Kodi mumayambanso tsiku lanu ndi kupweteka kwa msana ndi ululu mukangodzuka m'mawa? Kodi ululuwu umachepa mukayenda pang'ono, kuchita chinthu chothandiza, ndikuwonjezekanso mukadali chete? Izi zitha kukhala zizindikiro zodziwika bwino za matenda otchedwa Ankylosing Spondylitis (AS). Uwu ndi vuto losasangalatsa lomwe limasokoneza moyo watsiku ndi tsiku. Monga chithandizo cha izi, madokotala amayamba akupereka mankhwala ochepetsa ululu (NSAIDs). Ngati izi sizikulamulira matendawa, angakutumizireni jakisoni wotchedwa biologics. Komabe, anthu ena sapeza mpumulo kuchokera ku mankhwalawa, kapena zotsatira zake zimakhala zovuta kuzipirira. Kodi mukukumana ndi zomwezo? Ngati ndi choncho, musadandaule. Ndi kupita patsogolo kwa sayansi ya zamankhwala, chithandizo china chatsopano komanso chopambana tsopano chawonekera. Chimenecho ndi Janus Kinase (JAK) inhibitors . Tiyeni tikambirane za izi lero.
Kodi JAK Inhibitors ndi chiyani?
Mankhwala oletsa JAK ndi gulu latsopano la mankhwala ochizira ankylosing spondylitis. Monga mankhwala a biologic, ali m'gulu la mankhwala otchedwa disease-modifying antirheumatic drugs (DMARDs). "Disease-modifying" amatanthauza kuti mankhwalawa samangochepetsa ululu. Amawongoleranso kuwonongeka kwa msana ndi mafupa ena, zomwe zimapangitsa kuti matendawa achedwetse kupita patsogolo.
Koma izi sizigwiritsidwa ntchito pa Ankylosing Spondylitis yokha. Mankhwala amtundu uwu amavomerezedwanso pa matenda ena angapo odziteteza ku matenda ena. Ndiko kuti, matenda omwe chitetezo cha mthupi chimaukira maselo ake.
- Matenda a nyamakazi
- Matenda a nyamakazi a achinyamata (JIA) a polyarticular course
- Matenda a nyamakazi
- Matenda a m'matumbo
Chinthu chapadera ndichakuti mutha kumwa izi ngati mapiritsi m'malo molandira jakisoni monga mankhwala a biologics. Chifukwa chake izi ndi mpumulo waukulu kwa iwo omwe amaopa jakisoni.
Ndi mitundu iti ya matenda omwe amagwiritsidwa ntchito pochiza Ankylosing Spondylitis?
Pakadali pano, mitundu iwiri ya mankhwala oletsa JAK avomerezedwa kuti agwiritsidwe ntchito pochiza Ankylosing Spondylitis.
- Tofacitinib (dzina la mtundu: Xeljanz, Xeljanz-XR)
- Upadacitinib (dzina la kampani: Rinvoq)
Izi nthawi zambiri zimaperekedwa kwa odwala omwe zizindikiro zawo sizinathetsedwe ndi mankhwala amodzi kapena angapo otchedwa TNF inhibitors, kapena omwe sangathe kulekerera zotsatirapo zoyipa za mankhwalawa. Chifukwa chake, dokotala wanu adzawunikanso mosamala mbiri yanu yonse yazachipatala asanakupatseni mankhwalawa.
Kodi mankhwalawa amagwira ntchito bwanji?
Kuti timvetse izi, tiyeni titenge chitsanzo chaching'ono. Tangoganizani kuti chitetezo cha mthupi lathu ndi gulu lalikulu lankhondo. Mu matenda monga Ankylosing Spondylitis, gululi limalandira uthenga wolakwika ndipo limayamba kuukira mafupa a dziko lawo (thupi lathu). Kuukira kumeneku ndi komwe kumayambitsa kupweteka ndi kutupa (kutupa).
Pali "amithenga" ena omwe amatumiza mauthenga olakwika awa. Amatchedwa ma enzyme a JAK . Ma enzyme amenewa ndi omwe amauza maselo a chitetezo chamthupi kuti "apite kukaukira," mankhwala otchedwa ma cytokines.
