Zimene muyenera kudziwa zokhudza mankhwala ochepetsa ululu otchedwa COX-2 Inhibitors

Kodi nthawi zambiri mumavutika ndi ululu wa mafupa , kupweteka kwa msana , kapena kupweteka kwambiri komwe kumabwera ndi msambo? Kenako timamwa mankhwala ochepetsa ululu mwachangu. Koma kodi mumadziwa kuti pali mitundu yosiyanasiyana ya mankhwala ochepetsa ululu awa? Lero tikambirana za mtundu wa mankhwala ochepetsa ululu omwe amatenga malo apadera pakati pawo, ndipo amagwira ntchito mosiyana pang'ono. Amenewo ndi mankhwala oletsa COX-2 .

Mwachidule, kodi COX-2 Inhibitors awa ndi chiyani?

Mankhwala oletsa COX-2 kwenikweni ndi gulu la mankhwala omwe amachepetsa ululu ndikuchepetsa kutupa (oletsa kutupa). Dzina lachipatala la gululi ndi NSAIDs, lomwe limayimira Mankhwala Oletsa Kutupa Osagwiritsa Ntchito Ma steroid. Mankhwala monga Ibuprofen , Naproxen , ndi Diclofenac omwe mumamva nthawi zambiri nawonso ali m'gululi lotchedwa NSAIDs .

Komabe, mtundu uwu, wotchedwa COX-2 inhibitors, umagwira ntchito m'thupi mosiyana pang'ono ndi mankhwala achikhalidwe a NSAID omwe tonse timawadziwa. Tiyeni tiwone kusiyana kwake.

Kodi mankhwalawa amagwira ntchito bwanji m'thupi? Ndi njira yodabwitsa kwambiri!

Kuti timvetse izi, choyamba tiyenera kumvetsetsa mitundu iwiri ya ma enzyme m'thupi lathu. Awa ndi ma enzyme a COX-1 ndi COX-2 . Ma enzyme onsewa amapanga mankhwala m'thupi lathu otchedwa prostaglandins . Ma prostaglandins awa ndiye chifukwa chachikulu chomwe timamva kupweteka, kutupa (kutupa), ndi malungo.

Tangoganizirani izi: Pali antchito awiri mkati mwa fakitale yotchedwa thupi lathu.

• COX-1 (wogwira ntchito woyamba): Uyu ndi wothandiza kwambiri. Amapanga ma prostaglandins omwe amayambitsa kupweteka ndi kutupa. Koma kuwonjezera pa zimenezo, amachita zinthu ziwiri zofunika kwambiri . Choyamba ndikuteteza mkati mwa m'mimba ndi matumbo athu ku asidi m'mimba. Chinanso ndikuthandiza pakutseka magazi.
• COX-2 (Wogwira Ntchito 2): Vuto lenileni ndi ili. Ntchito yake yaikulu ndi kupanga ma prostaglandins omwe amayambitsa ululu ndi kutupa.

Tsopano onani, tikamamwa mankhwala ochepetsa ululu (NSAIDs zosasankha) monga Ibuprofen ndi Diclofenac, mankhwalawa amaletsa onse awiriwa. Kenako, chifukwa COX-2 yasiya, ululu ndi kutupa zimachepa. Koma chifukwa chakuti wogwira ntchito wabwino, ndiko kuti, COX-1, yasiya, chitetezo cha m'mimba chimatayika , ndipo mwayi wa gastritis, kutupa m'mimba, komanso mwina zilonda zimawonjezeka.

Kodi zoletsa za COX-2 zimagwiritsidwa ntchito pa matenda otani?

Madokotala amalimbikitsa mtundu uwu wa mankhwala kuti achepetse ululu wochepa mpaka wapakati komanso kutupa komwe kumachitika chifukwa cha matenda osiyanasiyana.

Komanso, dokotala wanu angaperekenso mankhwalawa pa matenda monga gout ndi migraine.

