Ngati wina m'banja mwanu, mwina amayi anu okondedwa, abambo anu, kapena agogo anu, akudwala matenda a Alzheimer's, tikudziwa momwe zimakhalira zopweteka. N'zomvetsa chisoni kwambiri kuona kukumbukira kwa wokondedwa wanu kukutha pang'onopang'ono. Komabe, pakati pa vutoli, tikulankhula za nkhani yomwe imabweretsa chiyembekezo pang'ono. Iyi si mankhwala athunthu a matendawa, koma ikhoza kukhala sitepe yofunika kwambiri.
Nkhani yatsopano iyi ndi yotani?
Posachedwapa, gulu la alangizi la US Food and Drug Administration (FDA) linavomereza motsimikiza kuti mankhwala atsopano a Alzheimer's ndi olondola. Dzina la mankhwalawa ndi
donanemab . Akulimbikitsidwa kwa odwala
omwe ali kumayambiriro kwa matendawa. Kuvomerezedwa kwa gulu la alangizili kumatanthauza kuti pali mwayi waukulu kuti FDA ivomereza mankhwalawa posachedwa. Izi ndi nkhani yaikulu, chifukwa kufika kwa chithandizo chatsopano cha matenda oopsa ngati Alzheimer's ndi chiyembekezo chachikulu.
Kodi Donanemab imagwira ntchito bwanji?
Chabwino, tsopano tiyeni tiwone momwe mankhwalawa amagwirira ntchito. Izi ndi zovuta pang'ono, koma ndifotokoza mwachidule. Donanemab ndi mtundu wa mankhwala otchedwa
monoclonal antibody . Mwachidule, ndi puloteni yapadera yomwe imapangidwa mu labu kuti iukire chinthu china pogwiritsa ntchito ziwalo zina za chitetezo chathu chamthupi. Kodi cholinga cha mankhwalawa ndi chiyani? Ndi
ma amyloid plaques , omwe amaganiziridwa kuti ndi omwe amachititsa kwambiri matenda a Alzheimer's. Monga momwe dzimbiri limakhalira m'mapaipi athu amadzi, ma plaques awa amasonkhana pakati pa maselo amitsempha muubongo ndikusokoneza ntchito yawo. Chomwe Donanemab amachita ndi kuzindikira ma plaques awa ndikuthandizira kuwachotsa.
Chofunika kwambiri ndichakuti izi si mankhwala a matendawa. Komabe, zimatha kuchepetsa kuchuluka kwa matendawa. Izi zikutanthauza kuti zingathandize wodwala kusunga kukumbukira kwawo komanso luso lawo lochita ntchito za tsiku ndi tsiku kwa nthawi yayitali.
Kodi mankhwalawa ndi othandiza bwanji?
Malinga ndi zotsatira za mayeso azachipatala omwe adasindikizidwa chaka chatha, chithandizochi
chingachepetse kuchuluka kwa matendawa mkati mwa miyezi ingapo.Zakhala zotheka. Izi zimayesedwa kudzera mu mayeso omwe amayesa luso la odwala la nzeru (monga kukumbukira, kuthetsa mavuto) komanso momwe amachitira bwino ntchito za tsiku ndi tsiku (monga kuyendetsa galimoto, kusamalira ndalama). Akatswiri ena amati zotsatirazi ndi zochepa kapena "zabwinobwino". Izi zikutanthauza kuti simungayembekezere kusiyana kwakukulu kuchokera pa izi. Koma ndikwabwinonso kuti matendawa amatha kuchepetsedwa m'miyezi ingapo yokha, m'malo mopitirira muyeso popanda chithandizo chilichonse. Ponena za momwe chithandizocho chimaperekedwera, mankhwalawa amaperekedwa kwa odwala mwezi uliwonse kudzera mu mtsempha (infusion). Omwe adatenga nawo mbali mu mayesowa apatsidwa chithandizochi kwa pafupifupi chaka chimodzi ndi theka.
Pali ubwino komanso zoopsa zazikulu.
