Kodi inunso muli ndi vuto la magazi? Tiyeni tikambirane za CMML (Chronic Myelomonocytic Leukemia)!

Kodi mudamvapo za matenda otchedwa `CMML` kapena Chronic Myelomonocytic Leukemia ? Mwina ayi. Chifukwa ndi khansa ya m'magazi yomwe siipezeka kawirikawiri. Koma ndikofunikira kwambiri kuti tidziwe izi. Chifukwa zimakhudza momwe thupi lathu limapangira magazi. Tiyeni tikambirane izi mosavuta, m'njira yomwe mungamvetse.

Kodi CMML ndi chiyani? Tiyeni timvetse mosavuta!

Mwachidule, mafuta a m'mafupa anu - gawo lopanda siponji mkati mwa mafupa anu - ndi lomwe limapanga magazi. Munthu amene ali ndi CMML amakhala ndi mtundu wochuluka wa maselo oyera a m'magazi otchedwa monocytes . Ma monocytes osazolowereka amenewa amadzaza maselo ofiira a m'magazi athanzi, ma platelet , ndi maselo ena oyera athanzi omwe timafunikira. Taganizirani izi ngati udzu m'munda womwe umadzaza mitengo yathanzi.

Madokotala amaika vutoli m'gulu la matenda a Myeloproliferative neoplasm/Myelodysplastic syndrome (MPN/ MDS ). Ngakhale kuti izi zingawoneke ngati kuphatikiza mawu kovuta, kwenikweni zimatanthauza:

• Myeloproliferative neoplasm (MPN): Apa ndi pamene mafupa anu amapanga maselo ambiri a mtundu umodzi wa magazi. Pamene maselo ambiri a mtundu umodzi apangidwa, magazi amasokonekera ndipo magazi sagwira ntchito bwino.
• Matenda a Myelodysplastic (MDS): Uwu ndi mkhalidwe umene maselo a m'magazi opangidwa ndi mafupa anu amakhala osazolowereka komanso osawoneka bwino . Makamaka, m'malo mwa maselo athanzi komanso okhwima a m'magazi, amapanga maselo osakhwima otchedwa blast cells.

Nthawi zina CMML imatha kukula pang'onopang'ono. Koma nthawi zina imatha kukula mofulumira komanso moopsa. Dokotala wanu adzakufotokozerani za mankhwala omwe angachepetse kukula kwake.

Kodi zizindikiro za CMML ndi ziti? Kodi inunso muli nazo izi?

Zizindikiro za CMML sizimaonekera nthawi zonse. Nthawi zina kuyezetsa magazi ndiye chizindikiro choyamba. Ngakhale zizindikiro zikaonekera, nthawi zambiri zimabwera pang'onopang'ono. Onani ngati zizindikirozi zikumveka zachilendo kwa inu:

• Kumva kutopa ndi kufooka nthawi zonse: Izi zimachitika chifukwa cha kuchepa kwa maselo ofiira a magazi, komwe ndi kuchepa kwa magazi m'thupi .
• Matenda ndi matenda opatsirana pafupipafupi:Izi zimachitika chifukwa cha kuchepa kwa maselo oyera amagazi, komwe kumatchedwa neutropenia.
• Kutuluka magazi m'mphuno pafupipafupi, kumasintha mtundu wa buluu ngakhale ndi kuvulala pang'ono: Izi zimachitika chifukwa cha kuchepa kwa ma platelet, komwe kumatchedwa thrombocytopenia.
• Splenomegaly : Kukula kwa ndulu, komwe kuli kumtunda kumanzere kwa mimba yanu.
• Hepatomegaly : Kukula kwa chiwindi.
• Kuchepetsa thupi kosamveka bwino.
• Thukuta la usiku.
• Kupweteka kwa mafupa.
• Malungo.

Kumbukirani, si aliyense amene ali ndi zizindikiro zimenezi amene ali ndi CMML. Koma ngati zizindikirozi zikupitirira, ndi bwino kupita kwa dokotala.

Kodi pali chifukwa chenicheni cha CMML?

Ofufuza sakudziwabe chomwe chimayambitsa CMML. Komabe, apeza kusintha kwa majini angapo komwe kumakhudzana ndi matendawa. Ngati mwapezeka ndi CMML, mwina muli ndi kusintha kwa majini kopitilira kamodzi. Zina mwa kusintha kwa majini komwe kumachitika kawirikawiri ndi izi:

• `TET2`
• `SRSF2`
• `ASXL1`
• `RAS` (iyi ndiyo yofala kwambiri)

Dokotala wanu adzakuuzani zambiri za jini iyi.

Ndani ali pachiwopsezo chachikulu chotenga CMML?