Mankhwala otchedwa JAK inhibitors amachita ndikuletsa ma messengers omwewo (ma JAK enzymes). Izi zimaletsa kufalikira kwa mauthenga olakwikawo ndikuchepetsa mphamvu ya chitetezo cha mthupi kuukira mafupa.
Mankhwala a biologic amagwira ntchito mosiyana pang'ono. Mankhwala a biologic amalimbana ndi kuletsa cytokine inayake, monga TNF kapena IL-17. JAK inhibitors amaletsa kupanga ma cytokine angapo nthawi imodzi. Mwachidule, amaletsa vutoli poyamba.
Kodi pali zotsatirapo zilizonse?
Monga mankhwala ena aliwonse, pali mwayi woti zotsatira zake zingakhalepo. Koma kwa anthu ambiri, zimakhala zotetezeka. Dokotala wanu adzakuyang'anirani mosamala musanayambe kumwa mankhwalawa komanso pamene mukumwa.
| Mtundu wa zotsatira zoyipa | Kufotokozera |
|---|---|
| Zotsatira zoyipa zofala (nthawi zambiri si zoopsa) |
|
| Zotsatira zoyipa zomwe sizichitika kawirikawiri (Chenjezo Lolembedwa M'bokosi) |
Zambiri pang'ono za zotsatirapo zoyipa
Popeza mankhwala amenewa amaletsa chitetezo chamthupi, mphamvu ya thupi yolimbana ndi majeremusi monga mabakiteriya ndi mavairasi imachepa pang'ono. Izi zimawonjezera chiopsezo cha matenda.
Kuyezetsa chifuwa chachikulu (TB): Musanayambe kumwa mankhwalawa, dokotala wanu adzakuyezeni chifuwa chachikulu. Anthu ena akhoza kukhala ndi mabakiteriya a chifuwa chachikulu m'thupi lawo. Mukagwiritsa ntchito mankhwala oletsa JAK, mabakiteriya amenewa amatha kugwira ntchito. Chifukwa chake, dokotala wanu adzakuyang'anirani izi panthawi ya chithandizo.
Chofunika: Mukamamwa mankhwalawa, muyenera kupewa kulandira katemera wamoyo. Zitsanzo zake ndi monga chikuku, mumps, rubella (MMR), ndi rotavirus. Katemerayu angakupangitseni kudwala chifukwa chitetezo chanu cha mthupi chimakhala chofooka panthawiyo. Onetsetsani kuti mwalankhula ndi dokotala wanu musanalandire katemera aliyense.
Kodi ndiyenera kuyembekezera chiyani ndikamayamba kumwa mankhwala?
Anthu ena amayamba kumva mpumulo ku zizindikiro zawo pasanathe milungu iwiri kuchokera pamene anayamba kumwa mankhwalawa. Komabe, zingatenge miyezi 6 kuti anthu ena amve mpumulo wonse. Izi zimasiyana malinga ndi munthu aliyense.
Ngati simukumva bwino mutamwa mankhwala kwa miyezi ingapo, musachite mantha ndipo lankhulani ndi dokotala wanu za vutoli ndipo funsani upangiri wa zomwe mungachite kenako.
Uthenga Wopita Nawo Kunyumba
- Mankhwala oletsa JAK ndi gulu latsopano la mankhwala omwe amapezeka ngati mapiritsi a ankylosing spondylitis. Nthawi zambiri amaperekedwa kwa anthu omwe alephera kulandira chithandizo china.
- Mankhwalawa samangochepetsa ululu, komanso amaletsa kuwonongeka kwa mafupa.
- Izi ndizosavuta kugwiritsa ntchito chifukwa sizifuna jakisoni monga mankhwala achilengedwe.
- Monga mankhwala ena onse, mankhwalawa akhoza kukhala ndi zotsatirapo zake. Chifukwa chake, ndikofunikira kuti muyeze magazi nthawi zonse motsogozedwa ndi dokotala.
- Musayambe, kusiya, kapena kusintha mlingo wa mankhwala awa popanda upangiri wa dokotala.
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