Monga mankhwala aliwonse amphamvu, donanemab ili ndi ubwino komanso zotsatirapo zake zoopsa. Ndikofunikira kumvetsetsa mbali zonse ziwiri musanapange chisankho.
| Ubwino | Zoopsa ndi Zoyipa |
|---|
| Kuchepetsa liwiro lomwe matendawa amakulirakulira. | Zotsatirapo zoyipa: Pali chiopsezo cha kutupa kwa ubongo kapena kutuluka magazi mu ubongo. |
| Kuthandiza kusunga kukumbukira ndi luso lochita ntchito za tsiku ndi tsiku kwa nthawi yayitali. | Pa nthawi ya mayeso azachipatala, anthu atatu omwe anamwalira chifukwa cha chithandizochi adanenedwa. |
| Kuyang'ana kwambiri ma plaque muubongo omwe amayambitsa matendawa. | Mtengo wokwera: Malinga ndi ziwerengero za ku America, mtengo wa chithandizo pachaka ukhoza kukhala pafupifupi $6,600 (pafupifupi ma rupee 2 miliyoni aku Sri Lanka). |
| Kubweretsa chiyembekezo chatsopano kwa odwala matenda a Alzheimer ndi mabanja awo. | Kubwera kuchipatala mwezi uliwonse kuti akalandire chithandizo ndikubayidwa mankhwala kudzera m'mitsempha. |
Ngakhale kuti panali zinthu zonsezi, gulu la alangizi la FDA linaganiza kuti
ubwino wa mankhwalawa ndi woposa zoopsa zake.Ndiko kuti, ngati iperekedwa kwa odwala oyenera, moyang'aniridwa bwino, ubwino wake umakhala waukulu.
Kodi iyi ndi mankhwala okhawo atsopano omwe alipo?
Ayi. Pali mankhwala ena omwe amagwira ntchito mofananamo. Amatchedwa
lecanemab . Mankhwalawa amagwiranso ntchito polimbana ndi ma platelet omwe amasonkhana muubongo. Adavomerezedwa ndi FDA mu Julayi 2023. Donanemab ndi gawo lina paulendowu. Mabungwe otsogola padziko lonse lapansi a Alzheimer's ali ndi chiyembekezo chachikulu cha mankhwala atsopano ngati awa. Amati, "Machiritso ovomerezedwa ngati awa akatuluka, mwayi wa odwala omwe akuyenera kulandira mankhwalawa umawonjezeka. Kupita patsogolo komveka bwino kukuchitika pankhani ya chithandizo." Pakadali pano, anthu mamiliyoni ambiri padziko lonse lapansi akuvutika ndi matenda a Alzheimer's. Palibe njira yopewera kapena kuchiritsa matendawa kwathunthu. Chifukwa chake, mankhwala monga donanemab ndi ofunika kwambiri paulendo wautaliwu.
Uthenga Wopita Nawo Kunyumba
- Donanemab ndi mankhwala atsopano omwe atsala pang'ono kuvomerezedwa kuti athandize matenda a Alzheimer's kumayambiriro .
- Izi sizingachiritse matendawa, koma zitha kuchepetsa kuchuluka kwa zizindikiro zomwe zimakula kwa miyezi ingapo .
- Kuphatikiza pa ubwino wa chithandizochi, palinso zoopsa zazikulu , monga kutupa kwa ubongo ndi kutuluka magazi .
- Chisankho chomwa mankhwala awa kapena ayi chiyenera kupangidwa mutakambirana bwino ndi dokotala wanu za matenda ndi zoopsa za wodwalayo, komanso mutaganizira bwino zabwino ndi zoyipa zake.
- Ndi bwino kudziwa za mankhwala atsopano ngati awa, koma onetsetsani kuti mwafunsa upangiri kwa dokotala wodziwa bwino ntchito musanapange chisankho chilichonse.
Matenda a Alzheimer's, donanemab, matenda a ubongo, kulephera kukumbukira, matenda a dementia, mankhwala atsopano, antibody ya monoclonal
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