Pali zinthu zingapo zomwe zingakhudze kukula kwa CMML:

• Zaka: Chiwopsezo chotenga matendawa chimawonjezeka mukamakula. Avereji ya zaka zomwe munthu amadwala matendawa ndi zaka zapakati pa 73 ndi 75. Izi zikutanthauza kuti theka la anthu omwe apezeka ndi matendawa ndi achichepere kuposa pamenepo, ndipo theka lina ndi achikulire.
• Jenda: CMML imapezeka kwambiri mwa amuna kuposa akazi.
• Chithandizo cha khansa m'mbuyomu: Pafupifupi munthu m'modzi mwa anthu khumi omwe ali ndi CMML adalandirapo kale chemotherapy kapena radiation ya khansa. Koma madokotala amapereka chithandizochi pokhapokha ngati ubwino wa chithandizocho ukuposa chiopsezo chotenga khansa mtsogolo.

Ndi mavuto ena ati omwe angachitike mu mkhalidwe uwu?

Anthu pafupifupi awiri mwa anthu khumi aliwonse omwe ali ndi CMML adzadwala khansa ina yoopsa yamagazi yotchedwa acute myeloid leukemia (AML). Lankhulani ndi dokotala wanu za chiopsezo chanu chokhala ndi AML kutengera matenda anu ndi zoopsa zomwe mwakumana nazo.

Kodi madokotala amazindikira bwanji CMML?

Dokotala wanu adzakufunsani za zizindikiro zanu ndikulemba mbiri yanu yachipatala. Kenako adzakuyesani kangapo kuti aone maselo anu a magazi. Mayesowa angaphatikizepo:

• Kuchuluka kwa magazi (CBC): Ngati chiwerengero cha ma monocytes chili chokwera kwambiri (monocytosis), chikhoza kukhala chizindikiro cha CMML.
• Kuyeza magazi m'thupi: Ngati ma monocytes akuoneka osakhazikika kapena osakhwima (maselo ophulika) akawonedwa pogwiritsa ntchito maikulosikopu, izi zitha kukhalanso chizindikiro cha CMML.
• Kufufuza za mafupa: Nthawi zina dokotala angafunike kutenga chitsanzo cha mafupa ndikuchiyesa mu labu kuti aone ngati pali ma monocytes osazolowereka.
• Kuyezetsa majini: Madokotala amafufuzanso kusintha kwa majini komwe kumakhudzana ndi khansa zina za m'magazi. Izi zimawathandiza kuti athetse matenda ena omwe ali ndi zizindikiro zofanana komanso zotsatira za kuyezetsa magazi.

Kodi magawo a CMML ndi ati?

Madokotala amafufuza momwe CMML yafalikira, kapena momwe yafalikira (kuchuluka kwa khansa), kutengera kuchuluka kwa maselo ophulika m'magazi ndi m'mafupa. Magawo awiriwa ndi awa:

• CMML-1: Maselo ochepera anayi mwa 100 m'magazi mwanu ndi maselo ophulika. Maselo ochepera 9 mwa 100 m'mafupa mwanu ndi maselo ophulika.
• CMML-2: Pakati pa maselo 5 ndi 19 mwa maselo 100 m'magazi mwanu pali maselo ophulika. Pakati pa maselo 10 ndi 19 mwa maselo 100 m'mafupa mwanu pali maselo ophulika.

Ndi panthawiyi pamene dokotala wanu adzasankha chithandizo choyenera komanso chothandiza kwambiri kwa inu.

Kodi mankhwala a CMML ndi ati?

Choyamba, mungafunike chithandizo kuti muwonetsetse kuti muli ndi maselo athanzi okwanira m'magazi. Izi zingaphatikizepo mankhwala owonjezera kuchuluka kwa maselo m'magazi mwanu kapena kuikidwa magazi nthawi zonse. Izi zitha kukhalanso gawo la chisamaliro chochepetsa zizindikiro.

Mankhwala ena omwe amayang'ana mwachindunji CMML ndi awa:

• Kusamutsa maselo oyambira a allogeneic: Iyi ndiyo njira yokhayo yochiritsira CMML kwathunthu . Komabe, si yoyenera aliyense. Ingayambitsenso mavuto omwe angawononge moyo monga matenda a graft-versus-host.
• Mankhwala Oletsa Khansa: Mankhwala Oletsa Khansa amaletsa kukula kosalamulirika kwa ma monocytes. Izi zingathandize kuchepetsa zizindikiro. Izi zimagwiritsa ntchito mankhwala monga Hydroxyurea ndi Hypomethylating agents (HMA).
• Mayeso azachipatala:Ngati njira zina zothandizira sizikuthandiza, dokotala wanu angakulangizeni kuti mutenge nawo mbali mu mayeso azachipatala. Mayeso azachipatala pakadali pano akufufuza momwe mankhwala atsopano (monga chithandizo cholunjika, chithandizo cha immunotherapy) amagwirira ntchito pa CMML.

