezi woyamba wa chithandizo kenako kamodzi pamwezi pambuyo pake.

Kodi ma SERM ndi ma SERD amaperekedwa m'mikhalidwe iti?

Pali zochitika zingapo zomwe dokotala wanu angakupatseni mankhwala awa.

Kodi zotsatirapo zake ndi zoopsa zake ndi ziti?

Monga mankhwala ena aliwonse, izi zitha kukhala ndi zotsatirapo zake. Koma si aliyense amene amalandira. Ndikofunikira kudziwa zotsatirapo zake.

Zotsatira zoyipa za SERMs

Zotsatirapo zomwe zimawonedwa nthawi zambiri zimakhala zofanana ndi zomwe zimachitika panthawi yosiya kusamba.

• Kutentha kwambiri
• Kuuma kwa nyini, kutuluka magazi pang'ono, kapena kutuluka magazi pang'ono
• Thukuta la usiku
• Kusanza
• Kusintha kwa maganizo

Zotsatira zoyipa zomwe zimachitika kawirikawiri koma zoopsa:

• Kuwonjezeka kochepa kwambiri kwa chiopsezo cha khansa ya m'mimba
• Magazi amaundana m'miyendo (Deep Vein Thrombosis, kapena DVT) kapena magazi amaundana m'mapapo (Pulmonary Embolism)
• Matenda a Cataract
• Kuchepa kwa mafupa mwa akazi asanayambe kusamba

Zotsatira zoyipa za SERDs

• Ululu wakanthawi pamalo obayira jakisoni
• Kusanza
• Kupweteka kwa mafupa, minofu, kapena mafupa
• Mutu
• Kugwira ntchito molimbika
• Kutentha kwambiri

Ngati dokotala wanu akupereka chithandizochi, kambiranani naye za chithandizochi. Musaope kufunsa mafunso monga, "Kodi mankhwalawa adzandipatsa ubwino wotani?", "Ndi zotsatirapo zotani zomwe ndingayembekezere?", ndi "Ndidzafunika kumwa mankhwalawa kwa nthawi yayitali bwanji?"