Kodi zoopsa ndi zotsatirapo zake zogwiritsa ntchito COX-2 Inhibitors ndi ziti?

Ngakhale kuti zotsatira zake zimakhala zochepa m'mimba, zoletsa za COX-2 si mankhwala opanda chiopsezo konse. Pakhoza kukhala zoopsa zina , makamaka zikagwiritsidwa ntchito pa mlingo waukulu komanso kwa nthawi yayitali .

Zoopsa zazikulu

• Matenda a mtima ndi sitiroko: Mankhwala oletsa COX-2 apezeka kuti akugwirizana ndi chiopsezo chowonjezeka pang'ono cha matenda a mtima ndi sitiroko. Chiwopsezochi chimakhala chachikulu kwambiri mwa anthu omwe ali kale ndi matenda a mtima kapena zinthu zomwe zimayambitsa matendawa. Pachifukwa ichi, mankhwala ena oletsa COX-2, monga `Rofecoxib (Vioxx®)` ndi `Valdecoxib (Bextra®)`, achotsedwa pamsika.
• Mavuto a m'mimba ndi m'matumbo: Ngakhale kuwonongeka kwa m'mimba kumachepa, sikumatha konse. Anthu ena amatha kutuluka magazi ndi zilonda .

Zotsatira zoyipa zofala

Ndani sayenera kumwa COX-2 Inhibitors?

Dokotala wanu adzawunikanso mbiri yanu yonse ya thanzi kuti adziwe ngati mankhwalawa ndi oyenera kwa inu. Muyenera kupewa kumwa mankhwalawa ngati muli ndi vuto lililonse mwa izi:

• Ngati munadwalapo sitiroko kale.
• Ngati mwachita opaleshoni ya mitsempha ya mtima posachedwapa kapena mukufuna kuchitidwa opaleshoni ya mtima.
• Ngati muli ndi matenda aakulu a impso kapena matenda a chiwindi .
• Ngati munayamba mwadwalapo mphumu kapena muli ndi vuto lalikulu la ziwengo chifukwa cha NSAID ina, aspirin, kapena mankhwala opha tizilombo toyambitsa matenda a sulfa.
• Ngati muli ndi mimba miyezi itatu yomaliza .
• Ngati ndinu mayi woyamwitsa (lankhulani ndi dokotala wanu za izi).

Kodi muyenera kupita kwa dokotala nthawi yomweyo liti?

Ngati mukukumana ndi zizindikiro zotsatirazi mukumwa mankhwalawa, musachedwe ndipo pitani kwa dokotala nthawi yomweyo kapena pitani ku chipatala chapafupi cha Emergency Department (ETU) .

• Zizindikiro za vuto la chiwindi: mkodzo wakuda, kutopa kwambiri, khungu kapena maso achikasu, ndowe zowala, kuvutika m'mimba.
• Zizindikiro za kutuluka magazi: kusanza magazi kapena kusanza komwe kumaoneka ngati khofi, kutuluka magazi m'chimbudzi (ndowe zakuda kapena zofiira zakuda), kutuluka magazi m'mkodzo, kutuluka magazi m'kamwa, kuvulala kosazolowereka pakhungu.
• Zizindikiro za vuto la impso: kulephera kukodza, kusintha kwa kuchuluka kwa mkodzo, kuwonjezeka kwa thupi mwadzidzidzi.
• Zizindikiro za vuto lalikulu la ziwengo: ziphuphu pakhungu kapena ziphuphu, kuyabwa, kupuma movutikira, kutupa kwa nkhope, milomo, kapena lilime.
• Zizindikiro za matenda a mtima: kupweteka pachifuwa, kupuma movutikira, kupweteka komwe kumafika pa nsagwada kapena paphewa.
• Zizindikiro za sitiroko: dzanzi mbali imodzi ya thupi, kuvutika kulankhula, nkhope kugwa.