Ndiyenera kupita kwa dokotala liti?

Muyenera kupita kwa dokotala nthawi zonse (nthawi zambiri kamodzi pamwezi mpaka kamodzi pa miyezi isanu ndi umodzi iliyonse). Ndikofunikira kwambiri kuti mupitirize kukaonana ndi dokotala nthawi zonse. Pa nthawi yokumana ndi dokotala nthawi zonse, dokotala wanu adzakufunsani za zizindikiro zanu, adzakuyesani magazi, adzayang'ana momwe chithandizo chanu chikuyendera, ndikusintha zina zofunika.

Pakadali pano, ngati mukukumana ndi zotsatirapo zoyipa zosayembekezereka komanso zoopsa kuchokera ku chithandizo chanu , lankhulani ndi dokotala wanu nthawi yomweyo . Dokotala wanu adzakuuzani zizindikiro zomwe muyenera kusamala nazo, kutengera chithandizo chomwe mukulandira.

Kodi mungayembekezere chiyani mukakhala ndi vutoli?

Chiyembekezo chapakati cha moyo wa munthu amene wapezeka ndi CMML ndi chaka chimodzi kapena zitatu. Apanso, "median" ndi mtengo wapakati. Izi zikutanthauza kuti theka la anthu akhoza kukhala ndi moyo wautali komanso theka la moyo wautali. Komabe, pali zinthu zambiri zomwe zimapangitsa kuti munthu akhale ndi matenda a shuga. Izi zikuphatikizapo:

• Zotsatira za mayeso a magazi: Kuchuluka kwa maselo a m'magazi anu kungakupatseni chidziwitso cha momwe matenda anu angayendere. Kuchuluka kwa monocyte, blast cell, ndi platelet ndi zinthu zofunika kwambiri. Kuchuluka kwa hemoglobin yanu ndi chinthu chofunikira chomwe dokotala wanu nthawi zambiri amachiyang'ana.
• Kusintha kwa majini: Kusintha kwina kwa majini, mwachitsanzo kusintha kwa majini a `ASXL1`, kumagwirizanitsidwa ndi chiopsezo choipa.
• Kuchuluka kwa magazi omwe amaikidwa: Pokhapokha ngati mukufuna magazi pafupipafupi kuti mubwezeretse maselo anu amagazi, zotsatira zake nthawi zambiri zimakhala zabwino.

Kuyezetsa matenda anu kumadaliranso ngati vuto lanu likupita patsogolo kukhala `AML` (acute myeloid leukemia). Izi zitha kuchitika ngati muli ndi `CMML-2`.

Kodi ndingatani kuti ndikhalebe bwino komanso wamphamvu?

Ngati muli ndi CMML, chimodzi mwazinthu zabwino kwambiri zomwe mungachite ndikutenga udindo pa thanzi lanu m'njira iliyonse yomwe mungathe . Pakadali pano, ndikofunikira kudya zakudya zopatsa thanzi ndikugona mokwanira. Kuyanjana pakati pa kuchita masewera olimbitsa thupi ndi kupuma mokwanira ndikofunikiranso. Kulumikizana ndi ena omwe ali ndi khansa ndi njira yabwino yothanirana ndi kusungulumwa. Lankhulani ndi katswiri wodziwa bwino ntchito ndi odwala khansa.

Khansa ingapangitse munthu kudzimva wopanda thandizo, koma kumbukirani kuti mudakali ndi mphamvu pa moyo wanu.Ndipo pali mankhwala okuthandizani.

Kukhala ndi CMML sikophweka. Zotsatira zanu zimadalira zinthu zambiri zomwe zimakukhudzani. Funsani dokotala wanu kuti akufotokozereni zomwe zimayambitsa matendawa komanso momwe zimakhudzira thanzi lanu. Mvetsetsani njira zomwe mungasankhe kuti mukhale otsimikiza kuti chithandizo chomwe mungasankhe chidzakwaniritsa zolinga zanu.

Uthenga wofunika kwambiri woti upite nawo kunyumba

CMML ndi matenda oopsa. Koma ngati mukudziwa, gwirani ntchito ndi dokotala wanu, pezani chithandizo choyenera, ndikusintha moyo wanu, mutha kuyesa kukhala bwino ndi vutoli. Musataye mtima. Banja lanu, anzanu, ndi madokotala alipo kuti akuthandizeni. Simuli nokha. Ngati muli ndi mafunso kapena nkhawa, musaope kufunsa dokotala wanu. Ndi ufulu wanu.

` CMML, Matenda a Myelomonocytic Leukemia Osatha, Khansa ya Magazi, Mafuta a M'mafupa, Ma monocytes, Zizindikiro, Chithandizo